{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:40:49Z","timestamp":1790199649166,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Korea Ministry of Science and ICT","doi-asserted-by":"publisher","award":["RS-2024-00405986"],"award-info":[{"award-number":["RS-2024-00405986"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.fsi.2025.110455","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T16:04:24Z","timestamp":1748275464000},"page":"110455","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Effect of exchange of viral hemorrhagic septicemia virus (VHSV) G protein's signal peptide with piscidin signal peptide on virus replication and immunogenicity"],"prefix":"10.1016","volume":"164","author":[{"given":"Mariem","family":"Bessaid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1140-8162","authenticated-orcid":false,"given":"Ki Hong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2025.110455_bib1","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1007\/s00018-017-2743-2","article-title":"Inhibitors of protein translocation across membranes of the secretory pathway: novel antimicrobial and anticancer agents","volume":"75","author":"Puyenbroeck","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.fsi.2025.110455_bib2","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0092-8674(00)80159-2","article-title":"Signal sequences: the same yet different","volume":"86","author":"Zheng","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.fsi.2025.110455_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003618","article-title":"Soluble HIV-1 env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies","volume":"9","author":"Sanders","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.fsi.2025.110455_bib4","doi-asserted-by":"crossref","first-page":"e366","DOI":"10.1016\/S2352-3018(18)30071-7","article-title":"H. 100 P. Team, Subtype C ALVAC-HIV and bivalent subtype C gp120\/MF59 HIV-1 vaccine in low-risk, HIV-uninfected, South African adults: a phase 1\/2 trial","volume":"5","author":"Bekker","year":"2018","journal-title":"Lancet HIV"},{"key":"10.1016\/j.fsi.2025.110455_bib5","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1073\/pnas.1722627115","article-title":"Signal peptide of HIV envelope protein impacts glycosylation and antigenicity of gp120","volume":"115","author":"Yolitz","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.fsi.2025.110455_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1476924","article-title":"Signal peptide exchange alters HIV-1 envelope antigenicity and immunogenicity","volume":"15","author":"Upadhyay","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2025.110455_bib7","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1365-2761.2005.00654.x","article-title":"Viral haemorrhagic septicaemia virus in marine fish and its implications for fish farming \u2013 a review","volume":"28","author":"Skall","year":"2005","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2025.110455_bib8","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.3390\/ani12111363","article-title":"Revised taxonomy of rhabdoviruses infecting fish and marine mammals","volume":"12","author":"Walker","year":"2022","journal-title":"Animals"},{"key":"10.1016\/j.fsi.2025.110455_bib9","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3389\/fphys.2016.00192","article-title":"Turbot (Scophthalmus maximus) vs. VHSV (viral hemorrhagic septicemia virus): a review","volume":"7","author":"Pereiro","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.fsi.2025.110455_bib10","series-title":"Eighth Report of the International Committee on Taxonomy of Viruses","first-page":"623","article-title":"Rhabdoviridae, in virus taxonomy","author":"Tordo","year":"2005"},{"key":"10.1016\/j.fsi.2025.110455_bib11","first-page":"413","article-title":"The glycoprotein of viral hemorrhagic septicemia virus (VHSV): antigenicity and role in virulence","volume":"26","author":"B\u00e9arzotti","year":"1995","journal-title":"Vet. Res."},{"key":"10.1016\/j.fsi.2025.110455_bib12","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1006\/viro.1998.9076","article-title":"Phospholipid interactions of a peptide from the fusion-related domain of the glycoprotein of VHSV, a fish rhabdovirus","volume":"243","author":"Nu\u00f1ez","year":"1998","journal-title":"Virology"},{"key":"10.1016\/j.fsi.2025.110455_bib13","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12985-019-1139-3","article-title":"The glycoprotein, non-virion protein, and polymerase of viral hemorrhagic septicemia virus are not determinants of host-specific virulence in rainbow trout","volume":"16","author":"Yusuff","year":"2019","journal-title":"Virol. J."},{"key":"10.1016\/j.fsi.2025.110455_bib14","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.3390\/vaccines11071205","article-title":"High-level expression of recombinant VHSV glycoprotein using transformed C. vulgaris and verification of vaccine efficacy","volume":"11","author":"Kim","year":"2023","journal-title":"Vaccines"},{"key":"10.1016\/j.fsi.2025.110455_bib15","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.vaccine.2008.12.007","article-title":"Dual DNA vaccination of rainbow trout (Oncorhynchus mykiss) against two different rhabdoviruses, VHSV and IHNV, induces specific divalent protection","volume":"27","author":"Einer-Jensen","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2025.110455_bib16","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1006\/fsim.2002.0422","article-title":"DNA vaccines as a tool for analysing the protective immune response against rhabdoviruses in rainbow trout","volume":"12","author":"Lorenzen","year":"2002","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110455_bib17","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.fsi.2012.03.004","article-title":"Protection and antibody response induced by intramuscular DNA vaccine encoding for viral haemorrhagic septicaemia virus (VHSV) G glycoprotein in turbot (Scophthalmus maximus)","volume":"32","author":"Pereiro","year":"2012","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110455_bib18","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/abbs\/gmq117","article-title":"Signal peptide replacements enhance expression and secretion of hepatitis C virus envelope glycoproteins","volume":"43","author":"Wen","year":"2011","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.fsi.2025.110455_bib19","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/sj.embor.7400002","article-title":"Identification of Lassa virus glycoprotein signal peptide as a trans\u2010acting maturation factor","volume":"4","author":"Eichler","year":"2003","journal-title":"EMBO Rep."