{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:46:14Z","timestamp":1788263174014,"version":"build-2803163510"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008011","name":"Gorgan University of Agricultural Sciences and Natural Resources","doi-asserted-by":"publisher","award":["211720"],"award-info":[{"award-number":["211720"]}],"id":[{"id":"10.13039\/501100008011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.fsi.2025.110659","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T07:55:00Z","timestamp":1755503700000},"page":"110659","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Immunogenicity and seasonal effect of formalin-killed bivalent vaccines against Streptococcus iniae and Yersinia ruckeri in rainbow trout (Oncorhynchus mykiss) under farm conditions"],"prefix":"10.1016","volume":"166","author":[{"given":"Mohammad","family":"Mazandarani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9821-1444","authenticated-orcid":false,"given":"Majid","family":"Khanzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somayeh","family":"Namroodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Hossein","family":"Hoseinifar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamed","family":"Paknejad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2600-3720","authenticated-orcid":false,"given":"Mazyar","family":"Ahmadi Golsefidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak","family":"Beikzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.fsi.2025.110659_bib1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1086\/721055","article-title":"Aquaculture: externalities and policy options","volume":"16","author":"Asche","year":"2022","journal-title":"Rev. Environ. Econ. Pol."},{"issue":"2","key":"10.1016\/j.fsi.2025.110659_bib2","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/jwas.12963","article-title":"The contribution of aquaculture systems to global aquaculture production","volume":"54","author":"Verdegem","year":"2023","journal-title":"J. World Aquacult. Soc."},{"issue":"9","key":"10.1016\/j.fsi.2025.110659_bib3","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.3390\/pathogens10091205","article-title":"Mediterranean aquaculture in a changing climate: temperature effects on pathogens and diseases of three farmed fish species","volume":"10","author":"Cascarano","year":"2021","journal-title":"Pathogens"},{"issue":"4","key":"10.1016\/j.fsi.2025.110659_bib4","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1111\/raq.12786","article-title":"Review of alternatives to antibiotic use in aquaculture","volume":"15","author":"Bondad\u2010Reantaso","year":"2023","journal-title":"Rev. Aquacult."},{"issue":"1","key":"10.1016\/j.fsi.2025.110659_bib5","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3390\/antibiotics14010090","article-title":"Antibiotic residues in animal products from some African countries and their possible impact on human health","volume":"14","author":"Oladeji","year":"2025","journal-title":"Antibiotics"},{"key":"10.1016\/j.fsi.2025.110659_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2022.108472","article-title":"A novel C1qDC (PoC1qDC) with a collagen domain in Paralichthys olivaceus mediates complement activation and against bacterial infection","volume":"132","author":"Li","year":"2023","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2025.110659_bib7","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3390\/antibiotics13010082","article-title":"Effects of antibiotic residues on fish gut microbiome dysbiosis and mucosal barrier-related pathogen susceptibility in zebrafish experimental model","volume":"13","author":"Yang","year":"2024","journal-title":"Antibiotics"},{"issue":"9","key":"10.1016\/j.fsi.2025.110659_bib8","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.3390\/microorganisms10091705","article-title":"Use of probiotic bacteria and bacteriocins as an alternative to antibiotics in aquaculture","volume":"10","author":"Pereira","year":"2022","journal-title":"Microorganisms"},{"issue":"2","key":"10.1016\/j.fsi.2025.110659_bib9","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3390\/vaccines11020333","article-title":"The potential role of vaccines in preventing antimicrobial resistance (AMR): an update and future perspectives","volume":"11","author":"Costanzo","year":"2023","journal-title":"Vaccines"},{"issue":"18","key":"10.1016\/j.fsi.2025.110659_bib10","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.3390\/ani14182692","article-title":"Current challenges of vaccination in fish health management","volume":"14","author":"Kumar","year":"2024","journal-title":"Animals"},{"key":"10.1016\/j.fsi.2025.110659_bib11","first-page":"1","article-title":"Efficacy of polyvalent vaccine on immune response and disease resistance against streptococcosis\/lactococcosis and yersiniosis in rainbow trout (Oncorhynchus mykiss)","author":"Erfanmanesh","year":"2023","journal-title":"Vet. Res. Commun."