{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T07:32:09Z","timestamp":1788939129155,"version":"build-2803163510"},"reference-count":94,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,5,1]],"date-time":"2027-05-01T00:00:00Z","timestamp":1809129600000},"content-version":"am","delay-in-days":304,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25H00939"],"award-info":[{"award-number":["25H00939"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24KK0126"],"award-info":[{"award-number":["24KK0126"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.fsi.2026.111389","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T23:46:56Z","timestamp":1777333616000},"page":"111389","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Transcriptome analysis revealed immune protection conferred by bath vaccination with formalin-killed Vibrio parahaemolyticus on Penaeus vannamei"],"prefix":"10.1016","volume":"174","author":[{"given":"Ma Ramela","family":"Angela Bermeo-Capunong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2753-6385","authenticated-orcid":false,"given":"John Paul","family":"Matthew Domingo Guzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garner Algo","family":"Langote Alolod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiko","family":"Nozaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jumroensri","family":"Thawonsuwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8890-8229","authenticated-orcid":false,"given":"Keiichiro","family":"Koiwai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5102-6831","authenticated-orcid":false,"given":"Hidehiro","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2355-3121","authenticated-orcid":false,"given":"Ikuo","family":"Hirono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2026.111389_bib1","series-title":"Shrimp Culture Technology","article-title":"Global scenario of shrimp industry: present status and future prospects","author":"Mandal","year":"2025"},{"key":"10.1016\/j.fsi.2026.111389_bib2","series-title":"The State of World Fisheries and Aquaculture 2022: towards Blue Transformation","year":"2022"},{"issue":"1","key":"10.1016\/j.fsi.2026.111389_bib3","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s10499-019-00451-w","article-title":"Diagnosis and potential treatments for acute hepatopancreatic necrosis disease (AHPND): a review","volume":"28","author":"Santos","year":"2020","journal-title":"Aquac. Int."},{"key":"10.1016\/j.fsi.2026.111389_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2022.105545","article-title":"Shrimp bacterial and parasitic disease listed in the OIE: a review","author":"Yu","year":"2022","journal-title":"Microb. Pathog."},{"issue":"8","key":"10.1016\/j.fsi.2026.111389_bib5","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3390\/toxins13080524","article-title":"Acute hepatopancreatic necrosis disease (AHPND): virulence, pathogenesis and mitigation strategies in shrimp aquaculture","volume":"13","author":"Kumar","year":"2021","journal-title":"Toxins"},{"key":"10.1016\/j.fsi.2026.111389_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2025.105429","article-title":"VPAHPND pathogenesis and its mediated immune response in shrimp","author":"Liu","year":"2025","journal-title":"Dev. Comp. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111389_bib7","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/raq.12482","article-title":"Immune responses and immunoprotection in crustaceans with special reference to shrimp","volume":"13","author":"Kulkarni","year":"2020","journal-title":"Rev. Aquacult."},{"issue":"8","key":"10.1016\/j.fsi.2026.111389_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0220993","article-title":"Transcriptomic analysis of Pacific white shrimp (Litopenaeus vannamei, Boone 1931) in response to acute hepatopancreatic necrosis disease caused by Vibrio parahaemolyticus","volume":"14","author":"Velazquez-Lizarraga","year":"2019","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.fsi.2026.111389_bib9","doi-asserted-by":"crossref","first-page":"7209","DOI":"10.4049\/jimmunol.179.11.7209","article-title":"Invertebrate immune systems\u2013specific, quasi-specific, or nonspecific?","volume":"179","author":"Rowley","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2026.111389_bib10","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1111\/raq.12438","article-title":"Trained immunity and perspectives for shrimp aquaculture","volume":"12","author":"Roy","year":"2020","journal-title":"Rev. Aquacult."