{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T07:16:41Z","timestamp":1783149401418,"version":"3.54.6"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023QC259"],"award-info":[{"award-number":["ZR2023QC259"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32403064"],"award-info":[{"award-number":["32403064"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD2400401"],"award-info":[{"award-number":["2022YFD2400401"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.fsi.2026.111374","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T23:39:19Z","timestamp":1776814759000},"page":"111374","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Functional antagonism and underlying regulatory pathways of haptoglobin splicing isoforms in the immune response of half-smooth tongue sole (Cynoglossus semilaevis)"],"prefix":"10.1016","volume":"174","author":[{"given":"Suxu","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixiao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0645-4201","authenticated-orcid":false,"given":"Wenwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yishuai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunpeng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoqing","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenxia","family":"Sha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.fsi.2026.111374_bib1","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1042\/bj2650621","article-title":"Interleukin-6 and the acute phase response","volume":"265","author":"Heinrich","year":"1990","journal-title":"Biochem. J."},{"issue":"6","key":"10.1016\/j.fsi.2026.111374_bib2","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1056\/NEJM199902113400607","article-title":"Acute-phase proteins and other systemic responses to inflammation","volume":"340","author":"Gabay","year":"1999","journal-title":"Engl. J. Med."},{"key":"10.1016\/j.fsi.2026.111374_bib3","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.3389\/fimmu.2019.01220","article-title":"Acute phase proteins in marine mammals: state of art, perspectives and challenges","volume":"10","author":"Gelain","year":"2019","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111374_bib4","doi-asserted-by":"crossref","first-page":"78","DOI":"10.2174\/0929866524666161121142221","article-title":"Acute phase proteins and their potential role as an indicator for fish health and in diagnosis of fish diseases","volume":"24","author":"Roy","year":"2017","journal-title":"Protein Pept. Lett."},{"issue":"8","key":"10.1016\/j.fsi.2026.111374_bib5","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1182\/blood-2012-11-451229","article-title":"Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins","volume":"121","author":"Schaer","year":"2013","journal-title":"Blood"},{"issue":"14","key":"10.1016\/j.fsi.2026.111374_bib6","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1089\/ars.2016.6793","article-title":"Haptoglobin, antioxid","volume":"26","author":"Andersen","year":"2017","journal-title":"Redox Signaling"},{"issue":"9","key":"10.1016\/j.fsi.2026.111374_bib7","first-page":"647","article-title":"Biological functions of haptoglobin--new pieces to an old puzzle","volume":"35","author":"Dobryszycka","year":"1997","journal-title":"Eur. J. Clin. Chem. Clin. Biochem."},{"issue":"4","key":"10.1016\/j.fsi.2026.111374_bib8","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1182\/blood-2009-01-198309","article-title":"Receptor targeting of hemoglobin mediated by the haptoglobins: roles beyond heme scavenging","volume":"114","author":"Nielsen","year":"2009","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.fsi.2026.111374_bib9","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1172\/JCI116319","article-title":"Identification of haptoglobin as an angiogenic factor in sera from patients with systemic vasculitis","volume":"91","author":"Cid","year":"1993","journal-title":"J. Clin. Investig."},{"issue":"11","key":"10.1016\/j.fsi.2026.111374_bib10","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.5966\/sctm.2015-0043","article-title":"Oral mucosal lamina propria-progenitor cells exert antibacterial properties via the secretion of osteoprotegerin and haptoglobin","volume":"4","author":"Board-Davies","year":"2015","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.fsi.2026.111374_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1401527","article-title":"Haptoglobin buffers lipopolysaccharides to delay activation of NF\u03baB","volume":"15","author":"Zein","year":"2024","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.fsi.2026.111374_bib12","first-page":"369","article-title":"Haptoglobin and the Th1\/Th2 balance: hints from in vitro and in vivo studies, redox report","volume":"6","author":"Arredouani","year":"2001","journal-title":"Free Radic. Res. Commun."