{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:25:36Z","timestamp":1790774736345,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2023YFD2402700"],"award-info":[{"award-number":["2023YFD2402700"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.fsi.2025.110332","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T11:16:39Z","timestamp":1744370199000},"page":"110332","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Development and evaluation of recombinant multi-epitopes vaccine against nervous necrosis virus"],"prefix":"10.1016","volume":"162","author":[{"given":"Chen","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Nan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Ye","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Hua","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-Fei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Qi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Can","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2025.110332_bib1","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/jfd.12541","article-title":"Viral encephalopathy and retinopathy in aquaculture: a review","volume":"40","author":"Doan","year":"2017","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2025.110332_bib2","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.3390\/vaccines9121441","article-title":"Update on the inactivation procedures for the vaccine development prospects of a new highly virulent RGNNV isolate","volume":"9","author":"Falco","year":"2021","journal-title":"Vaccines"},{"key":"10.1016\/j.fsi.2025.110332_bib3","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1099\/jgv.0.001112","article-title":"Modification of betanodavirus virulence by substitutions in the 3\u2032 terminal region of RNA2","volume":"99","author":"Souto","year":"2018","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.fsi.2025.110332_bib4","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.3390\/v14122818","article-title":"Characterization of nervous necrosis virus (NNV) nonstructural protein B2 and its enhancement on virus proliferation","volume":"14","author":"Zhang","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.fsi.2025.110332_bib5","first-page":"1256","article-title":"Identification of host-specificity determinants in betanodaviruses by using reassortants between striped jack nervous necrosis virus and sevenband grouper nervous necrosis virus","author":"Tokinori","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.fsi.2025.110332_bib6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.fsi.2016.03.033","article-title":"Understanding the interaction between Betanodavirus and its host for the development of prophylactic measures for viral encephalopathy and retinopathy","volume":"53","author":"Costa","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110332_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2022.739177","article-title":"Immune and protective effects of subunit vaccines from S-domain or P-domain in capsid protein against nervous necrosis virus in pearl gentian grouper","volume":"566","author":"Lin","year":"2023","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2025.110332_bib8","article-title":"In-silico designing of epitope-based vaccine against the seven banded grouper nervous necrosis virus affecting fish species","volume":"vol. 10","author":"Joshi","year":"2021"},{"key":"10.1016\/j.fsi.2025.110332_bib9","article-title":"Development and evaluation of a multi-epitope subunit vaccine against Mycoplasma synoviae infection","volume":"253","author":"Zhang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.fsi.2025.110332_bib10","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3389\/fimmu.2019.02776","article-title":"Editorial: reverse vaccinology","volume":"10","author":"Moxon","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2025.110332_bib11","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1745-7580-6-6","article-title":"Identification of conformational B-cell Epitopes in an antigen from its primary sequence","volume":"6","author":"Ansari","year":"2010","journal-title":"Immunome Res."},{"key":"10.1016\/j.fsi.2025.110332_bib12","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1007\/s10989-019-09918-z","article-title":"Epitope prediction by novel immunoinformatics approach: a state-of-the-art review","volume":"26","author":"Raoufi","year":"2020","journal-title":"Int. J. Pept. Res. Therapeut."},{"key":"10.1016\/j.fsi.2025.110332_bib13","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1080\/21645515.2016.1160977","article-title":"The promise and challenge of epitope-focused vaccines","volume":"12","author":"Oscherwitz","year":"2016","journal-title":"Hum. Vaccines Immunother."},{"key":"10.1016\/j.fsi.2025.110332_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.humimm.2024.110804","article-title":"Multi-epitope vaccines, from design to expression; an in silico approach","volume":"85","author":"Mortazavi","year":"2024","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.fsi.2025.110332_bib15","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/vaccines11030624","article-title":"Development and evaluation of recombinant B-cell multi-epitopes of PDHA1 and GAPDH as subunit vaccines against Streptococcus iniae infection in flounder (Paralichthys olivaceus)","volume":"11","author":"Sheng","year":"2023","journal-title":"Vaccines"},{"key":"10.1016\/j.fsi.2025.110332_bib16","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s13073-015-0245-0","article-title":"Immunoinformatics and epitope prediction in the age of genomic medicine","volume":"7","author":"Backert","year":"2015","journal-title":"Genome Med."