{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T12:08:31Z","timestamp":1778587711837,"version":"3.51.4"},"reference-count":93,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017526","name":"International Cooperation Project of Ningbo City","doi-asserted-by":"publisher","award":["2023H015"],"award-info":[{"award-number":["2023H015"]}],"id":[{"id":"10.13039\/501100017526","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.fsi.2025.110228","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T11:16:34Z","timestamp":1740568594000},"page":"110228","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Analysis of gill and skin microbiota in Larimichthys crocea reveals bacteria associated with cryptocaryoniasis resistance potential"],"prefix":"10.1016","volume":"161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5241-6900","authenticated-orcid":false,"given":"Xiao","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kangshuai","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aowei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rujiang","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0539-4876","authenticated-orcid":false,"given":"Fei","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.fsi.2025.110228_bib1","first-page":"1043","article-title":"Disease measurement and control of large yellow croaker in Zhejiang Province from 2014 to 2016","volume":"58","author":"Cao","year":"2017","journal-title":"Journal of Zhejiang Agricultural Sciences"},{"issue":"1\u20132","key":"10.1016\/j.fsi.2025.110228_bib2","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/0044-8486(87)90041-X","article-title":"Biology of Cryptocaryon irritans and strategies for its control","volume":"67","author":"Colorni","year":"1987","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2025.110228_bib3","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0065-2881(01)40004-6","article-title":"Structural, histochemical and functional aspects of the epidermis of fishes","volume":"40","author":"Zaccone","year":"2001","journal-title":"Adv. Mar. Biol."},{"issue":"11","key":"10.1016\/j.fsi.2025.110228_bib4","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.tree.2019.07.012","article-title":"The pathobiome in animal and plant diseases","volume":"34","author":"Bass","year":"2019","journal-title":"Trends Ecol. Evol."},{"issue":"6","key":"10.1016\/j.fsi.2025.110228_bib5","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/j.fsi.2013.09.032","article-title":"The mucosal immune system of fish: the evolution of tolerating commensals while fighting pathogens","volume":"35","author":"Gomez","year":"2013","journal-title":"Fish Shellfish Immun"},{"issue":"11","key":"10.1016\/j.fsi.2025.110228_bib6","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.it.2015.09.009","article-title":"Impact of early-life exposures on immune maturation and susceptibility to disease","volume":"36","author":"Gollwitzer","year":"2015","journal-title":"Trends Immunol."},{"issue":"10","key":"10.1016\/j.fsi.2025.110228_bib7","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1038\/ismej.2014.44","article-title":"Deciphering microbial landscapes of fish eggs to mitigate emerging diseases","volume":"8","author":"Liu","year":"2014","journal-title":"Isme J"},{"key":"10.1016\/j.fsi.2025.110228_bib8","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.3389\/fimmu.2018.02972","article-title":"The change of teleost skin commensal microbiota is associated with skin mucosal transcriptomic responses during parasitic infection by Ichthyophthirius multifillis","volume":"9","author":"Zhang","year":"2018","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.fsi.2025.110228_bib9","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1111\/mec.16901","article-title":"A longitudinal survey in the wild reveals major shifts in fish host microbiota after parasite infection","volume":"32","author":"Mathieu-Begne","year":"2023","journal-title":"Mol. Ecol."