},{"key":"10.1016\/j.fsi.2025.110659_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2022.104518","article-title":"Identification and characterization of a novel peptide from rainbow trout (Oncorhynchus mykiss) with antimicrobial activity against Streptococcus iniae","volume":"137","author":"Varga","year":"2022","journal-title":"Dev. Comp. Immunol."},{"issue":"3","key":"10.1016\/j.fsi.2025.110659_bib13","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.aaf.2020.05.009","article-title":"Enteric red mouth disease and its causative bacterium, Yersinia ruckeri, in Indian major carps from culture ponds in Andhra Pradesh, India","volume":"6","author":"Ummey","year":"2021","journal-title":"Aquaculture and Fisheries"},{"issue":"12","key":"10.1016\/j.fsi.2025.110659_bib14","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1111\/jfd.13507","article-title":"Immersion vaccines against Yersinia ruckeri infection in rainbow trout: comparative effects of strain differences","volume":"44","author":"Yang","year":"2021","journal-title":"J. Fish. Dis."},{"issue":"4","key":"10.1016\/j.fsi.2025.110659_bib15","doi-asserted-by":"crossref","first-page":"368","DOI":"10.3390\/vaccines9040368","article-title":"Vaccine efficacy of a newly developed feed-based whole-cell polyvalent vaccine against vibriosis, streptococcosis and motile aeromonad septicemia in Asian seabass, Lates calcarifer","volume":"9","author":"Mohamad","year":"2021","journal-title":"Vaccines"},{"issue":"5","key":"10.1016\/j.fsi.2025.110659_bib16","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.fsi.2012.01.028","article-title":"Effectiveness of bivalent vaccines against Aeromonas hydrophila and Lactococcus garvieae infections in rainbow trout Oncorhynchus mykiss (walbaum)","volume":"32","author":"Bastardo","year":"2012","journal-title":"Fish Shellfish Immunol."},{"issue":"9","key":"10.1016\/j.fsi.2025.110659_bib17","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.3390\/biology11091268","article-title":"Effect of an oral bivalent vaccine on immune response and immune gene profiling in vaccinated red tilapia (oreochromis spp.) during infections with Streptococcus iniae and Aeromonas hydrophila","volume":"11","author":"Monir","year":"2022","journal-title":"Biology"},{"key":"10.1016\/j.fsi.2025.110659_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.109226","article-title":"Effect of killed autogenous polyvalent vaccines against Vibrio harveyi, V. alginolyticus and Streptococcus iniae on survival and immunogenicity of Asian seabass (Lates calcarifer)","volume":"143","author":"Ahangarzadeh","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110659_bib19","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.fsi.2020.10.011","article-title":"Efficiency of monovalent and polyvalent Vibrio alginolyticus and Vibrio parahaemolyticus vaccines on the immune response and protection in gilthead sea bream, Sparus aurata (L.) against vibriosis","volume":"111","author":"Aly","year":"2021","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110659_bib20","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.fsi.2020.05.029","article-title":"Immunogenicity and protective efficacy of Yersinia ruckeri lipopolysaccharide (LPS), encapsulated by alginate-chitosan micro\/nanoparticles in rainbow trout (oncorhyncus mykiss)","volume":"104","author":"Dezfuly","year":"2020","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2025.110659_bib75","first-page":"83","article-title":"Fish hematology and associated disorders","volume":"18","author":"Grant","year":"2015","journal-title":"Veterinary Clinics: Exotic Animal Practice"},{"issue":"2","key":"10.1016\/j.fsi.2025.110659_bib21","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1136\/jcp.22.2.246-b","article-title":"Determination of blood glucose using 4-amino phenazone as oxygen acceptor","volume":"22","author":"Trinder","year":"1969","journal-title":"J. Clin. Pathol."},{"issue":"5","key":"10.1016\/j.fsi.2025.110659_bib22","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1111\/j.0022-1112.2004.00499.x","article-title":"A non\u2010invasive stress assay based upon measurement of free cortisol released into the water by rainbow trout","volume":"65","author":"Ellis","year":"2004","journal-title":"J. Fish. Biol."