{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:48:13Z","timestamp":1792478893919,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002510","name":"Kongju National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002510","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["RS-2023-00242225"],"award-info":[{"award-number":["RS-2023-00242225"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.fsi.2025.110982","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T16:58:20Z","timestamp":1762361900000},"page":"110982","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Oral transmission of rock bream iridovirus (RBIV) drives delayed systemic infection and organ specific immune reprogramming in rock bream (Oplegnathus fasciatus)"],"prefix":"10.1016","volume":"168","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6801-8635","authenticated-orcid":false,"given":"Su-Mi","family":"Shin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeon-Seo","family":"Yun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9521-3804","authenticated-orcid":false,"given":"Myung-Hwa","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2025.110982_bib1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3147\/jsfp.29.29","article-title":"Biological and physico-chemical properties of the iridovirus isolated from cultured red sea bream, Pagrus major","volume":"29","author":"Nakajima","year":"1994","journal-title":"Fish Pathol."},{"key":"10.1016\/j.fsi.2025.110982_bib2","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1365-2761.1994.tb00237.x","article-title":"Investigation of outbreaks of a novel disease,\u2018sleepy grouper disease\u2019, affecting the brown\u2010spotted grouper, Epinephelus tauvina Forskal","volume":"17","author":"Chua","year":"1994","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2025.110982_bib3","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3147\/jsfp.31.233","article-title":"Cultured fish species affected by red sea bream iridoviral disease from 1991 to 1995","volume":"31","author":"Matsuoka","year":"1996","journal-title":"Fish Pathol."},{"key":"10.1016\/j.fsi.2025.110982_bib4","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1046\/j.1365-2761.1997.d01-115.x","article-title":"Genetic similarity of iridoviruses from Japan and Thailand","volume":"20","author":"Miyata","year":"1997","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2025.110982_bib5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0044-8486(01)00639-1","article-title":"Experimental transmission, pathogenicity and physical\u2013chemical properties of infectious spleen and kidney necrosis virus (ISKNV)","volume":"204","author":"He","year":"2002","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2025.110982_bib6","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3354\/dao03267","article-title":"Red seabream iridovirus associated with cultured Florida pompano Trachinotus carolinus mortality in Central America","volume":"130","author":"Lopez-Porras","year":"2018","journal-title":"Dis. Aquat. Organ."},{"key":"10.1016\/j.fsi.2025.110982_bib7","doi-asserted-by":"crossref","first-page":"440","DOI":"10.3390\/v11050440","article-title":"Characterization of a novel megalocytivirus isolated from European chub (Squalius cephalus)","volume":"11","author":"Halaly","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.fsi.2025.110982_bib8","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1046\/j.1365-2761.2000.00212.x","article-title":"Iridovirus-like infection associated with high mortalities of striped beakperch, Oplegnathus fasciatus (Temminck et Schlegel), in southern coastal areas of the Korean peninsula","volume":"23","author":"Jung","year":"2000","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2025.110982_bib9","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.fsi.2014.01.012","article-title":"Gene expression of pro- and anti-apoptotic proteins in rock bream (Oplegnathus fasciatus) infected with megalocytivirus (family Iridoviridae)","volume":"37","author":"Jung","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110982_bib10","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/jfd.12286","article-title":"Effects of water temperature on mortality in Megalocytivirus-infected rock bream Oplegnathus fasciatus (Temminck et Schlegel) and development of protective immunity","volume":"38","author":"Jung","year":"2015","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2025.110982_bib11","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1111\/jfd.12459","article-title":"Low pathogenicity of flounder iridovirus (FLIV) and the absence of cross-protection between FLIV and rock bream iridovirus","volume":"39","author":"Jung","year":"2016","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2025.110982_bib12","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.fsi.2017.09.038","article-title":"Rock bream iridovirus (RBIV) replication in rock bream (Oplegnathus fasciatus) exposed for different time periods to susceptible water temperatures","volume":"70","author":"Jung","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110982_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.00160","article-title":"The megalocytivirus RBIV induces apoptosis and MHC class I presentation in rock bream (Oplegnathus fasciatus) red blood cells","volume":"10","author":"Jung","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2025.110982_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2023.199278","article-title":"Abnormalities in red blood cell production and pathogenesis of anemia in the progression of rock bream iridovirus (RBIV)","volume":"339","author":"Kim","year":"2024","journal-title":"Virus Res."