{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T09:20:04Z","timestamp":1777886404522,"version":"3.51.4"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100014717","name":"National Natural Science Foundation of China National Outstanding Youth Science Fund Project","doi-asserted-by":"publisher","award":["42376087"],"award-info":[{"award-number":["42376087"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42306100"],"award-info":[{"award-number":["42306100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012601","name":"South China Agricultural University","doi-asserted-by":"publisher","award":["NSYYKY202304"],"award-info":[{"award-number":["NSYYKY202304"]}],"id":[{"id":"10.13039\/501100012601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2023E04J0121"],"award-info":[{"award-number":["2023E04J0121"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2023A04J0909"],"award-info":[{"award-number":["2023A04J0909"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD2402700"],"award-info":[{"award-number":["2023YFD2402700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD2400501"],"award-info":[{"award-number":["2022YFD2400501"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.fsi.2025.110571","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T15:10:39Z","timestamp":1753369839000},"page":"110571","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Analysis of antiviral functions, differences and apoptotic effects of two novel MHC-I\u03b1 genotypes in orange-spotted grouper (Epinephelus coioides)"],"prefix":"10.1016","volume":"166","author":[{"given":"Jinpeng","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bangsong","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxuan","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1188-9023","authenticated-orcid":false,"given":"Qiwei","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2025.110571_bib1","first-page":"295","article-title":"Evolution of the major histocompatibility complex","volume":"6","author":"Klein","year":"1986","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.fsi.2025.110571_bib2","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1146\/annurev.iy.11.040193.002125","article-title":"The molecular basis of allorecognition","volume":"11","author":"Sherman","year":"1993","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.fsi.2025.110571_bib3","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/S1286-4579(01)01477-0","article-title":"How the immune system protects the host from infection","volume":"3","author":"Janeway","year":"2001","journal-title":"Microb. Infect."},{"key":"10.1016\/j.fsi.2025.110571_bib4","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.it.2016.08.010","article-title":"Present yourself! by MHC class I and MHC class II molecules","volume":"37","author":"Rock","year":"2016","journal-title":"Trends Immunol."},{"key":"10.1016\/j.fsi.2025.110571_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1179846","article-title":"Chaperone function in antigen presentation by MHC class I molecules\u2014tapasin in the PLC and TAPBPR beyond","volume":"14","author":"Margulies","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2025.110571_bib6","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1146\/annurev-immunol-032712-095910","article-title":"Pathways of antigen processing","volume":"31","author":"Blum","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.fsi.2025.110571_bib7","doi-asserted-by":"crossref","first-page":"292","DOI":"10.3389\/fimmu.2017.00292","article-title":"Major Histocompatibility Complex (MHC) class I and MHC class II proteins: conformational plasticity in antigen presentation","volume":"8","author":"Wieczorek","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2025.110571_bib8","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1007\/s00251-002-0509-x","article-title":"Induction of the rainbow trout MHC class I pathway during acute IHNV infection","volume":"54","author":"Hansen","year":"2002","journal-title":"Immunogenetics"},{"key":"10.1016\/j.fsi.2025.110571_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.729017","article-title":"Dynamics of polarized macrophages and activated CD8+ cells in heart tissue of Atlantic salmon infected with piscine Orthoreovirus-1","volume":"12","author":"Malik","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2025.110571_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.00160","article-title":"The megalocytivirus RBIV induces apoptosis and MHC class I presentation in rock bream (Oplegnathus fasciatus) red blood cells","volume":"10","author":"Jung","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2025.110571_bib11","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1111\/jfd.12451","article-title":"Down-regulation of MHC class I mRNA expression in the course of KHV infection","volume":"39","author":"Reichert","year":"2016","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2025.110571_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1050323","article-title":"Atlantic cod (Gadus morhua) MHC I localizes to endolysosomal compartments independently of cytosolic sorting signals","volume":"11","author":"Bj\u00f8rnestad","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.fsi.2025.110571_bib13","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00251-013-0749-y","article-title":"Multiple divergent haplotypes express completely distinct sets of class I MHC genes in zebrafish","volume":"66","author":"McConnell","year":"2014","journal-title":"Immunogenetics"},{"key":"10.1016\/j.fsi.2025.110571_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2019.103494","article-title":"Molecular