},{"issue":"1\u20134","key":"10.1016\/j.fsi.2025.110659_bib23","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.aquaculture.2003.11.036","article-title":"Effect of immunization with two commercial vaccines on feed intake, growth, and lysozyme activity in European whitefish (Coregonus lavaretus L.)","volume":"234","author":"Koskela","year":"2004","journal-title":"Aquaculture"},{"issue":"1","key":"10.1016\/j.fsi.2025.110659_bib24","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.cbpa.2006.05.007","article-title":"The activity of several components of the innate immune system in diploid and triploid turbot","volume":"145","author":"Budi\u00f1o","year":"2006","journal-title":"Comp. Biochem. Physiol. Mol. Integr. Physiol."},{"key":"10.1016\/j.fsi.2025.110659_bib25","article-title":"Nonspecific defense mechanisms assay in fish. II. Potential killing activity of neutrophils and monocytes, lysozyme activity in serum and organs and total immunoglobulin (ig) level in serum","author":"Siwicki","year":"1993","journal-title":"Fish Diseases Diagnosis and Prevention Methods"},{"key":"10.1016\/j.fsi.2025.110659_bib26","first-page":"1","article-title":"Fermentation of Sargassum ilicifolium with probiotics (Lactobacillus plantarum and Saccharomyces cerevisiae) enhances growth, immunity, and gene expression in rainbow trout before and after challenge with Streptococcus iniae","author":"Khanzadeh","year":"2025","journal-title":"Probiotics and Antimicrobial Proteins"},{"issue":"1","key":"10.1016\/j.fsi.2025.110659_bib27","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0006-291X(88)81230-0","article-title":"The interaction of aminogroups with pyrroloquinoline quinone as detected by the reduction of nitroblue tetrazolium","volume":"153","author":"Fl\u00fcckiger","year":"1988","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.fsi.2025.110659_bib28","first-page":"325","article-title":"[44] glutathione peroxidase","volume":"77","author":"Wendel","year":"1981"},{"key":"10.1016\/j.fsi.2025.110659_bib29","first-page":"121","article-title":"[13] catalase in vitro","volume":"105","author":"Aebi","year":"1984"},{"issue":"3","key":"10.1016\/j.fsi.2025.110659_bib30","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/clinchem\/34.3.497","article-title":"A simple method for clinical assay of superoxide dismutase","volume":"34","author":"Sun","year":"1988","journal-title":"Clin. Chem."},{"key":"10.1016\/j.fsi.2025.110659_bib31","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.aquaculture.2018.04.011","article-title":"Effects of soluble immunostimulants on mucosal immune responses in rainbow trout immersion-vaccinated against Yersinia ruckeri","volume":"492","author":"Skov","year":"2018","journal-title":"Aquaculture"},{"issue":"4","key":"10.1016\/j.fsi.2025.110659_bib32","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.fsi.2025.110659_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.aqrep.2022.101371","article-title":"Development of formalin killed vaccine candidate against streptococcosis caused by enterococcus sp. in nile tilapia","volume":"27","author":"Akter","year":"2022","journal-title":"Aquaculture Reports"},{"issue":"9","key":"10.1016\/j.fsi.2025.110659_bib34","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.3390\/vaccines11091470","article-title":"Recombinant attenuated Edwardsiella piscicida vaccine displaying regulated lysis to confer biological containment and protect catfish against edwardsiellosis","volume":"11","author":"Swain","year":"2023","journal-title":"Vaccines"},{"issue":"11","key":"10.1016\/j.fsi.2025.110659_bib35","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.3390\/vaccines9111234","article-title":"Transcriptome analysis in the head kidney of rainbow trout (Oncorhynchus mykiss) immunized with a combined vaccine of formalin-inactivated Aeromonas salmonicida and Vibrio anguillarum","volume":"9","author":"Lim","year":"2021","journal-title":"Vaccines"},{"issue":"10","key":"10.1016\/j.fsi.2025.110659_bib36","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1139\/f96-191","article-title":"Downstream gradients in bioindicator responses: point source contaminant effects on fish health","volume":"53","author":"Adams","year":"1996","journal-title":"Can. J. Fish. Aquat. Sci."