{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:48:19Z","timestamp":1780105699311,"version":"3.54.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.fsi.2024.110108","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:18:02Z","timestamp":1735604282000},"page":"110108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["The haemocyte highly-expressed E-type prostanoid receptor regulates TNF expression during immune response of oyster Crassostrea gigas"],"prefix":"10.1016","volume":"157","author":[{"given":"Xuemei","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2094-2161","authenticated-orcid":false,"given":"Weilin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miren","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junlei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3085-3392","authenticated-orcid":false,"given":"Jiajun","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linsheng","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.fsi.2024.110108_bib1","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.4049\/jimmunol.167.5.2831","article-title":"Roles of cyclooxygenase (COX)-1 and COX-2 in prostanoid production by human endothelial cells: selective up-regulation of prostacyclin synthesis by COX-2","volume":"167","author":"Caughey","year":"2001","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.fsi.2024.110108_bib2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.plefa.2013.08.003","article-title":"Anti-inflammatory properties of prostaglandin E2: deletion of microsomal prostaglandin E synthase-1 exacerbates non-immune inflammatory arthritis in mice","volume":"89","author":"Frolov","year":"2013","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"issue":"6","key":"10.1016\/j.fsi.2024.110108_bib3","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1189\/jlb.1002483","article-title":"Prostaglandin E2 modulates dendritic cell function via EP2 and EP4 receptor subtypes","volume":"73","author":"Harizi","year":"2003","journal-title":"J. Leukoc. Biol."},{"issue":"6","key":"10.1016\/j.fsi.2024.110108_bib4","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nm.1968","article-title":"Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion","volume":"15","author":"Yao","year":"2009","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.fsi.2024.110108_bib5","article-title":"Sequence analysis and identification of new isoform of EP4 receptors in different atlantic salmon tissues (Salmo salar L.) and its role in PGE2 induced immunomodulation in vitro","volume":"10","author":"Guo","year":"2015","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.fsi.2024.110108_bib6","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/intimm\/dxz021","article-title":"Molecular mechanisms underlying prostaglandin E2-exacerbated inflammation and immune diseases","volume":"31","author":"Tsuge","year":"2019","journal-title":"Int. Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2024.110108_bib7","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1124\/mol.51.2.343","article-title":"The long cytoplasmic carboxyl terminus of the prostaglandin E2 receptor EP4 subtype is essential for agonist-induced desensitization","volume":"51","author":"Bastepe","year":"1997","journal-title":"Mol. Pharmacol."},{"issue":"1","key":"10.1016\/j.fsi.2024.110108_bib8","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41589-018-0131-3","article-title":"Ligand binding to human prostaglandin E receptor EP(4) at the lipid-bilayer interface","volume":"15","author":"Toyoda","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.fsi.2024.110108_bib9","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1100\/tsw.2007.184","article-title":"Prostanoid receptors in the human vascular wall","volume":"7","author":"Norel","year":"2007","journal-title":"TheScientificWorldJOURNAL"},{"issue":"3","key":"10.1016\/j.fsi.2024.110108_bib10","doi-asserted-by":"crossref","first-page":"289","DOI":"10.7888\/juoeh.24.289","article-title":"[Regulation of immune responses by prostaglandin]","volume":"24","author":"Kuroda","year":"2002","journal-title":"J. UOEH"},{"issue":"4","key":"10.1016\/j.fsi.2024.110108_bib11","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.4049\/jimmunol.180.4.2125","article-title":"Prostaglandin E2 suppresses lipopolysaccharide-stimulated IFN-beta production","volume":"180","author":"Xu","year":"2008","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2024.110108_bib12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4049\/jimmunol.1101029","article-title":"Regulation of immune responses by prostaglandin E2","volume":"188","author":"Kalinski","year":"2012","journal-title":"J. Immunol."