},{"key":"10.1016\/j.fsi.2025.110332_bib17","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1080\/08830185.2019.1657426","article-title":"Immunoinformatics: in silico approaches and computational design of a multi-epitope, immunogenic protein","volume":"38","author":"Bahrami","year":"2019","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.fsi.2025.110332_bib18","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/ijms22063210","article-title":"Linear B-cell epitope prediction for in silico vaccine design: a performance review of methods available via command-line interface","volume":"22","author":"Galanis","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fsi.2025.110332_bib19","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/pro.4785","article-title":"Multi - perspectives and challenges in identifying B - cell epitopes","volume":"32","author":"Kumar","year":"2023","journal-title":"Protein Sci."},{"key":"10.1016\/j.fsi.2025.110332_bib20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.smim.2023.101725","article-title":"Viral T-cell epitopes - identification, characterization and clinical application","volume":"66","author":"Schroeder","year":"2023","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.fsi.2025.110332_bib21","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/s41586-021-03828-1","article-title":"Highly accurate protein structure prediction for the human proteome","volume":"596","author":"Tunyasuvunakool","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2025.110332_bib22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.7717\/peerj.9541","article-title":"Anti-COVID-19 multi-epitope vaccine designs employing global viral genome sequences","volume":"8","author":"Zaheer","year":"2020","journal-title":"Peerj"},{"key":"10.1016\/j.fsi.2025.110332_bib23","doi-asserted-by":"crossref","first-page":"7024","DOI":"10.1080\/07391102.2023.2240059","article-title":"Development of a novel multi-epitope vaccine based on capsid and envelope protein against Chikungunya virus","volume":"42","author":"Ma","year":"2024","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.fsi.2025.110332_bib24","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/vaccines9111327","article-title":"Annotation of potential vaccine targets and design of a multi-epitope subunit vaccine against Yersinia pestis through reverse vaccinology and validation through an agent-based modeling approach","volume":"9","author":"Haq","year":"2021","journal-title":"Vaccines"},{"key":"10.1016\/j.fsi.2025.110332_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1269774","article-title":"Development of a multi-epitope vaccine candidate for leishmanial parasites applying immunoinformatics and in vitro approaches","volume":"14","author":"Jyotisha","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2025.110332_bib26","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3390\/diagnostics12122981","article-title":"Immunoinformatics approach for epitope-based vaccine design: Key steps for breast cancer vaccine","volume":"12","author":"Prawiningrum","year":"2022","journal-title":"Diagnostics"},{"key":"10.1016\/j.fsi.2025.110332_bib27","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1093\/bioinformatics\/14.4.378","article-title":"SOSUI: classification and secondary structure prediction system for membrane proteins","volume":"14","author":"Hirokawa","year":"1998","journal-title":"Bioinformatics"},{"key":"10.1016\/j.fsi.2025.110332_bib28","author":"Jeppe"},{"key":"10.1016\/j.fsi.2025.110332_bib29","doi-asserted-by":"crossref","first-page":"W535","DOI":"10.1093\/nar\/gkab354","article-title":"PredictProtein-predicting protein structure and function for 29 Years","volume":"49","author":"Bernhofer","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.fsi.2025.110332_bib30","doi-asserted-by":"crossref","first-page":"W402","DOI":"10.1093\/nar\/gkz297","article-title":"The PSIPRED protein analysis workbench: 20 years on","volume":"47","author":"Buchan","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.fsi.2025.110332_bib31","doi-asserted-by":"crossref","DOI":"10.1002\/pro.4497","article-title":"BepiPred-3.0: improved B-cell epitope prediction using protein language models","volume":"31","author":"Clifford","year":"2022","journal-title":"Protein Sci."},{"key":"10.1016\/j.fsi.2025.110332_bib32","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/BF02789332","article-title":"Macintosh sequence analysis software. DNAStar's LaserGene","volume":"3","author":"Clewley","year":"1995","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.fsi.2025.110332_bib33","doi-asserted-by":"crossref","first-page":"W513","DOI":"10.1093\/nar\/gkn254","article-title":"Immune epitope database analysis resource (IEDB-AR)","volume":"36","author":"Zhang","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.fsi.2025.110332_bib34","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1186\/1471-2105-8-424","article-title":"Large-scale validation of methods for cytotoxic T-lymphocyte epitope prediction","volume":"8","author":"Larsen","year":"2007","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.fsi.2025.110332_bib35","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s11030-021-10292-6","article-title":"ABCpred: a webserver for the discovery of acetyl- and butyryl-cholinesterase inhibitors","volume":"26","author":"Malik","year":"2022","journal-title":"Mol. Divers."},{"key":"10.1016\/j.fsi.2025.110332_bib36","doi-asserted-by":"crossref","first-page":"398","DOI":"10.2174\/1573409915666190318121838","article-title":"VaxiJen dataset of bacterial immunogens: an update","volume":"15","author":"Zaharieva","year":"2019","journal-title":"Curr. Comput. Aided Drug Des."