},{"issue":"2","key":"10.1016\/j.fsi.2026.111374_bib13","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1046\/j.1365-2567.2003.01569.x","article-title":"Haptoglobin directly affects T cells and suppresses T helper cell type 2 cytokine release","volume":"108","author":"Arredouani","year":"2003","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111374_bib14","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1189\/jlb.0208100","article-title":"The acute phase protein haptoglobin regulates host immunity","volume":"84","author":"Huntoon","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.fsi.2026.111374_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2020.100851","article-title":"Haptoglobin: from hemoglobin scavenging to human health","volume":"73","author":"di Masi","year":"2020","journal-title":"Mol. Aspect. Med."},{"issue":"1","key":"10.1016\/j.fsi.2026.111374_bib16","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1182\/blood-2005-03-1014","article-title":"CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin","volume":"107","author":"Schaer","year":"2006","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.fsi.2026.111374_bib17","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1038\/s41467-025-56524-3","article-title":"Fucosylated haptoglobin promotes inflammation via mincle in sepsis: an observational study","volume":"16","author":"Roh","year":"2025","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.fsi.2026.111374_bib18","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.4049\/jimmunol.1800661","article-title":"Haptoglobin acts as a TLR4 ligand to suppress osteoclastogenesis via the TLR4-IFN-\u03b2 axis","volume":"202","author":"Kwon","year":"2019","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2026.111374_bib19","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s00239-007-9002-3","article-title":"Convergent evolution of human and bovine haptoglobin: partial duplication of the genes","volume":"65","author":"Wicher","year":"2007","journal-title":"J. Mol. Evol."},{"issue":"8","key":"10.1016\/j.fsi.2026.111374_bib20","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.4049\/jimmunol.1800508","article-title":"Haptoglobin is a divergent MASP family member that neofunctionalized to recycle hemoglobin via CD163 in mammals","volume":"201","author":"Redmond","year":"2018","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2026.111374_bib21","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.dci.2017.06.006","article-title":"Molecular identification and characterization of haptoglobin in teleosts revealed an important role on fish viral infections","volume":"76","author":"Cordero","year":"2017","journal-title":"Dev. Comp. Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111374_bib22","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.fsi.2015.05.020","article-title":"Molecular characterization of two immunity-related acute-phase proteins: Haptoglobin and serum amyloid A from black rockfish (Sebastes schlegeli)","volume":"45","author":"Jayasinghe","year":"2015","journal-title":"Fish Shellfish Immunol."},{"issue":"11","key":"10.1016\/j.fsi.2026.111374_bib23","doi-asserted-by":"crossref","first-page":"4168","DOI":"10.1073\/pnas.0508723103","article-title":"Haptoglobin, a hemoglobin-binding plasma protein, is present in bony fish and mammals but not in frog and chicken","volume":"103","author":"Wicher","year":"2006","journal-title":"Proc. Nat. Acad. Sci."},{"issue":"Pt 6","key":"10.1016\/j.fsi.2026.111374_bib24","article-title":"A tale of two genes: divergent evolutionary fate of haptoglobin and hemopexin in hemoglobinless antarctic icefishes","volume":"222","author":"Bilyk","year":"2019","journal-title":"J. Exp. Biol."},{"issue":"7","key":"10.1016\/j.fsi.2026.111374_bib25","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1007\/s00424-018-2136-x","article-title":"Alternative splicing isoforms in health and disease","volume":"470","author":"Kim","year":"2018","journal-title":"Pflugers Arch. - Eur. J. Physiol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111374_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17010003","article-title":"The role of alternative splicing in the control of immune homeostasis and cellular differentiation","volume":"17","author":"Yabas","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.fsi.2026.111374_bib27","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nrg3052","article-title":"Functional consequences of developmentally regulated alternative splicing","volume":"12","author":"Kalsotra","year":"2011","journal-title":"Nat. Rev. Genet."