{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:20:52Z","timestamp":1783099252707,"version":"3.54.6"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"publisher","award":["320994"],"award-info":[{"award-number":["320994"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012895","name":"Zoetis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.fsi.2026.111401","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T15:32:33Z","timestamp":1778167953000},"page":"111401","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Efficacy evaluation of live attenuated vaccines against Streptococcus agalactiae Ia, administered to Nile tilapia (Oreochromis niloticus) by immersion or intraperitoneal injection"],"prefix":"10.1016","volume":"175","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4093-1605","authenticated-orcid":false,"given":"Kjetil","family":"Fyrand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8ystein","family":"Evensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2026.111401_bib1","doi-asserted-by":"crossref","unstructured":"FAO, The state of world fisheries and aquaculture 2024 \u2013 Blue transformation in action, (n.d.). https:\/\/doi.org\/10.4060\/cd0683en.","DOI":"10.4060\/cd0683en"},{"key":"10.1016\/j.fsi.2026.111401_bib2","unstructured":"Tilapia market size, share, trends and forecast by farmed Vs wild capture, species, product, sector, and region, 2025-2033, (n.d.). https:\/\/www.imarcgroup.com\/tilapia-market (accessed December 5, 2024)."},{"key":"10.1016\/j.fsi.2026.111401_bib3","unstructured":"FishStatJ - Software for fishery and aquaculture statistical time series - fisheries and aquaculture, (n.d.). https:\/\/www.fao.org\/fishery\/en\/statistics\/software\/fishstatj (accessed December 5, 2024)."},{"key":"10.1016\/j.fsi.2026.111401_bib4","article-title":"Current updates on viral infections affecting tilapia","author":"Clyde","year":"2024","journal-title":"Aquac. Fish."},{"key":"10.1016\/j.fsi.2026.111401_bib5","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/raq.12743","article-title":"Bacterial diseases of tilapia, their zoonotic potential and risk of antimicrobial resistance","volume":"15","author":"Haenen","year":"2023","journal-title":"Rev. Aquacult."},{"key":"10.1016\/j.fsi.2026.111401_bib6","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.3390\/ani13061088","article-title":"Prevalence and morphological investigation of parasitic infection in freshwater fish (nile tilapia) from upper Egypt","volume":"13","author":"Abd-Elrahman","year":"2023","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.fsi.2026.111401_bib7","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.3390\/ani12182443","article-title":"Streptococcosis a Re-Emerging disease in aquaculture: significance and phytotherapy","volume":"12","author":"Van Doan","year":"2022","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.fsi.2026.111401_bib8","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1089\/fpd.2019.2687","article-title":"Genetic relatedness among Streptococcus agalactiae isolated from cattle, fish, and humans","volume":"17","author":"Boonyayatra","year":"2020","journal-title":"Foodborne Pathogen. Disease"},{"key":"10.1016\/j.fsi.2026.111401_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens12040525","article-title":"Geographical, temporal and host-species distribution of potentially human-pathogenic group B streptococcus in aquaculture species in southeast Asia","volume":"12","author":"Sirimanapong","year":"2023","journal-title":"Pathogens"},{"key":"10.1016\/j.fsi.2026.111401_bib10","doi-asserted-by":"crossref","DOI":"10.1099\/jmm.0.001729","article-title":"Fish-associated Streptococcus agalactiae ST283: first human cases reported from Malaysia","volume":"72","author":"Zohari","year":"2023","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.fsi.2026.111401_bib11","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1471-2180-13-41","article-title":"Human Streptococcus agalactiae strains in aquatic mammals and fish","volume":"13","author":"Delannoy","year":"2013","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.fsi.2026.111401_bib12","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1099\/jmm.0.47815-0","article-title":"Phylogenetic relationships among Streptococcus agalactiae isolated from piscine, dolphin, bovine and human sources: a dolphin and piscine lineage associated with a fish epidemic in Kuwait is also associated with human neonatal infections in Japan","volume":"57","author":"Evans","year":"2008","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.fsi.2026.111401_bib21","first-page":"89","volume":"vol. 4","author":"Sommerset","year":"2005"},{"key":"10.1016\/j.fsi.2026.111401_bib13","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.aquaculture.2017.05.013","article-title":"Emergence of a new multidrug-resistant and highly virulent serotype of Streptococcus agalactiae in fish farms from Brazil","volume":"479","author":"Chideroli","year":"2017","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2026.111401_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109919","article-title":"Characterization of Streptococcus agalactiae 1a isolated from farmed Nile tilapia (Oreochromis niloticus) in North America, Central America, and Southeast Asia","volume":"154","author":"Fyrand","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111401_bib15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3354\/dao03780","article-title":"Serotype distribution, virulence and antibiotic resistance of Streptococcus agalactiae isolated from cultured tilapia Oreochromis niloticus in Lake Volta, Ghana","volume":"158","author":"Duodu","year":"2024","journal-title":"Dis. Aquat. Org."