},{"key":"10.1016\/j.fsi.2025.110332_bib37","doi-asserted-by":"crossref","first-page":"709","DOI":"10.3390\/vaccines8040709","article-title":"Bacterial immunogenicity prediction by machine learning methods","volume":"8","author":"Dimitrov","year":"2020","journal-title":"Vaccines"},{"key":"10.1016\/j.fsi.2025.110332_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073957","article-title":"In silico approach for predicting toxicity of peptides and proteins","volume":"8","author":"Gupta","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2025.110332_bib39","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2025.110332_bib40","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Varadi","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2025.110332_bib41","doi-asserted-by":"crossref","first-page":"W296","DOI":"10.1093\/nar\/gky427","article-title":"SWISS-MODEL: homology modelling of protein structures and complexes","volume":"46","author":"Waterhouse","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.fsi.2025.110332_bib42","doi-asserted-by":"crossref","first-page":"W407","DOI":"10.1093\/nar\/gkm290","article-title":"ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins","volume":"35","author":"Wiederstein","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.fsi.2025.110332_bib43","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1021\/acsami.3c14305","article-title":"Rationally designed self-assembling nanovaccines elicit robust mucosal and systemic immunity against rhabdovirus","volume":"16","author":"Zhang","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.fsi.2025.110332_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024657","article-title":"Accelerating protein docking in ZDOCK using an advanced 3D convolution library","volume":"6","author":"Pierce","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2025.110332_bib45","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394Ct method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.fsi.2025.110332_bib46","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.aquaculture.2020.735663","article-title":"Identification and characterization of a new strain of nervous necrosis virus isolated from pearl gentian grouper (Epinephelus lanceolatus x Epinephelus fuscoguttatus) in China","volume":"529","author":"Xing","year":"2020","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2025.110332_bib47","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.meegid.2015.03.027","article-title":"Identification of putative vaccine candidates against Helicobacter pylori exploiting exoproteome and secretome: a reverse vaccinology-based approach","volume":"32","author":"Naz","year":"2015","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.fsi.2025.110332_bib48","doi-asserted-by":"crossref","first-page":"53","DOI":"10.7717\/peerj.16419","article-title":"Riding the wave of innovation: immunoinformatics in fish disease control","volume":"11","author":"Razali","year":"2023","journal-title":"Peerj"},{"key":"10.1016\/j.fsi.2025.110332_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2024.108056","article-title":"Immunoinformatics-driven in silico vaccine design for Nipah virus (NPV): integrating machine learning and computational epitope prediction","volume":"170","author":"Shahab","year":"2024","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.fsi.2025.110332_bib50","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.865180","article-title":"Immunoinformatics aided design and in-vivo validation of a cross-reactive peptide based multi-epitope vaccine targeting multiple serotypes of dengue virus","volume":"13","author":"Kaushik","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2025.110332_bib51","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.compbiomed.2016.06.015","article-title":"Effect of linker length and residues on the structure and stability of a fusion protein with malaria vaccine application","volume":"76","author":"Shamriz","year":"2016","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.fsi.2025.110332_bib52","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.vaccine.2012.12.083","article-title":"A novel method for enhancement of peptide vaccination utilizing T-cell epitopes from conventional vaccines","volume":"31","author":"Yano","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2025.110332_bib53","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.meegid.2017.12.008","article-title":"Structural vaccinology considerations for in silico designing of a multi-epitope vaccine","volume":"58","author":"Negahdaripour","year":"2018","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.fsi.2025.110332_bib54","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.dci.2010.05.008","article-title":"MHC class II\u03b1 gene polymorphism and its association with resistance\/susceptibility to Vibrio anguillarum in Japanese flounder (Paralichthys olivaceus)","volume":"34","author":"Xu","year":"2010","journal-title":"Dev. Comp. Immunol."}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464825002219?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464825002219?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T15:06:48Z","timestamp":1762355208000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464825002219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":54,"alternative-id":["S1050464825002219"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2025.110332","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and evaluation of recombinant multi-epitopes vaccine against nervous necrosis virus","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2025.110332","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110332"}}