{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T23:54:49Z","timestamp":1789343689196,"version":"build-2803163510"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42376104"],"award-info":[{"award-number":["42376104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.fsi.2025.110893","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T01:12:11Z","timestamp":1758589931000},"page":"110893","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Integrated metabolome-SNP-gut microbiome analysis deciphers the molecular basis of EHP resistance in Penaeus vannamei"],"prefix":"10.1016","volume":"167","author":[{"given":"Yang","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangrong","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2025.110893_bib1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/raq.12843","article-title":"Retrospect of fish meal substitution in Pacific white shrimp (Litopenaeus vannamei) feed: alternatives, limitations and future prospects","volume":"16","author":"Chen","year":"2024","journal-title":"Rev. Aquacult."},{"key":"10.1016\/j.fsi.2025.110893_bib2","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.3390\/foods12112143","article-title":"Survey of colistin resistance in commensal bacteria from Penaeus vannamei farms in China","volume":"12","author":"Zhang","year":"2023","journal-title":"Foods"},{"key":"10.1016\/j.fsi.2025.110893_bib3","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00203-022-03376-w","article-title":"Investigation of antibiotic-resistant vibrios associated with shrimp (Penaeus vannamei) farms","volume":"205","author":"Prabina","year":"2023","journal-title":"Arch. Microbiol."},{"key":"10.1016\/j.fsi.2025.110893_bib4","doi-asserted-by":"crossref","first-page":"388","DOI":"10.24272\/j.issn.2095-8137.2024.364","article-title":"Beneficial effects of probiotics on Litopenaeus vannamei growth and immune function via the recruitment of gut Rhodobacteraceae symbionts","volume":"46","author":"Sha","year":"2025","journal-title":"Zool. Res."},{"key":"10.1016\/j.fsi.2025.110893_bib5","author":"Jangam"},{"key":"10.1016\/j.fsi.2025.110893_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1040336","article-title":"Current status and development prospects of aquatic vaccines","volume":"13","author":"Du","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2025.110893_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2022.738105","article-title":"Effect of Enterocytozoon hepatopenaei (EHP) infection on physiology, metabolism, immunity, and growth of Penaeus vannamei","volume":"553","author":"Sathish Kumar","year":"2022","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2025.110893_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109902","article-title":"Transcriptomic analysis provides insights into the mechanisms underlying the resistance of Penaeus vannamei to Enterocytozoon hepatopenaei (EHP)","volume":"154","author":"Tian","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110893_bib9","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.3390\/ani11113150","article-title":"First report of Enterocytozoon hepatopenaei infection in pacific whiteleg shrimp (Litopenaeus vannamei) cultured in korea","volume":"11","author":"Kim","year":"2021","journal-title":"Animals"},{"key":"10.1016\/j.fsi.2025.110893_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2021.737685","article-title":"Farm-level economic cost of Enterocytozoon hepatopenaei (EHP) to Indian Penaeus vannamei shrimp farming","volume":"548","author":"Geetha","year":"2022","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2025.110893_bib11","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.aquaculture.2017.07.043","article-title":"Detection of the microsporidian Enterocytozoon hepatopenaei (EHP) and Taura syndrome virus in Penaeus vannamei cultured in Venezuela","volume":"480","author":"Tang","year":"2017","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2025.110893_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jip.2016.08.004","article-title":"Dense populations of the microsporidian Enterocytozoon hepatopenaei (EHP) in feces of Penaeus vannamei exhibiting white feces syndrome and pathways of their transmission to healthy shrimp","volume":"140","author":"Tang","year":"2016","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.fsi.2025.110893_bib13","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.aquaculture.2016.12.038","article-title":"Enterocytozoon hepatopenaei (EHP) is a risk factor for acute hepatopancreatic necrosis disease (AHPND) and septic hepatopancreatic necrosis (SHPN) in the Pacific white shrimp Penaeus vannamei","volume":"471","author":"Aranguren","year":"2017","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2025.110893_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108605","article-title":"Transcriptome analysis of the hepatopancreas in Penaeus vannamei under experimental infection with Enterocytozoon hepatopenaei (EHP)","volume":"134","author":"Cao","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110893_bib15","doi-asserted-by":"crossref","first-page":"3","DOI":"10.24272\/j.issn.2095-8137.2024.409","article-title":"Palmitoylation-mediated NLRP3 inflammasome activation in teleosts highlights evolutionary divergence in immune regulation","volume":"46","author":"Nie","year":"2025","journal-title":"Zool. Res."