{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T19:14:31Z","timestamp":1781118871517,"version":"3.54.1"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["OP VVV CZ.02.1.01\/0.0\/0.0\/18_046\/0016045"],"award-info":[{"award-number":["OP VVV CZ.02.1.01\/0.0\/0.0\/18_046\/0016045"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["LM2023050"],"award-info":[{"award-number":["LM2023050"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018707","name":"European Commission Reforming and enhancing the European Research and Innovation system","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018707","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.fsi.2025.110427","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T11:51:24Z","timestamp":1747655484000},"page":"110427","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Common carp (Cyprinus carpio) blood cells are modulated by a parasitic antimicrobial peptide, A-2S and Edwardsiella spp. strains"],"prefix":"10.1016","volume":"164","author":[{"given":"Oluwabusayo Israel","family":"Okeleye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7416-3908","authenticated-orcid":false,"given":"Jovana","family":"Majstorovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3083-1636","authenticated-orcid":false,"given":"Anupa","family":"Sudharaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Triga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manolis","family":"Mandalakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pantelis","family":"Katharios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1364-3593","authenticated-orcid":false,"given":"Ivona","family":"Mladineo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2025.110427_bib1","doi-asserted-by":"crossref","first-page":"1149514","DOI":"10.3389\/fvets.2023.1149514","article-title":"Exploring the roles of phytobiotics in relieving the impacts of Edwardsiella tarda infection on fish: a mini-review","volume":"10","author":"Goh","year":"2023","journal-title":"Front. Vet. Sci."},{"issue":"2","key":"10.1016\/j.fsi.2025.110427_bib2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s15010-011-0080-1","article-title":"Osteomyelitis due to trimethoprim\/sulfamethoxazole-resistant Edwardsiella tarda infection in a patient with X-linked chronic granulomatous disease","volume":"39","author":"Kawai","year":"2011","journal-title":"Infection"},{"issue":"5","key":"10.1016\/j.fsi.2025.110427_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0036987","article-title":"Edwardsiella comparative phylogenomics reveal the new intra\/inter-species taxonomic relationships, virulence evolution and niche adaptation mechanisms","volume":"7","author":"Yang","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.fsi.2025.110427_bib4","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.syapm.2017.09.004","article-title":"Genetic studies to re-affiliate Edwardsiella tarda fish strains to Edwardsiella piscicida and Edwardsiella anguillarum species","volume":"41","author":"Buj\u00e1n","year":"2018","journal-title":"Syst. Appl. Microbiol."},{"key":"10.1016\/j.fsi.2025.110427_bib5","first-page":"345","article-title":"Edwardsiellosis","author":"Pakingking","year":"2021","journal-title":"Aquaculture Pathophysiology"},{"key":"10.1016\/j.fsi.2025.110427_bib6","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.aquaculture.2013.12.001","article-title":"Edwardsiella tarda: an intriguing problem in aquaculture","volume":"431","author":"Xu","year":"2014","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2025.110427_bib7","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/s12917-015-0482-x","article-title":"First report of edwardsiellosis in cage-cultured sharpsnout sea bream, Diplodus puntazzo, from the Mediterranean","volume":"11","author":"Katharios","year":"2015","journal-title":"BMC Vet. Res."},{"issue":"7","key":"10.1016\/j.fsi.2025.110427_bib8","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1007\/s12038-007-0143-8","article-title":"Edwardsiellosis in fish: a brief review","volume":"32","author":"Mohanty","year":"2007","journal-title":"J. Biosci."},{"issue":"5","key":"10.1016\/j.fsi.2025.110427_bib9","first-page":"393","article-title":"Edwardsiella tarda associated with human disease","volume":"37","author":"Bockem\u00fchl","year":"1971","journal-title":"Pathol. Microbiol."},{"issue":"2","key":"10.1016\/j.fsi.2025.110427_bib10","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s11274-014-1758-1","article-title":"Quantitative and qualitative analyses of the bacterial microbiota of tilapia (Oreochromis niloticus) cultured in earthen ponds in the Philippines","volume":"31","author":"Pakingking","year":"2015","journal-title":"World J. Microbiol. Biotechnol."