},{"key":"10.1016\/j.fsi.2025.110228_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108562","article-title":"Effects of Cryptocaryon irritans infection on the histopathology, oxidative stress, immune response, and intestinal microbiota in the orange-spotted grouper Epinephelus coioides","volume":"133","author":"Zeng","year":"2023","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2025.110228_bib11","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.fsi.2015.09.013","article-title":"Stress, antioxidant defence and mucosal immune responses of the large yellow croaker Pseudosciaena crocea challenged with Cryptocaryon irritans","volume":"47","author":"Yin","year":"2015","journal-title":"Fish Shellfish Immun"},{"issue":"2","key":"10.1016\/j.fsi.2025.110228_bib12","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00436-007-0766-6","article-title":"Comparative studies on the immunogenicity of theronts, tomonts and trophonts of Cryptocaryon irritans in grouper","volume":"102","author":"Bai","year":"2008","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.fsi.2025.110228_bib13","unstructured":"I. Misumi, The Ciliated Protozoan Parasite, Cryptocaryon Irritans, and Protective Immunity in Marine Fish, University of Hawaii at Manoa2009."},{"issue":"10","key":"10.1016\/j.fsi.2025.110228_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0007401","article-title":"Conservative fragments in bacterial 16S rRNA genes and primer design for 16S ribosomal DNA amplicons in metagenomic studies","volume":"4","author":"Wang","year":"2009","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.fsi.2025.110228_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: high-resolution sample inference from Illumina amplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat. Methods"},{"issue":"8","key":"10.1016\/j.fsi.2025.110228_bib16","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","article-title":"Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2","volume":"37","author":"Bolyen","year":"2019","journal-title":"Nat. Biotechnol."},{"issue":"5","key":"10.1016\/j.fsi.2025.110228_bib17","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1093\/nar\/gkh340","article-title":"MUSCLE: multiple sequence alignment with high accuracy and high throughput","volume":"32","author":"Edgar","year":"2004","journal-title":"Nucleic Acids Res."},{"issue":"7","key":"10.1016\/j.fsi.2025.110228_bib18","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1093\/molbev\/msp077","article-title":"FastTree: computing large minimum evolution trees with profiles instead of a distance matrix","volume":"26","author":"Price","year":"2009","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.fsi.2025.110228_bib19","series-title":"R: A Language and Environment for Statistical Computing","author":"Team","year":"2018"},{"issue":"4","key":"10.1016\/j.fsi.2025.110228_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0061217","article-title":"phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data","volume":"8","author":"McMurdie","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.fsi.2025.110228_bib21","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1111\/j.1654-1103.2003.tb02228.x","article-title":"VEGAN, a package of R functions for community ecology","volume":"14","author":"Dixon","year":"2003","journal-title":"J. Veg. Sci."},{"key":"10.1016\/j.fsi.2025.110228_bib22","article-title":"Analysis of composition of microbiomes: a novel method for studying microbial composition","volume":"26","author":"Mandal","year":"2015","journal-title":"Microb. Ecol. Health Dis."},{"issue":"6","key":"10.1016\/j.fsi.2025.110228_bib23","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol."},{"issue":"18","key":"10.1016\/j.fsi.2025.110228_bib24","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics"},{"issue":"6","key":"10.1016\/j.fsi.2025.110228_bib25","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/s41587-020-0548-6","article-title":"PICRUSt2 for prediction of metagenome functions","volume":"38","author":"Douglas","year":"2020","journal-title":"Nat. Biotechnol."},{"issue":"21","key":"10.1016\/j.fsi.2025.110228_bib26","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1093\/bioinformatics\/btu494","article-title":"STAMP: statistical analysis of taxonomic and functional profiles","volume":"30","author":"Parks","year":"2014","journal-title":"Bioinformatics"},{"issue":"15","key":"10.1016\/j.fsi.2025.110228_bib27","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1093\/nar\/gks596","article-title":"Primer3--new capabilities and interfaces","volume":"40","author":"Untergasser","year":"2012","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.fsi.2025.110228_bib28","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/j.fsi.2011.04.012","article-title":"Orange-spotted grouper (Epinephelus coioides) TLR2, MyD88 and IL-1beta involved in anti-Cryptocaryon irritans response","volume":"30","author":"Li","year":"2011","journal-title":"Fish Shellfish Immunol."