{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T20:07:33Z","timestamp":1772050053318,"version":"3.50.1"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U2106232"],"award-info":[{"award-number":["U2106232"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32320103012"],"award-info":[{"award-number":["32320103012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.fsi.2025.110535","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T22:34:39Z","timestamp":1751582079000},"page":"110535","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Nuciferine supplement improved intestinal function and inflammatory response in juvenile large yellow croaker (Larmichthys crocea) fed diets with high palm oil level"],"prefix":"10.1016","volume":"165","author":[{"given":"Zengqi","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeru","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zixian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunlang","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baolin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongtao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueru","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kangsen","family":"Mai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3958-474X","authenticated-orcid":false,"given":"Qinghui","family":"Ai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.fsi.2025.110535_bib1","doi-asserted-by":"crossref","DOI":"10.1111\/raq.12991","article-title":"Lipid droplets in aquatic animals: diversity, biogenesis, and functional implications","volume":"17","author":"Zhu","year":"2025","journal-title":"Rev. Aquacult."},{"key":"10.1016\/j.fsi.2025.110535_bib2","doi-asserted-by":"crossref","DOI":"10.1111\/raq.12905","article-title":"Modelling the impact of replacing fish oil with plant oils: a meta\u2010analysis to match the optimal plant oil for major cultured fish","author":"Qian","year":"2024","journal-title":"Rev. Aquacult."},{"key":"10.1016\/j.fsi.2025.110535_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109635","article-title":"Dietary lipid sources affect growth performance, lipid deposition, antioxidant capacity and inflammatory response of largemouth bass (Micropterus salmoides)","volume":"150","author":"Gong","year":"2024","journal-title":"Fish Shellfish Immunol."},{"issue":"1\u20134","key":"10.1016\/j.fsi.2025.110535_bib4","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.aquaculture.2008.01.035","article-title":"Effects of replacement of dietary fish oil by soybean oil on growth performance and liver biochemical composition in juvenile Black seabream, Acanthopagrus schlegeli","volume":"276","author":"Peng","year":"2008","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2025.110535_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2023.739731","article-title":"Effects of vegetable oil replacement on intramuscular fat deposition and flesh quality of large yellow croaker (Larimichthys crocea) juveniles","volume":"575","author":"Gong","year":"2023","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2025.110535_bib6","first-page":"30","article-title":"Crude palm oil is a sustainable alternative to the growing fish oil scarcity particularly for the aquaculture of warm freshwater fish species","author":"Aliyu-Paiko","year":"2012","journal-title":"Aquaculture Asia"},{"issue":"1\u20134","key":"10.1016\/j.fsi.2025.110535_bib7","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0044-8486(02)00067-4","article-title":"Dietary lipid and palm oil source affects growth, fatty acid composition and muscle \u03b1-tocopherol concentration of African catfish, Clarias gariepinus","volume":"215","author":"Ng","year":"2003","journal-title":"Aquaculture"},{"issue":"2","key":"10.1016\/j.fsi.2025.110535_bib8","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1093\/jn\/132.2.222","article-title":"Substituting fish oil with crude palm oil in the diet of Atlantic salmon (Salmo salar) affects muscle fatty acid composition and hepatic fatty acid metabolism","volume":"132","author":"Bell","year":"2002","journal-title":"J. Nutr."},{"key":"10.1016\/j.fsi.2025.110535_bib9","first-page":"1","article-title":"Dietary palm oil enhances sterol regulatory element-binding protein 2-mediated cholesterol biosynthesis through inducing endoplasmic reticulum stress in muscle of large yellow croaker (Larimichthys crocea)","author":"Zhao","year":"2023","journal-title":"Br. J. Nutr."},{"issue":"12","key":"10.1016\/j.fsi.2025.110535_bib10","article-title":"Tip60-mediated rheb acetylation links palmitic acid with mTORC1 activation and insulin resistance","volume":"223","author":"Zhao","year":"2024","journal-title":"JCB (J. Cell Biol.)"