{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T19:52:54Z","timestamp":1783626774610,"version":"3.55.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002701","name":"Korea Ministry of Education","doi-asserted-by":"publisher","award":["RS-2019- NR040078"],"award-info":[{"award-number":["RS-2019- NR040078"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011705","name":"Korea Institute of Marine Science and Technology promotion","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011705","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003566","name":"Korea Ministry of Oceans and Fisheries","doi-asserted-by":"publisher","award":["RS-2022- KS221670"],"award-info":[{"award-number":["RS-2022- KS221670"]}],"id":[{"id":"10.13039\/501100003566","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.fsi.2025.110499","type":"journal-article","created":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T10:55:41Z","timestamp":1749898541000},"page":"110499","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Molecular characterization and functional analysis of MyD88 in red-spotted grouper (Epinephelus akaara): Insights into immune regulation and antiviral defense"],"prefix":"10.1016","volume":"165","author":[{"given":"Jeganathan Tharshan","family":"Jeyakanesh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5495-6160","authenticated-orcid":false,"given":"E.M.T.","family":"Tharanga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.M.K.P.","family":"Sirisena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.D.H.E.","family":"Jayasinghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheong Uk","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanchang","family":"Sohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4025-4622","authenticated-orcid":false,"given":"Jehee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2025.110499_bib1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.dci.2014.12.013","article-title":"Identification, expression pattern and functional characterization of As-MyD88 in bacteria challenge and during different developmental stages of Artemia sinica","volume":"50","author":"Qin","year":"2015","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2025.110499_bib2","first-page":"1095","article-title":"Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6","volume":"5","author":"Lord","year":"1990","journal-title":"Oncogene"},{"key":"10.1016\/j.fsi.2025.110499_bib3","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.ajpath.2013.06.013","article-title":"MyD88-Dependent signaling prolongs survival and reduces bacterial burden during pulmonary infection with virulent Francisella tularensis","volume":"183","author":"Russo","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.fsi.2025.110499_bib4","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/S0002-9440(10)62359-0","article-title":"Lethal encephalitis in Myeloid differentiation factor 88-Deficient mice infected with Herpes simplex virus 1","volume":"166","author":"Mansur","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.fsi.2025.110499_bib5","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1177\/0022034510381264","article-title":"TLR-signaling networks","volume":"90","author":"Brown","year":"2011","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.fsi.2025.110499_bib6","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/s00109-004-0622-4","article-title":"Modulation of toll-interleukin 1 receptor mediated signaling","volume":"83","author":"Li","year":"2005","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.fsi.2025.110499_bib7","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.dci.2003.09.016","article-title":"The interleukin 1 receptor family","volume":"28","author":"Subramaniam","year":"2004","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2025.110499_bib8","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/nrg2303","article-title":"Toll-like receptors taking an evolutionary approach","volume":"9","author":"Leulier","year":"2008","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.fsi.2025.110499_bib9","doi-asserted-by":"crossref","first-page":"25404","DOI":"10.1074\/jbc.M109.022392","article-title":"An oligomeric signaling platform formed by the toll-like receptor signal transducers MyD88 and IRAK-4","volume":"284","author":"Motshwene","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fsi.2025.110499_bib10","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1021\/jm5016044","article-title":"Recent advances in the discovery of small molecule inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4) as a therapeutic target for inflammation and oncology disorders","volume":"58","author":"Chaudhary","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.fsi.2025.110499_bib11","doi-asserted-by":"crossref","first-page":"15136","DOI":"10.1073\/pnas.0607181103","article-title":"Evidence for licensing of IFN-\u03b3-induced IFN regulatory factor 1 transcription factor by MyD88 in toll-like receptor-dependent gene induction program","volume":"103","author":"Negishi","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.fsi.2025.110499_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2014.00367","article-title":"Toll-like receptors and cancer: MYD88 mutation and inflammation","volume":"5","author":"Wang","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2025.110499_bib13","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.jaci.2006.02.023","article-title":"Toll-like receptor function and signaling","volume":"117","author":"Kaisho","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.fsi.2025.110499_bib14","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.fsi.2025.110499_bib15","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/nature07959","article-title":"Ubiquitylation in innate and adaptive immunity","volume":"458","author":"Bhoj","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2025.110499_bib16","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0925-4773(00)00447-0","article-title":"The Toll\/IL-1 receptor binding protein MyD88 is required for Xenopus axis formation","volume":"97","author":"Prothmann","year":"2000","journal-title":"Mech. Dev."