},{"issue":"16","key":"10.1016\/j.fsi.2024.110108_bib13","doi-asserted-by":"crossref","first-page":"11873","DOI":"10.1016\/S0021-9258(17)32654-6","article-title":"Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype","volume":"269","author":"Bastien","year":"1994","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.fsi.2024.110108_bib14","doi-asserted-by":"crossref","first-page":"7759","DOI":"10.1016\/S0021-9258(18)53022-2","article-title":"Cloning and expression of a cDNA for mouse prostaglandin E receptor EP2 subtype","volume":"268","author":"Honda","year":"1993","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.fsi.2024.110108_bib15","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ygcen.2008.04.001","article-title":"Molecular cloning and characterization of chicken prostaglandin E receptor subtypes 2 and 4 (EP2 and EP4)","volume":"157","author":"Kwok","year":"2008","journal-title":"Gen. Comp. Endocrinol."},{"issue":"1","key":"10.1016\/j.fsi.2024.110108_bib16","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1101\/gad.1374506","article-title":"Cyclooxygenase-1-derived PGE2 promotes cell motility via the G-protein-coupled EP4 receptor during vertebrate gastrulation","volume":"20","author":"Cha","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.fsi.2024.110108_bib17","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1186\/1471-2164-11-279","article-title":"Salmo salar and Esox lucius full-length cDNA sequences reveal changes in evolutionary pressures on a post-tetraploidization genome","volume":"11","author":"Leong","year":"2010","journal-title":"BMC Genom."},{"key":"10.1016\/j.fsi.2024.110108_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2022.104376","article-title":"The receptor CgIL-17R1 expressed in granulocytes mediates the CgIL-17 induced haemocytes proliferation in Crassostrea gigas","volume":"131","author":"Cao","year":"2022","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2024.110108_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2019.103467","article-title":"The sensing pattern and antitoxic response of Crassostrea gigas against extracellular products of Vibrio splendidus","volume":"102","author":"Wang","year":"2020","journal-title":"Dev. Comp. Immunol."},{"issue":"7418","key":"10.1016\/j.fsi.2024.110108_bib20","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nature11413","article-title":"The oyster genome reveals stress adaptation and complexity of shell formation","volume":"490","author":"Zhang","year":"2012","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.fsi.2024.110108_bib21","doi-asserted-by":"crossref","first-page":"640","DOI":"10.4049\/jimmunol.2100007","article-title":"CLec-TM1-ERK-GSK3\u03b2 pathway regulates Vibrio splendidus-induced IL-17 production in oyster","volume":"207","author":"Sun","year":"2021","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2024.110108_bib22","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.dci.2015.08.002","article-title":"CgIL17-5, an ancient inflammatory cytokine in Crassostrea gigas exhibiting the heterogeneity functions compared with vertebrate interleukin17 molecules","volume":"53","author":"Xin","year":"2015","journal-title":"Dev. Comp. Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2024.110108_bib23","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.jaci.2018.09.030","article-title":"Imatinib stimulates prostaglandin E(2) and attenuates cytokine release via EP4 receptor activation","volume":"143","author":"B\u00e4rnthaler","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"issue":"8","key":"10.1016\/j.fsi.2024.110108_bib24","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00018-023-04865-x","article-title":"Dietary restriction to optimize T cell immunity is an ancient survival strategy conserved in vertebrate evolution","volume":"80","author":"Li","year":"2023","journal-title":"Cell. Mol. Life Sci. : CM"},{"issue":"Pt 1","key":"10.1016\/j.fsi.2024.110108_bib25","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1242\/jeb.01275","article-title":"Prostaglandins in non-insectan invertebrates: recent insights and unsolved problems","volume":"208","author":"Rowley","year":"2005","journal-title":"J. Exp. Biol."},{"issue":"46","key":"10.1016\/j.fsi.2024.110108_bib26","doi-asserted-by":"crossref","first-page":"44147","DOI":"10.1074\/jbc.M204810200","article-title":"Prostaglandin E2 suppresses chemokine production in human macrophages through the EP4 receptor","volume":"277","author":"Takayama","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.fsi.2024.110108_bib27","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.pharmthera.2013.03.006","article-title":"E-type prostanoid receptor 4 (EP4) in disease and therapy","volume":"138","author":"Konya","year":"2013","journal-title":"Pharmacol. Therapeut."},{"issue":"2","key":"10.1016\/j.fsi.2024.110108_bib28","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.fsi.2015.07.024","article-title":"Characterization of interleukin-1\u03b2 as a proinflammatory cytokine in grass carp (Ctenopharyngodon idella)","volume":"46","author":"Bo","year":"2015","journal-title":"Fish Shellfish Immunol."