{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T09:20:26Z","timestamp":1777886426134,"version":"3.51.4"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2020YFD0900705-1"],"award-info":[{"award-number":["2020YFD0900705-1"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.fsi.2026.111182","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T17:14:00Z","timestamp":1770225240000},"page":"111182","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Integrated mortality rates and transcriptome comparative analysis between wild and artificially selected ark shell (Scapharca subcrenata) populations in response to Vibrio anguillarum infection"],"prefix":"10.1016","volume":"171","author":[{"given":"Peizhen","family":"Tian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanming","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XingLei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1079-7154","authenticated-orcid":false,"given":"Feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5204-8880","authenticated-orcid":false,"given":"Yuming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2026.111182_bib1","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1007\/s10592-008-9742-7","article-title":"Polymorphic microsatellite DNA markers for the ark shell Scapharca subcrenata (bivalve: Arcidae)","volume":"10","author":"Chen","year":"2009","journal-title":"Conserv. Genet."},{"key":"10.1016\/j.fsi.2026.111182_bib2","first-page":"437","article-title":"A review: research progress of biology in ark shell Scapharca subcrenata insight from aquaculture","volume":"30","author":"Wang","year":"2015","journal-title":"J. Dalian Fish. Univ."},{"key":"10.1016\/j.fsi.2026.111182_bib3","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.aquaculture.2011.10.015","article-title":"Reproductive cycle and gross biochemical composition of the ark shell Scapharca subcrenata (Lischke, 1869) reared on subtidal mudflats in a temperate Bay of Korea","volume":"322","author":"Park","year":"2011","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2026.111182_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.109301","article-title":"Transcriptome analysis reveals tissue-specific responses of Mytilus unguiculatus to Vibrio alginolyticus infection","volume":"144","author":"Li","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111182_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2024.740810","article-title":"Sarafloxacin hydrochloride exposure disrupts gut microbiota shrimp susceptibility to Vibrio anguillarum infection","volume":"586","author":"Sha","year":"2024","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2026.111182_bib7","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.fsi.2019.01.024","article-title":"Transcriptome analysis and discovery of genes involved in immune pathways in Solen strictus (Gould, 1861) under Vibrio anguillarum","volume":"88","author":"Wang","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111182_bib8","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.ecoenv.2018.08.068","article-title":"Transcriptome analysis of the effects of Cd and nanomaterial-loaded Cd on the liver in zebrafish","volume":"164","author":"Gao","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fsi.2026.111182_bib9","article-title":"Characterization of the mantle transcriptome of Yesso scallop (Patinopecten yessoensis): identification of genes potentially involved in biomineralization and pigmentation","volume":"10","author":"Sun","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2026.111182_bib10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.margen.2017.01.001","article-title":"Differential mantle transcriptomics and characterization of growth-related genes in the diploid and triploid pearl oyster Pinctada fucata","volume":"33","author":"Guan","year":"2017","journal-title":"Mar. Genom."},{"key":"10.1016\/j.fsi.2026.111182_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2021.737527","article-title":"Comparative transcriptome analysis of the Cyclina sinensis hepatopancreas provides evidence that toll-like receptors protect against Vibrio anguillarum infection","volume":"547","author":"Ren","year":"2022","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2026.111182_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2023.739365","article-title":"Transcriptomic analysis provides molecular insights into immune response of Ruditapes philippinarum under Vibrio parahaemolyticus challenge","volume":"569","author":"Yu","year":"2023","journal-title":"Aquaculture"},{"issue":"7","key":"10.1016\/j.fsi.2026.111182_bib13","doi-asserted-by":"crossref","first-page":"giz067","DOI":"10.1093\/gigascience\/giz067","article-title":"Chromosomal-level assembly of the blood clam, Scapharca (Anadara) broughtonii, using long sequence reads and Hi-C","volume":"8","author":"Bai","year":"2019","journal-title":"GigaScience"},{"issue":"3","key":"10.1016\/j.fsi.2026.111182_bib14","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nbt.3122","article-title":"StringTie enables improved reconstruction of a transcriptome from RNA-seq reads","volume":"33","author":"Pertea","year":"2015","journal-title":"Nat. Biotechnol."