{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:27:23Z","timestamp":1787750843415,"version":"build-2784847793"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["21232117"],"award-info":[{"award-number":["21232117"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1231206"],"award-info":[{"award-number":["1231206"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.fsi.2025.110511","type":"journal-article","created":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T02:42:08Z","timestamp":1750473728000},"page":"110511","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Modulation of innate and adaptive immunity in Atlantic salmon (Salmo salar) fed diets containing commercial-like additives under farming conditions in seawater phase"],"prefix":"10.1016","volume":"165","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2807-5800","authenticated-orcid":false,"given":"Byron","family":"Morales-Lange","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6899-8466","authenticated-orcid":false,"given":"Felipe","family":"Stambuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5357-3086","authenticated-orcid":false,"given":"Felipe","family":"Ram\u00edrez-Cepeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian A.","family":"Valenzuela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rn","family":"Bethke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Soto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Mercado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2025.110511_bib1","unstructured":"Sernapesca, informe sectorial de pesca y acuicultura, 2023. https:\/\/www.subpesca.cl\/portal\/618\/articles-118321_documento.pdf. (Accessed 10 June 2025)."},{"key":"10.1016\/j.fsi.2025.110511_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpol.2021.104705","article-title":"Scientific warnings could help to reduce farmed salmon mortality due to harmful algal blooms","volume":"132","author":"Soto","year":"2021","journal-title":"Mar. Pol."},{"key":"10.1016\/j.fsi.2025.110511_bib3","year":"2023"},{"key":"10.1016\/j.fsi.2025.110511_bib4","series-title":"informe sanitario con informaci\u00f3n sanitaria de agua dulce Y mar a\u00f1o 2022","year":"2023"},{"key":"10.1016\/j.fsi.2025.110511_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0203641","article-title":"Extended antibiotic treatment in salmon farms select multiresistant gut bacteria with a high prevalence of antibiotic resistance genes","volume":"13","author":"Higuera-Llant\u00e9n","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2025.110511_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/are.13161","article-title":"Application of immunostimulants in aquaculture: current knowledge and future perspectives","volume":"48","author":"Wang","year":"2017","journal-title":"Aquac. Res."},{"key":"10.1016\/j.fsi.2025.110511_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/ani14152275","article-title":"Immunonutrition-contributing to the future of sustainable aquaculture by supporting animal performance, health and welfare","volume":"14","author":"Rocha","year":"2024","journal-title":"Animals"},{"key":"10.1016\/j.fsi.2025.110511_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1125702","article-title":"From a cell model to a fish trial: immunomodulatory effects of heat-killed lactiplantibacillus plantarum as a functional ingredient in aquafeeds for salmonids","volume":"14","author":"Rocha","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2025.110511_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aquaculture.2019.05.009","article-title":"Role of dietary Spirulina platensis in improving mucosal immune responses and disease resistance of rainbow trout (Oncorhynchus mykiss)","volume":"510","author":"Sheikhzadeh","year":"2019","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2025.110511_bib10","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.fsi.2017.10.027","article-title":"Physiological and immune response of juvenile rainbow trout to dietary bovine lactoferrin","volume":"71","author":"Khuyen","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110511_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2023.740035","article-title":"Immunomodulatory effects of hydrolyzed Debaryomyces hansenii in Atlantic salmon (Salmo salar L): from the in vitro model to a natural pathogen challenge after seawater transfer","volume":"578","author":"Morales-Lange","year":"2024","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2025.110511_bib12","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.aquaculture.2015.12.016","article-title":"The effects of supplemented diets with a phytopharmaceutical preparation from herbal and macroalgal origin on disease resistance in rainbow trout against Piscirickettsia salmonis","volume":"454","author":"Hern\u00e1ndez","year":"2016","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2025.110511_bib13","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1007\/s10499-019-00436-9","article-title":"Dietary \u03b2-1,3\/1,6-glucans improve the effect of a multivalent vaccine in Atlantic salmon infected with Moritella viscosa or infectious salmon anemia virus","volume":"27","author":"Roberti Filho","year":"2019","journal-title":"Aquac. Int."},{"key":"10.1016\/j.fsi.2025.110511_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222312714","article-title":"Vitamin c mitigates oxidative stress and behavioral impairments induced by deltamethrin and lead toxicity in zebrafish","volume":"22","author":"Paduraru","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fsi.2025.110511_bib15","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.aquaculture.2005.01.009","article-title":"Nucleotide nutrition in fish: current knowledge and future applications","volume":"251","author":"Li","year":"2006","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2025.110511_bib16","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.fsi.2025.110511_bib17","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1471-2199-6-21","article-title":"Evaluation of potential reference genes in real-time RT-PCR studies of Atlantic salmon","volume":"6","author":"Olsvik","year":"2005","journal-title":"BMC Mol. Biol."