},{"key":"10.1016\/j.fsi.2025.110427_bib11","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.jprot.2015.05.008","article-title":"Comparative proteomic study of Edwardsiella tarda strains with different degrees of virulence","volume":"127","author":"Buj\u00e1n","year":"2015","journal-title":"J. Proteonomics"},{"issue":"3\u20134","key":"10.1016\/j.fsi.2025.110427_bib12","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.vetmic.2012.12.027","article-title":"Edwardsiella tarda invasion of fish cell lines and the activation of divergent cell death pathways","volume":"163","author":"Wang","year":"2013","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.fsi.2025.110427_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2021.737643","article-title":"Prevalence, antimicrobial resistance (AMR) pattern, virulence determinant and AMR genes of emerging multi-drug resistant Edwardsiella tarda in Nile tilapia and African catfish","volume":"548","author":"Algammal","year":"2022","journal-title":"Aquaculture"},{"issue":"2","key":"10.1016\/j.fsi.2025.110427_bib14","doi-asserted-by":"crossref","first-page":"141","DOI":"10.4194\/1303-2712-v19_2_06","article-title":"Antibiotic resistance and virulence-associated gene profile of Edwardsiella tarda isolated from cultured fish in Japan","volume":"19","author":"Wimalasena","year":"2019","journal-title":"Turk. J. Fish. Aquat. Sci."},{"issue":"5","key":"10.1016\/j.fsi.2025.110427_bib15","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.micpath.2012.01.006","article-title":"Large antibiotic-resistance plasmid of Edwardsiella tarda contributes to virulence in fish","volume":"52","author":"Yu","year":"2012","journal-title":"Microb. Pathog."},{"issue":"5","key":"10.1016\/j.fsi.2025.110427_bib16","doi-asserted-by":"crossref","first-page":"668","DOI":"10.4014\/jmb.2301.01008","article-title":"Resistance patterns of frequently applied antimicrobials and occurrence of antibiotic resistance genes in Edwardsiella tarda detected in Edwardsiellosis-infected tilapia species of fish farms of Punjab in Pakistan","volume":"33","author":"Manzoor","year":"2023","journal-title":"J. Microbiol. Biotechnol."},{"issue":"1","key":"10.1016\/j.fsi.2025.110427_bib17","doi-asserted-by":"crossref","first-page":"171","DOI":"10.21608\/scvmj.2021.184978","article-title":"Antibiotic resistance and antibiotic resistance genes among Edwardsiella tarda isolated from fish","volume":"26","author":"Mahmoud","year":"2021","journal-title":"Suez Canal Veterinary Medical Journal (SCVMJ)"},{"key":"10.1016\/j.fsi.2025.110427_bib18","first-page":"95","article-title":"Antibiotics resistance pattern and plasmid profiling of Edwardsiella tarda isolated from Heterobranchus longifilis","volume":"6","author":"Ogbonne","year":"2018","journal-title":"J. Biosci. Med."},{"issue":"1","key":"10.1016\/j.fsi.2025.110427_bib19","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1365-2109.2008.02101.x","article-title":"Isolation and identification of fish pathogen Edwardsiella tarda from mariculture in China","volume":"40","author":"Xiao","year":"2009","journal-title":"Aquac. Res."},{"issue":"1","key":"10.1016\/j.fsi.2025.110427_bib20","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/21505594.2021.2006890","article-title":"Versatile lifestyles of Edwardsiella: free-living, pathogen, and core bacterium of the aquatic resistome","volume":"13","author":"Leung","year":"2022","journal-title":"Virulence"},{"issue":"1\u20132","key":"10.1016\/j.fsi.2025.110427_bib21","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.aquaculture.2008.12.021","article-title":"Genetic mechanisms of multi-antimicrobial resistance in a pathogenic Edwardsiella tarda strain","volume":"289","author":"Sun","year":"2009","journal-title":"Aquaculture"},{"issue":"1","key":"10.1016\/j.fsi.2025.110427_bib22","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cimid.2006.10.003","article-title":"Genotyping of Edwardsiella tarda isolated from freshwater fish culture system","volume":"30","author":"Acharya","year":"2007","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"issue":"5","key":"10.1016\/j.fsi.2025.110427_bib23","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.pt.2023.02.004","article-title":"Helminthic host defense peptides: using the parasite to defend the host","volume":"39","author":"Mladineo","year":"2023","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.fsi.2025.110427_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.637427","article-title":"Marine peptide-n6nh2 and its derivative-guon6nh2 have potent antimicrobial activity against intracellular Edwardsiella tarda in vitro and in vivo","volume":"12","author":"Han","year":"2021","journal-title":"Front. Microbiol."},{"issue":"5","key":"10.1016\/j.fsi.2025.110427_bib25","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1128\/AAC.49.5.1727-1732.2005","article-title":"Immunomodulatory activities of small host defense peptides","volume":"49","author":"Bowdish","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.fsi.2025.110427_bib26","doi-asserted-by":"crossref","first-page":"582779","DOI":"10.3389\/fmicb.2020.582779","article-title":"Antimicrobial peptides: classification, design, application and research progress in multiple fields","volume":"11","author":"Huan","year":"2020","journal-title":"Front. Microbiol."