},{"issue":"4","key":"10.1016\/j.fsi.2025.110535_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0196100","article-title":"Replacement of fish oil with palm oil: effects on growth performance, innate immune response, antioxidant capacity and disease resistance in nile tilapia (Oreochromis niloticus)","volume":"13","author":"Larbi Ayisi","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2025.110535_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s41240-019-0139-y","article-title":"Effects of replacing fish oil with palm oil in diets of nile tilapia (Oreochromis niloticus) on muscle biochemical composition, enzyme activities, and mRNA expression of growth-related genes","volume":"22","author":"Ayisi","year":"2019","journal-title":"Fisheries and Aquatic Sciences"},{"issue":"6","key":"10.1016\/j.fsi.2025.110535_bib13","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/jwas.12307","article-title":"Effects of dietary fish oil replacement with palm oil on the growth, feed utilization, biochemical composition, and antioxidant status of juvenile Chu's croaker, Nibea coibor","volume":"47","author":"Huang","year":"2016","journal-title":"J. World Aquacult. Soc."},{"issue":"2","key":"10.1016\/j.fsi.2025.110535_bib14","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s10499-022-01005-3","article-title":"Substituting palm oil for fish oil in feeds for juvenile rohu, Labeo rohita: effects on growth performance, fillet fatty acid composition, and antioxidant capacity","volume":"31","author":"Siddiqua","year":"2023","journal-title":"Aquac. Int."},{"key":"10.1016\/j.fsi.2025.110535_bib15","series-title":"Fish Nutrition","first-page":"367","article-title":"Nutritional physiology","author":"Rust","year":"2003"},{"issue":"1","key":"10.1016\/j.fsi.2025.110535_bib16","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/raq.12492","article-title":"Nutritional immunity of fish intestines: important insights for sustainable aquaculture","volume":"13","author":"Dawood","year":"2021","journal-title":"Rev. Aquacult."},{"key":"10.1016\/j.fsi.2025.110535_bib17","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s11160-020-09614-y","article-title":"Research progress on gut health of farmers teleost fish: a viewpoint concerning the intestinal mucosal barrier and the impact of its damage","volume":"30","author":"Zhang","year":"2020","journal-title":"Rev. Fish Biol. Fish."},{"key":"10.1016\/j.fsi.2025.110535_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.984508","article-title":"Palmitic acid induces intestinal lipid metabolism disorder, endoplasmic reticulum stress and inflammation by affecting phosphatidylethanolamine content in large yellow croaker Larimichthys crocea","volume":"13","author":"Fang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2025.110535_bib19","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.fsi.2022.04.011","article-title":"Eicosapentaenoic acid mitigates palmitic acid-induced heat shock response, inflammation and repair processes in fish intestine","volume":"124","author":"Shi","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110535_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.106002","article-title":"Nuciferine, an active ingredient derived from lotus leaf, lights up the way for the potential treatment of obesity and obesity-related diseases","volume":"175","author":"Wan","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.fsi.2025.110535_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106820","article-title":"Structure-activity relationship, bioactivities, molecular mechanisms, and clinical application of nuciferine on inflammation-related diseases","volume":"193","author":"Zhao","year":"2023","journal-title":"Pharmacol. Res."},{"issue":"12","key":"10.1016\/j.fsi.2025.110535_bib22","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1038\/s12276-020-00534-2","article-title":"Nuciferine modulates the gut microbiota and prevents obesity in high-fat diet-fed rats","volume":"52","author":"Wang","year":"2020","journal-title":"Exp. Mol. Med."},{"issue":"13","key":"10.1016\/j.fsi.2025.110535_bib23","doi-asserted-by":"crossref","first-page":"5850","DOI":"10.1039\/D1FO00367D","article-title":"Nuciferine improves high-fat diet-induced obesity via reducing intestinal permeability by increasing autophagy and remodeling the gut microbiota","volume":"12","author":"Shi","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.fsi.2025.110535_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109613","article-title":"Nuciferine alleviates intestinal inflammation by inhibiting MAPK\/NF-\u03baB and NLRP3\/Caspase 1 pathways in vivo and in vitro","volume":"115","author":"Kulhari","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"10.1016\/j.fsi.2025.110535_bib25","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.cbpb.2004.09.007","article-title":"Hormonal regulation of the fish gastrointestinal tract","volume":"139","author":"Buddington","year":"2004","journal-title":"Comp. Biochem. Physiol. Mol. Integr. Physiol."},{"issue":"10","key":"10.1016\/j.fsi.2025.110535_bib26","doi-asserted-by":"crossref","first-page":"3392","DOI":"10.1111\/are.13803","article-title":"Effect of Indian lotus (Nelumbo nucifera Gaertn.) leaf powder on immune status and disease resistance of Nile tilapia","volume":"49","author":"Abdel Rahman","year":"2018","journal-title":"Aquac. Res."},{"issue":"11","key":"10.1016\/j.fsi.2025.110535_bib27","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1111\/are.14276","article-title":"Growth performance, haematology and intestinal histo\u2010morphology of Nile tilapia fed on Indian Lotus (Nelumbo nucifera Gaertn.) leaf powder at different concentrations","volume":"50","author":"Abdel Rahman","year":"2019","journal-title":"Aquac. Res."