},{"key":"10.1016\/j.fsi.2025.110893_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jip.2020.107458","article-title":"The shrimp microsporidian Enterocytozoon hepatopenaei (EHP): biology, pathology, diagnostics and control","volume":"186","author":"Chaijarasphong","year":"2021","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.fsi.2025.110893_bib17","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12917-021-02778-0","article-title":"The effect of salinity on Enterocytozoon hepatopenaei infection in Penaeus vannamei under experimental conditions","volume":"17","author":"Aranguren Caro","year":"2021","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.fsi.2025.110893_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-19127-2","article-title":"The emerging pathogen Enterocytozoon hepatopenaei drives a degenerative cyclic pattern in the hepatopancreas microbiome of the shrimp (Penaeus vannamei)","volume":"12","author":"L\u00f3pez-Carvallo","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fsi.2025.110893_bib19","article-title":"Comprehensive transcriptomic and metabolomic analysis of the Litopenaeus vannamei hepatopancreas after WSSV challenge","volume":"13","author":"Yu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2025.110893_bib20","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3354\/dao03538","article-title":"Association between ALFPm3 single nucleotide polymorphism and white spot syndrome virus resistance in black tiger shrimp Penaeus monodon","volume":"142","author":"Pooljun","year":"2020","journal-title":"Dis. Aquat. Org."},{"key":"10.1016\/j.fsi.2025.110893_bib21","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.ecoenv.2019.05.029","article-title":"Stress response and tolerance mechanisms of ammonia exposure based on transcriptomics and metabolomics in Litopenaeus vannamei","volume":"180","author":"Xiao","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fsi.2025.110893_bib22","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.aquaculture.2019.02.055","article-title":"Evaluation on the genomic selection in Litopenaeus vannamei for the resistance against Vibrio parahaemolyticus","volume":"505","author":"Wang","year":"2019","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2025.110893_bib23","article-title":"Integrated application of transcriptomics and metabolomics provides insights into acute hepatopancreatic necrosis disease resistance of Pacific white shrimp Litopenaeus vannamei","volume":"8","author":"Sun","year":"2023","journal-title":"mSystems"},{"key":"10.1016\/j.fsi.2025.110893_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.134416","article-title":"Integrated analysis of physiological, transcriptomic and metabolomic responses and tolerance mechanism of nitrite exposure in Litopenaeus vannamei","volume":"711","author":"Xiao","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fsi.2025.110893_bib25","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.febslet.2011.12.038","article-title":"SNPs of hemocyanin C\u2010terminal fragment in shrimp Litopenaeus vannamei","volume":"586","author":"Zhao","year":"2012","journal-title":"FEBS Lett."},{"key":"10.1016\/j.fsi.2025.110893_bib26","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3390\/agronomy11030420","article-title":"Conversion and validation of uniplex SNP markers for selection of resistance to cassava Mosaic disease in Cassava breeding programs","volume":"11","author":"Ige","year":"2021","journal-title":"Agronomy"},{"key":"10.1016\/j.fsi.2025.110893_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.772442","article-title":"Comparison of gene expression between resistant and susceptible families against VPAHPND and identification of biomarkers used for resistance evaluation in Litopenaeus vannamei","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Genet."},{"key":"10.1016\/j.fsi.2025.110893_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109902","article-title":"Transcriptomics provides insights into the resistance of Penaeus vannamei to Enterocytozoon hepatopenaei (EHP)","volume":"154","author":"Tian","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110893_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/cmi.13127","article-title":"Bile acid and bile acid transporters are involved in the pathogenesis of acute hepatopancreatic necrosis disease in white shrimp Litopenaeus vannamei","volume":"22","author":"Kumar","year":"2020","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.fsi.2025.110893_bib30","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12886-017-0555-7","article-title":"Plasma metabolomic study in Chinese patients with wet age-related macular degeneration","volume":"17","author":"Luo","year":"2017","journal-title":"BMC Ophthalmol."},{"key":"10.1016\/j.fsi.2025.110893_bib31","doi-asserted-by":"crossref","first-page":"12889","DOI":"10.1021\/acs.jafc.8b02862","article-title":"Metabolomics reveals that crossbred Dairy Buffaloes are more Thermotolerant than Holstein Cows under chronic heat stress","volume":"66","author":"Gu","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fsi.2025.110893_bib32","doi-asserted-by":"crossref","DOI":"10.1111\/raq.70039","article-title":"The current state of Knowledge of the economic impact of diseases in global aquaculture","volume":"17","author":"Maezono","year":"2025","journal-title":"Rev. Aquacult."},{"key":"10.1016\/j.fsi.2025.110893_bib33","doi-asserted-by":"crossref","first-page":"61","DOI":"10.56566\/ijses.v2i1.326","article-title":"Eco-friendly shrimp farming: Balancing economic growth and environmental sustainability in agriculture","volume":"2","author":"Ahmed","year":"2025","journal-title":"Int. J. Sci. Edu. Sci."