{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:51:14Z","timestamp":1790887874964,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32573551"],"award-info":[{"award-number":["32573551"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.fsi.2026.111225","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T08:09:28Z","timestamp":1771488568000},"page":"111225","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Molecular characterization and functional analysis of EBF1 reveals its critical role in B-cell immunity in Nile tilapia"],"prefix":"10.1016","volume":"172","author":[{"given":"Jiayi","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxiong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7589-0974","authenticated-orcid":false,"given":"Yu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jichang","family":"Jian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2026.111225_bib1","doi-asserted-by":"crossref","DOI":"10.1007\/s00427-017-0591-6","article-title":"The structure, splicing, synteny and expression of lamprey COE genes and the evolution of the COE gene family in chordates","volume":"227","author":"Lara-Ram\u00edrez","year":"2017","journal-title":"Dev. Gene. Evol."},{"key":"10.1016\/j.fsi.2026.111225_bib2","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1196\/annals.1402.045","article-title":"B lymphocytes and the skeleton","volume":"1117","author":"Horowitz","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.fsi.2026.111225_bib3","article-title":"COE loss-of-function analysis reveals a genetic program underlying maintenance and regeneration of the nervous system in planarians","volume":"10","author":"Mw","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.fsi.2026.111225_bib4","article-title":"Olf-1\/early B cell factor is a regulator of glut4 gene expression in 3T3-L1 adipocytes","volume":"277","author":"P","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fsi.2026.111225_bib5","doi-asserted-by":"crossref","first-page":"8389","DOI":"10.1128\/MCB.22.24.8389-8397.2002","article-title":"The EBF\/Olf\/Collier family of transcription factors: regulators of differentiation in cells originating from all three embryonal germ layers","volume":"22","author":"Liberg","year":"2002","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.fsi.2026.111225_bib6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0960-9822(98)70084-3","article-title":"XCoe2, a transcription factor of the col\/olf-1\/EBF family involved in the specification of primary neurons in xenopus","volume":"8","author":"Dubois","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.fsi.2026.111225_bib7","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ydbio.2007.12.030","article-title":"Control of multidendritic neuron differentiation in drosophila: the role of collier","volume":"315","author":"Crozatier","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.fsi.2026.111225_bib8","first-page":"1447","article-title":"The C. elegans COE transcription factor UNC-3 activates lineage-specific apoptosis and affects neurite growth in the RID lineage","volume":"142","author":"Wang","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.fsi.2026.111225_bib9","unstructured":"Nieminen-Pihala, V. TRANSCRIPTION FACTORS Ebf1 AND Ebf2 IN BONE METABOLISM."},{"key":"10.1016\/j.fsi.2026.111225_bib10","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1101\/gad.187328.112","article-title":"Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferation, and survival of B cells","volume":"26","author":"Gy\u00f6ry","year":"2012","journal-title":"Genes Dev."},{"key":"10.1016\/j.fsi.2026.111225_bib11","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/376263a0","article-title":"Failure of B-cell differentiation in mice lacking the transcription factor EBF","volume":"376","author":"Lin","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2026.111225_bib12","doi-asserted-by":"crossref","first-page":"7869","DOI":"10.1073\/pnas.1003525107","article-title":"Compound haploinsufficiencies of Ebf1 and Runx1 genes impede B cell lineage progression","volume":"107","author":"Lukin","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.fsi.2026.111225_bib13","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.dci.2011.01.009","article-title":"Dissecting teleost B cell differentiation using transcription factors","volume":"35","author":"Zwollo","year":"2011","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2026.111225_bib14","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/imr.12206","article-title":"The regulatory network of B-cell differentiation: a focused view of early B-cell factor 1 function","volume":"261","author":"Boller","year":"2014","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.fsi.2026.111225_bib15","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1084\/jem.20121187","article-title":"Coordinated transcriptional regulation of bone homeostasis by Ebf1 and Zfp521 in both mesenchymal and hematopoietic lineages","volume":"210","author":"Kiviranta","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.fsi.2026.111225_bib16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1749-8104-6-19","article-title":"EBF factors drive expression of multiple classes of target genes governing neuronal development","volume":"6","author":"Green","year":"2011","journal-title":"Neural Dev."