},{"issue":"3","key":"10.1016\/j.fsi.2025.110427_bib27","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.imbio.2010.07.003","article-title":"Host defense peptides and their antimicrobial-immunomodulatory duality","volume":"216","author":"Steinstraesser","year":"2011","journal-title":"Immunobiology"},{"issue":"6","key":"10.1016\/j.fsi.2025.110427_bib28","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S1471-4906(02)02246-9","article-title":"Mammalian defensins in immunity: more than just microbicidal","volume":"23","author":"Yang","year":"2002","journal-title":"Trends Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2025.110427_bib29","doi-asserted-by":"crossref","first-page":"947","DOI":"10.4049\/jimmunol.163.2.947","article-title":"Neutrophil defensins induce histamine secretion from mast cells: mechanisms of action","volume":"163","author":"Befus","year":"1999","journal-title":"J. Immunol."},{"issue":"22","key":"10.1016\/j.fsi.2025.110427_bib30","doi-asserted-by":"crossref","first-page":"5713","DOI":"10.3390\/ijms20225713","article-title":"Antimicrobial peptides as anti-infective agents in the pre-post-antibiotic era?","volume":"20","author":"Ron\u010devi\u0107","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fsi.2025.110427_bib31","doi-asserted-by":"crossref","first-page":"1567505","DOI":"10.3389\/fimmu.2025.1567505","article-title":"Cecropin anisaxin-2S has in vitro immunomodulatory, but not antiproliferative and antiviral properties","volume":"16","author":"Majstorovi\u0107","year":"2025","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2025.110427_bib32","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3390\/molecules25010148","article-title":"Comparative evaluation of essential oils from medicinal-aromatic plants of Greece: chemical composition, antioxidant capacity and antimicrobial activity against bacterial fish pathogens","volume":"25","author":"Anastasiou","year":"2019","journal-title":"Molecules"},{"issue":"9","key":"10.1016\/j.fsi.2025.110427_bib33","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"issue":"12","key":"10.1016\/j.fsi.2025.110427_bib34","doi-asserted-by":"crossref","first-page":"3466","DOI":"10.1128\/JCM.00970-17","article-title":"Comparative phenotypic and genotypic analysis of Edwardsiella isolates from different hosts and geographic origins, with emphasis on isolates formerly classified as E. tarda, and evaluation of diagnostic methods","volume":"55","author":"Reichley","year":"2017","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.fsi.2025.110427_bib35","doi-asserted-by":"crossref","first-page":"235680","DOI":"10.3389\/fmicb.2017.00069","article-title":"Outer membrane proteins form specific patterns in antibiotic-resistant Edwardsiella tarda","volume":"8","author":"Peng","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.fsi.2025.110427_bib36","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.micpath.2016.02.020","article-title":"Influence of lipopolysaccharide outer-core in the intrinsic resistance to antimicrobial peptides and virulence in Edwardsiella ictaluri","volume":"93","author":"Martin","year":"2016","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.fsi.2025.110427_bib37","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.2147\/JIR.S275595","article-title":"Reactive oxygen species: drivers of physiological and pathological processes","volume":"13","author":"Checa","year":"2020","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.fsi.2025.110427_bib38","doi-asserted-by":"crossref","first-page":"716406","DOI":"10.3389\/fcell.2021.716406","article-title":"Reactive oxygen species: not omnipresent but important in many locations","volume":"9","author":"Herb","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"12","key":"10.1016\/j.fsi.2025.110427_bib39","article-title":"Ce-Duox1\/BLI-3 generated reactive oxygen species trigger protective SKN-1 activity via p38 MAPK signaling during infection in C. elegans","volume":"7","author":"Hoeven","year":"2011","journal-title":"PLoS Pathog."},{"issue":"7344","key":"10.1016\/j.fsi.2025.110427_bib40","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/nature09973","article-title":"TLR signaling augments macrophage bactericidal activity through mitochondrial ROS","volume":"472","author":"West","year":"2011","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.fsi.2025.110427_bib41","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.freeradbiomed.2009.11.012","article-title":"Hydrogen peroxide is the major oxidant product of xanthine oxidase","volume":"48","author":"Kelley","year":"2010","journal-title":"Free Radical Biol. Med."},{"issue":"6","key":"10.1016\/j.fsi.2025.110427_bib42","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3109\/03014460.2013.807878","article-title":"An estimation of the number of cells in the human body","volume":"40","author":"Bianconi","year":"2013","journal-title":"Ann. Hum. Biol."