},{"key":"10.1016\/j.fsi.2025.110893_bib34","series-title":"Shrimp Culture Technology","first-page":"223","article-title":"An overview of Enterocytozoon hepatopenaei (EHP) infection in shrimp","author":"Naveen Kumar","year":"2025"},{"key":"10.1016\/j.fsi.2025.110893_bib35","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.fsi.2019.01.051","article-title":"Proteomic and metabolomic responses in hepatopancreas of whiteleg shrimp Litopenaeus vannamei infected by microsporidian Enterocytozoon hepatopenaei","volume":"87","author":"Ning","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110893_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.129984","article-title":"Genome-wide analysis of ATP-binding cassette (ABC) transporter in Penaeus vannamei and identification of two ABC genes involved in immune defense against Vibrio parahaemolyticus by affecting NF-\u03baB signaling pathway","volume":"262","author":"Luo","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.fsi.2025.110893_bib37","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.cbpc.2009.06.012","article-title":"Molecular cloning and characterization of an ATP-binding cassette (ABC) transmembrane transporter from the white shrimp Litopenaeus vannamei","volume":"150","author":"Zhou","year":"2009","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.fsi.2025.110893_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108695","article-title":"Identification of key immune and stress related genes and pathways by comparative analysis of the gene expression profile under multiple environmental stressors in pacific white shrimp (Litopenaeus vannamei)","volume":"135","author":"Farhadi","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110893_bib39","doi-asserted-by":"crossref","first-page":"12919","DOI":"10.1128\/JVI.05385-11","article-title":"White spot syndrome virus induces metabolic changes resembling the warburg effect in shrimp hemocytes in the early stage of infection","volume":"85","author":"Chen","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.fsi.2025.110893_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.634152","article-title":"Differentially expressed genes in hepatopancreas of acute hepatopancreatic necrosis disease tolerant and susceptible shrimp (Penaeus vannamei)","volume":"12","author":"Mai","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2025.110893_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.jip.2020.107424","article-title":"Acute hepatopancreatic necrosis disease (VPAHPND), a chronic disease in shrimp (Penaeus vannamei) population raised in Latin America","volume":"174","author":"Aranguren Caro","year":"2020","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.fsi.2025.110893_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2020.736174","article-title":"Metabolic responses of penaeid shrimp to acute hepatopancreatic necrosis disease caused by Vibrio parahaemolyticus","volume":"533","author":"Nguyen","year":"2021","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2025.110893_bib43","article-title":"Integrated application of transcriptomics and metabolomics provides insights into acute hepatopancreatic necrosis disease","volume":"24","author":"Guo","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fsi.2025.110893_bib44","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201899319","article-title":"MRC1 and Rad9 cooperate to regulate initiation and elongation of DNA replication in response to DNA damage","volume":"37","author":"Bacal","year":"2018","journal-title":"EMBO J."},{"key":"10.1016\/j.fsi.2025.110893_bib45","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1016\/j.molcel.2024.07.002","article-title":"MRC1 regulates parental histone segregation and heterochromatin inheritance","volume":"84","author":"Toda","year":"2024","journal-title":"Mol. Cell"},{"key":"10.1016\/j.fsi.2025.110893_bib46","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.630777","article-title":"MRC1-Dependent chromatin compaction represses DNA double-stranded break repair by homologous recombination upon replication stress","volume":"9","author":"Xing","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.fsi.2025.110893_bib47","doi-asserted-by":"crossref","first-page":"15074","DOI":"10.3390\/ijms140715074","article-title":"Defective homocysteine metabolism: potential implications for skeletal muscle malfunction","volume":"14","author":"Veeranki","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fsi.2025.110893_bib48","article-title":"Characterization and regulatory analysis of betaine homocysteine S-methyltransferase gene 1 (BHMT1) in mud crab: a gene responsive to salinity and feeding behavior","volume":"38","author":"Yin","year":"2025","journal-title":"Gene Rep."},{"key":"10.1016\/j.fsi.2025.110893_bib49","first-page":"126","article-title":"Comparative transcriptome analysis on the alteration of gene expression in ayu (Plecoglossus altivelis) larvae associated with salinity change","volume":"37","author":"Lu","year":"2016","journal-title":"Zool. Res."