},{"key":"10.1016\/j.fsi.2026.111225_bib17","doi-asserted-by":"crossref","first-page":"dev202054","DOI":"10.1242\/dev.202054","article-title":"The transcription factor EBF1 non-cell-autonomously regulates cardiac growth and differentiation","volume":"150","author":"Kim","year":"2023","journal-title":"Development"},{"key":"10.1016\/j.fsi.2026.111225_bib18","doi-asserted-by":"crossref","first-page":"35925","DOI":"10.1074\/jbc.M113.491936","article-title":"Early B-cell factor-1 (EBF1) is a key regulator of metabolic and inflammatory signaling pathways in mature adipocytes","volume":"288","author":"Griffin","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fsi.2026.111225_bib19","article-title":"Thyme-synthesized silver nanoparticles mitigate immunosuppression, oxidative damage, and histopathological alterations induced by multidrug-resistant enterococcus faecalis in Oreochromis niloticus: in vitro and in vivo assays","volume":"51","author":"Da","year":"2025","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.fsi.2026.111225_bib20","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biol."},{"key":"10.1016\/j.fsi.2026.111225_bib21","doi-asserted-by":"crossref","first-page":"R19","DOI":"10.1186\/gb-2007-8-2-r19","article-title":"qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data","volume":"8","author":"Hellemans","year":"2007","journal-title":"Genome Biol."},{"key":"10.1016\/j.fsi.2026.111225_bib22","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1158\/0008-5472.CAN-18-3238","article-title":"EBF1-mediated upregulation of ribosome assembly factor PNO1 contributes to cancer progression by negatively regulating the p53 signaling pathway","volume":"79","author":"Shen","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.fsi.2026.111225_bib23","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.fsi.2017.10.008","article-title":"Conservation of structural and interactional features of CD28 and CD80\/86 molecules from nile tilapia (Oreochromis niloticus)","volume":"72","author":"Huang","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111225_bib24","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/s42003-024-06055-2","article-title":"CircEYA3 aggravates intervertebral disc degeneration through the miR-196a-5p\/EBF1 axis and NF-\u03baB signaling","volume":"7","author":"Wang","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.fsi.2026.111225_bib25","doi-asserted-by":"crossref","first-page":"W285","DOI":"10.1093\/nar\/gkab295","article-title":"IPC 2.0: prediction of isoelectric point and pKa dissociation constants","volume":"49","author":"Kozlowski","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.fsi.2026.111225_bib26","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1101\/gad.1976610","article-title":"Structure of an Ebf1:DNA complex reveals unusual DNA recognition and structural homology with rel proteins","volume":"24","author":"Treiber","year":"2010","journal-title":"Genes Dev."},{"key":"10.1016\/j.fsi.2026.111225_bib27","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1101\/gad.349696.122","article-title":"Tnpo3 enables EBF1 function in conditions of antagonistic notch signaling","volume":"36","author":"Bayer","year":"2022","journal-title":"Genes Dev."},{"key":"10.1016\/j.fsi.2026.111225_bib28","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/1471-2148-8-131","article-title":"The metazoan history of the COE transcription factors. Selection of a variant HLH motif by mandatory inclusion of a duplicated exon in vertebrates","volume":"8","author":"Daburon","year":"2008","journal-title":"BMC Evol. Biol."},{"key":"10.1016\/j.fsi.2026.111225_bib29","series-title":"Comparative Transcriptomics Reveal that Adaptive Evolution in Immune Genes Drives the Local Adaptation and Speciation of Schizothoracine Fish","author":"Qi","year":"2019"},{"key":"10.1016\/j.fsi.2026.111225_bib30","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1360\/N972015-01355","article-title":"Will there ever be a tree of life that systematists can agree on?","volume":"61","author":"Lu","year":"2016","journal-title":"Chin. Sci. Bull."