},{"key":"10.1016\/j.fsi.2025.110511_bib18","author":"Taiyun"},{"key":"10.1016\/j.fsi.2025.110511_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.902941","article-title":"Haematopoiesis in zebrafish (Danio Rerio)","volume":"13","author":"Stosik","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2025.110511_bib21","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.dci.2016.03.014","article-title":"Transcriptomic responses in the fish intestine","volume":"64","author":"Martin","year":"2016","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2025.110511_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2015.00354","article-title":"Mucosal immunity and B cells in teleosts: effect of vaccination and stress","volume":"6","author":"Parra","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2025.110511_bib23","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3390\/biology4030525","article-title":"The mucosal immune system of teleost fish","volume":"4","author":"Salinas","year":"2015","journal-title":"Biology"},{"key":"10.1016\/j.fsi.2025.110511_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.773193","article-title":"Gut immune system and the implications of oral-administered immunoprophylaxis in finfish aquaculture","volume":"12","author":"Lee","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2025.110511_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.567941","article-title":"Immunoglobulins, mucosal immunity and vaccination in teleost fish","volume":"11","author":"Yu","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2025.110511_bib26","series-title":"Fiskehelserapporten, 2023","author":"Sommerset","year":"2024"},{"key":"10.1016\/j.fsi.2025.110511_bib27","article-title":"Editorial: functional feed additives: current trends","volume":"3","author":"Zuberi","year":"2024","journal-title":"Front. Aquacult."},{"key":"10.1016\/j.fsi.2025.110511_bib28","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/j.fsi.2013.09.032","article-title":"The mucosal immune system of fish: the evolution of tolerating commensals while fighting pathogens","volume":"35","author":"Gomez","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110511_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031675","article-title":"Effects of yeast species and processing on intestinal health and transcriptomic profiles of Atlantic salmon (Salmo salar) fed soybean meal-based diets in seawater","volume":"23","author":"Agboola","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fsi.2025.110511_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.708747","article-title":"The spleen as a target to characterize immunomodulatory effects of down-stream processed Cyberlindnera jadinii yeasts in Atlantic salmon exposed to a dietary soybean meal challenge","volume":"12","author":"Morales-Lange","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2025.110511_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.836810","article-title":"Dietary inclusion of hydrolyzed Debaryomyces hansenii yeasts modulates physiological responses in plasma and immune organs of Atlantic salmon (Salmo salar) parr exposed to acute hypoxia stress","volume":"13","author":"Morales-Lange","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.fsi.2025.110511_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/biology5020023","article-title":"The function of fish cytokines","volume":"5","author":"Zou","year":"2016","journal-title":"Biology"},{"key":"10.1016\/j.fsi.2025.110511_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/fishes8020093","article-title":"Main components of fish immunity: an overview of the fish immune system","volume":"8","author":"Mokhtar","year":"2023","journal-title":"Fishes"},{"key":"10.1016\/j.fsi.2025.110511_bib34","series-title":"Macrophages - Celebrating 140 Years of Discovery","article-title":"Macrophage: a key player of teleost immune system","author":"Sinha","year":"2022"},{"key":"10.1016\/j.fsi.2025.110511_bib35","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.hal.2018.05.004","article-title":"Quantifying harmful algal bloom thresholds for farmed salmon in southern Chile","volume":"77","author":"Montes","year":"2018","journal-title":"Harmful Algae"},{"key":"10.1016\/j.fsi.2025.110511_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/fishes8090461","article-title":"Effects of microalgal blooms on aquaculture and fisheries","volume":"8","author":"D\u00edaz","year":"2023","journal-title":"Fishes"},{"key":"10.1016\/j.fsi.2025.110511_bib37","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1007\/s10695-019-00614-9","article-title":"Fish response to hypoxia stress: growth, physiological, and immunological biomarkers","volume":"45","author":"Abdel-Tawwab","year":"2019","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.fsi.2025.110511_bib38","doi-asserted-by":"crossref","first-page":"369","DOI":"10.4049\/jimmunol.0902110","article-title":"The host defense peptide cathelicidin is required for NK cell-mediated suppression of tumor growth","volume":"184","author":"B\u00fcchau","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2025.110511_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0055893","article-title":"Eomesodermin of Atlantic salmon: an important regulator of cytolytic gene and interferon gamma expression in spleen lymphocytes","volume":"8","author":"Kumari","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2025.110511_bib40","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.fsi.2019.03.034","article-title":"In vitro immunomodulatory activities of peptides derived from Salmo Salar NK-lysin and cathelicidin in fish cells","volume":"88","author":"Acosta","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110511_bib41","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.fsi.2021.07.022","article-title":"Characterisation and analysis of IFN-gamma producing cells in rainbow trout Oncorhynchus mykiss","volume":"117","author":"Hu","year":"2021","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110511_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.109344","article-title":"Molecular characteristics and functional analysis of non-specific cytotoxic cell receptor (NCCRP1) in golden pompano (Trachinotus ovatus)","volume":"145","author":"Huang","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110511_bib43","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3354\/aei00368","article-title":"Hydrodynamic connectivity, water temperature, and salinity are major drivers of piscirickettsiosis prevalence and transmission among salmonid farms in Chile","author":"Bravo","year":"2020","journal-title":"Aquacult. Environ. Interact."},{"key":"10.1016\/j.fsi.2025.110511_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1253577","article-title":"Cohabitation of Piscirickettsia salmonis genogroups (LF-89 and EM-90): synergistic effect on growth dynamics","volume":"13","author":"Carril","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464825004000?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464825004000?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T19:33:43Z","timestamp":1772048023000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464825004000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":43,"alternative-id":["S1050464825004000"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2025.110511","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulation of innate and adaptive immunity in Atlantic salmon (Salmo salar) fed diets containing commercial-like additives under farming conditions in seawater phase","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2025.110511","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"110511"}}