},{"issue":"1","key":"10.1016\/j.fsi.2026.111374_bib28","doi-asserted-by":"crossref","first-page":"38","DOI":"10.7150\/ijbs.34422","article-title":"The function of Pre-mRNA alternative splicing in mammal spermatogenesis","volume":"16","author":"Song","year":"2020","journal-title":"Int. J. Biol. Sci."},{"issue":"7","key":"10.1016\/j.fsi.2026.111374_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18071530","article-title":"Alternative Pre-mRNA splicing in mammals and teleost fish: a effective strategy for the regulation of immune responses against pathogen infection","volume":"18","author":"Chang","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.fsi.2026.111374_bib30","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1093\/hmg\/ddx123","article-title":"A rare splice donor mutation in the haptoglobin gene associates with blood lipid levels and coronary artery disease","volume":"26","author":"Bjornsson","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.fsi.2026.111374_bib31","article-title":"Inflammatory reaction and immune response of half-smooth tongue sole (Cynoglossus semilaevis) after infection with Vibrio anguillarum","volume":"141","author":"Wang","year":"2023","journal-title":"Adv. Colloid Interface Sci."},{"issue":"1","key":"10.1016\/j.fsi.2026.111374_bib32","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.fsi.2014.11.018","article-title":"Transcriptome analysis revealed changes of multiple genes involved in immunity in Cynoglossus semilaevis during Vibrio anguillarum infection","volume":"43","author":"Zhang","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111374_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2023.740526","article-title":"Analysis of alternative splicing provides insights into its vital roles in immune responses of half-smooth tongue sole (Cynoglossus semilaevis) against Vibrio anguillarum","volume":"582","author":"Han","year":"2024","journal-title":"Aquaculture"},{"issue":"4","key":"10.1016\/j.fsi.2026.111374_bib34","doi-asserted-by":"crossref","first-page":"648","DOI":"10.2144\/97234bm22","article-title":"Simplified agar plate method for quantifying viable bacteria","volume":"23","author":"Jett","year":"1997","journal-title":"Biotechniques"},{"key":"10.1016\/j.fsi.2026.111374_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.109043","article-title":"Inflammatory reaction and immune response of half-smooth tongue sole (Cynoglossus semilaevis) after infection with Vibrio anguillarum","volume":"141","author":"Wang","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111374_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109706","article-title":"Manipulated C5aR1 over\/down-expression associates with IL-6 expression during bacterial inflammation in half-smooth tongue sole (Cynoglossus semilaevis)","volume":"151","author":"Wu","year":"2024","journal-title":"Fish Shellfish Immunol."},{"issue":"8\u20139","key":"10.1016\/j.fsi.2026.111374_bib37","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0145-305X(01)00033-7","article-title":"The acute phase response and innate immunity of fish","volume":"25","author":"Bayne","year":"2001","journal-title":"Dev. Comp. Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2026.111374_bib38","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1006\/fsim.1998.0181","article-title":"The morphology of the immune system in teleost fishes","volume":"9","author":"Press","year":"1999","journal-title":"Fish Shellfish Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111374_bib39","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.fsi.2004.09.005","article-title":"Ontogeny of the immune system of fish","volume":"20","author":"Zapata","year":"2006","journal-title":"Fish Shellfish Immunol."},{"issue":"5","key":"10.1016\/j.fsi.2026.111374_bib40","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.fsi.2010.09.001","article-title":"Teleost intestinal immunology","volume":"31","author":"Rombout","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111374_bib41","series-title":"Mucosal Health in Aquaculture","first-page":"135","article-title":"6 - fish mucosal immunity: intestine","author":"Salinas","year":"2015"},{"key":"10.1016\/j.fsi.2026.111374_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2025.110375","article-title":"SHP-1 negatively regulates LPS-induced M1 polarization, phagocytic activity, inflammation and oxidative stress in primary macrophages of Chinese tongue sole (Cynoglossus semilaevis)","volume":"163","author":"Wang","year":"2025","journal-title":"Fish Shellfish Immunol."