},{"issue":"12","key":"10.1016\/j.fsi.2025.110228_bib29","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/j.1365-3024.2011.01337.x","article-title":"Immune-related genes expression profile in orange-spotted grouper during exposure to Cryptocaryon irritans","volume":"33","author":"Li","year":"2011","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.fsi.2025.110228_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetpar.2021.109533","article-title":"Integration of metabolomic and transcriptomic analyses to characterize the influence of the gill metabolism of Nibea albiflora on the response to Cryptocaryon irritans infection","volume":"298","author":"Xie","year":"2021","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.fsi.2025.110228_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/srep43465","article-title":"Parasitism perturbs the mucosal microbiome of Atlantic Salmon","volume":"7","author":"Llewellyn","year":"2017","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.fsi.2025.110228_bib32","first-page":"15","article-title":"Isolation and identification of the pathogen of secondary infection in Sclerichthyosis punctatus with white spot disaees","author":"Hu","year":"2009","journal-title":"Hebei fisheries"},{"issue":"1","key":"10.1016\/j.fsi.2025.110228_bib33","first-page":"11","article-title":"Research on death caused by secondary bacterial infection of Cryptocaryon irritans on Pseudosciaena crocea","volume":"34","author":"Liu","year":"2012","journal-title":"Journal of Fujian Fisheries"},{"key":"10.1016\/j.fsi.2025.110228_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108879","article-title":"Vibrio harveyi co-infected with Cryptocaryon irritans to orange-spotted groupers Epinephelus coioides","volume":"139","author":"Lai","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110228_bib35","doi-asserted-by":"crossref","first-page":"662","DOI":"10.3389\/fmicb.2020.00662","article-title":"Biotechnological potential of Bdellovibrio and like organisms and their secreted enzymes","volume":"11","author":"Bratanis","year":"2020","journal-title":"Front. Microbiol."},{"issue":"3","key":"10.1016\/j.fsi.2025.110228_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032696","article-title":"A novel betaproteobacterial agent of gill epitheliocystis in seawater farmed Atlantic salmon (Salmo salar)","volume":"7","author":"Toenshoff","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2025.110228_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsirep.2021.100026","article-title":"Multi-agent in situ hybridization confirms Ca. Branchiomonas cysticola as a major contributor in complex gill disease in Atlantic salmon","volume":"2","author":"Gjessing","year":"2021","journal-title":"Fish and Shellfish Immunology Reports"},{"key":"10.1016\/j.fsi.2025.110228_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2020.06.042","article-title":"Histopathological changes and piscidin 5-like location in infected Larimichthys crocea with parasite Cryptocaryon irritans (vol 99, pg 52, 2020)","volume":"111","author":"Zheng","year":"2021","journal-title":"Fish Shellfish Immun"},{"issue":"4","key":"10.1016\/j.fsi.2025.110228_bib39","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1023\/A:1018360323287","article-title":"The cause of \u2018white spot disease\u2019 in marine fish: an update","volume":"1","author":"Colorni","year":"1951","journal-title":"Aquarium Sciences and Conservation"},{"issue":"2","key":"10.1016\/j.fsi.2025.110228_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0243684","article-title":"Effects of ploidy and salmonid alphavirus infection on the skin and gill microbiome of Atlantic salmon (Salmo salar)","volume":"16","author":"Brown","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2025.110228_bib41","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.fsi.2018.11.079","article-title":"Analysis of the gut and gill microbiome of resistant and susceptible lines of rainbow trout (Oncorhynchus mykiss)","volume":"86","author":"Brown","year":"2019","journal-title":"Fish Shellfish