},{"key":"10.1016\/j.fsi.2025.110455_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0159423","article-title":"A diverse family of host-defense peptides (piscidins) exhibit specialized anti-bacterial and anti-Protozoal activities in fishes","volume":"11","author":"Salger","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2025.110455_bib21","doi-asserted-by":"crossref","first-page":"855","DOI":"10.3390\/antibiotics12050855","article-title":"Teleost piscidins\u2014in silico perspective of natural peptide antibiotics from marine sources","volume":"12","author":"Asensio-Calavia","year":"2023","journal-title":"Antibiotics"},{"key":"10.1016\/j.fsi.2025.110455_bib22","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.aquaculture.2011.01.050","article-title":"Protection of olive flounder, Paralichthys olivaceus, against viral hemorrhagic septicemia virus (VHSV) by immunization with NV gene-knockout recombinant VHSV","volume":"314","author":"Kim","year":"2011","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2025.110455_bib23","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.fsi.2015.05.031","article-title":"Generation of G gene-deleted viral hemorrhagic septicemia virus (VHSV) and evaluation of its vaccine potential in olive flounder (Paralichthys olivaceus)","volume":"45","author":"Kim","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110455_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252413534","article-title":"Signal peptides and their fragments in post-translation: novel insights of signal peptides","volume":"25","author":"Ono","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fsi.2025.110455_bib25","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/16729","article-title":"Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase","volume":"397","author":"Harding","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2025.110455_bib26","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3389\/fmolb.2019.00011","article-title":"Structure and molecular mechanism of ER stress signaling by the unfolded protein response signal activator IRE1","volume":"6","author":"Adams","year":"2019","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.fsi.2025.110455_bib27","doi-asserted-by":"crossref","first-page":"12747","DOI":"10.1128\/JVI.78.23.12747-12761.2004","article-title":"Resistance to vesicular stomatitis virus infection requires a functional cross talk between the eukaryotic translation initiation factor 2\u03b1 kinases PERK and PKR","volume":"78","author":"Baltzis","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.fsi.2025.110455_bib28","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3390\/v12050499","article-title":"Effect of the viral hemorrhagic septicemia virus nonvirion protein on translation via PERK-eIF2\u03b1 pathway","volume":"12","author":"Kesterson","year":"2020","journal-title":"Viruses"},{"key":"10.1016\/j.fsi.2025.110455_bib29","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00431-18","article-title":"The PERK arm of the unfolded protein response negatively regulates transmissible gastroenteritis virus replication by suppressing protein translation and promoting type I interferon production","volume":"92","author":"Xue","year":"2018","journal-title":"J. Virol."},{"key":"10.1016\/j.fsi.2025.110455_bib30","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3109\/1040841X.2013.813899","article-title":"The expanding roles of endoplasmic reticulum stress in virus replication and pathogenesis","volume":"41","author":"Li","year":"2015","journal-title":"Crit. Rev. Microbiol."},{"key":"10.1016\/j.fsi.2025.110455_bib31","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1099\/vir.0.057448-0","article-title":"High virulence differences among phylogenetically distinct isolates of the fish rhabdovirus viral hemorrhagic septicaemia virus are not explained by variability of the surface glycoprotein G or the non-virion protein Nv","volume":"95","author":"Einer-Jensen","year":"2014","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.fsi.2025.110455_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006812","article-title":"Alterations of HIV-1 envelope phenotype and antibody-mediated neutralization by signal peptide mutations","volume":"14","author":"Upadhyay","year":"2018","journal-title":"PLoS Pathog."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464825003444?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464825003444?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T22:44:09Z","timestamp":1750286649000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464825003444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":32,"alternative-id":["S1050464825003444"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2025.110455","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of exchange of viral hemorrhagic septicemia virus (VHSV) G protein's signal peptide with piscidin signal peptide on virus replication and immunogenicity","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2025.110455","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110455"}}