},{"key":"10.1016\/j.fsi.2026.111389_bib11","series-title":"Fish Immune System and Vaccines","article-title":"Shrimp Immune System and Immune responses","author":"Rajendran","year":"2022"},{"issue":"6953","key":"10.1016\/j.fsi.2026.111389_bib12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/425037a","article-title":"Evidence for memory in invertebrate immunity","volume":"425","author":"Kurtz","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2026.111389_bib13","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.106597","article-title":"Trained immunity and immune priming in plants and invertebrates","volume":"14","author":"Kurtz","year":"2025","journal-title":"eLife"},{"key":"10.1016\/j.fsi.2026.111389_bib14","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1586\/14760584.4.1.89","article-title":"Vaccines for fish in aquaculture","volume":"4","author":"Sommerset","year":"2005","journal-title":"Expert Rev. Vaccines"},{"issue":"6","key":"10.1016\/j.fsi.2026.111389_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0020960","article-title":"Enhanced cellular immunity in shrimp (Litopenaeus vannamei) after \u2018vaccination\u2019","volume":"6","author":"Pope","year":"2011","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.fsi.2026.111389_bib16","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jip.2011.02.006","article-title":"Enhanced immune defenses in Pacific white shrimp (Litopenaeus vannamei) post-exposure to a vibrio vaccine","volume":"107","author":"Powell","year":"2011","journal-title":"J. Invertebr. Pathol."},{"issue":"7","key":"10.1016\/j.fsi.2026.111389_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0069722","article-title":"Vaccination enhances early immune responses in white shrimp Litopenaeus vannamei after secondary exposure to Vibrio alginolyticus","volume":"8","author":"Lin","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.fsi.2026.111389_bib18","article-title":"Isolation of the bacterium, Vibrio harveyi from cultured shrimp, Penaeus monodon and production of vaccines against the bacterium","volume":"33","author":"Hettiarachchi","year":"2005","journal-title":"J. Natl. Sci. Found. Sri Lanka"},{"key":"10.1016\/j.fsi.2026.111389_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1040336","article-title":"Current status and development prospects of aquatic vaccines","volume":"13","author":"Du","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2026.111389_bib20","series-title":"Vaccination Trials Against Vibriosis in Shrimp: a Review. Aquaculture Reports","author":"Amatul-Samahah","year":"2020"},{"issue":"1\u20134","key":"10.1016\/j.fsi.2026.111389_bib21","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.aquaculture.2005.04.011","article-title":"Routes of immunostimulation vis-a-vis survival and growth of Penaeus monodon postlarvae","volume":"248","author":"Azad","year":"2005","journal-title":"Aquaculture"},{"issue":"6","key":"10.1016\/j.fsi.2026.111389_bib22","first-page":"246","article-title":"Effect of vaccination on vibriosis resistance of Fenneropenaeus indicus","volume":"5","author":"Pereira","year":"2009","journal-title":"Chennai, Tamilnadu J.Veterinary Animal Sci."},{"issue":"1\u20134","key":"10.1016\/j.fsi.2026.111389_bib83","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0044-8486(98)00200-2","article-title":"Influence of vaccination on vibriosis resistance of the giant black tiger shrimp Penaeus monodon (Fabricius)","volume":"164","author":"Teunissen","year":"1998","journal-title":"Aquaculture"},{"issue":"1\u20132","key":"10.1016\/j.fsi.2026.111389_bib95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0044-8486(99)00131-3","article-title":"The efficacy of immersion as opposed to oral vaccination of Penaeus indicus larvae against Vibrio harveyi","volume":"178","author":"Alabi","year":"1999","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2026.111389_bib23","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.dci.2017.03.003","article-title":"What vaccination studies tell us about immunological memory within the innate immune system of cultured shrimp and crayfish","volume":"80","author":"Chang","year":"2018","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2026.111389_bib24","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/B978-0-323-91240-2.00011-7","article-title":"Recent advances in fish disease diagnosis, therapeutics, and vaccine development","author":"Mishra","year":"2023","journal-title":"Front.Aquacult. Biotechnol."},{"key":"10.1016\/j.fsi.2026.111389_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109920","article-title":"Comparative analysis of transcriptomics and metabolomics provides insights into the mechanisms of VPAHPND invasion and hepatopancreatic damage in Litopenaeus vannamei","author":"Zhao","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111389_bib26","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-52656-x","article-title":"The gene structure and hypervariability of the complete Penaeus monodon Dscam gene","volume":"9","author":"Apitanyasai","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fsi.2026.111389_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2019.103539","article-title":"Dscam in immunity: a question of diversity in insects and crustaceans","volume":"105","author":"Ng","year":"2020","journal-title":"Dev. Comp. Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111389_bib28","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/genomeA.00221-14","article-title":"Draft genome sequences of six strains of Vibrio parahaemolyticus isolated from early mortality syndrome\/acute hepatopancreatic necrosis disease shrimp in Thailand","volume":"2","author":"Kondo","year":"2014","journal-title":"Genome Announc."