polymorphism and expression of MHC I \u03b1, II \u03b1, II \u03b2 and II invariant chain in the critically endangered Dabry's sturgeon (Acipenser dabryanus)","volume":"103","author":"Chen","year":"2020","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2025.110571_bib15","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.fsi.2006.02.001","article-title":"How specific MHC class I and class II combinations affect disease resistance against infectious salmon anaemia in Atlantic salmon (Salmo salar)","volume":"21","author":"Kj\u00f8glum","year":"2006","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110571_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000150","article-title":"Signal peptide-dependent inhibition of MHC class I heavy chain translation by rhesus cytomegalovirus","volume":"4","author":"Powers","year":"2008","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.fsi.2025.110571_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aquaculture.2010.09.011","article-title":"Molecular studies, disease status and prophylactic measures in grouper aquaculture: economic importance, diseases and immunology","volume":"309","author":"Harikrishnan","year":"2010","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2025.110571_bib18","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/raq.12226","article-title":"A review of grouper (Family Serranidae: subfamily Epinephelinae) aquaculture from a sustainability science perspective","volume":"11","author":"Rimmer","year":"2019","journal-title":"Rev. Aquacult."},{"key":"10.1016\/j.fsi.2025.110571_bib19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0166-0934(01)00350-0","article-title":"Electron microscopic observations of a marine fish iridovirus isolated from brown-spotted grouper, Epinephelus tauvina","volume":"98","author":"Qin","year":"2001","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.fsi.2025.110571_bib20","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0044-8486(02)00092-3","article-title":"Characterization, pathogenicity and neutralization studies of a nervous necrosis virus isolated from grouper, Epinephelus tauvina, in Singapore","volume":"213","author":"Hegde","year":"2002","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2025.110571_bib21","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.fsi.2022.01.030","article-title":"Functional analysis of a novel MHC-I\u03b1 genotype in orange-spotted grouper: effects on Singapore grouper iridovirus (SGIV) replication and apoptosis","volume":"121","author":"Chen","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110571_bib22","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/j.1749-6632.1965.tb14302.x","article-title":"A permanent cell line from the fathead minnow (Pimephales promelas)","volume":"126","author":"Gravell","year":"1965","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.fsi.2025.110571_bib23","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.aquaculture.2009.04.019","article-title":"Characterization of two grouper Epinephelus akaara cell lines: application to studies of Singapore grouper iridovirus (SGIV) propagation and virus\u2013host interaction","volume":"292","author":"Huang","year":"2009","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2025.110571_bib24","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.aquaculture.2010.11.037","article-title":"Establishment of a cell line from the brain of grouper (Epinephelus akaara) for cytotoxicity testing and virus pathogenesis","volume":"311","author":"Huang","year":"2011","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2025.110571_bib25","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.dci.2018.09.003","article-title":"Transcriptomics analysis reveals candidate genes and pathways for susceptibility or resistance to Singapore grouper iridovirus in orange-spotted grouper (Epinephelus coioides)","volume":"90","author":"Yang","year":"2019","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2025.110571_bib26","author":"Suchman"},{"key":"10.1016\/j.fsi.2025.110571_bib27","doi-asserted-by":"crossref","first-page":"790","DOI":"10.3389\/fmicb.2020.00790","article-title":"Autophagy participates in lysosomal vacuolation-mediated cell death in RGNNV-Infected cells","volume":"11","author":"Huang","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.fsi.2025.110571_bib28","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.dci.2015.04.016","article-title":"Local and systemic adaptive immune responses toward viral infection via gills in ginbuna crucian carp","volume":"52","author":"Somamoto","year":"2015","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2025.110571_bib29","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.fsi.2019.10.041","article-title":"Teleost cytotoxic T cells","volume":"95","author":"Yamaguchi","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110571_bib30","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrg2703","article-title":"Origin and evolution of the adaptive immune system: genetic events and selective pressures","volume":"11","author":"Flajnik","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.fsi.2025.110571_bib31","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1016\/j.cell.2023.07.016","article-title":"A membrane-associated MHC-I inhibitory axis for cancer immune evasion","volume":"186","author":"Chen","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.fsi.2025.110571_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000024","article-title":"Defining the role of the MHC in autoimmunity: a review and pooled analysis","volume":"4","author":"Fernando","year":"2008","journal-title":"PLoS Genet."