},{"issue":"3","key":"10.1016\/j.fsi.2025.110659_bib37","first-page":"271","article-title":"Hematological parameters for the Brycon orbignyanus valenciennes, 1850 (osteichthyes: characidae) intensively bred","volume":"16","author":"Tavares-Dias","year":"2006","journal-title":"HIDROBIOLOGICA"},{"key":"10.1016\/j.fsi.2025.110659_bib38","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.fsi.2020.07.051","article-title":"Efficacy of two adjuvants administrated with a novel hydrogen peroxide-inactivated vaccine against Streptococcus agalactiae in nile tilapia fingerlings","volume":"105","author":"Ramos-Espinoza","year":"2020","journal-title":"Fish Shellfish Immunol."},{"issue":"3","key":"10.1016\/j.fsi.2025.110659_bib39","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3390\/vaccines8030476","article-title":"Effect of different routes of vaccination against Aeromonas salmonicida on rearing indicators and survival after an experimental challenge of pikeperch (sander lucioperca) in controlled rearing","volume":"8","author":"Schulz","year":"2020","journal-title":"Vaccines"},{"key":"10.1016\/j.fsi.2025.110659_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.109269","article-title":"Efficacy of whole-cell-based monovalent and bivalent vaccines against Streptococcus iniae and flavobacterium covae in fingerling Asian seabass (Lates calcarifer)","volume":"144","author":"Tumree","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110659_bib41","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.aquaculture.2018.10.030","article-title":"Fish hematology analysis as an important tool of aquaculture: a review","volume":"500","author":"Fazio","year":"2019","journal-title":"Aquaculture"},{"issue":"1","key":"10.1016\/j.fsi.2025.110659_bib42","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-67198-0","article-title":"New vaccination approach using formalin-killed Streptococcus pyogenes vaccine on the liver of Oreochromis niloticus fingerlings","volume":"14","author":"Nasr-Eldahan","year":"2024","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.fsi.2025.110659_bib43","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12917-024-03935-x","article-title":"Immuno-protective response of Asian seabass (Lates calcarifer) to inactivated vaccines against Streptococcus iniae and Vibrio harveyi","volume":"20","author":"Erfanmanesh","year":"2024","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.fsi.2025.110659_bib44","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.fsi.2021.04.006","article-title":"Immuno-protective efficiency of feed-based whole-cell inactivated bivalent vaccine against streptococcus and aeromonas infections in red hybrid tilapia (oreochromis niloticus\u00d7 Oreochromis mossambicus)","volume":"113","author":"Monir","year":"2021","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110659_bib45","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1007\/s10499-021-00776-5","article-title":"Growth performance, blood biochemical parameters, immune response, and antioxidant defense of Asian seabass (Lates calcarifer) fingerlings exposed to monovalent and bivalent vaccines against Streptococcus iniae and Vibrio harveyi","volume":"29","author":"Mohammadi","year":"2021","journal-title":"Aquac. Int."},{"key":"10.1016\/j.fsi.2025.110659_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12917-020-02443-y","article-title":"Haemato-immunological responses and effectiveness of feed-based bivalent vaccine against Streptococcus iniae and Aeromonas hydrophila infections in hybrid red tilapia (oreochromis mossambicus\u00d7 O. niloticus)","volume":"16","author":"Monir","year":"2020","journal-title":"BMC Vet. Res."},{"issue":"6","key":"10.1016\/j.fsi.2025.110659_bib47","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3390\/fishes7060398","article-title":"Efficacy of different routes of formalin-killed vaccine administration on immunity and disease resistance of nile tilapia (Oreochromis niloticus) challenged with Streptococcus agalactiae","volume":"7","author":"Linh","year":"2022","journal-title":"Fishes"},{"key":"10.1016\/j.fsi.2025.110659_bib48","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.fsi.2018.06.041","article-title":"Modulation of immune response and protective efficacy of recombinant outer-membrane protein F (rOmpF) of Aeromonas hydrophila in labeo rohita","volume":"80","author":"Yadav","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110659_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtherbio.2021.102928","article-title":"Effects of temperature, dissolved oxygen, and their interaction on the growth performance and condition of rainbow trout (Oncorhynchus mykiss)","volume":"98","author":"Jiang","year":"2021","journal-title":"J. Therm. Biol."