{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:40:49Z","timestamp":1790199649011,"version":"4.1.0"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Korea Ministry of Science and ICT","doi-asserted-by":"publisher","award":["RS-2024-00405986"],"award-info":[{"award-number":["RS-2024-00405986"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.fsi.2025.110409","type":"journal-article","created":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T17:43:18Z","timestamp":1746985398000},"page":"110409","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Superior protective efficacy of genotype IVa-based single-cycle viral hemorrhagic septicemia virus (VHSV) vaccine compared to formalin-killed VHSV vaccine against VHSV genotype Ia in rainbow trout (Oncorhynchus mykiss)"],"prefix":"10.1016","volume":"163","author":[{"given":"Kyung Min","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5312-737X","authenticated-orcid":false,"given":"So Yeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1140-8162","authenticated-orcid":false,"given":"Ki Hong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2025.110409_bib1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1365-2761.2005.00654.x","article-title":"Viral haemorrhagic septicaemia virus in marine fish and its implications for fish farming \u2013 a review","volume":"28","author":"Skall","year":"2005","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2025.110409_bib2","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1016\/j.vaccine.2011.01.097","article-title":"A comparative review on European-farmed finfish RNA viruses and their vaccines","volume":"29","author":"Gomez-Casado","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2025.110409_bib3","series-title":"Manual of Diagnostic Tests for Aquatic Animals","year":"2003"},{"key":"10.1016\/j.fsi.2025.110409_bib4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1023\/A:1008140707132","article-title":"Complete genomic sequence of viral hemorrhagic septicemia virus, a fish rhabdovirus","volume":"19","author":"Sch\u00fctze","year":"1999","journal-title":"Virus Genes"},{"key":"10.1016\/j.fsi.2025.110409_bib5","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1099\/vir.0.79820-0","article-title":"Evolution of the fish rhabdovirus viral haemorrhagic septicaemia virus","volume":"85","author":"Einer-Jensen","year":"2004","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.fsi.2025.110409_bib6","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.ympev.2011.12.024","article-title":"Evolution and biogeography of an emerging quasispecies: diversity patterns of the fish Viral Hemorrhagic Septicemia virus (VHSv)","volume":"63","author":"Pierce","year":"2012","journal-title":"Mol. Phylogenet. Evol."},{"key":"10.1016\/j.fsi.2025.110409_bib7","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3354\/dao02671","article-title":"Virulence of viral hemorrhagic septicemia virus (VHSV) genotypes Ia, IVa, IVb, and IVc in five fish species","volume":"107","author":"Emmenegger","year":"2013","journal-title":"Dis. Aquat. Org."},{"key":"10.1016\/j.fsi.2025.110409_bib8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.7847\/jfp.2014.27.1.077","article-title":"Monitoring of the mortalities and medications in the inland farms of olive flounder, Paralichthys olivaceus, in South Korea","volume":"27","author":"Jee","year":"2014","journal-title":"J. Fish Pathol."},{"key":"10.1016\/j.fsi.2025.110409_bib9","first-page":"741","article-title":"Detection of viruses in farmed rainbow trout (Oncorhynchus mykiss) in Korea by RT-LAMP assay","volume":"49","author":"Suebsing","year":"2011","journal-title":"J. Microbiol. (Seoul, Korea)"},{"key":"10.1016\/j.fsi.2025.110409_bib10","first-page":"201","article-title":"Immunization with viral antigens: viral haemorrhagic septicaemia","volume":"90","author":"Lorenzen","year":"1997","journal-title":"Dev. Biol. Stand."},{"key":"10.1016\/j.fsi.2025.110409_bib11","first-page":"211","article-title":"Immunization with viral antigens: infectious haematopoietic necrosis","volume":"90","author":"Winton","year":"1997","journal-title":"Dev. Biol. Stand."},{"key":"10.1016\/j.fsi.2025.110409_bib12","doi-asserted-by":"crossref","first-page":"201","DOI":"10.20506\/rst.24.1.1565","article-title":"DNA vaccines for aquacultured fish","volume":"24","author":"Lorenzen","year":"2005","journal-title":"Rev. Sci. Tech. (Int. Off. Epizoot.)"},{"key":"10.1016\/j.fsi.2025.110409_bib13","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1006\/fsim.1999.0195","article-title":"Recombinant vaccines: experimental and applied aspects","volume":"9","author":"Lorenzen","year":"1999","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110409_bib14","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.fsi.2019.10.031","article-title":"Genetically engineered viral hemorrhagic septicemia virus (VHSV) vaccines","volume":"95","author":"Kim","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110409_bib15","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1007\/s10499-022-00884-w","article-title":"A review on the recent advances and application of vaccines against fish pathogens in aquaculture","volume":"30","author":"Mondal","year":"2022","journal-title":"Aquac. Int."