},{"key":"10.1016\/j.fsi.2025.110571_bib33","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.vetimm.2013.10.012","article-title":"Molecular cloning, organization, expression and 3D structural analysis of the MHC class Ia gene in the whitespotted bamboo shark (Chiloscyllium plagiosum)","volume":"157","author":"Shen","year":"2014","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.fsi.2025.110571_bib34","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00251-017-1009-3","article-title":"MHC and adaptive immunity in teleost fishes","volume":"69","author":"Wilson","year":"2017","journal-title":"Immunogenetics"},{"key":"10.1016\/j.fsi.2025.110571_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231810688","article-title":"Molecular characterization of MHC Class I Alpha 1 and 2 domains in Asian Seabass (Lates calcarifer)","volume":"23","author":"Loh","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fsi.2025.110571_bib36","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.dci.2012.10.002","article-title":"Molecular cloning and characterization of sea bass (Dicentrarchus labrax, L.) MHC class I heavy chain and \u03b22-microglobulin","volume":"39","author":"Pinto","year":"2013","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2025.110571_bib37","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/368711a0","article-title":"Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen","volume":"368","author":"Jardetzky","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2025.110571_bib38","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s00251-011-0516-x","article-title":"Characterization and locus-specific typing of MHC class I genes in the red-billed gull (Larus scopulinus) provides evidence for major, minor, and nonclassical loci","volume":"63","author":"Cloutier","year":"2011","journal-title":"Immunogenetics"},{"key":"10.1016\/j.fsi.2025.110571_bib39","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2108104118","article-title":"Discovery of an ancient MHC category with both class I and class II features","volume":"118","author":"Okamura","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.fsi.2025.110571_bib40","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s00251-003-0567-8","article-title":"MHC polymorphism and disease resistance in Atlantic salmon (Salmo salar); facing pathogens with single expressed major histocompatibility class I and class II loci","volume":"55","author":"Grimholt","year":"2003","journal-title":"Immunogenetics"},{"key":"10.1016\/j.fsi.2025.110571_bib41","doi-asserted-by":"crossref","first-page":"308","DOI":"10.4049\/jimmunol.2001165","article-title":"The structure of a peptide-loaded shark MHC class I molecule reveals features of the binding between \u03b22-Microglobulin and H chain conserved in evolution","volume":"207","author":"Wu","year":"2021","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2025.110571_bib42","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.4049\/jimmunol.1600229","article-title":"The structure of the MHC class I molecule of bony fishes provides insights into the conserved nature of the antigen-presenting system","volume":"199","author":"Chen","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2025.110571_bib43","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/jfd.13307","article-title":"Molecular cloning, characterization and expression analysis of major histocompatibility complex class I alpha gene of pufferfish (Takifugu obscurus)","volume":"44","author":"Fu","year":"2021","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2025.110571_bib44","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/j.1444-2906.2003.00800.x","article-title":"Cloning, characterization and expression of cDNA containing major histocompatibility complex class I, II\u03b1 and II\u03b2 genes of Japanese flounder Paralichthys olivaceus","volume":"70","author":"Srisapoome","year":"2004","journal-title":"Fish. Sci."},{"key":"10.1016\/j.fsi.2025.110571_bib45","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.fsi.2017.05.058","article-title":"Identification, polymorphism and expression of MHC class I\u03b1 in golden pompano, Trachinotus ovatus","volume":"67","author":"Cao","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110571_bib46","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0145-305X(96)00030-4","article-title":"Conservation of an alpha 2 domain within the teleostean world, mhc class i from the rainbow trout Oncorhynchus mykiss","volume":"20","author":"Hansen","year":"1996","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2025.110571_bib47","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1007\/PL00008525","article-title":"In situ hybridisation identifies the gill as a portal of entry for PKX (Phylum Myxozoa), the causative agent of proliferative kidney disease in salmonids","volume":"86","author":"Morris","year":"2000","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.fsi.2025.110571_bib48","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.bbagen.2015.01.003","article-title":"HIV-1 Nef: a master manipulator of the membrane trafficking machinery mediating immune evasion","volume":"1850","author":"Pawlak","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.fsi.2025.110571_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/fsim.2001.0407","article-title":"The rainbow trout classical MHC class I molecule Onmy-UBA\u2217501 is expressed in similar cell types as mammalian classical MHC class I molecules","volume":"14","author":"Dijkstra","year":"2003","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110571_bib50","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.4049\/jimmunol.141.8.2577","article-title":"Receptor-like nature of class I HLA: endocytosis via coated pits","volume":"141","author":"Dasgupta","year":"1988","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2025.110571_bib51","first-page":"315","article-title":"Recycling class I MHC antigens: dynamics of internalization, acidification, and ligand-degradation in murine T lymphoblasts","volume":"2","author":"Tse","year":"1986","journal-title":"J. Mol. Cell Immunol."