},{"issue":"17","key":"10.1016\/j.fsi.2026.111374_bib43","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"Fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"issue":"3","key":"10.1016\/j.fsi.2026.111374_bib44","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/ng.2890","article-title":"Whole-genome sequence of a flatfish provides insights into ZW sex chromosome evolution and adaptation to a benthic lifestyle","volume":"46","author":"Chen","year":"2014","journal-title":"Nat. Genet."},{"issue":"8","key":"10.1016\/j.fsi.2026.111374_bib45","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat. Biotechnol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111374_bib46","doi-asserted-by":"crossref","first-page":"giab008","DOI":"10.1093\/gigascience\/giab008","article-title":"Twelve years of SAMtools and BCFtools","volume":"10","author":"Danecek","year":"2021","journal-title":"GigaScience"},{"issue":"10","key":"10.1016\/j.fsi.2026.111374_bib47","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1093\/bioinformatics\/btac166","article-title":"Analysing high-throughput sequencing data in python with HTSeq 2.0","volume":"38","author":"Putri","year":"2022","journal-title":"Bioinformatics"},{"issue":"12","key":"10.1016\/j.fsi.2026.111374_bib48","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.fsi.2026.111374_bib49","doi-asserted-by":"crossref","first-page":"D353","DOI":"10.1093\/nar\/gkw1092","article-title":"KEGG: new perspectives on genomes, pathways, diseases and drugs","volume":"45","author":"Kanehisa","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"5","key":"10.1016\/j.fsi.2026.111374_bib50","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"issue":"43","key":"10.1016\/j.fsi.2026.111374_bib51","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Nat. Acad. Sci."},{"key":"10.1016\/j.fsi.2026.111374_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinf."},{"issue":"1","key":"10.1016\/j.fsi.2026.111374_bib53","article-title":"Biological network exploration with cytoscape 3, curr. Protoc","volume":"47","author":"Su","year":"2014","journal-title":"Bioinform"},{"issue":"1","key":"10.1016\/j.fsi.2026.111374_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003098","article-title":"Teleost fish mount complex clonal IgM and IgT responses in spleen upon systemic viral infection","volume":"9","author":"Castro","year":"2013","journal-title":"PLoS Pathog."},{"issue":"4","key":"10.1016\/j.fsi.2026.111374_bib55","doi-asserted-by":"crossref","DOI":"10.3390\/biology5040045","article-title":"Fish immunoglobulins","volume":"5","author":"Mashoof","year":"2016","journal-title":"Biology"},{"issue":"6","key":"10.1016\/j.fsi.2026.111374_bib56","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s00439-020-02154-2","article-title":"Role of IRF8 in immune cells functions, protection against infections, and susceptibility to inflammatory diseases","volume":"139","author":"Salem","year":"2020","journal-title":"Hum. Genet."},{"issue":"2","key":"10.1016\/j.fsi.2026.111374_bib57","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.fsi.2015.05.019","article-title":"Functions of the two zebrafish MAVS variants are opposite in the induction of IFN1 by targeting IRF7","volume":"45","author":"Lu","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111374_bib58","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3389\/fimmu.2018.00084","article-title":"TANK-binding kinase 1 (TBK1) isoforms negatively regulate type I interferon induction by inhibiting TBK1-IRF3 interaction and IRF3 phosphorylation","volume":"9","author":"Hu","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2026.111374_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2021.104049","article-title":"Identification and functional analysis of NOD2 and its two splicing variants associated with a novel pattern of signal regulation in teleost fishes","volume":"120","author":"Li","year":"2021","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2026.111374_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109601","article-title":"Role of alternative splicing in fish immunity","volume":"149","author":"Wang","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111374_bib61","first-page":"1","article-title":"Harnessing alternative splicing for off-the-shelf mRNA neoantigen vaccines in hepatocellular carcinoma","author":"Zhao","year":"2025","journal-title":"Cell Res."