},{"key":"10.1016\/j.fsi.2025.110499_bib17","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.cell.2012.03.036","article-title":"DICER1 loss and alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88","volume":"149","author":"Tarallo","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.fsi.2025.110499_bib18","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1093\/emboj\/19.13.3325","article-title":"The apoptotic signaling pathway activated by toll-like receptor-2","volume":"19","author":"Aliprantis","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.fsi.2025.110499_bib19","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1080\/10425170701295856","article-title":"Molecular cloning and expression analysis of chicken MyD88 and TRIF genes","volume":"18","author":"Wheaton","year":"2007","journal-title":"DNA Sequence"},{"key":"10.1016\/j.fsi.2025.110499_bib20","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.molimm.2003.10.001","article-title":"Toll-like receptor gene family and TIR-domain adapters in Danio rerio","volume":"40","author":"Jault","year":"2004","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.fsi.2025.110499_bib21","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.dci.2005.11.003","article-title":"Identification and characterization of a myeloid differentiation factor 88 (MyD88) cDNA and gene in Japanese flounder, Paralichthys olivaceus","volume":"30","author":"Takano","year":"2006","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2025.110499_bib22","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1007\/s13205-018-1448-z","article-title":"Identification and characterization of the myeloid differentiation factor 88 gene in yellow catfish","volume":"8","author":"Yu","year":"2018","journal-title":"3 Biotech"},{"key":"10.1016\/j.fsi.2025.110499_bib23","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.dci.2009.04.007","article-title":"Identification and characterization of TLR8 and MyD88 homologs in Atlantic salmon (Salmo salar)","volume":"33","author":"Skj\u00e6veland","year":"2009","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2025.110499_bib24","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.fsi.2019.04.035","article-title":"Spotted knifejaw (Oplegnathus punctatus) MyD88: intracellular localization, signal transduction function and immune responses to bacterial infection","volume":"89","author":"Liu","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110499_bib25","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.fsi.2014.10.041","article-title":"Grouper (Epinephelus coioides) MyD88 and Tollip: intracellular localization and signal transduction function","volume":"42","author":"Li","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110499_bib26","doi-asserted-by":"crossref","first-page":"127","DOI":"10.12717\/DR.2014.18.3.127","article-title":"Induction of primary Male in juvenile red spotted grouper (Epinephelus akaara) by immersion of 17\u03b1-Methyltestosterone","volume":"18","author":"Lee","year":"2014","journal-title":"Dev. Reprod."},{"key":"10.1016\/j.fsi.2025.110499_bib27","first-page":"99","article-title":"Efficacy of live NNV immersion vaccination in three grouper species (seven band grouper Hyporthodus septemfasciatus, red spotted grouper Epinephelus akaara, long tooth grouper Epinephelus bruneus)","volume":"34","author":"Kim","year":"2021","journal-title":"J. Fish Pathol."},{"key":"10.1016\/j.fsi.2025.110499_bib28","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.fsi.2025.110499_bib29","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.fsi.2019.06.015","article-title":"Molecular characterization and expression analysis of rockfish (Sebastes schlegelii) viperin, and its ability to enervate RNA virus transcription and replication in vitro","volume":"92","author":"Shanaka","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110499_bib30","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.3390\/v6052204","article-title":"Development and application of quantitative detection method for viral hemorrhagic septicemia virus (VHSV) genogroup IVa","volume":"6","author":"Kim","year":"2014","journal-title":"Viruses"},{"key":"10.1016\/j.fsi.2025.110499_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0054156","article-title":"Phylogeny of toll-like receptor signaling: adapting the innate response","volume":"8","author":"Roach","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2025.110499_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2023.105610","article-title":"Molecular characterization of MyD88 as a potential biomarker for pesticide-induced stress in Bombyx mori","volume":"196","author":"Hao","year":"2023","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.fsi.2025.110499_bib33","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1107\/S2059798324008210","article-title":"Microcrystal electron diffraction structure of toll-like receptor 2 TIR-domain-nucleated MyD88 TIR-Domain higher-order assembly","volume":"80","author":"Li","year":"2024","journal-title":"Acta Crystallogr. D Struct. Biol."