},{"key":"10.1016\/j.fsi.2026.111225_bib31","first-page":"568","article-title":"Relationships between gene trees and species trees","volume":"5","author":"Pamilo","year":"1988","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.fsi.2026.111225_bib32","unstructured":"M.K. Anderson, R. Pant, A.L. Miracle, X. Sun, C.A. Luer, C.J. Walsh, J.C. Telfer, G.W. Litman, E.V. Rothenberg, Evolutionary Origins of Lymphocytes: Ensembles of T Cell and B Cell Transcriptional Regulators in a Cartilaginous Fish1, (n.d.)."},{"key":"10.1016\/j.fsi.2026.111225_bib33","article-title":"LECT2 protects nile tilapia (Oreochromis niloticus) against streptococcus agalatiae infection","volume":"12","author":"Li","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2026.111225_bib34","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1681\/ASN.2018070699","article-title":"Early B cell factor 1 (EBF1) regulates glomerular development by controlling mesangial maturation and consequently COX-2 expression","volume":"30","author":"Nelson","year":"2019","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.fsi.2026.111225_bib35","article-title":"Distribution and localization of Streptococcus agalactiae in different tissues of artificially infected tilapia (Oreochromis niloticus)","volume":"546","year":"2022","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2026.111225_bib36","doi-asserted-by":"crossref","first-page":"101","DOI":"10.14202\/vetworld.2017.101-111","article-title":"Molecular identification and histopathological study of natural Streptococcus agalactiae infection in hybrid tilapia (Oreochromis niloticus)","volume":"10","author":"Laith","year":"2017","journal-title":"Vet. World"},{"key":"10.1016\/j.fsi.2026.111225_bib37","doi-asserted-by":"crossref","first-page":"914","DOI":"10.3390\/biology13110914","article-title":"Streptococcus agalactiae infection in Nile Tilapia (Oreochromis niloticus): a review","volume":"13","author":"Abdallah","year":"2024","journal-title":"Biology"},{"key":"10.1016\/j.fsi.2026.111225_bib38","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00418-023-02192-7","article-title":"MicroRNA-598 inhibition ameliorates LPS-induced acute lung injury in mice through upregulating Ebf1 expression","volume":"160","author":"Zhao","year":"2023","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.fsi.2026.111225_bib39","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1080\/15476286.2024.2368304","article-title":"Silencing LINC00663 inhibits inflammation and angiogenesis through downregulation of NR2F1 via EBF1 in bladder cancer","volume":"21","author":"Zhong","year":"2024","journal-title":"RNA Biol."},{"key":"10.1016\/j.fsi.2026.111225_bib40","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41420-024-02226-6","article-title":"Mitophagy: insights into its signaling molecules, biological functions, and therapeutic potential in breast cancer","volume":"10","author":"Chen","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.fsi.2026.111225_bib41","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2119518119","article-title":"EBF1 promotes triple-negative breast cancer progression by surveillance of the HIF1\u03b1 pathway","volume":"119","author":"Qiu","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.fsi.2026.111225_bib42","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2210595119","article-title":"EBF1 is continuously required for stabilizing local chromatin accessibility in pro-B cells","volume":"119","author":"Zolotarev","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.fsi.2026.111225_bib43","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1084\/jem.20112422","article-title":"Essential role of EBF1 in the generation and function of distinct mature B cell types","volume":"209","author":"Vilagos","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.fsi.2026.111225_bib44","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.coi.2005.03.001","article-title":"Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex","volume":"17","author":"Rickert","year":"2005","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.fsi.2026.111225_bib45","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.2174\/1381612033454351","article-title":"Regulation of B-cell activation by complement receptors CD21 and CD35","volume":"9","author":"Erdei","year":"2003","journal-title":"Curr. Pharm. Des."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826001294?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826001294?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T03:39:45Z","timestamp":1777606785000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464826001294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":45,"alternative-id":["S1050464826001294"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111225","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular characterization and functional analysis of EBF1 reveals its critical role in B-cell immunity in Nile tilapia","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111225","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"111225"}}