},{"issue":"7221","key":"10.1016\/j.fsi.2026.111182_bib15","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nature07509","article-title":"Alternative isoform regulation in human tissue transcriptomes","volume":"456","author":"Wang","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2026.111182_bib16","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1080\/01621459.1931.10503208","article-title":"The test of significance for the correlation coefficient","volume":"26","author":"Pearson","year":"1931","journal-title":"J. Am. Stat. Assoc."},{"key":"10.1016\/j.fsi.2026.111182_bib17","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1198\/106186006X113430","article-title":"Sparse principal component analysis","volume":"15","author":"Zou","year":"2006","journal-title":"J. Comput. Graph Stat."},{"issue":"12","key":"10.1016\/j.fsi.2026.111182_bib18","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.fsi.2026.111182_bib19","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res."},{"issue":"S2","key":"10.1016\/j.fsi.2026.111182_bib20","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/nar\/gkr483","article-title":"Kobas 2.0: a web server for annotation and identification of enricheded pathways and diseases","volume":"39","author":"Xie","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.fsi.2026.111182_bib21","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jip.2016.06.002","article-title":"Effect of \u201cheat shock\u201d treatments on QPX disease and stress response in the hard clam, Mercenaria mercenaria","volume":"138","author":"Wang","year":"2016","journal-title":"J. Invertebr. Pathol."},{"issue":"4","key":"10.1016\/j.fsi.2026.111182_bib22","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real- time quantitative PCR and the 2\u2610\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"3","key":"10.1016\/j.fsi.2026.111182_bib23","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/j.1523-1739.1998.96456.x","article-title":"Inbreeding and extinction: island populations","volume":"12","author":"Frankham","year":"1998","journal-title":"Conserv. Biol."},{"issue":"5","key":"10.1016\/j.fsi.2026.111182_bib24","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0169-5347(02)02489-8","article-title":"Inbreeding effects in wild populations","volume":"17","author":"Keller","year":"2002","journal-title":"Trends Ecol. Evol."},{"key":"10.1016\/j.fsi.2026.111182_bib25","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.fsi.2020.08.016","article-title":"Transcriptomic analysis and expression of C-type lectins in response to Vibrio parahaemolyticus challenge in Scapharca subcrenata","volume":"106","author":"Lin","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111182_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2022.738824","article-title":"Transcriptome analysis and pattern recognition receptors (PRRs) identification in different tissues of adult Pacific oysters infected with Vibrio parahaemolyticus","volume":"562","author":"Namwong","year":"2023","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2026.111182_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2025.169056","article-title":"Mechanistic insights into protein biogenesis and maturation on the ribosome","author":"Lentzsch","year":"2025","journal-title":"J. Mol. Biol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111182_bib28","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.tig.2024.12.010","article-title":"Ribosome profiling reveals hidden world of small proteins","volume":"41","author":"Tong","year":"2025","journal-title":"Trends Genet."},{"issue":"4","key":"10.1016\/j.fsi.2026.111182_bib29","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.00426-21","article-title":"Serine metabolism tunes immune responses to promote Oreochromis niloticus survival upon edwardsiella tarda infection","volume":"6","author":"Yang","year":"2021","journal-title":"mSystems"},{"key":"10.1016\/j.fsi.2026.111182_bib30","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jprot.2018.05.006","article-title":"Identification and efficacy of glycine, serine and threonine metabolism in potentiating kanamycin-mediated killing of Edwardsiella piscicida","volume":"183","author":"Ye","year":"2018","journal-title":"J. Proteonomics"},{"issue":"1","key":"10.1016\/j.fsi.2026.111182_bib31","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/s41467-023-36630-w","article-title":"Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism","volume":"14","author":"Upadhyayula","year":"2023","journal-title":"Nat. Commun."},{"issue":"6 suppl","key":"10.1016\/j.fsi.2026.111182_bib32","doi-asserted-by":"crossref","first-page":"1636S","DOI":"10.1093\/jn\/136.6.1636S","article-title":"The sulfur-containing amino acids: an overview","volume":"136","author":"Brosnan","year":"2006","journal-title":"J. Nutr."},{"issue":"6","key":"10.1016\/j.fsi.2026.111182_bib33","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.3390\/cells10061547","article-title":"Pentose phosphate pathway reactions in photosynthesizing cells","volume":"10","author":"Sharkey","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.fsi.2026.111182_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2021.111095","article-title":"The bifunctional 6-phosphofructokinase-2\/fructose-2, 6-bisphosphatase from the shrimp Litopenaeus vannamei: molecular characterization and down-regulation of expression in response to severe hypoxia","volume":"263","author":"Flores-Sauceda","year":"2022","journal-title":"Comp. Biochem. Physiol. Mol. Integr. Physiol."