Immun"},{"issue":"1","key":"10.1016\/j.fsi.2025.110228_bib42","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s40249-019-0560-6","article-title":"Infection against infection: parasite antagonism against parasites, viruses and bacteria","volume":"8","author":"Shen","year":"2019","journal-title":"Infect Dis Poverty"},{"key":"10.1016\/j.fsi.2025.110228_bib43","doi-asserted-by":"crossref","unstructured":"E. Rosenberg, E.F. DeLong, S. Lory, E. Stackebrandt, F. Thompson, The Prokaryotes: Deltaproteobacteria and Epsilonproteobacteria, Springer2014.","DOI":"10.1007\/978-3-642-39044-9"},{"issue":"7","key":"10.1016\/j.fsi.2025.110228_bib44","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.4315\/0362-028X-64.7.1030","article-title":"Nannocystis exedens: a potential biocompetitive agent against Aspergillus flavus and Aspergillus parasiticus","volume":"64","author":"Taylor","year":"2001","journal-title":"J. Food Protect."},{"issue":"11","key":"10.1016\/j.fsi.2025.110228_bib45","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1021\/np500632c","article-title":"Nannozinones and sorazinones, unprecedented pyrazinones from Myxobacteria","volume":"77","author":"Jansen","year":"2014","journal-title":"J Nat Prod"},{"issue":"6","key":"10.1016\/j.fsi.2025.110228_bib46","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s12275-023-00056-2","article-title":"Tubulysins are essential for the preying of ciliates by Myxobacteria","volume":"61","author":"Yu","year":"2023","journal-title":"J. Microbiol."},{"issue":"35","key":"10.1016\/j.fsi.2025.110228_bib47","doi-asserted-by":"crossref","first-page":"10149","DOI":"10.1002\/anie.201505069","article-title":"Nannocystin A: an elongation factor 1 inhibitor from Myxobacteria with differential anti-cancer properties","volume":"54","author":"Krastel","year":"2015","journal-title":"Angew Chem Int Edit"},{"issue":"9","key":"10.1016\/j.fsi.2025.110228_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens9090702","article-title":"Evaluation on elongation factor 1 alpha of entamoeba histolytica interaction with the intermediate subunit of the gal\/GalNAc lectin and actin in phagocytosis","volume":"9","author":"Zhou","year":"2020","journal-title":"Pathogens"},{"key":"10.1016\/j.fsi.2025.110228_bib49","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.fsi.2020.02.024","article-title":"Transcriptome analysis reveals the temporal gene expression patterns in skin of large yellow croaker (Larimichthys crocea) in response to Cryptocaryon irritans infection","volume":"99","author":"Bai","year":"2020","journal-title":"Fish Shellfish Immun"},{"key":"10.1016\/j.fsi.2025.110228_bib50","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.fsi.2019.09.027","article-title":"Skin metabolome reveals immune responses in yellow drum Nibea albiflora to Cryptocaryon irritans infection","volume":"94","author":"Maha","year":"2019","journal-title":"Fish Shellfish Immun"},{"issue":"5","key":"10.1016\/j.fsi.2025.110228_bib51","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.02581-20","article-title":"The roseobacter-group bacterium phaeobacter as a safe probiotic solution for aquaculture","volume":"87","author":"Sonnenschein","year":"2021","journal-title":"Appl. Environ. Microbiol."},{"issue":"4","key":"10.1016\/j.fsi.2025.110228_bib52","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1128\/AEM.70.4.2560-2565.2003","article-title":"Antibiotic production by a Roseobacter clade-affiliated species from the German Wadden Sea and its antagonistic effects on indigenous isolates","volume":"70","author":"Brinkhoff","year":"2004","journal-title":"Appl Environ Microb"},{"issue":"6","key":"10.1016\/j.fsi.2025.110228_bib53","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1073\/pnas.1518034113","article-title":"Mode of action and resistance studies unveil new roles for tropodithietic acid as an anticancer agent and the gamma-glutamyl cycle as a proton sink","volume":"113","author":"Wilson","year":"2016","journal-title":"P Natl Acad Sci USA"},{"issue":"3","key":"10.1016\/j.fsi.2025.110228_bib54","doi-asserted-by":"crossref","DOI":"10.1093\/femsre\/fuac007","article-title":"Role is in the eye of the beholder-the multiple functions of the antibacterial compound tropodithietic acid produced by marine Rhodobacteraceae","volume":"46","author":"Henriksen","year":"2022","journal-title":"Fems Microbiol Rev"},{"issue":"8","key":"10.1016\/j.fsi.2025.110228_bib55","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1128\/IAI.00336-16","article-title":"Fecal indole as a biomarker of susceptibility to Cryptosporidium infection","volume":"84","author":"Chappell","year":"2016","journal-title":"Infect. Immun."