},{"issue":"5","key":"10.1016\/j.fsi.2025.110535_bib28","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.tjnut.2024.02.031","article-title":"Sterol regulatory element binding protein 1: a mediator for high-fat diet\u2013induced hepatic gluconeogenesis and glucose intolerance in fish","volume":"154","author":"Zhao","year":"2024","journal-title":"J. Nutr."},{"issue":"8","key":"10.1016\/j.fsi.2025.110535_bib29","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1093\/jn\/nxac125","article-title":"Docosahexaenoic acid ameliorates the toll-like receptor 22\u2013Triggered inflammation in fish by disrupting lipid raft Formation","volume":"152","author":"Zhu","year":"2022","journal-title":"J. Nutr."},{"key":"10.1016\/j.fsi.2025.110535_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2024.740821","article-title":"Effects of nuciferine on growth performance, body composition, lipid metabolism and antioxidant capacity of juvenile large yellow croaker (Larmichthys crocea) fed diets with high palm oil level","volume":"586","author":"Zhao","year":"2024","journal-title":"Aquaculture"},{"issue":"4","key":"10.1016\/j.fsi.2025.110535_bib31","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1111\/j.0022-1112.2005.00812.x","article-title":"A histological study on the development of the digestive system of Pseudosciaena crocea larvae and juveniles","volume":"67","author":"Mai","year":"2005","journal-title":"J. Fish. Biol."},{"key":"10.1016\/j.fsi.2025.110535_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2023.740476","article-title":"Role of sodium octanoate in regulating survival, growth, intestinal development, digestive and absorptive capacities, antioxidant capacity and innate immunity of large yellow croaker (Larimichthys crocea) larvae","volume":"582","author":"Liu","year":"2024","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2025.110535_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.109031","article-title":"Glycerol monolaurate improved intestinal barrier, antioxidant capacity, inflammatory response and microbiota dysbiosis in large yellow croaker (Larimichthys crocea) fed with high soybean oil diets","volume":"141","author":"Tang","year":"2023","journal-title":"Fish Shellfish Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2025.110535_bib34","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"11","key":"10.1016\/j.fsi.2025.110535_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.103244","article-title":"Acetyl-CoA derived from hepatic mitochondrial fatty acid \u03b2-oxidation aggravates inflammation by enhancing p65 acetylation","volume":"24","author":"Chen","year":"2021","journal-title":"iScience"},{"issue":"2","key":"10.1016\/j.fsi.2025.110535_bib36","article-title":"Palmitic acid activates NLRP3 inflammasome through NF-\u03baB and AMPK-mitophagy-ROS pathways to induce IL-1\u03b2 production in large yellow croaker (Larimichthys crocea)","volume":"1869","author":"Li","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.fsi.2025.110535_bib37","doi-asserted-by":"crossref","first-page":"S473","DOI":"10.1046\/j.1440-6047.11.s.7.7.x","article-title":"Potential of palm oil utilisation in aquaculture feeds","volume":"11","author":"Ng","year":"2002","journal-title":"Asia Pac. J. Clin. Nutr."},{"issue":"4","key":"10.1016\/j.fsi.2025.110535_bib38","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/ejlt.200600209","article-title":"The use of palm oil in aquaculture feeds for salmonid species","volume":"109","author":"Ng","year":"2007","journal-title":"Eur. J. Lipid Sci. Technol."},{"issue":"2","key":"10.1016\/j.fsi.2025.110535_bib39","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/jpn.13299","article-title":"The relationship between villous height and growth performance, small intestinal mucosal enzymes activities and nutrient transporters expression in weaned piglets","volume":"104","author":"Wang","year":"2020","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"issue":"1","key":"10.1016\/j.fsi.2025.110535_bib40","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41575-018-0081-y","article-title":"Tales from the crypt: new insights into intestinal stem cells","volume":"16","author":"Gehart","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"3","key":"10.1016\/j.fsi.2025.110535_bib41","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0278-6915(00)00136-8","article-title":"Anatomical and physiological parameters affecting gastrointestinal absorption in humans and rats","volume":"39","author":"DeSesso","year":"2001","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fsi.2025.110535_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2021.104859","article-title":"Nuciferine prevents hepatic steatosis associated with improving intestinal mucosal integrity, mucus-related microbiota and inhibiting TLR4\/MyD88\/NF-\u03baB pathway in high-fat induced rats","volume":"88","author":"Fan","year":"2022","journal-title":"J. Funct.Foods"},{"key":"10.1016\/j.fsi.2025.110535_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2022.939377","article-title":"Nuciferine regulates immune function and gut microbiota in DSS-induced ulcerative colitis","volume":"9","author":"Zhu","year":"2022","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.fsi.2025.110535_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156800","article-title":"Nuciferine activates intestinal TAS2R46 to attenuate metabolic disorders and hyperlipidemia via hepatic VLDL regulation","author":"Ding","year":"2025","journal-title":"Phytomedicine"},{"issue":"11","key":"10.1016\/j.fsi.2025.110535_bib45","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.3390\/ijms20112777","article-title":"Progress in mycotoxins affecting intestinal mucosal barrier function","volume":"20","author":"Ren","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.fsi.2025.110535_bib46","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/2294942","article-title":"The role of lncRNAs in regulating the intestinal mucosal mechanical barrier","volume":"2021","author":"Chen","year":"2021","journal-title":"BioMed Res. Int."