},{"key":"10.1016\/j.fsi.2026.111182_bib35","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1111\/anu.12671","article-title":"The effect of taurine supplementation to a plant-based diet for barramundi (Lates calcarifer) with varying methionine content","volume":"24","author":"Poppi","year":"2018","journal-title":"Aquac. Nutr."},{"key":"10.1016\/j.fsi.2026.111182_bib36","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.vas.2017.04.002","article-title":"Effects of diets with whole plant-origin proteins added with different ratios of taurine:methionine on the growth, macrophage activity and antioxidant capacity of rainbow trout (Oncorhynchus mykiss) fingerlings","volume":"3","author":"Hern\u00e1ndez","year":"2017","journal-title":"Veterinary and Animal Science"},{"key":"10.1016\/j.fsi.2026.111182_bib37","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s13205-020-02312-3","article-title":"Glutathione S-transferase: a versatile protein family","volume":"10","author":"Vaish","year":"2020","journal-title":"3 Biotech"},{"key":"10.1016\/j.fsi.2026.111182_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.109088","article-title":"A comparative transcriptome analysis of how shrimp endure and adapt to long-term symbiosis with Enterocytozoon hepatopenaei infection","volume":"142","author":"Zhang","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111182_bib39","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.fsi.2019.05.055","article-title":"Neuroendocrine immune-regulatory of a neuropeptide ChGnRH from the Hongkong oyster, Crassostrea Hongkongensis","volume":"93","author":"Huang","year":"2019","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111182_bib40","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ygcen.2010.02.010","article-title":"Neurohormones and neuropeptides encoded by the genome of Lottiagigantea, with reference to other mollusks and insects","volume":"167","author":"Veenstra","year":"2010","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.fsi.2026.111182_bib41","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.peptides.2012.01.017","article-title":"Characterization of GnRH-related peptides from the pacific oyster Crassostrea gigas","volume":"34","author":"Bigot","year":"2012","journal-title":"Peptides"},{"issue":"1","key":"10.1016\/j.fsi.2026.111182_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ygcen.2010.12.014","article-title":"Evolution of GnRH: diving deeper","volume":"171","author":"Roch","year":"2011","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.fsi.2026.111182_bib43","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1098\/rspl.1904.0022","article-title":"Further observations on the role of the blood fluids in connection with phagocytosis","volume":"73","author":"Wright","year":"1904","journal-title":"Proc. Roy. Soc. Lond."},{"issue":"13","key":"10.1016\/j.fsi.2026.111182_bib44","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1056\/NEJM197403282901306","article-title":"Phagocytosis (first of three parts)","volume":"290","author":"Stossel","year":"1974","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.fsi.2026.111182_bib45","first-page":"35","volume":"220","author":"Yada","year":"2002"},{"key":"10.1016\/j.fsi.2026.111182_bib46","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1046\/j.1365-3032.2003.00314.x","article-title":"Interactions between the endocrine and immune systems in locusts","volume":"28","author":"Goldsworthy","year":"2003","journal-title":"Physiol. Entomol."},{"key":"10.1016\/j.fsi.2026.111182_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/3628501","article-title":"Sunlight effects on immune System: is there something else in addition to UV-Induced immunosuppression?","author":"Gonz\u00e1lez","year":"2016","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.fsi.2026.111182_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108979","article-title":"Effects of light and circadian clock on the antiviral immune response in zebrafish","author":"Mazur","year":"2023","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111182_bib49","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/imr.12647","article-title":"Innate immune memory: an evolutionary perspective","volume":"283","author":"Gourbal","year":"2018","journal-title":"Immunol. Rev."},{"issue":"6284","key":"10.1016\/j.fsi.2026.111182_bib50","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaf1098","article-title":"Trained immunity: a program of innate immune memory in health and disease","volume":"352","author":"Netea","year":"2016","journal-title":"Science"}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826000860?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826000860?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T03:37:48Z","timestamp":1777606668000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464826000860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":49,"alternative-id":["S1050464826000860"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111182","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrated mortality rates and transcriptome comparative analysis between wild and artificially selected ark shell (Scapharca subcrenata) populations in response to Vibrio anguillarum infection","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111182","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111182"}}