},{"issue":"4","key":"10.1016\/j.fsi.2025.110427_bib43","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1046\/j.1365-2958.1997.3971760.x","article-title":"Iron-regulated haemolysin gene from Edwardsiella tarda","volume":"24","author":"Hirono","year":"1997","journal-title":"Mol. Microbiol."},{"issue":"5","key":"10.1016\/j.fsi.2025.110427_bib44","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.4049\/jimmunol.1800565","article-title":"The evolving erythrocyte: RBCs as modulators of innate immunity","volume":"201","author":"Anderson","year":"2018","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.fsi.2025.110427_bib45","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/sj.bjp.0707311","article-title":"Stimulation of rat erythrocyte P2X7 receptor induces the release of epoxyeicosatrienoic acids","volume":"151","author":"Jiang","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.fsi.2025.110427_bib46","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.micpath.2017.08.028","article-title":"Proteomic analysis of macrophage in response to Edwardsiella tarda-infection","volume":"111","author":"Qin","year":"2017","journal-title":"Microb. Pathog."},{"issue":"9","key":"10.1016\/j.fsi.2025.110427_bib47","doi-asserted-by":"crossref","first-page":"5689","DOI":"10.1128\/IAI.69.9.5689-5697.2001","article-title":"Opsonized virulent Edwardsiella tarda strains are able to adhere to and survive and replicate within fish phagocytes but fail to stimulate reactive oxygen intermediates","volume":"69","author":"Srinivasa Rao","year":"2001","journal-title":"Infect. Immun."},{"issue":"5","key":"10.1016\/j.fsi.2025.110427_bib48","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02021-19","article-title":"Cathelicidin peptides restrict bacterial growth via membrane perturbation and induction of reactive oxygen species","volume":"10","author":"Rowe-Magnus","year":"2019","journal-title":"mBio"},{"issue":"8","key":"10.1016\/j.fsi.2025.110427_bib49","doi-asserted-by":"crossref","first-page":"6211","DOI":"10.1074\/jbc.M110.181206","article-title":"Antimicrobial peptides increase tolerance to oxidant stress in Drosophila melanogaster","volume":"286","author":"Zhao","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.fsi.2025.110427_bib50","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.chom.2013.05.012","article-title":"The normalcy of dormancy: common themes in microbial quiescence","volume":"13","author":"Rittershaus","year":"2013","journal-title":"Cell Host Microbe"},{"issue":"2","key":"10.1016\/j.fsi.2025.110427_bib51","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nrmicro1340","article-title":"Long-term survival during stationary phase: evolution and the GASP phenotype","volume":"4","author":"Finkel","year":"2006","journal-title":"Nat. Rev. Microbiol."},{"issue":"7518","key":"10.1016\/j.fsi.2025.110427_bib52","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/nature13469","article-title":"Optimization of lag time underlies antibiotic tolerance in evolved bacterial populations","volume":"513","author":"Fridman","year":"2014","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.fsi.2025.110427_bib53","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1574-6968.2012.02528.x","article-title":"Resistance to antimicrobial peptides in Gram-negative bacteria","volume":"330","author":"Gruenheid","year":"2012","journal-title":"FEMS (Fed. Eur. Microbiol. Soc.) Microbiol. Lett."},{"key":"10.1016\/j.fsi.2025.110427_bib54","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.actbio.2022.04.025","article-title":"Anisaxins, helical antimicrobial peptides from marine parasites, kill resistant bacteria by lipid extraction and membrane disruption","volume":"146","author":"Ron\u010devi\u0107","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.fsi.2025.110427_bib55","doi-asserted-by":"crossref","first-page":"1005546","DOI":"10.3389\/fimmu.2022.1005546","article-title":"Editorial: the role of red blood cells in the immune response of fish","volume":"13","author":"Ortega-Villaizan","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2025.110427_bib56","doi-asserted-by":"crossref","first-page":"1407237","DOI":"10.3389\/fimmu.2024.1407237","article-title":"Erythrocytes of the common carp are immune sentinels that sense pathogen molecular patterns, engulf particles and secrete pro-inflammatory cytokines against bacterial infection","volume":"15","author":"Majstorovi\u0107","year":"2024","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.fsi.2025.110427_bib57","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/jfb.15465","article-title":"Red blood cells of Labeo rohita express Toll-like receptors, NOD-like receptors, interleukins, and interferon-I in response to Gram-negative bacterial infections and lipopolysaccharide stimulations","volume":"103","author":"Mahapatra","year":"2023","journal-title":"J. Fish. Biol."