},{"issue":"4","key":"10.1016\/j.fsi.2026.111389_bib29","first-page":"159","article-title":"Development of PCR diagnosis for shrimp acute hepatopancreatic necrosis disease (AHPND) strain of Vibrio parahaemolyticus","volume":"49","author":"Tinwongger","year":"2014","journal-title":"\u9b5a\u75c5\u7814\u7a76"},{"key":"10.1016\/j.fsi.2026.111389_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.110091","article-title":"Transcriptome analyses of mRNA and circular RNA reveal dietary supplementation with freeze-dried Lactiplantibacillus plantarum primes immune memory of Whiteleg shrimp (Penaeus vannamei) against pathogens","volume":"157","author":"Guzman","year":"2025","journal-title":"Fish Shellfish Immunol."},{"issue":"6","key":"10.1016\/j.fsi.2026.111389_bib84","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.fsi.2007.04.004","article-title":"Tissue expressions of nine genes important to immune defense of the Pacific white shrimp Litopenaeus vannamei","volume":"23","author":"Wang","year":"2007","journal-title":"Fish Shellfish Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111389_bib85","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.fsi.2015.05.041","article-title":"Rearing effect of biofloc on antioxidant and antimicrobial transcriptional response in Litopenaeus stylirostris shrimp facing an experimental sub-lethal hydrogen peroxide stress","volume":"45","author":"Cardona","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111389_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2019.103577","article-title":"Induction of innate immune response in whiteleg shrimp (Litopenaeus vannamei) embryos","volume":"105","author":"Alvarez-Lee","year":"2020","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2026.111389_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2022.104557","article-title":"Comparative study of five anti-lipopolysaccharide factor genes in Litopenaeus vannamei","volume":"139","author":"Yin","year":"2023","journal-title":"Dev. Comp. Immunol."},{"issue":"6","key":"10.1016\/j.fsi.2026.111389_bib94","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1111\/are.15090","article-title":"Dietary Haematococcus pluvialis powder supplementation affect carotenoid content, astaxanthin isomer, antioxidant capacity and immune\u2010related gene expression in Pacific white shrimp, Litopenaeus vannamei","volume":"52","author":"Yu","year":"2021","journal-title":"Aquac. Res."},{"key":"10.1016\/j.fsi.2026.111389_bib73","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1111\/are.12661","article-title":"Potential role of LvDscam in specific immune response of Litopenaeus vannamei against white spot syndrome virus by oral delivery of VP28 using Bacillus subtilis","volume":"47","author":"Fu","year":"2016","journal-title":"Aquac. Res."},{"key":"10.1016\/j.fsi.2026.111389_bib87","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s10126-018-9852-2","article-title":"Effects of 5-Aminolevulinic acid on gene expression, immunity, and ATP levels in Pacific white shrimp, Litopenaeus vannamei","volume":"20","author":"Pedrosa-Gerasmio","year":"2018","journal-title":"Mar. Biotechnol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111389_bib31","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/jwas.12589","article-title":"A future vision for disease control in shrimp aquaculture","volume":"50","author":"Flegel","year":"2019","journal-title":"J. World Aquacult. Soc."},{"key":"10.1016\/j.fsi.2026.111389_bib32","series-title":"Fish Immune System and Vaccines","first-page":"181","article-title":"Prospects of vaccination in crustaceans with special reference to shrimp","author":"Sreedharan","year":"2022"},{"issue":"10","key":"10.1016\/j.fsi.2026.111389_bib33","doi-asserted-by":"crossref","first-page":"25325","DOI":"10.1007\/s11356-021-18433-y","article-title":"Immunostimulants for shrimp aquaculture: paving pathway towards shrimp sustainability","volume":"30","author":"Kumar","year":"2023","journal-title":"Environ. Sci. Pollut. Control Ser."},{"key":"10.1016\/j.fsi.2026.111389_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.vaccine.2025.128049","article-title":"Vaccines as a strategic approach to combat Vibrio parahaemolyticus and control of early mortality syndrome sin shrimp aquaculture: a comprehensive review","volume":"71","author":"Sen","year":"2026","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2026.111389_bib35","series-title":"Fish Immune System and Vaccines","first-page":"45","article-title":"Types of vaccines used in aquaculture","author":"Bedekar","year":"2022"},{"key":"10.1016\/j.fsi.2026.111389_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.aqrep.2022.101371","article-title":"Development of formalin killed vaccine candidate against streptococcosis caused by Enterococcus sp. in Nile tilapia","author":"Akter","year":"2022","journal-title":"Aquac. Rep."