},{"key":"10.1016\/j.fsi.2026.111401_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2021.736735","article-title":"Systems-thinking approach to identify and assess feasibility of potential interventions to reduce antibiotic use in tilapia farming in Egypt","volume":"540","author":"Desbois","year":"2021","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2026.111401_bib17","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.envpol.2014.04.002","article-title":"Use, fate and ecological risks of antibiotics applied in tilapia cage farming in Thailand","volume":"191","author":"Rico","year":"2014","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.fsi.2026.111401_bib18","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1111\/raq.12344","article-title":"Antibiotic use in aquaculture, policies and regulation, health and environmental risks: a review of the top 15 major producers","volume":"12","author":"Lulijwa","year":"2020","journal-title":"Rev. Aquacult."},{"key":"10.1016\/j.fsi.2026.111401_bib19","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.tim.2018.05.002","article-title":"Biological approaches for disease control in aquaculture: advantages, limitations and challenges","volume":"26","author":"P\u00e9rez-S\u00e1nchez","year":"2018","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.fsi.2026.111401_bib20","first-page":"365","article-title":"Reduction of antibacterial drug use in Norwegian fish farming due to vaccination","volume":"90","author":"Markestad","year":"1997","journal-title":"Dev. Biol. Stand."},{"key":"10.1016\/j.fsi.2026.111401_bib22","article-title":"Virbac delivers vaccines \u2013 and hope \u2013 to Colombia's beleaguered tilapia farmers","year":"2023","journal-title":"Fish Site"},{"key":"10.1016\/j.fsi.2026.111401_bib23","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1016\/j.fsi.2013.05.029","article-title":"Status and future perspectives of vaccines for industrialised fin-fish farming","volume":"35","author":"Brudeseth","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111401_bib24","first-page":"55","article-title":"Bacterial vaccines for fish--an update of the current situation worldwide","volume":"121","author":"Hastein","year":"2005","journal-title":"Dev. Biol. (Basel)"},{"key":"10.1016\/j.fsi.2026.111401_bib25","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3390\/vaccines9020140","article-title":"State-of-the-Art vaccine research for aquaculture use: the case of three economically relevant fish species","volume":"9","author":"Miccoli","year":"2021","journal-title":"Vaccines"},{"key":"10.1016\/j.fsi.2026.111401_bib26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.fsi.2018.01.035","article-title":"What could be the mechanisms of immunological memory in fish?","volume":"85","author":"Yamaguchi","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111401_bib27","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.fsi.2021.05.022","article-title":"Immunological memory in teleost fish","volume":"115","author":"Stosik","year":"2021","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111401_bib67","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.fsi.2003.10.002","article-title":"Sequential study of antigen persistence and concomitant inflammatory reactions relative to side-effects and growth of Atlantic salmon (Salmo salar L.) following intraperitoneal injection with oil-adjuvanted vaccines","volume":"16","author":"Mutoloki","year":"2004","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111401_bib28","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/j.1749-7345.2009.00279.x","article-title":"Use of modified live vaccines in aquaculture","volume":"40","author":"Shoemaker","year":"2009","journal-title":"J. World Aquacult. Soc."},{"key":"10.1016\/j.fsi.2026.111401_bib29","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/ni0504-460","article-title":"Vaccine development strategies for improving immunization: the role of modern immunology","volume":"5","author":"Levine","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.fsi.2026.111401_bib30","article-title":"Development and efficacy of Streptococcus iniae live-attenuated vaccines in Nile tilapia, Oreochromis niloticus","author":"Heckman","year":"2021","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111401_bib31","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.fsi.2019.07.081","article-title":"Development of an attenuated oral vaccine strain of tilapia group B streptococci serotype Ia by gene knockout technology","volume":"93","author":"Li","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111401_bib32","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.fsi.2014.10.009","article-title":"Effect of size and temperature at vaccination on immunization and protection conferred by a live attenuated Francisella noatunensis immersion vaccine in red hybrid tilapia","volume":"41","author":"Soto","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111401_bib33","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1577\/H08-056.1","article-title":"Attenuation of the fish pathogen francisella sp. by mutation of the iglC\u2217 gene","volume":"21","author":"Soto","year":"2009","journal-title":"J. Aquat. Anim. Health"},{"key":"10.1016\/j.fsi.2026.111401_bib34","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.vaccine.2010.06.040","article-title":"Attenuated