},{"key":"10.1016\/j.fsi.2025.110499_bib34","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.coi.2003.11.002","article-title":"Blood cells of Drosophila: cell lineages and role in host defence","volume":"16","author":"Meister","year":"2004","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.fsi.2025.110499_bib35","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1111\/febs.13235","article-title":"Drosophila blood cells and their role in immune responses","volume":"282","author":"Vlisidou","year":"2015","journal-title":"FEBS J."},{"key":"10.1016\/j.fsi.2025.110499_bib36","article-title":"Dynamic immune response in the spleens of rainbow trout (Oncorhynchus mykiss) to infectious hematopoietic necrosis virus revealed by transcriptome and immune-related genes expression analysis","volume":"29","author":"Pan","year":"2023","journal-title":"Aquac Rep."},{"key":"10.1016\/j.fsi.2025.110499_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.925168","article-title":"Molecular characterization of MyD88 in Anodonta woodiana and its involvement in the innate immune response to bacterial infection","volume":"13","author":"Qu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2025.110499_bib38","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.fsi.2019.10.036","article-title":"Characterization, subcellular localization and function analysis of myeloid differentiation factor 88 (Pt-MyD88) in swimming crab, Portunus trituberculatus","volume":"95","author":"Zhou","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110499_bib39","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1111\/jfb.14289","article-title":"Molecular cloning and expression analysis of myd88 from oriental weatherfish (Misgurnus anguillicaudatus) in response to bacterial challenge","volume":"96","author":"Chen","year":"2020","journal-title":"J. Fish. Biol."},{"key":"10.1016\/j.fsi.2025.110499_bib40","doi-asserted-by":"crossref","first-page":"12713","DOI":"10.1128\/JVI.01675-10","article-title":"MyD88 signaling is indispensable for primary influenza A virus infection but dispensable for secondary infection","volume":"84","author":"Seo","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.fsi.2025.110499_bib41","doi-asserted-by":"crossref","first-page":"R99","DOI":"10.1152\/ajpregu.00087.2021","article-title":"LPS versus Poly I:C model: comparison of long-term effects of bacterial and viral maternal immune activation on the offspring","volume":"322","author":"Bao","year":"2022","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.fsi.2025.110499_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.574231","article-title":"The viral hemorrhagic septicemia virus (VHSV) markers of virulence in rainbow trout (Oncorhynchus mykiss)","volume":"11","author":"Baillon","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.fsi.2025.110499_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2020.104854","article-title":"A small molecule inhibitor of MyD88 exhibits broad spectrum antiviral activity by up regulation of type I interferon","volume":"181","author":"Saikh","year":"2020","journal-title":"Antivir. Res."},{"key":"10.1016\/j.fsi.2025.110499_bib44","article-title":"Viperin inhibits rabies virus replication via reduced cholesterol and sphingomyelin and is regulated upstream by TLR4","volume":"6","author":"Tang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fsi.2025.110499_bib45","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.3390\/v13071373","article-title":"Immunity and viral infections: modulating antiviral response via CRISPR\u2013cas systems","volume":"13","author":"Brezgin","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.fsi.2025.110499_bib46","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1240094","article-title":"Immune responses to Tilapia lake virus infection: what we know and what we don't know","volume":"14","author":"Kembou-Ringert","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2025.110499_bib47","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S1074-7613(00)80402-1","article-title":"MyD88: an adapter that recruits IRAK to the IL-1 receptor complex","volume":"7","author":"Wesche","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/j.fsi.2025.110499_bib48","doi-asserted-by":"crossref","first-page":"5567","DOI":"10.1073\/pnas.082100399","article-title":"IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase","volume":"99","author":"Li","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.fsi.2025.110499_bib49","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/383443a0","article-title":"TRAF6 is a signal transducer for interleukin-1","volume":"383","author":"Cao","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2025.110499_bib50","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0014-5793(03)00747-6","article-title":"MyD88S, a splice variant of MyD88, differentially modulates NF\u2010\u03baB\u2010 and AP\u20101\u2010dependent gene expression","volume":"548","author":"Janssens","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.fsi.2025.110499_bib51","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.fsi.2020.01.060","article-title":"Characterization and expression analysis of rockfish (Sebastes schlegelii) myeloid differentiation factor-88 (SsMyD88) and evaluation of its ability to induce inflammatory cytokines through NF-\u0138B","volume":"99","author":"Shanaka","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110499_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fsi.2018.09.001","article-title":"Molecular