},{"key":"10.1016\/j.fsi.2026.111389_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-67198-0","article-title":"New vaccination approach using formalin-killed Streptococcus pyogenes vaccine on the liver of Oreochromis niloticus fingerlings","volume":"14","author":"Nasr-Eldahan","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fsi.2026.111389_bib38","series-title":"Advanced Vaccination Technologies for Infectious and Chronic Diseases","first-page":"37","article-title":"Conventional vaccination methods: inactivated and live attenuated vaccines","author":"Andey","year":"2024"},{"key":"10.1016\/j.fsi.2026.111389_bib39","series-title":"Shrimp Acute Hepatopancreatic Necrosis Disease Strategy Manual. FAO Fisheries and Aquaculture Circular No. 1190","author":"Tang","year":"2020"},{"key":"10.1016\/j.fsi.2026.111389_bib40","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3354\/dao03443","article-title":"Cytopathology and immune response in the hepatopancreas of decapod crustaceans","volume":"138","author":"Vogt","year":"2020","journal-title":"Dis. Aquat. Org."},{"issue":"4","key":"10.1016\/j.fsi.2026.111389_bib41","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.fsi.2012.08.019","article-title":"Prophenoloxidase system and its role in shrimp immune responses against major pathogens","volume":"34","author":"Amparyup","year":"2013","journal-title":"Fish Shellfish Immunol."},{"issue":"6","key":"10.1016\/j.fsi.2026.111389_bib42","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1111\/jam.13256","article-title":"Virulence of acute hepatopancreatic necrosis disease PirAB\u2010like relies on secreted proteins not on gene copy number","volume":"121","author":"Tinwongger","year":"2016","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.fsi.2026.111389_bib43","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.imlet.2020.07.002","article-title":"A review: progress in the development of fish Vibrio spp. vaccines","volume":"226","author":"Ji","year":"2020","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.fsi.2026.111389_bib44","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3390\/biology12030417","article-title":"Transcriptome analysis on hepatopancreas reveals the Metabolic dysregulation caused by Vibrio parahaemolyticus infection in Litopenaeus vannamei","volume":"12","author":"Miao","year":"2023","journal-title":"Biology"},{"issue":"8","key":"10.1016\/j.fsi.2026.111389_bib45","doi-asserted-by":"crossref","first-page":"920","DOI":"10.3390\/biology14080920","article-title":"Decoding stress responses in farmed crustaceans: comparative insights for sustainable aquaculture management","volume":"14","author":"Hapsari","year":"2025","journal-title":"Biology"},{"key":"10.1016\/j.fsi.2026.111389_bib46","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.3389\/fimmu.2018.01915","article-title":"Innate immune memory in invertebrate metazoans: a critical appraisal","volume":"9","author":"Melillo","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2026.111389_bib47","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.fsi.2017.12.032","article-title":"Comparative transcriptomic analysis of shrimp hemocytes in response to acute hepatopancreas necrosis disease (AHPND) causing Vibrio parahemolyticus infection","volume":"74","author":"Zheng","year":"2018","journal-title":"Fish Shellfish Immunol."},{"issue":"6","key":"10.1016\/j.fsi.2026.111389_bib48","first-page":"517","article-title":"Acute phase response in animals: a review","volume":"59","author":"Cray","year":"2009","journal-title":"Comp. Med."},{"issue":"4","key":"10.1016\/j.fsi.2026.111389_bib49","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.fsi.2012.08.008","article-title":"Pattern recognition receptors acting in innate immune system of shrimp against pathogen infections","volume":"34","author":"Wang","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111389_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2020.103708","article-title":"The functional relevance of shrimp C-type lectins in host-pathogen interactions","volume":"109","author":"Wang","year":"2020","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2026.111389_bib51","doi-asserted-by":"crossref","first-page":"4001","DOI":"10.1111\/are.13394","article-title":"Participation of lectins in crustacean immune system","volume":"48","author":"S\u00e1nchez-Salgado","year":"2017","journal-title":"Aquac. Res."},{"key":"10.1016\/j.fsi.2026.111389_bib52","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.679767","article-title":"Hepatopancreas-Specific lectin participates in the antibacterial immune response by regulating the expression of antibacterial proteins","volume":"12","author":"Cao","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2026.111389_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2020.103914","article-title":"Planarian gamma-interferon-inducible lysosomal thiol reductase (GILT) is required for gram-negative bacterial clearance","volume":"116","author":"Gao","year":"2021","journal-title":"Developmental & Comparative Immunology"},{"key":"10.1016\/j.fsi.2026.111389_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2022.104514","article-title":"Antibacterial responses and functional characterization of the interferon gamma inducible lysosomal thiol reductase (GILT) protein in Chinese