},{"key":"10.1016\/j.fsi.2025.110409_bib16","doi-asserted-by":"crossref","first-page":"569","DOI":"10.3390\/microorganisms7110569","article-title":"A review of fish vaccine development strategies: conventional methods and modern biotechnological approaches","volume":"7","author":"Ma","year":"2019","journal-title":"Microorganisms"},{"key":"10.1016\/j.fsi.2025.110409_bib17","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3147\/jsfp.47.121","article-title":"Protective efficacy of a formalin-inactivated vaccine against viral hemorrhagic septicemia in Japanese flounder Paralichthys olivaceus","volume":"47","author":"Isshiki","year":"2012","journal-title":"Fish Pathol."},{"key":"10.1016\/j.fsi.2025.110409_bib18","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.vaccine.2018.12.063","article-title":"PLGA encapsulated inactivated-viral vaccine: formulation and evaluation of its protective efficacy against viral haemorrhagic septicaemia virus (VHSV) infection in olive flounder (Paralichthys olivaceus) vaccinated by mucosal delivery routes","volume":"37","author":"Kole","year":"2019","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2025.110409_bib19","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.fsi.2019.05.017","article-title":"Nanoencapsulation of inactivated-viral vaccine using chitosan nanoparticles: evaluation of its protective efficacy and immune modulatory effects in olive flounder (Paralichthys olivaceus) against viral haemorrhagic septicaemia virus (VHSV) infection","volume":"91","author":"Kole","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110409_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2025.110217","article-title":"Comparative analysis of immunogenicity for viral hemorrhagic septicemia virus (VHSV) vaccines inactivated by different methods","volume":"160","author":"Kim","year":"2025","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110409_bib21","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/ni0504-460","article-title":"Vaccine development strategies for improving immunization: the role of modern immunology","volume":"5","author":"Levine","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.fsi.2025.110409_bib22","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.fsi.2015.11.035","article-title":"Comparison of the efficacy of Poly(I:C) immunization with live vaccine and formalin-killed vaccine against viral hemorrhagic septicemia virus (VHSV) in olive flounder (Paralichthys olivaceus)","volume":"48","author":"Kim","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110409_bib23","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/j.1749-7345.2009.00279.x","article-title":"Use of modified live vaccines in aquaculture","volume":"40","author":"Shoemaker","year":"2009","journal-title":"J. World Aquacult. Soc."},{"key":"10.1016\/j.fsi.2025.110409_bib24","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jviromet.2015.03.012","article-title":"High throughput screening of scFv antibodies against viral hemorrhagic septicaemia virus by flow cytometry","volume":"219","author":"Zhou","year":"2015","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.fsi.2025.110409_bib25","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.vaccine.2007.11.065","article-title":"Development of an oral vaccine for immunisation of rainbow trout (Oncorhynchus mykiss) against viral haemorrhagic septicaemia","volume":"26","author":"Adelmann","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2025.110409_bib26","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.vaccine.2015.12.051","article-title":"Stability and efficacy of the 3\u2032-UTR A4G-G5A variant of viral hemorrhagic septicemia virus (VHSV) as a live attenuated immersion VHSV vaccine in olive flounder (Paralichthys olivaceus)","volume":"34","author":"Kim","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2025.110409_bib27","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.aquaculture.2011.01.050","article-title":"Protection of olive flounder, Paralichthys olivaceus, against viral hemorrhagic septicemia virus (VHSV) by immunization with NV gene-knockout recombinant VHSV","volume":"314","author":"Kim","year":"2011","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2025.110409_bib28","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.fsi.2011.05.003","article-title":"Oral immunization of olive flounder (Paralichthys olivaceus) with recombinant live viral hemorrhagic septicemia virus (VHSV) induces protection against VHSV