characterization and functional analysis of MyD88 from the tropical sea cucumber, Holothuria leucospilota","volume":"83","author":"Zhao","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110499_bib53","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.bbrc.2009.08.062","article-title":"Toll-like receptors and innate immunity","volume":"388","author":"Kumar","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.fsi.2025.110499_bib54","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s10495-014-1073-1","article-title":"Toll\/interleukin-1 receptor (TIR) domain-mediated cellular signaling pathways","volume":"20","author":"Narayanan","year":"2015","journal-title":"Apoptosis"},{"key":"10.1016\/j.fsi.2025.110499_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpb.2020.110485","article-title":"Functional characterization of myeloid differentiation factor 88 in Nile tilapia (Oreochromis niloticus)","volume":"250","author":"Trung","year":"2020","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"10.1016\/j.fsi.2025.110499_bib56","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1002\/eji.200737744","article-title":"Toll\u2010like receptors' two\u2010edged sword: when immunity meets apoptosis","volume":"37","author":"Salaun","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.fsi.2025.110499_bib57","doi-asserted-by":"crossref","first-page":"6245","DOI":"10.1038\/onc.2008.301","article-title":"JNK signaling in apoptosis","volume":"27","author":"Dhanasekaran","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.fsi.2025.110499_bib58","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1073\/pnas.0438011100","article-title":"JNK phosphorylation of bim-related members of the Bcl2 family induces Bax-dependent apoptosis","volume":"100","author":"Lei","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.fsi.2025.110499_bib59","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1126\/science.288.5467.870","article-title":"Requirement of JNK for Stress- induced activation of the cytochrome c-Mediated death pathway","volume":"288","author":"Tournier","year":"1979","journal-title":"Science"},{"key":"10.1016\/j.fsi.2025.110499_bib60","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1006\/excr.1998.4131","article-title":"Ultrastructural distribution of the death-domain-containing MyD88 protein in HeLa cells","volume":"243","author":"Jaunin","year":"1998","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.fsi.2025.110499_bib61","doi-asserted-by":"crossref","DOI":"10.1038\/cti.2016.83","article-title":"Caspase\u20108: not so silently deadly","volume":"6","author":"Feltham","year":"2017","journal-title":"Clin. Transl. Immunology"},{"key":"10.1016\/j.fsi.2025.110499_bib62","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01084","article-title":"Macrophage polarization: different gene signatures in M1(LPS+) vs. classically and M2(LPS\u2013) vs. alternatively activated macrophages","volume":"10","author":"Orecchioni","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2025.110499_bib63","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41419-022-04802-z","article-title":"MyD88 in hepatic stellate cells enhances liver fibrosis via promoting macrophage M1 polarization","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.fsi.2025.110499_bib64","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042476","article-title":"MyD88-Dependent signaling influences fibrosis and alternative macrophage activation during Staphylococcus aureus biofilm infection","volume":"7","author":"Hanke","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2025.110499_bib65","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1096\/fasebj.6.12.1381691","article-title":"Nitric oxide as a secretory product of mammalian cells","volume":"6","author":"Nathan","year":"1992","journal-title":"FASEB J."},{"key":"10.1016\/j.fsi.2025.110499_bib66","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.1016\/S0021-9258(17)37600-7","article-title":"Role of transcription factor NF-kappa B\/Rel in induction of nitric oxide synthase","volume":"269","author":"Xie","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fsi.2025.110499_bib67","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1093\/intimm\/dxg126","article-title":"Dominant-negative effect of the c-fos family gene products on inducible NO synthase expression in macrophages","volume":"15","author":"Okada","year":"2003","journal-title":"Int. Immunol."},{"key":"10.1016\/j.fsi.2025.110499_bib68","doi-asserted-by":"crossref","first-page":"8445","DOI":"10.1074\/jbc.M009563200","article-title":"Mitogen-activated protein kinases Mediate activator Protein-1-dependent human inducible nitric-oxide synthase promoter activation","volume":"276","author":"Kristof","year":"2001","journal-title":"J. Biol. Chem."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464825003882?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464825003882?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T21:58:38Z","timestamp":1778795918000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464825003882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":68,"alternative-id":["S1050464825003882"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2025.110499","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular characterization and functional analysis of MyD88 in red-spotted grouper (Epinephelus akaara): Insights into immune regulation and antiviral defense","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2025.110499","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110499"}}