mitten crab (Eriocheir sinensis)","volume":"136","author":"Nan","year":"2022","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2026.111389_bib54","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3389\/fimmu.2017.00611","article-title":"C-terminal domain of hemocyanin, a major antimicrobial protein from Litopenaeus vannamei: structural homology with immunoglobulins and molecular diversity","volume":"8","author":"Zhang","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2026.111389_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.109347","article-title":"The evolutionary adaptation of shrimp hemocyanin subtypes and the consequences on their structure and functions","volume":"145","author":"Li","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111389_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2021.736615","article-title":"Identification of a novel crustacyanin-like lipocalin in Penaeus monodon: molecular cloning, tissue distribution and its functional studies in astaxanthin accumulation","volume":"539","author":"Zhao","year":"2021","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2026.111389_bib89","article-title":"Crustacyanins as regulators of functional complementation, cuticle development, lipid metabolism, pigmentation, and immunity in shrimp","author":"Feng","year":"2025","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2026.111389_bib57","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.dci.2016.02.027","article-title":"A novel ubiquitin-protein ligase E3 functions as a modulator of immune response against lipopolysaccharide in Pacific oyster, Crassostrea gigas","volume":"60","author":"Cheng","year":"2016","journal-title":"Dev. Comp. Immunol."},{"issue":"5","key":"10.1016\/j.fsi.2026.111389_bib58","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.molmed.2019.02.002","article-title":"Ubiquitin ligases in cancer immunotherapy - balancing antitumor and autoimmunity","volume":"25","author":"Fujita","year":"2019","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.fsi.2026.111389_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.116875","article-title":"E3 ubiquitin ligases and their therapeutic potential in disease Management","author":"Madhukar","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.fsi.2026.111389_bib59","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.dci.2018.03.010","article-title":"Hemocyanin of Litopenaeus vannamei agglutinates Vibrio parahaemolyticus AHPND (VPAHPND) and neutralizes its toxin","volume":"84","author":"Boonchuen","year":"2018","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2026.111389_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2020.05.046","article-title":"A typical C-type lectin, perlucin-like protein, is involved in the innate immune defense of whiteleg shrimp Litopenaeus vannamei","author":"Bi","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111389_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108932","article-title":"A novel perlucin-like protein (PLP) protects Litopenaeus vannamei against Vibrio harveyi infection","volume":"139","author":"Feng","year":"2023","journal-title":"Fish Shellfish Immunol."},{"issue":"21","key":"10.1016\/j.fsi.2026.111389_bib62","doi-asserted-by":"crossref","first-page":"7973","DOI":"10.3390\/ijms21217973","article-title":"Identification of peritrophins and antiviral effect of Bm01504 against BmNPV in the silkworm, Bombyx mori","volume":"21","author":"Zha","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fsi.2026.111389_bib63","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.fsi.2022.05.035","article-title":"Litopenaeus vannamei peritrophin interacts with WSSV and AHPND-causing V. parahaemolyticus to regulate disease pathogenesis","volume":"126","author":"Chen","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111389_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2024.741457","article-title":"Characterization of a new peritrophin homolog from Scylla paramamosain and its role in molting and immune defense","volume":"594","author":"Chen","year":"2025","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2026.111389_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2025.110581","article-title":"Dual function of a zinc finger transcription factor PvBr-C in Penaeus vannamei","author":"Shi","year":"2025","journal-title":"Fish Shellfish Immunol."},{"issue":"3","key":"10.1016\/j.fsi.2026.111389_bib97","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jip.2009.12.006","article-title":"Expression of HSP60 and HSP70 in white shrimp, Litopenaeus vannamei in response to bacterial challenge","volume":"103","author":"Zhou","year":"2010","journal-title":"Journal of Invertebrate Pathology"},{"issue":"2","key":"10.1016\/j.fsi.2026.111389_bib66","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.dci.2014.06.004","article-title":"Reactive oxygen species generated by a heat shock protein (Hsp) inducing product contributes to Hsp70 production and Hsp70-mediated protective immunity in Artemia franciscana against pathogenic vibrios","volume":"46","author":"Baruah","year":"2014","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2026.111389_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2024.741814","article-title":"Heat shock protein 70 (HSP70) regulates innate immunity and intestinal microbial homeostasis against Vibrio parahaemolyticus in shrimp","volume":"596","author":"Xiao","year":"2025","journal-title":"Aquaculture"},{"issue":"1","key":"10.1016\/j.fsi.2026.111389_bib68","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.fsi.2015.08.021","article-title":"Catalase eliminates reactive oxygen species and influences the intestinal microbiota of shrimp","volume":"47","author":"Yang","year":"2015","journal-title":"Fish Shellfish Immunol."