Francisella asiatica iglC mutant induces protective immunity to francisellosis in tilapia","volume":"29","author":"Soto","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2026.111401_bib35","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.fsi.2014.07.028","article-title":"Construction of a Streptococcus iniae sortase A mutant and evaluation of its potential as an attenuated modified live vaccine in Nile tilapia (Oreochromis niloticus)","volume":"40","author":"Wang","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111401_bib36","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.fsi.2019.11.044","article-title":"An effective live attenuated vaccine against Streptococcus agalactiae infection in farmed Nile tilapia Oreochromis niloticus)","volume":"98","author":"Zhang","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111401_bib37","doi-asserted-by":"crossref","first-page":"63","DOI":"10.29239\/j.akuatikisle.5.2.63-66","article-title":"Efficacy of attenuated bacteria vaccine against streptococcal infection in larvae tilapia ( Oreochromis niloticus )","volume":"5","author":"Suryahman","year":"2021","journal-title":"Akuatikisle: J. Aqua. Coast. Isle"},{"key":"10.1016\/j.fsi.2026.111401_bib38","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1111\/jam.15706","article-title":"Construction of Streptococcus agalactiae sialic acid mutant and evaluation of its potential as a live attenuated vaccine in Nile tilapia (Oreochromis niloticus)","volume":"133","author":"Hao","year":"2022","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.fsi.2026.111401_bib39","series-title":"Fish Vaccination","first-page":"255","article-title":"Vaccination against bacterial kidney disease","author":"Elliott","year":"2014"},{"key":"10.1016\/j.fsi.2026.111401_bib40","doi-asserted-by":"crossref","first-page":"416","DOI":"10.3390\/vaccines12040416","article-title":"The effect of an attenuated live vaccine against Salmonid rickettsial septicemia in Atlantic salmon (Salmo salar) is highly dependent on water temperature during immunization","volume":"12","author":"Olsen","year":"2024","journal-title":"Vaccines"},{"key":"10.1016\/j.fsi.2026.111401_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12088-016-0625-1","article-title":"Bacterial virulence factors: secreted for survival","volume":"57","author":"Sharma","year":"2017","journal-title":"Indian J. Microbiol."},{"key":"10.1016\/j.fsi.2026.111401_bib42","series-title":"Streptococcus Pyogenes: Basic Biology to Clinical Manifestations","article-title":"Secreted extracellular virulence factors","author":"Hynes","year":"2016"},{"key":"10.1016\/j.fsi.2026.111401_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms10122483","article-title":"Group B streptococcus: virulence factors and pathogenic mechanism","volume":"10","author":"Liu","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/j.fsi.2026.111401_bib44","doi-asserted-by":"crossref","first-page":"569","DOI":"10.3390\/microorganisms7110569","article-title":"A review of fish vaccine development strategies: conventional methods and modern biotechnological approaches","volume":"7","author":"Ma","year":"2019","journal-title":"Microorganisms"},{"key":"10.1016\/j.fsi.2026.111401_bib46","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines12040416","article-title":"The effect of an attenuated live vaccine against salmonid rickettsial septicemia in Atlantic salmon (Salmo salar) is highly dependent on water temperature during immunization","author":"Olsen","year":"2024","journal-title":"Vaccines"},{"key":"10.1016\/j.fsi.2026.111401_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2026.111097","article-title":"Streptococcus agalactiae 1a capsule (cpsE) and hemolysin (cylE) deletion mutants display attenuated virulence in Nile tilapia (Oreochromis niloticus)","volume":"170","author":"Fyrand","year":"2026","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111401_bib48","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.micpath.2016.08.040","article-title":"Capsule impairs efficient adherence of Streptococcus agalactiae to intestinal epithelium in tilapias Oreochromis sp","volume":"100","author":"Barato","year":"2016","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.fsi.2026.111401_bib51","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1093\/biomet\/93.3.491","article-title":"Adaptive linear step-up procedures that control the false discovery rate","volume":"93","author":"Benjamini","year":"2006","journal-title":"Biometrika"},{"key":"10.1016\/j.fsi.2026.111401_bib52","series-title":"PHARMAQ","year":"2024"},{"key":"10.1016\/j.fsi.2026.111401_bib53","article-title":"MSD animal health launches AQUAVAC\u00ae Strep Sa-Si vaccine against Streptococcis in fish in Latin America","year":"2019","journal-title":"Corporate Home Page MSD Animal Health"},{"key":"10.1016\/j.fsi.2026.111401_bib45","series-title":"Streptococcus Pyogenes: Basic Biology to Clinical Manifestations","article-title":"Secreted virulence factors of Streptococcus pyogenes","author":"Barnett","year":"2022"},{"key":"10.1016\/j.fsi.2026.111401_bib60","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003846","article-title":"Group B Streptococcus engages an inhibitory Siglec through sialic acid mimicry to blunt innate immune and inflammatory responses in vivo","volume":"10","author":"Chang","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.fsi.2026.111401_bib61","doi-asserted-by":"crossref","first-page":"3986","DOI":"10.1128\/iai.60.10.3986-3993.1992","article-title":"Prevention of C3 deposition by capsular polysaccharide is a virulence mechanism of type III group B streptococci","volume":"60","author":"Marques","year":"1992","journal-title":"Infect. Immun."