},{"key":"10.1016\/j.fsi.2025.110571_bib52","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.4049\/jimmunol.1000347","article-title":"MHC class I presentation and regulation by IFN in bony fish determined by molecular analysis of the class I locus in grass carp","volume":"185","author":"Chen","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2025.110571_bib53","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.dci.2007.05.010","article-title":"Cell-mediated immune responses in rainbow trout after DNA immunization against the viral hemorrhagic septicemia virus","volume":"32","author":"Utke","year":"2008","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2025.110571_bib54","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/imm.12038","article-title":"Recent advances in understanding viral evasion of type I interferon","volume":"138","author":"Taylor","year":"2013","journal-title":"Immunology"},{"key":"10.1016\/j.fsi.2025.110571_bib55","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/5370706","article-title":"MHC class I molecules exacerbate viral infection by disrupting type I interferon signaling","volume":"2019","author":"Xia","year":"2019","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.fsi.2025.110571_bib56","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/ni.2283","article-title":"Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps\u2013SHP-2 pathway","volume":"13","author":"Xu","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.fsi.2025.110571_bib57","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1006\/clim.2000.4871","article-title":"MHC-Class I antigens regulate both the function and the survival of human peripheral blood NK cells: role of endogenously secreted TNF-\u03b1","volume":"96","author":"Jewett","year":"2000","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.fsi.2025.110571_bib58","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3389\/fimmu.2018.00167","article-title":"IFN-\u03c4 mediated control of Bovine Major histocompatibility complex class I expression and function via the regulation of bta-miR-148b\/152 in bovine endometrial epithelial cells","volume":"9","author":"Wu","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2025.110571_bib59","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1083\/jcb.139.6.1523","article-title":"Ligation of major histocompatability complex (MHC) class I molecules on human T cells induces cell death through PI-3 kinase-induced c-Jun NH2-terminal kinase activity: a novel apoptotic pathway distinct from Fas-induced apoptosis","volume":"139","author":"Skov","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.fsi.2025.110571_bib60","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1093\/intimm\/9.4.599","article-title":"Ligation of MHC class I induces apoptosis in human pre-B cell lines, in promyelocytic cell lines and in CD40-stimulated mature B cells","volume":"9","author":"Wall\u00e9n-Ohman","year":"1997","journal-title":"Int. Immunol."},{"key":"10.1016\/j.fsi.2025.110571_bib61","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1093\/intimm\/dxf058","article-title":"MHC class II-mediated apoptosis of mature dendritic cells proceeds by activation of the protein kinase C-delta isoenzyme","volume":"14","author":"Bertho","year":"2002","journal-title":"Int. Immunol."},{"key":"10.1016\/j.fsi.2025.110571_bib62","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1093\/intimm\/dxf073","article-title":"Differential regulation of maturation and apoptosis of human monocyte-derived dendritic cells mediated by MHC class II","volume":"14","author":"Lokshin","year":"2002","journal-title":"Int. Immunol."},{"key":"10.1016\/j.fsi.2025.110571_bib63","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1146\/annurev-immunol-042617-053010","article-title":"Apoptosis and clearance of apoptotic cells","volume":"36","author":"Nagata","year":"2018","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.fsi.2025.110571_bib64","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/sj.cdd.4400823","article-title":"Host defense, viruses and apoptosis","volume":"8","author":"Barber","year":"2001","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.fsi.2025.110571_bib65","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.3390\/v13112199","article-title":"Apoptosis enhances the replication of human coronavirus OC43","volume":"13","author":"Maharjan","year":"2021","journal-title":"Viruses"}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464825004607?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464825004607?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T03:37:02Z","timestamp":1777606622000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464825004607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":65,"alternative-id":["S1050464825004607"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2025.110571","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of antiviral functions, differences and apoptotic effects of two novel MHC-I\u03b1 genotypes in orange-spotted grouper (Epinephelus coioides)","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2025.110571","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110571"}}