},{"issue":"7","key":"10.1016\/j.fsi.2025.110228_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112680","article-title":"Microbiota-produced indole metabolites disrupt mitochondrial function and inhibit Cryptosporidium parvum growth","volume":"42","author":"Funkhouser-Jones","year":"2023","journal-title":"Cell Rep."},{"issue":"5014","key":"10.1016\/j.fsi.2025.110228_bib57","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/2081001c0","article-title":"Disruption of protozoa by indole and related compounds","volume":"208","author":"Bailey","year":"1965","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.fsi.2025.110228_bib58","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27010319","article-title":"Recent progress in the development of indole-based compounds active against malaria, trypanosomiasis and leishmaniasis","volume":"27","author":"Pacheco","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.fsi.2025.110228_bib59","doi-asserted-by":"crossref","first-page":"510","DOI":"10.3389\/fmicb.2019.00510","article-title":"Harmful effect of Rheinheimera sp. EpRS3 (Gammaproteobacteria) against the protist Euplotes aediculatus (Ciliophora, spirotrichea): insights into the ecological role of antimicrobial compounds from environmental bacterial strains","volume":"10","author":"Chiellini","year":"2019","journal-title":"Front. Microbiol."},{"issue":"2","key":"10.1016\/j.fsi.2025.110228_bib60","doi-asserted-by":"crossref","first-page":"142","DOI":"10.14202\/vetworld.2016.142-146","article-title":"Loktanella spp. Gb03 as an algicidal bacterium, isolated from the culture of Dinoflagellate Gambierdiscus belizeanus","volume":"9","author":"Bloh","year":"2016","journal-title":"Vet. World"},{"issue":"2","key":"10.1016\/j.fsi.2025.110228_bib61","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s42770-021-00463-w","article-title":"Combined characterization of a new member of Marivita cryptomonadis strain LZ-15-2 isolated from cultivable phycosphere microbiota of highly toxic HAB dinoflagellate Alexandrium catenella LZT09","volume":"52","author":"Zhou","year":"2021","journal-title":"Braz. J. Microbiol."},{"key":"10.1016\/j.fsi.2025.110228_bib62","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.vetpar.2015.12.034","article-title":"Anti-parasitic effects of Leptomycin B isolated from Streptomyces sp. CJK17 on marine fish ciliate Cryptocaryon irritans","volume":"217","author":"Yin","year":"2016","journal-title":"Vet. Parasitol."},{"issue":"8","key":"10.1016\/j.fsi.2025.110228_bib63","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1007\/s00436-014-4020-8","article-title":"Anti-parasitic activities of specific bacterial extracellular products of Streptomyces griseus SDX-4 against Ichthyophthirius multifiliis","volume":"113","author":"Yao","year":"2014","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.fsi.2025.110228_bib64","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1099\/ijs.0.025031-0","article-title":"Rubritalea halochordaticola sp nov., a carotenoid-producing verrucomicrobial species isolated from a marine chordate","volume":"61","author":"Yoon","year":"2011","journal-title":"Int J Syst Evol Micr"},{"key":"10.1016\/j.fsi.2025.110228_bib65","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1099\/ijs.0.65540-0","article-title":"Rubritalea sabuli sp nov., a carotenoid- and squalene-producing member of the family Verrucomicrobiaceae, isolated from marine sediment","volume":"58","author":"Yoon","year":"2008","journal-title":"Int J Syst Evol Micr"},{"issue":"3","key":"10.1016\/j.fsi.2025.110228_bib66","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.it.2016.12.006","article-title":"Retinoic acid and immune homeostasis: a balancing act","volume":"38","author":"Erkelens","year":"2017","journal-title":"Trends Immunol."