},{"issue":"16","key":"10.1016\/j.fsi.2024.110108_bib29","doi-asserted-by":"crossref","first-page":"11613","DOI":"10.1074\/jbc.R600038200","article-title":"Prostaglandin E receptors","volume":"282","author":"Sugimoto","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fsi.2024.110108_bib30","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1100\/tsw.2007.182","article-title":"Prostaglandin receptor signaling in disease","volume":"7","author":"Matsuoka","year":"2007","journal-title":"TheScientificWorldJOURNAL"},{"issue":"3","key":"10.1016\/j.fsi.2024.110108_bib31","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2332\/allergolint.R-08-161","article-title":"Prostaglandin as a target molecule for pharmacotherapy of allergic inflammatory diseases","volume":"57","author":"Nagai","year":"2008","journal-title":"Allergol. Int."},{"issue":"1","key":"10.1016\/j.fsi.2024.110108_bib32","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1124\/mol.105.017749","article-title":"EP(4) prostanoid receptor coupling to a pertussis toxin-sensitive inhibitory G protein","volume":"69","author":"Fujino","year":"2006","journal-title":"Mol. Pharmacol."},{"issue":"28","key":"10.1016\/j.fsi.2024.110108_bib33","doi-asserted-by":"crossref","first-page":"29797","DOI":"10.1074\/jbc.M313989200","article-title":"Colon carcinoma cell growth is associated with prostaglandin E2\/EP4 receptor-evoked ERK activation","volume":"279","author":"Pozzi","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"22","key":"10.1016\/j.fsi.2024.110108_bib34","doi-asserted-by":"crossref","first-page":"5239","DOI":"10.1111\/bph.13331","article-title":"Prostaglandin E2 and the EP receptors in malignancy: possible therapeutic targets?","volume":"172","author":"O'Callaghan","year":"2015","journal-title":"Br. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.fsi.2024.110108_bib35","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1002\/glia.20658","article-title":"Regulation of prostaglandin E2 synthase expression in activated primary rat microglia: evidence for uncoupled regulation of mPGES-1 and COX-2","volume":"56","author":"de Oliveira","year":"2008","journal-title":"Glia"},{"issue":"2","key":"10.1016\/j.fsi.2024.110108_bib36","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1213\/ANE.0b013e3181e3a2a2","article-title":"Release of prostaglandin E(2) and nitric oxide from spinal microglia is dependent on activation of p38 mitogen-activated protein kinase","volume":"111","author":"Matsui","year":"2010","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.fsi.2024.110108_bib37","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1742-2094-9-2","article-title":"Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia","volume":"9","author":"de Oliveira","year":"2012","journal-title":"J. Neuroinflammation"},{"issue":"3","key":"10.1016\/j.fsi.2024.110108_bib38","first-page":"133","article-title":"Molecular characterization of an IL-1\u03b2 gene from the large yellow croaker (Larimichthys crocea) and its effect on fish defense against Vibrio alginolyticus infection","volume":"36","author":"Wu","year":"2015","journal-title":"Dong wu xue yan jiu = Zoological research"},{"issue":"1","key":"10.1016\/j.fsi.2024.110108_bib39","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.fsi.2015.09.016","article-title":"A synthetic peptide derived from the D1 domain of flagellin induced the expression of proinflammatory cytokines in fish macrophages","volume":"47","author":"Gonz\u00e1lez-Stegmaier","year":"2015","journal-title":"Fish Shellfish Immunol."},{"issue":"11","key":"10.1016\/j.fsi.2024.110108_bib40","doi-asserted-by":"crossref","first-page":"5472","DOI":"10.4049\/jimmunol.1401343","article-title":"Prostaglandin E2 inhibits NLRP3 inflammasome activation through EP4 receptor and intracellular cyclic AMP in human macrophages","volume":"194","author":"Sokolowska","year":"2015","journal-title":"J. Immunol."}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105046482400754X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105046482400754X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:44:46Z","timestamp":1740530686000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S105046482400754X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":40,"alternative-id":["S105046482400754X"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2024.110108","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The haemocyte highly-expressed E-type prostanoid receptor regulates TNF expression during immune response of oyster Crassostrea gigas","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2024.110108","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110108"}}