},{"key":"10.1016\/j.fsi.2025.110659_bib50","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.fsi.2019.12.021","article-title":"Cross-immunity in nile tilapia vaccinated with Streptococcus agalactiae and Streptococcus iniae vaccines","volume":"97","author":"Wang","year":"2020","journal-title":"Fish Shellfish Immunol."},{"issue":"3","key":"10.1016\/j.fsi.2025.110659_bib51","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.dci.2012.07.010","article-title":"Cloning of the IL-1\u03b23 gene and IL-1\u03b24 pseudogene in salmonids uncovers a second type of IL-1\u03b2 gene in teleost fish","volume":"38","author":"Husain","year":"2012","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2025.110659_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108802","article-title":"Immunological response of 35 and 42 days old Asian seabass (Lates calcarifer, bloch 1790) fry following immersion immunization with Streptococcus iniae heat-killed vaccine","volume":"138","author":"Vinh","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110659_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108837","article-title":"Efficacy of bivalent vaccine against Aeromonas salmonicida and Edwardsiella tarda infections in turbot","author":"Su","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110659_bib54","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1378111","article-title":"Unveiling the multifaceted role of toll-like receptors in immunity of aquatic animals: pioneering strategies for disease management","volume":"15","author":"Ghani","year":"2024","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2025.110659_bib55","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.dci.2008.07.001","article-title":"Innate immune response in rainbow trout (Oncorhynchus mykiss) against primary and secondary infections with Yersinia ruckeri O1","volume":"33","author":"Raida","year":"2009","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2025.110659_bib56","series-title":"The Role of TLR4\/NF-kB Signaling Axis in Pneumonia: from Molecular Mechanisms to Regulation by Phytochemicals","first-page":"1","author":"Yin","year":"2025"},{"key":"10.1016\/j.fsi.2025.110659_bib57","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1109461","article-title":"The effect of environmental stressors on growth in fish and its endocrine control","volume":"14","author":"Canosa","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.fsi.2025.110659_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2020.110989","article-title":"Cortisol regulates insulin-like growth-factor binding protein (igfbp) gene expression in Atlantic salmon parr","volume":"518","author":"Breves","year":"2020","journal-title":"Mol. Cell. Endocrinol."},{"issue":"1","key":"10.1016\/j.fsi.2025.110659_bib59","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1146\/annurev.ph.48.030186.003301","article-title":"Oxy-radicals and related species: their formation, lifetimes, and reactions","volume":"48","author":"Pryor","year":"1986","journal-title":"Annu. Rev. Physiol."},{"issue":"10","key":"10.1016\/j.fsi.2025.110659_bib60","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1007\/s00204-023-03562-9","article-title":"Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging","volume":"97","author":"Jomova","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.fsi.2025.110659_bib61","first-page":"1289","article-title":"Tissue-specific responses of oxidative stress biomarkers and antioxidant defenses in rainbow trout Oncorhynchus mykiss during a vaccination against furunculosis","volume":"40","author":"Tkachenko","year":"2014","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.fsi.2025.110659_bib62","article-title":"Antioxidant defense in the hepatic tissue of rainbow trout (Oncorhynchus mykiss) following first month after vaccination against Yersinia ruckeri","volume":"167","author":"Tkachenko","year":"2017","journal-title":"\u0422\u0440\u0443\u0434\u044b"},{"key":"10.1016\/j.fsi.2025.110659_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2024.740714","article-title":"Phytogenics enhance welfare and vaccine efficacy against Vibrio anguillarum in European seabass (dicentrarchus Labrax) juveniles","volume":"585","author":"Montero","year":"2024","journal-title":"Aquaculture"},{"issue":"1\u20132","key":"10.1016\/j.fsi.2025.110659_bib64","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.mrrev.2007.11.006","article-title":"Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults","volume":"659","author":"Osburn","year":"2008","journal-title":"Mutat. Res., Rev. Mutat. Res."