infection","volume":"31","author":"Kim","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110409_bib29","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.fsi.2015.05.031","article-title":"Generation of G gene-deleted viral hemorrhagic septicemia virus (VHSV) and evaluation of its vaccine potential in olive flounder (Paralichthys olivaceus)","volume":"45","author":"Kim","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110409_bib30","doi-asserted-by":"crossref","first-page":"5580","DOI":"10.1016\/j.vaccine.2023.07.058","article-title":"Differences between DNA vaccine and single-cycle viral vaccine in the ability of cross-protection against viral hemorrhagic septicemia virus (VHSV) and infectious hematopoietic necrosis virus (IHNV)","volume":"41","author":"Kim","year":"2023","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2025.110409_bib31","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/nri888","article-title":"Viruses and interferon: a fight for supremacy","volume":"2","author":"Katze","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.fsi.2025.110409_bib32","article-title":"The persistence of viral hemorrhagic septicemia virus (VHSV) mRNA in juvenile olive flounder, Paralichthys olivaceus following live VHSV vaccination","volume":"33","author":"Jang","year":"2023","journal-title":"Aquac. Rep."},{"key":"10.1016\/j.fsi.2025.110409_bib33","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.fsi.2019.04.303","article-title":"Lineage\/species-specific expansion of the Mx gene family in teleosts: differential expression and modulation of nine Mx genes in rainbow trout Oncorhynchus mykiss","volume":"90","author":"Wang","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110409_bib34","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1089\/zeb.2019.1843","article-title":"Proteomic profiling of zebrafish challenged by spring viremia of carp virus provides insight into skin antiviral response","volume":"17","author":"Liu","year":"2020","journal-title":"Zebrafish"},{"key":"10.1016\/j.fsi.2025.110409_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2020.736084","article-title":"Temperature effects on SVCV propagation and the related IFN response in zebrafish","volume":"533","author":"Zhou","year":"2021","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2025.110409_bib36","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1186\/s12864-015-1759-y","article-title":"Infectious hematopoietic necrosis virus (IHNV) persistence in Sockeye Salmon: influence on brain transcriptome and subsequent response to the viral mimic poly(I:C)","volume":"16","author":"M\u00fcller","year":"2015","journal-title":"BMC Genom."},{"key":"10.1016\/j.fsi.2025.110409_bib37","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.fsi.2010.10.021","article-title":"Interferon response following infection with genetically similar isolates of viral haemorrhagic septicaemia virus (VHSV) exhibiting contrasting virulence in rainbow trout","volume":"30","author":"Campbell","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110409_bib38","author":"Mu\u00f1oz-Carrillo"},{"key":"10.1016\/j.fsi.2025.110409_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.crimmu.2023.100062","article-title":"Interplay of host and viral factors in inflammatory pathway mediated cytokine storm during RNA virus infection","volume":"4","author":"Chaudhary","year":"2023","journal-title":"Curr. Res. Immunol."},{"key":"10.1016\/j.fsi.2025.110409_bib40","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.cyto.2012.05.020","article-title":"Functions of IL-15 in anti-viral immunity: multiplicity and variety","volume":"59","author":"Verbist","year":"2012","journal-title":"Cytokine"},{"key":"10.1016\/j.fsi.2025.110409_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.128192","article-title":"First in vitro and in vivo evaluation of recombinant IL-1\u03b2 protein as a potential immunomodulator against viral infection in fish","volume":"255","author":"Deng","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.fsi.2025.110409_bib42","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.fsi.2022.07.040","article-title":"Red sea bream interleukin (IL)-1\u03b2 and IL-8 expression, subcellular localization, and antiviral activity against red sea bream iridovirus (RSIV)","volume":"128","author":"Joo","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110409_bib43","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1016\/j.bbamcr.2014.05.014","article-title":"Cytokines and chemokines: at the crossroads of cell signalling and inflammatory disease","volume":"1843","author":"Turner","year":"2014","journal-title":"Biochim. Biophys. Acta (BBA) Mol. Cell Res."},{"key":"10.1016\/j.fsi.2025.110409_bib44","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.aaf.2023.01.008","article-title":"Advances in chemokines of teleost fish species","volume":"9","author":"Xu","year":"2024","journal-title":"Aquac. Fish."