},{"key":"10.1016\/j.fsi.2025.110982_bib15","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.vaccine.2017.12.077","article-title":"DNA vaccine encoding myristoylated membrane protein (MMP) of rock bream iridovirus (RBIV) induces protective immunity in rock bream (Oplegnathus fasciatus)","volume":"36","author":"Jung","year":"2018","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2025.110982_bib16","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.fsi.2021.12.047","article-title":"Efficacy of saponin-based inactivated rock bream iridovirus (RBIV) vaccine in rock bream (Oplegnathus fasciatus)","volume":"121","author":"Jung","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110982_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2022.198827","article-title":"Protective immunity induced by ankyrin repeat-containing protein-based DNA vaccine against rock bream iridovirus (RBIV) in rock bream (Oplegnathus fasciatus)","volume":"318","author":"Jung","year":"2022","journal-title":"Virus Res."},{"key":"10.1016\/j.fsi.2025.110982_bib18","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.jcpa.2016.09.003","article-title":"Laboratory-controlled challenges of Nile Tilapia (Oreochromis niloticus) with Streptococcus agalactiae: comparisons between immersion, oral, intracoelomic and intramuscular routes of infection","volume":"155","author":"Soto","year":"2016","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.fsi.2025.110982_bib19","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.fsi.2021.11.039","article-title":"Laboratory-controlled challenges of streptococcosis in Nile tilapia using the oral route (infected-feed) for infection","volume":"120","author":"Owatari","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110982_bib20","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.aquaculture.2006.04.033","article-title":"Experimental transmission and virulence of a megalocytivirus (Family Iridoviridae) of dwarf gourami (Colisa lalia) from Asia in Murray cod (Maccullochella peelii peelii) in Australia","volume":"258","author":"Go","year":"2006","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2025.110982_bib21","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.fsi.2025.110982_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109858","article-title":"Effect of rock bream iridovirus (RBIV) contained tissue intake on rock bream (Oplegnathus fasciatus) mortality and blood cell distribution","volume":"153","author":"Kim","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2025.110982_bib23","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.aquaculture.2016.10.020","article-title":"Effect of dietary essential oils of clove basil and ginger on Nile tilapia (Oreochromis niloticus) following challenge with Streptococcus agalactiae","volume":"468","author":"Brum","year":"2017","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2025.110982_bib24","series-title":"Streptococcal Infections of Fish, Florida Coop. Ext. Serv. IFAS","first-page":"1","author":"Yanong","year":"2002"},{"key":"10.1016\/j.fsi.2025.110982_bib25","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.anifeedsci.2011.12.015","article-title":"Fish immune system and its nutritional modulation for preventive health care","volume":"173","author":"Kiron","year":"2012","journal-title":"Anim. Feed Sci. Technol."},{"key":"10.1016\/j.fsi.2025.110982_bib26","series-title":"Fish Pathology","author":"Roberts","year":"2012"},{"key":"10.1016\/j.fsi.2025.110982_bib27","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1365-2761.2012.01358.x","article-title":"Oral transmission as a route of infection for viral haemorrhagic septicaemia virus in rainbow trout, Oncorhynchus mykiss (Walbaum)","volume":"35","author":"Sch\u00f6nherz","year":"2012","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2025.110982_bib28","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s10495-011-0616-y","article-title":"Singapore grouper iridovirus, a large DNA virus, induces nonapoptotic cell death by a cell type dependent fashion and evokes ERK signaling","volume":"16","author":"Huang","year":"2011","journal-title":"Apoptosis"},{"key":"10.1016\/j.fsi.2025.110982_bib29","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.virol.2017.06.007","article-title":"Ranaviruses and other members of the family Iridoviridae: their place in the virosphere","volume":"511","author":"Chinchar","year":"2017","journal-title":"Virology"}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105046482500871X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105046482500871X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:24:40Z","timestamp":1773296680000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S105046482500871X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":29,"alternative-id":["S105046482500871X"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2025.110982","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oral transmission of rock bream iridovirus (RBIV) drives delayed systemic infection and organ specific immune reprogramming in rock bream (Oplegnathus fasciatus)","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2025.110982","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110982"}}