},{"key":"10.1016\/j.fsi.2025.110659_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2025.110503","article-title":"Oral adjuvanted vibrio vaccine enhances antibody production and lysozyme activity in the serum and mucus of marine-cultured red hybrid tilapia (Oreochromis sp.) against V. harveyi and V. alginolyticus","author":"Manchanayake","year":"2025","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110659_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2021.737158","article-title":"An inactivated bivalent vaccine effectively protects turbot (Scophthalmus maximus) against Vibrio anguillarum and Vibrio harveyi infection","volume":"544","author":"Zhang","year":"2021","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2025.110659_bib67","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.fsi.2020.11.014","article-title":"Systemic and mucosal antibody response of freshwater cultured Asian seabass (Lates calcarifer) to monovalent and bivalent vaccines against Streptococcus agalactiae and Streptococcus iniae","volume":"108","author":"Lan","year":"2021","journal-title":"Fish Shellfish Immunol."},{"issue":"8","key":"10.1016\/j.fsi.2025.110659_bib68","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.3390\/ani13081346","article-title":"Immunogenicity and efficacy of a feed-based bivalent vaccine against streptococcosis and motile aeromonad septicemia in red hybrid tilapia (Oreochromis sp.)","volume":"13","author":"Mohd Ali","year":"2023","journal-title":"Animals"},{"issue":"2","key":"10.1016\/j.fsi.2025.110659_bib69","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1006\/fsim.1993.1015","article-title":"Protective immunity in Atlantic salmon (Salmo salar L.) vaccinated at different water temperatures","volume":"3","author":"Lillehaug","year":"1993","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110659_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.109353","article-title":"Immune response and protective efficacy of Streptococcus agalactiae vaccine coated with chitosan oligosaccharide for different immunization strategy in nile tilapia (Oreochromis niloticus)","volume":"145","author":"Lu","year":"2024","journal-title":"Fish Shellfish Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2025.110659_bib71","article-title":"Mucosal immune responses and protective efficacy in yellow catfish after immersion vaccination with bivalent inactivated Aeromonas veronii and Edwardsiella ictaluri vaccine","volume":"1","author":"Kong","year":"2022","journal-title":"Water Biol. Secur."},{"key":"10.1016\/j.fsi.2025.110659_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2025.107190","article-title":"Efficacy of chitosan conjugated bivalent vaccine on immune response and disease resistance against Aeromonas hydrophila, and Aeromonas caviae in Goldfish Carassius auratus","author":"Rajeswari","year":"2025","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.fsi.2025.110659_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.109008","article-title":"Vaccination with bacterial ghosts of Streptococcus iniae and Lactococcus garvieae originated from outbreak of marine fish streptococcosis, induce potential protection against the disease in Nile tilapia, Oreochromis niloticus (Linnaeus, 1758)","volume":"141","author":"Hussein","year":"2023","journal-title":"Fish Shellfish Immunol."},{"issue":"10","key":"10.1016\/j.fsi.2025.110659_bib74","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.3390\/vaccines10101625","article-title":"Trial evaluation of protection and immunogenicity of piscine bivalent streptococcal vaccine: from the lab to the farms","volume":"10","author":"Kannika","year":"2022","journal-title":"Vaccines"}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464825005480?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464825005480?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T11:03:42Z","timestamp":1772881422000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464825005480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":75,"alternative-id":["S1050464825005480"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2025.110659","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunogenicity and seasonal effect of formalin-killed bivalent vaccines against Streptococcus iniae and Yersinia ruckeri in rainbow trout (Oncorhynchus mykiss) under farm conditions","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2025.110659","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110659"}}