},{"key":"10.1016\/j.fsi.2025.110228_bib67","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/3067126","article-title":"Impact of retinoic acid on immune cells and inflammatory diseases","volume":"2018","author":"Oliveira","year":"2018","journal-title":"Mediators Inflamm"},{"issue":"12","key":"10.1016\/j.fsi.2025.110228_bib68","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/s41590-018-0230-z","article-title":"Human retinoic acid-regulated CD161(+) regulatory T cells support wound repair in intestinal mucosa","volume":"19","author":"Povoleri","year":"2018","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2025.110228_bib69","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.2014772","article-title":"Interleukin-1beta secretion induced by mucosa-associated gut commensal bacteria promotes intestinal barrier repair","volume":"14","author":"Wu","year":"2022","journal-title":"Gut Microbes"},{"issue":"12","key":"10.1016\/j.fsi.2025.110228_bib70","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s11274-016-2155-8","article-title":"Production of squalene by microbes: an update","volume":"32","author":"Xu","year":"2016","journal-title":"World J. Microbiol. Biotechnol."},{"key":"10.1016\/j.fsi.2025.110228_bib71","series-title":"Extraction and Purification of Squalene and Product Research of Soft Capsules Carrying Oxygen","author":"Xie","year":"2017"},{"issue":"02","key":"10.1016\/j.fsi.2025.110228_bib72","first-page":"52","article-title":"Study on the effects of squalene softgel on enhancing anoxia endurance function","volume":"28","author":"Guangling","year":"2013","journal-title":"Journal of the Chinese Cereals and Oils Association"},{"key":"10.1016\/j.fsi.2025.110228_bib73","article-title":"Cryptocaryon irritans infections (marine white spot disease) in fish","volume":"2","author":"Yanong","year":"2010","journal-title":"Environ. Data Inf. Serv."},{"issue":"5","key":"10.1016\/j.fsi.2025.110228_bib74","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms9050964","article-title":"Alteration of the immune response and the microbiota of the skin during a natural infection by Vibrio harveyi in European seabass (Dicentrarchus labrax)","volume":"9","author":"Camara-Ruiz","year":"2021","journal-title":"Microorganisms"},{"issue":"6","key":"10.1016\/j.fsi.2025.110228_bib75","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1365-2095.2011.00904.x","article-title":"Vitamin K in fish nutrition","volume":"17","author":"Krossoy","year":"2011","journal-title":"Aquac. Nutr."},{"key":"10.1016\/j.fsi.2025.110228_bib76","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1027064","article-title":"Dietary Aflatoxin B1 attenuates immune function of immune organs in grass carp (Ctenopharyngodon idella) by modulating NF-kappaB and the TOR signaling pathway","volume":"13","author":"He","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2025.110228_bib77","article-title":"Impacts of different levels of vitamin K on the growth performance, hematological parameters, and immunological response of juvenile Nile tilapia (Oreochromis niloticus)","author":"Abdelhamid","year":"2023","journal-title":"Aquac. Int."},{"issue":"5","key":"10.1016\/j.fsi.2025.110228_bib78","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nrmicro.2018.9","article-title":"The microbial nitrogen-cycling network","volume":"16","author":"Kuypers","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.fsi.2025.110228_bib79","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.775794","article-title":"A Review of ammonia-oxidizing archaea and anaerobic ammonia-oxidizing bacteria in the aquaculture pond environment in China","volume":"12","author":"Lu","year":"2021","journal-title":"Front. Microbiol."},{"issue":"2","key":"10.1016\/j.fsi.2025.110228_bib80","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00274-20","article-title":"Microbial nitrogen metabolism in chloraminated drinking water reservoirs","volume":"5","author":"Potgieter","year":"2020","journal-title":"mSphere"},{"issue":"8","key":"10.1016\/j.fsi.2025.110228_bib81","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1111\/jfd.13382","article-title":"The gill transcriptome reveals unique antimicrobial features that protect Nibea albiflora from Cryptocaryon irritans infection","volume":"44","author":"Xie","year":"2021","journal-title":"J. Fish. Dis."},{"issue":"6","key":"10.1016\/j.fsi.2025.110228_bib82","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23063129","article-title":"Evaluation of ammonia nitrogen exposure in immune defenses present on spleen and head-kidney of wuchang bream (Megalobrama amblycephala)","volume":"23","author":"Guo","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.fsi.2025.110228_bib83","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1111\/1462-2920.12881","article-title":"A Rickettsiales symbiont of amoebae with ancient features","volume":"18","author":"Schulz","year":"2016","journal-title":"Environ. Microbiol."