},{"issue":"9","key":"10.1016\/j.fsi.2025.110427_bib58","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1111\/jth.13041","article-title":"Procoagulant and proinflammatory effects of red blood cells on lipopolysaccharide\u2010stimulated monocytes","volume":"13","author":"\u00d8sterud","year":"2015","journal-title":"J. Thromb. Haemostasis"},{"issue":"9","key":"10.1016\/j.fsi.2025.110427_bib59","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.3390\/ijms21093094","article-title":"Transcriptome analysis of Paralichthys olivaceus erythrocytes reveals profound immune responses induced by Edwardsiella tarda infection","volume":"21","author":"Sun","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1\u20132","key":"10.1016\/j.fsi.2025.110427_bib60","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.vetimm.2013.02.004","article-title":"Adaptive immune response to Edwardsiella tarda infection in ginbuna crucian carp, Carassius auratus langsdorfii","volume":"153","author":"Yamasaki","year":"2013","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.fsi.2025.110427_bib61","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.fsi.2019.03.034","article-title":"In vitro immunomodulatory activities of peptides derived from Salmo salar NK-lysin and cathelicidin in fish cells","volume":"88","author":"Acosta","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110427_bib62","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.fsi.2021.07.022","article-title":"Characterisation and analysis of IFN-gamma producing cells in rainbow trout Oncorhynchus mykiss","volume":"117","author":"Hu","year":"2021","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110427_bib63","doi-asserted-by":"crossref","first-page":"1439082","DOI":"10.3389\/fimmu.2024.1439082","article-title":"Upregulation of interferon-\u03b3 response genes in monocytes and T cells identified by single-cell transcriptomics in patients with anti-citrullinated peptide antibody-positive early rheumatoid arthritis","volume":"15","author":"Hong","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2025.110427_bib64","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.dci.2017.02.005","article-title":"The role of type I interferons in innate and adaptive immunity against viruses in Atlantic salmon","volume":"80","author":"Robertsen","year":"2018","journal-title":"Dev. Comp. Immunol."},{"issue":"5","key":"10.1016\/j.fsi.2025.110427_bib65","doi-asserted-by":"crossref","DOI":"10.4110\/in.2018.18.e33","article-title":"Direct antiviral mechanisms of interferon-gamma","volume":"18","author":"Kang","year":"2018","journal-title":"Immune Network"},{"key":"10.1016\/j.fsi.2025.110427_bib66","first-page":"41","article-title":"Regulation of interferon\u2010\u03b3 during innate and adaptive immune responses","volume":"96","author":"Schoenborn","year":"2006","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.fsi.2025.110427_bib67","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.fsi.2021.10.001","article-title":"The antibacterial activity of erythrocytes from Clarias fuscus associated with phagocytosis and respiratory burst generation","volume":"119","author":"Xu","year":"2021","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110427_bib68","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.fsi.2019.06.008","article-title":"Antibacterial activity of erythrocyte from grass carp (Ctenopharyngodon idella) is associated with phagocytosis and reactive oxygen species generation","volume":"92","author":"Qin","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110427_bib69","doi-asserted-by":"crossref","first-page":"824","DOI":"10.3389\/fimmu.2020.00824","article-title":"Recent advances on phagocytic B cells in teleost fish","volume":"11","author":"Wu","year":"2020","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2025.110427_bib70","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.aaf.2021.12.008","article-title":"Antimicrobial roles of phagocytosis in teleost fish: phagocytic B cells vs professional phagocytes","volume":"9","author":"Wu","year":"2024","journal-title":"Aquaculture & Fisheries"},{"issue":"6","key":"10.1016\/j.fsi.2025.110427_bib71","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.4049\/jimmunol.1301312","article-title":"B cells in teleost fish act as pivotal initiating APCs in priming adaptive immunity: an evolutionary perspective on the origin of the B-1 cell subset and B7 molecules","volume":"192","author":"Zhu","year":"2014","journal-title":"J. Immunol."}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105046482500316X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105046482500316X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T15:02:21Z","timestamp":1762354941000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S105046482500316X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":71,"alternative-id":["S105046482500316X"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2025.110427","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Common carp (Cyprinus carpio) blood cells are modulated by a parasitic antimicrobial peptide, A-2S and Edwardsiella spp. strains","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2025.110427","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110427"}}