},{"key":"10.1016\/j.fsi.2025.110409_bib45","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.dci.2013.05.006","article-title":"Phylogenetic analysis of vertebrate CXC chemokines reveals novel lineage specific groups in teleost fish","volume":"41","author":"Chen","year":"2013","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2025.110409_bib46","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.molimm.2016.01.006","article-title":"Comparative study of CXC chemokines modulation in brown trout (Salmo trutta) following infection with a bacterial or viral pathogen","volume":"71","author":"Gorgoglione","year":"2016","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.fsi.2025.110409_bib47","doi-asserted-by":"crossref","first-page":"37021","DOI":"10.1074\/jbc.M506594200","article-title":"Interleukin-8-induced priming of neutrophil oxidative burst requires sequential recruitment of NADPH oxidase components into lipid rafts","volume":"280","author":"Guichard","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fsi.2025.110409_bib48","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41423-023-00974-6","article-title":"The chemokines CXCL8 and CXCL12: molecular and functional properties, role in disease and efforts towards pharmacological intervention","volume":"20","author":"Cambier","year":"2023","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.fsi.2025.110409_bib49","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.dci.2008.05.004","article-title":"Interleukin 8 and CK-6 chemokines specifically attract rainbow trout (Oncorhynchus mykiss) RTS11 monocyte\u2013macrophage cells and have variable effects on their immune functions","volume":"32","author":"Montero","year":"2008","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2025.110409_bib50","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.fsi.2011.03.023","article-title":"Interleukin-8 of Cynoglossus semilaevis is a chemoattractant with immunoregulatory property","volume":"30","author":"Sun","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110409_bib51","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.dci.2011.11.011","article-title":"Pro-inflammatory functions of carp CXCL8-like and CXCb chemokines","volume":"36","author":"van der Aa","year":"2012","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2025.110409_bib52","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.fsi.2014.04.006","article-title":"N-terminal region is responsible for chemotaxis-inducing activity of flounder IL-8","volume":"38","author":"Kurata","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110409_bib53","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.fsi.2015.03.026","article-title":"Molecular characterization and biological effects of a CXCL8 homologue in large yellow croaker (Larimichthys crocea)","volume":"44","author":"Mu","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110409_bib54","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.3389\/fimmu.2020.01738","article-title":"Molecular characterization and chemotactic function of CXCL8 in Northeast Chinese lamprey (Lethenteron morii)","volume":"11","author":"Zhu","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2025.110409_bib55","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.3390\/biom10101382","article-title":"Comparative characterization of two cxcl8 Homologs in Oplegnathus fasciatus: genomic, transcriptional and functional analyses","volume":"10","author":"Umasuthan","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.fsi.2025.110409_bib56","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.dci.2007.10.005","article-title":"The biological effects of rainbow trout (Oncorhynchus mykiss) recombinant interleukin-8","volume":"32","author":"Harun","year":"2008","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2025.110409_bib57","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41577-020-0285-6","article-title":"Defining trained immunity and its role in health and disease","volume":"20","author":"Netea","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.fsi.2025.110409_bib58","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.immuni.2020.10.011","article-title":"The intersection of epigenetics and metabolism in trained immunity","volume":"54","author":"Fanucchi","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.fsi.2025.110409_bib59","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.fsi.2018.05.044","article-title":"Immunostimulation and trained immunity in marine fish larvae","volume":"80","author":"Rojo-Cebreros","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110409_bib60","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1111\/raq.12863","article-title":"Progress and perspective of trained immunity in teleost fish","volume":"16","author":"You","year":"2024","journal-title":"Rev. Aquacult."