},{"issue":"12","key":"10.1016\/j.fsi.2025.110228_bib84","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.1128\/AEM.03105-09","article-title":"\"Candidatus anadelfobacter veles\" and \"Candidatus cyrtobacter comes,\" two new Rickettsiales species hosted by the protist ciliate Euplotes harpa (Ciliophora, spirotrichea)","volume":"76","author":"Vannini","year":"2010","journal-title":"Appl Environ Microb"},{"issue":"10","key":"10.1016\/j.fsi.2025.110228_bib85","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s13131-017-1050-y","article-title":"Pathogenic bacterium Vibrio harveyi: an endosymbiont in the marine parasitic ciliate protozoan Cryptocaryon irritans","volume":"36","author":"Qiao","year":"2017","journal-title":"Acta Oceanol. Sin."},{"key":"10.1016\/j.fsi.2025.110228_bib86","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3389\/fmicb.2012.00288","article-title":"Act together-implications of symbioses in aquatic ciliates","volume":"3","author":"Dziallas","year":"2012","journal-title":"Front. Microbiol."},{"issue":"3","key":"10.1016\/j.fsi.2025.110228_bib87","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00574-21","article-title":"Modeling the life cycle of the intramitochondrial bacterium \"Candidatus midichloria mitochondrii\" using electron microscopy data","volume":"12","author":"Comandatore","year":"2021","journal-title":"mBio"},{"issue":"11","key":"10.1016\/j.fsi.2025.110228_bib88","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1111\/mec.14094","article-title":"Evolutionary changes in symbiont community structure in ticks","volume":"26","author":"Duron","year":"2017","journal-title":"Mol. Ecol."},{"issue":"12","key":"10.1016\/j.fsi.2025.110228_bib89","doi-asserted-by":"crossref","first-page":"5341","DOI":"10.1111\/1462-2920.15245","article-title":"Parasitic 'CandidatusAquarickettsia rohweri' is a marker of disease susceptibility inAcropora cervicornisbut is lost during thermal stress","volume":"22","author":"Klinges","year":"2020","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.fsi.2025.110228_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2020.735485","article-title":"Investigating the involvement of a Midichloria-like organism (MLO) in red mark syndrome in rainbow trout Oncorhynchus mykiss","volume":"528","author":"Metselaar","year":"2020","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2025.110228_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2020.736230","article-title":"Double trouble: could Ichthyophthirius multifiliis be a vehicle for the bacterium associated with red mark syndrome in rainbow trout, Oncorhynchus mykiss?","volume":"533","author":"Pasqualetti","year":"2021","journal-title":"Aquaculture"},{"issue":"1","key":"10.1016\/j.fsi.2025.110228_bib92","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/bib\/bbz155","article-title":"Current challenges and best-practice protocols for microbiome analysis","volume":"22","author":"Bharti","year":"2021","journal-title":"Brief Bioinform"},{"issue":"3","key":"10.1016\/j.fsi.2025.110228_bib93","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001556","article-title":"Systematically assessing microbiome-disease associations identifies drivers of inconsistency in metagenomic research","volume":"20","author":"Tierney","year":"2022","journal-title":"PLoS Biol."}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464825001172?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464825001172?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:12:06Z","timestamp":1778584326000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464825001172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":93,"alternative-id":["S1050464825001172"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2025.110228","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of gill and skin microbiota in Larimichthys crocea reveals bacteria associated with cryptocaryoniasis resistance potential","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2025.110228","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110228"}}