},{"key":"10.1016\/j.fsi.2025.110893_bib50","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1007\/s00018-006-6249-6","article-title":"Betaine homocysteine S-methyltransferase: just a regulator of homocysteine metabolism?","volume":"63","author":"Pajares","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.fsi.2025.110893_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0134084","article-title":"Evolutionary analyses and Natural selection of betaine-homocysteine S-methyltransferase (BHMT) and BHMT2 genes","volume":"10","author":"Ganu","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2025.110893_bib52","article-title":"SNP identification by transcriptome sequencing and candidate gene-based association analysis for heat tolerance in the bay scallop Argopecten irradians","volume":"9","author":"Du","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2025.110893_bib53","doi-asserted-by":"crossref","first-page":"ar153","DOI":"10.1091\/mbc.E24-08-0355","article-title":"Mannose receptor (MRC1) mediates uptake of dextran by bone marrow\u2013derived macrophages","volume":"35","author":"Wollman","year":"2024","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.fsi.2025.110893_bib54","doi-asserted-by":"crossref","DOI":"10.1128\/JB.00046-12","article-title":"Draft genome sequence of Sphingomonas echinoides ATCC 14820","volume":"194","author":"Shin","year":"2012","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.fsi.2025.110893_bib55","doi-asserted-by":"crossref","DOI":"10.1093\/lifemeta\/load052","article-title":"Abnormal adipose tissue-derived microbes drive metabolic disorder and exacerbate postnatal growth retardation in piglet","volume":"3","author":"Song","year":"2024","journal-title":"Life Metabol."},{"key":"10.1016\/j.fsi.2025.110893_bib56","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.fsi.2022.08.066","article-title":"Enhancement of growth, survival, immunity and disease resistance in Litopenaeus vannamei, by the probiotic, Lactobacillus plantarum Ep-M17","volume":"129","author":"Du","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110893_bib57","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3390\/biology12030417","article-title":"Transcriptome analysis on hepatopancreas reveals the metabolic dysregulation caused by Vibrio parahaemolyticus infection in Litopenaeus vannamei","volume":"12","author":"Miao","year":"2023","journal-title":"Biology"},{"key":"10.1016\/j.fsi.2025.110893_bib58","article-title":"Diploid and triploid Chinook salmon (Oncorhynchus tshawytscha) have altered microRNA responses in immune tissues after infection with Vibrio anguillarum","volume":"48","author":"Cadonic","year":"2023","journal-title":"Comp. Biochem. Physiol., Part D: Genomics Proteomics"},{"key":"10.1016\/j.fsi.2025.110893_bib59","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1128\/AEM.01412-07","article-title":"Conservation of the chitin utilization pathway in the Vibrionaceae","volume":"74","author":"Hunt","year":"2008","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.fsi.2025.110893_bib60","doi-asserted-by":"crossref","DOI":"10.1128\/mSystems.00141-16","article-title":"Growth on chitin impacts the transcriptome and metabolite profiles of antibiotic-Producing Vibrio coralliilyticus S2052 and Photobacterium galatheae S2753","volume":"2","author":"Giubergia","year":"2017","journal-title":"mSystems"},{"key":"10.1016\/j.fsi.2025.110893_bib61","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3390\/md14120230","article-title":"Biological potential of chitinolytic marine bacteria","volume":"14","author":"Paulsen","year":"2016","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.fsi.2025.110893_bib62","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3390\/md19020108","article-title":"Chitin degradation machinery and secondary metabolite profiles in the marine bacterium Pseudoalteromonas rubra S4059","volume":"19","author":"Wang","year":"2021","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.fsi.2025.110893_bib63","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.03191-22","article-title":"Oxidative stress regulates a pivotal metabolic switch in dimethylsulfoniopropionate degradation by the marine bacterium Ruegeria pomeroyi","volume":"10","author":"Wang","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.fsi.2025.110893_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.eti.2023.103450","article-title":"Heterotrophic bacteria dominate the sulfide oxidation process in coastal sediments","volume":"32","author":"Cao","year":"2023","journal-title":"Environ. Technol. Innov."},{"key":"10.1016\/j.fsi.2025.110893_bib65","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00329-20","article-title":"Dimethylsulfoniopropionate sulfur and methyl carbon assimilation in Ruegeria species","volume":"11","author":"Wirth","year":"2020","journal-title":"mBio"},{"key":"10.1016\/j.fsi.2025.110893_bib66","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s44149-023-00073-z","article-title":"Lactobacillus plantarum A3 attenuates ulcerative colitis by modulating gut microbiota and metabolism","volume":"3","author":"Qin","year":"2023","journal-title":"Animal Dis."},{"key":"10.1016\/j.fsi.2025.110893_bib67","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s44149-024-00125-y","article-title":"Lactobacillus alleviates intestinal epithelial barrier function through GPR43-mediated M2 macrophage polarization","volume":"4","author":"Yao","year":"2024","journal-title":"Animal Dis."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105046482500782X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105046482500782X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T21:06:54Z","timestamp":1779916014000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S105046482500782X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":67,"alternative-id":["S105046482500782X"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2025.110893","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrated metabolome-SNP-gut microbiome analysis deciphers the molecular basis of EHP resistance in Penaeus vannamei","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2025.110893","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110893"}}