},{"key":"10.1016\/j.fsi.2025.110409_bib61","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1146\/annurev-virology-091919-072546","article-title":"Shifting the immune memory paradigm: trained immunity in viral infections","volume":"9","author":"Taks","year":"2022","journal-title":"Annu. Rev. Virol."},{"key":"10.1016\/j.fsi.2025.110409_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2024.109930","article-title":"Trained immunity-inducing vaccines: harnessing innate memory for vaccine design and delivery","volume":"261","author":"Baydemir","year":"2024","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.fsi.2025.110409_bib63","doi-asserted-by":"crossref","first-page":"41","DOI":"10.25259\/IJMS_176_2021","article-title":"Live-attenuated oral polio vaccine as a potential source of protection against COVID-19 \u2013 review of literature","volume":"73","author":"Us","year":"2021","journal-title":"Indian J. Med. Sci."},{"key":"10.1016\/j.fsi.2025.110409_bib64","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.fsi.2018.08.056","article-title":"Chromatin immunoprecipitation and high throughput sequencing of SVCV-infected zebrafish reveals novel epigenetic histone methylation patterns involved in antiviral immune response","volume":"82","author":"Medina-Gali","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110409_bib65","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0111084","article-title":"Early immune responses in rainbow trout liver upon viral hemorrhagic septicemia virus (VHSV) infection","volume":"9","author":"Castro","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2025.110409_bib66","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.fsi.2015.05.045","article-title":"An oral DNA vaccine against infectious haematopoietic necrosis virus (IHNV) encapsulated in alginate microspheres induces dose-dependent immune responses and significant protection in rainbow trout (Oncorrhynchus mykiss)","volume":"45","author":"Ballesteros","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110409_bib67","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.fsi.2015.07.012","article-title":"Length-dependent innate antiviral effects of double-stranded RNA in the rainbow trout (Oncorhynchus mykiss) cell line, RTG-2","volume":"46","author":"Poynter","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110409_bib68","doi-asserted-by":"crossref","first-page":"112222","DOI":"10.18632\/oncotarget.23095","article-title":"Effects of different cytokines on immune responses of rainbow trout in a virus DNA vaccination model","volume":"8","author":"Cao","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.fsi.2025.110409_bib69","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.aquaculture.2018.04.011","article-title":"Effects of soluble immunostimulants on mucosal immune responses in rainbow trout immersion-vaccinated against Yersinia ruckeri","volume":"492","author":"Skov","year":"2018","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2025.110409_bib70","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.fsi.2017.07.056","article-title":"Dissecting the immune pathways stimulated following injection vaccination of rainbow trout (Oncorhynchus mykiss) against enteric redmouth disease (ERM)","volume":"85","author":"Wangkahart","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110409_bib71","doi-asserted-by":"crossref","first-page":"708","DOI":"10.4049\/jimmunol.1001203","article-title":"Functional characterization of a nonmammalian IL-21: rainbow trout Oncorhynchus mykiss IL-21 Upregulates the expression of the Th cell signature cytokines IFN-\u03b3, IL-10, and IL-22","volume":"186","author":"Wang","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2025.110409_bib72","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/j.molimm.2011.05.027","article-title":"Bioactivity studies of rainbow trout (Oncorhynchus mykiss) interleukin-6: effects on macrophage growth and antimicrobial peptide gene expression","volume":"48","author":"Costa","year":"2011","journal-title":"Mol. Immunol."}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464825002980?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464825002980?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T17:38:53Z","timestamp":1748281133000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464825002980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":72,"alternative-id":["S1050464825002980"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2025.110409","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Superior protective efficacy of genotype IVa-based single-cycle viral hemorrhagic septicemia virus (VHSV) vaccine compared to formalin-killed VHSV vaccine against VHSV genotype Ia in rainbow trout (Oncorhynchus mykiss)","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2025.110409","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110409"}}