},{"issue":"Suppl 1","key":"10.1016\/j.fsi.2026.111389_bib69","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1134\/S0006297921140066","article-title":"Control of genome through variative nature of histone-modifying ubiquitin ligases","volume":"86","author":"Bacheva","year":"2021","journal-title":"Biochemistry (Mosc.)"},{"issue":"5","key":"10.1016\/j.fsi.2026.111389_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0036295","article-title":"Novel E3 ubiquitin ligases that regulate histone protein levels in the budding yeast Saccharomyces cerevisiae","volume":"7","author":"Singh","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2026.111389_bib90","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/nrm.2017.94","article-title":"Emerging roles of linker histones in regulating chromatin structure and function","volume":"19","author":"Fyodorov","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.fsi.2026.111389_bib71","article-title":"Histones: the critical players in innate immunity","volume":"13","author":"Li","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2026.111389_bib72","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.fsi.2020.06.047","article-title":"Peculiarities of innate immune memory in crustaceans","volume":"104","author":"Low","year":"2020","journal-title":"Fish Shellfish Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111389_bib74","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.dci.2014.03.004","article-title":"Dscam and pancrustacean immune memory\u2013a review of the evidence","volume":"48","author":"Armitage","year":"2015","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2026.111389_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2021.104228","article-title":"Strategy for understanding the biological defense mechanism involved in immune priming in kuruma shrimp","volume":"125","author":"Mekata","year":"2021","journal-title":"Dev. Comp. Immunol."},{"issue":"7","key":"10.1016\/j.fsi.2026.111389_bib76","doi-asserted-by":"crossref","first-page":"5735","DOI":"10.1007\/s11033-021-06556-x","article-title":"Zinc finger proteins: insights into the transcriptional and post transcriptional regulation of immune response","volume":"48","author":"Rakhra","year":"2021","journal-title":"Mol. Biol. Rep."},{"issue":"17","key":"10.1016\/j.fsi.2026.111389_bib77","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2320938121","article-title":"The Myc-associated zinc finger protein epigenetically controls expression of interferon-\u03b3-stimulated genes by recruiting STAT1 to chromatin","volume":"121","author":"Xiao","year":"2024","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.fsi.2026.111389_bib78","article-title":"Ubiquitination as an important host-immune response strategy in penaeid shrimp: inferences from other species","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2026.111389_bib79","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.zool.2016.03.006","article-title":"Immune priming in arthropods: an update focusing on the red flour beetle","volume":"119","author":"Milutinovi\u0107","year":"2016","journal-title":"Zoology"},{"key":"10.1016\/j.fsi.2026.111389_bib80","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.745332","article-title":"Molecular and cellular mechanisms modulating trained immunity by various cell types in response to pathogen encounter","volume":"12","author":"Acevedo","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2026.111389_bib81","article-title":"Current knowledge of immune priming in invertebrates, emphasizing studies on Tenebrio molitor","volume":"127","author":"Kojour","year":"2022","journal-title":"Dev. Comp. Immunol."}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826002937?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826002937?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T10:03:58Z","timestamp":1783073038000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464826002937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":94,"alternative-id":["S1050464826002937"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111389","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptome analysis revealed immune protection conferred by bath vaccination with formalin-killed Vibrio parahaemolyticus on Penaeus vannamei","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111389","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111389"}}