},{"issue":"5","key":"10.1016\/j.fsi.2025.110535_bib47","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.3390\/ijms22052506","article-title":"Tight junctions as a key for pathogens invasion in intestinal epithelial cells","volume":"22","author":"Paradis","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.fsi.2025.110535_bib48","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5217\/ir.2015.13.1.11","article-title":"Intestinal permeability regulation by tight junction: implication on inflammatory bowel diseases","volume":"13","author":"Lee","year":"2015","journal-title":"Intestinal research"},{"issue":"1","key":"10.1016\/j.fsi.2025.110535_bib49","doi-asserted-by":"crossref","first-page":"G124","DOI":"10.1152\/ajpgi.00297.2006","article-title":"Na-K-ATPase regulates tight junction permeability through occludin phosphorylation in pancreatic epithelial cells","volume":"292","author":"Rajasekaran","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"2","key":"10.1016\/j.fsi.2025.110535_bib50","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1242\/jcs.193482","article-title":"The mucosal barrier at a glance","volume":"130","author":"France","year":"2017","journal-title":"J. Cell Sci."},{"issue":"1","key":"10.1016\/j.fsi.2025.110535_bib51","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/fft2.292","article-title":"Nuciferine ameliorates high\u2010fat diet\u2010induced disorders of glucose and lipid metabolism in obese mice based on the gut\u2013liver axis","volume":"5","author":"Zhu","year":"2024","journal-title":"Food Frontiers"},{"issue":"38","key":"10.1016\/j.fsi.2025.110535_bib52","doi-asserted-by":"crossref","first-page":"12014","DOI":"10.1021\/acs.jafc.2c04817","article-title":"Nuciferine protects against high-fat diet-induced hepatic steatosis via modulation of gut microbiota and bile acid metabolism in rats","volume":"70","author":"Sun","year":"2022","journal-title":"J. Agric. Food Chem."},{"issue":"2","key":"10.1016\/j.fsi.2025.110535_bib53","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.immuni.2020.07.010","article-title":"Paneth cell-derived lysozyme defines the composition of mucolytic microbiota and the inflammatory tone of the intestine","volume":"53","author":"Yu","year":"2020","journal-title":"Immunity"},{"issue":"6","key":"10.1016\/j.fsi.2025.110535_bib54","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.chom.2007.10.010","article-title":"Intestinal alkaline phosphatase detoxifies lipopolysaccharide and prevents inflammation in zebrafish in response to the gut microbiota","volume":"2","author":"Bates","year":"2007","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.fsi.2025.110535_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111014","article-title":"Akkermansia muciniphila: a potential novel mechanism of nuciferine to improve hyperlipidemia","volume":"133","author":"Yu","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.fsi.2025.110535_bib56","article-title":"The immunological basis of inflammatory bowel disease","volume":"2016","author":"Silva","year":"2016","journal-title":"Gastroenterology research and practice"},{"issue":"42","key":"10.1016\/j.fsi.2025.110535_bib57","doi-asserted-by":"crossref","first-page":"7899","DOI":"10.1021\/acs.jafc.6b03031","article-title":"Nuciferine alleviates renal injury by inhibiting inflammatory responses in fructose-fed rats","volume":"64","author":"Wang","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fsi.2025.110535_bib58","doi-asserted-by":"crossref","first-page":"939","DOI":"10.3389\/fphar.2017.00939","article-title":"Nuciferine ameliorates inflammatory responses by inhibiting the TLR4-mediated pathway in lipopolysaccharide-induced acute lung injury","volume":"8","author":"Wu","year":"2017","journal-title":"Front. Pharmacol."}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464825004243?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464825004243?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T19:33:30Z","timestamp":1772048010000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464825004243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":58,"alternative-id":["S1050464825004243"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2025.110535","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nuciferine supplement improved intestinal function and inflammatory response in juvenile large yellow croaker (Larmichthys crocea) fed diets with high palm oil level","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2025.110535","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"110535"}}