},{"key":"10.1016\/j.fsi.2026.111374_bib62","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2147\/DDDT.S25716","article-title":"New treatments for myasthenia: a focus on antisense oligonucleotides, drug design","volume":"7","author":"Angelini","year":"2013","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.fsi.2026.111374_bib63","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.713540","article-title":"Alternative splicing: a new cause and potential therapeutic target in autoimmune disease","volume":"12","author":"Ren","year":"2021","journal-title":"Front. Immunol."},{"issue":"21","key":"10.1016\/j.fsi.2026.111374_bib64","doi-asserted-by":"crossref","first-page":"5847","DOI":"10.1016\/j.cell.2025.07.032","article-title":"Conversion of IscB and Cas9 into RNA-guided RNA editors","volume":"188","author":"Xu","year":"2025","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.fsi.2026.111374_bib65","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1038\/s41467-020-16806-4","article-title":"CRISPR artificial splicing factors","volume":"11","author":"Du","year":"2020","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.fsi.2026.111374_bib66","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1002\/eji.200939291","article-title":"Haptoglobin deficiency facilitates the development of autoimmune inflammation","volume":"39","author":"Galicia","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.fsi.2026.111374_bib67","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.3389\/fimmu.2018.01105","article-title":"Mechanisms of fish macrophage antimicrobial immunity","volume":"9","author":"Grayfer","year":"2018","journal-title":"Front. Immunol."},{"issue":"S1","key":"10.1016\/j.fsi.2026.111374_bib68","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1002\/eji.200737638","article-title":"The macrophage: past, present and future","volume":"37","author":"Gordon","year":"2007","journal-title":"Eur. J. Immunol."},{"issue":"23","key":"10.1016\/j.fsi.2026.111374_bib69","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1056\/NEJMra2026131","article-title":"Cytokine storm","volume":"383","author":"Fajgenbaum","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"8","key":"10.1016\/j.fsi.2026.111374_bib70","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.it.2021.06.001","article-title":"The \u2018cytokine storm\u2019: molecular mechanisms and therapeutic prospects","volume":"42","author":"Karki","year":"2021","journal-title":"Trends Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2026.111374_bib71","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/wrr.12814","article-title":"Anti\u2010inflammatory effects of haptoglobin on LPS\u2010stimulated macrophages: role of HMGB1 signaling and implications in chronic wound healing","volume":"28","author":"Krzyszczyk","year":"2020","journal-title":"Wound Repair Regen."},{"issue":"11","key":"10.1016\/j.fsi.2026.111374_bib72","first-page":"2563","article-title":"Cytokines and chemokines: at the crossroads of cell signalling and inflammatory disease","volume":"1843","author":"Turner","year":"2014","journal-title":"BBA Mol. Cell Res."},{"issue":"9","key":"10.1016\/j.fsi.2026.111374_bib73","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nri3495","article-title":"Mitogen-activated protein kinases in innate immunity","volume":"13","author":"Arthur","year":"2013","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111374_bib74","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3349\/ymj.2016.57.1.5","article-title":"NOD-like receptors in infection, immunity, and diseases","volume":"57","author":"Kim","year":"2016","journal-title":"Yonsei Med. J."},{"issue":"7","key":"10.1016\/j.fsi.2026.111374_bib75","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat. Rev. Immunol."},{"issue":"8","key":"10.1016\/j.fsi.2026.111374_bib76","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1038\/mt.2012.103","article-title":"Targeting the hemoglobin scavenger receptor CD163 in macrophages highly increases the anti-inflammatory potency of dexamethasone","volume":"20","author":"Graversen","year":"2012","journal-title":"Mol. Ther."},{"issue":"6817","key":"10.1016\/j.fsi.2026.111374_bib77","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/35051594","article-title":"Identification of the haemoglobin scavenger receptor","volume":"409","author":"Kristiansen","year":"2001","journal-title":"Nature"},{"issue":"13","key":"10.1016\/j.fsi.2026.111374_bib78","doi-asserted-by":"crossref","first-page":"7543","DOI":"10.1074\/jbc.270.13.7543","article-title":"Binding of human plasma sialoglycoproteins by the B cell-specific lectin CD22: selective recognition of immunoglobulin M and haptoglobin","volume":"270","author":"Hanasaki","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.fsi.2026.111374_bib79","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1515\/cclm.1997.35.3.199","article-title":"Distribution of lymphocyte subsets in bone marrow and peripheral blood is associated with haptoglobin type. Binding of haptoglobin to the B-cell lectin CD22","volume":"35","author":"Langlois","year":"1997","journal-title":"Clin. Chem. Lab. Med."