},{"key":"10.1016\/j.fsi.2026.111401_bib62","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1172\/JCI200317335","article-title":"Group B streptococcal \u03b2-hemolysin\/cytolysin activates neutrophil signaling pathways in brain endothelium and contributes to development of meningitis","volume":"112","author":"Doran","year":"2003","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.fsi.2026.111401_bib63","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1203\/00006450-199905010-00003","article-title":"Group B streptococcal \u03b2-Hemolysin promotes injury of lung Microvascular endothelial cells","volume":"45","author":"Gibson","year":"1999","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.fsi.2026.111401_bib64","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.1128\/iai.64.9.3818-3826.1996","article-title":"Group B streptococcal beta-hemolysin expression is associated with injury of lung epithelial cells","volume":"64","author":"Nizet","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/j.fsi.2026.111401_bib65","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0966-842X(02)02473-3","article-title":"Streptococcal beta-hemolysins: genetics and role in disease pathogenesis","volume":"10","author":"Nizet","year":"2002","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.fsi.2026.111401_bib54","first-page":"63","article-title":"Efficacy of attenuated bacteria vaccine against streptococcal infection in larvae tilapia","volume":"5","author":"Suryahman","year":"2021","journal-title":"Oreochromis niloticus )"},{"key":"10.1016\/j.fsi.2026.111401_bib55","article-title":"Construction of Streptococcus agalactiae sialic acid mutant and evaluation of its potential as a live attenuated vaccine in Nile tilapia ( Oreochromis niloticus )","author":"Jingwen","year":"2022","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.fsi.2026.111401_bib56","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.fsi.2021.12.043","article-title":"Development and efficacy of Streptococcus iniae live-attenuated vaccines in Nile tilapia, Oreochromis niloticus","volume":"121","author":"Heckman","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111401_bib57","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.fsi.2015.06.014","article-title":"Development of live attenuated Streptococcus agalactiae vaccine for tilapia via continuous passage in vitro","volume":"45","author":"Li","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111401_bib58","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3354\/dao02192","article-title":"Evaluation of Streptococcus iniae killed bacterin and live attenuated vaccines in hybrid striped bass through injection and bath immersion","volume":"89","author":"Locke","year":"2010","journal-title":"Dis. Aquat. Org."},{"key":"10.1016\/j.fsi.2026.111401_bib59","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0002824","article-title":"Streptococcus iniae M-Like protein contributes to virulence in fish and is a target for live attenuated vaccine development","volume":"3","author":"Locke","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2026.111401_bib47","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/jfd.12935","article-title":"Capsular polysaccharide of Streptococcus agalactiae is an essential virulence factor for infection in Nile tilapia (Oreochromis niloticus Linn.)","volume":"42","author":"Zhang","year":"2018","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2026.111401_bib66","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002812","article-title":"The pore-forming toxin \u03b2 hemolysin\/cytolysin triggers p38 MAPK-Dependent IL-10 production in macrophages and inhibits innate immunity","volume":"8","author":"Bebien","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.fsi.2026.111401_bib70","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.fsi.2013.08.009","article-title":"Enhanced efficacy of an attenuated Flavobacterium psychrophilum strain cultured under iron-limited conditions","volume":"35","author":"Long","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111401_bib71","doi-asserted-by":"crossref","first-page":"5582","DOI":"10.1016\/j.vaccine.2008.07.083","article-title":"Isolation of rifampicin resistant Flavobacterium psychrophilum strains and their potential as live attenuated vaccine candidates","volume":"26","author":"LaFrentz","year":"2008","journal-title":"Vaccine"}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826003050?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826003050?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T16:42:54Z","timestamp":1783096974000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464826003050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":68,"alternative-id":["S1050464826003050"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111401","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy evaluation of live attenuated vaccines against Streptococcus agalactiae Ia, administered to Nile tilapia (Oreochromis niloticus) by immersion or intraperitoneal injection","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111401","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"111401"}}