},{"issue":"7","key":"10.1016\/j.fsi.2026.111374_bib80","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.tcm.2005.07.004","article-title":"Two-way interactions between inflammation and coagulation","volume":"15","author":"Levi","year":"2005","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.fsi.2026.111374_bib81","article-title":"Complements and the wound healing cascade: an updated review","volume":"2013","author":"Sinno","year":"2013","journal-title":"Plast Surg Int."},{"issue":"7","key":"10.1016\/j.fsi.2026.111374_bib82","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3003264","article-title":"Structural elucidation of the haptoglobin\u2013hemoglobin clearance mechanism by macrophage scavenger receptor CD163","volume":"23","author":"Huang","year":"2025","journal-title":"PLoS Biol."},{"issue":"7","key":"10.1016\/j.fsi.2026.111374_bib83","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1093\/glycob\/cww016","article-title":"Insights on N-glycosylation of human haptoglobin and its association with cancers","volume":"26","author":"Zhang","year":"2016","journal-title":"Glycobiology"},{"issue":"26","key":"10.1016\/j.fsi.2026.111374_bib84","doi-asserted-by":"crossref","first-page":"18834","DOI":"10.1074\/jbc.M113.471060","article-title":"CD163 binding to haptoglobin-hemoglobin complexes involves a dual-point electrostatic receptor-ligand pairing","volume":"288","author":"Nielsen","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.fsi.2026.111374_bib85","article-title":"Identification of CD163 as an antiinflammatory receptor for HMGB1-haptoglobin complexes","volume":"1","author":"Yang","year":"2016","journal-title":"Nano Energy"},{"issue":"4","key":"10.1016\/j.fsi.2026.111374_bib86","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/ni.2549","article-title":"Fishing for mammalian paradigms in the teleost immune system","volume":"14","author":"Sunyer","year":"2013","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111374_bib87","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrg2703","article-title":"Origin and evolution of the adaptive immune system: genetic events and selective pressures","volume":"11","author":"Flajnik","year":"2010","journal-title":"Nat. Rev. Genet."},{"issue":"7","key":"10.1016\/j.fsi.2026.111374_bib88","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s00204-003-0458-7","article-title":"Markers of experimental acute inflammation in the wistar Han rat with particular reference to haptoglobin and C-reactive protein","volume":"77","author":"Giffen","year":"2003","journal-title":"Archives of Toxicology, Arch. Toxicol."},{"issue":"7","key":"10.1016\/j.fsi.2026.111374_bib89","doi-asserted-by":"crossref","first-page":"699","DOI":"10.2746\/042516402776250405","article-title":"Dynamics in serum of the inflammatory markers serum amyloid A (SAA), haptoglobin, fibrinogen and \u03b12\u2010globulins during induced noninfectious arthritis in the horse","volume":"34","author":"Hult\u00e9n","year":"2002","journal-title":"Equine Vet. J."},{"issue":"1","key":"10.1016\/j.fsi.2026.111374_bib90","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/jdv.19495","article-title":"Haptoglobin is an independent marker for disease severity and risk for metabolic complications in hidradenitis suppurativa: a prospective study","volume":"38","author":"Abu Rached","year":"2024","journal-title":"J. Eur. Acad. Dermatol. Venereol."}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826002780?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826002780?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T06:31:31Z","timestamp":1783146691000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464826002780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":90,"alternative-id":["S1050464826002780"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111374","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional antagonism and underlying regulatory pathways of haptoglobin splicing isoforms in the immune response of half-smooth tongue sole (Cynoglossus semilaevis)","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111374","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"111374"}}