{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:58:51Z","timestamp":1786989531740,"version":"build-2736575974"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32460271"],"award-info":[{"award-number":["32460271"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009620","name":"Gansu Provincial Science and Technology Department","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018554","name":"Science and Technology Program of Gansu Province","doi-asserted-by":"publisher","award":["24CXNA040"],"award-info":[{"award-number":["24CXNA040"]}],"id":[{"id":"10.13039\/501100018554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018554","name":"Science and Technology Program of Gansu Province","doi-asserted-by":"publisher","award":["24CXNA078"],"award-info":[{"award-number":["24CXNA078"]}],"id":[{"id":"10.13039\/501100018554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018554","name":"Science and Technology Program of Gansu Province","doi-asserted-by":"publisher","award":["25CXNA033"],"award-info":[{"award-number":["25CXNA033"]}],"id":[{"id":"10.13039\/501100018554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007932","name":"Gansu Agricultural University","doi-asserted-by":"publisher","award":["GAU-XKTD-2022-23"],"award-info":[{"award-number":["GAU-XKTD-2022-23"]}],"id":[{"id":"10.13039\/501100007932","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.fsi.2026.111418","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T06:32:36Z","timestamp":1778481156000},"page":"111418","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The synergistic toxic effects of ammonia nitrogen and IHNV co-stress on the immune and intestinal health of rainbow trout"],"prefix":"10.1016","volume":"175","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0821-0849","authenticated-orcid":false,"given":"Jianfu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingqiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Hai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujun","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3\u20134","key":"10.1016\/j.fsi.2026.111418_bib1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0044-8486(95)01151-X","article-title":"The potential for integrated biological treatment systems in recirculating fish culture \u2013 a review","volume":"139","author":"van Rijn","year":"1996","journal-title":"Aquaculture"},{"issue":"1\u20134","key":"10.1016\/j.fsi.2026.111418_bib2","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.aquaculture.2006.03.019","article-title":"Engineering analysis of the stoichiometry of photoautotrophic, autotrophic, and heterotrophic removal of ammonia\u2013nitrogen in aquaculture systems","volume":"257","author":"Ebeling","year":"2006","journal-title":"Aquaculture"},{"issue":"1\u20134","key":"10.1016\/j.fsi.2026.111418_bib3","first-page":"267","article-title":"Effect of ammonia on survival, growth, and food conversion of juvenile rainbow trout","volume":"111","author":"Wajsbrot","year":"1993","journal-title":"Aquaculture"},{"issue":"21","key":"10.1016\/j.fsi.2026.111418_bib4","first-page":"3719","article-title":"Effects of temperature on ammonia and urea excretion in the swamp eel, Monopterus albus, in air and water","volume":"204","author":"Ip","year":"2001","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.fsi.2026.111418_bib5","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.fsi.2019.04.066","article-title":"Progress, challenges and opportunities in fish vaccine development","volume":"90","author":"Adams","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111418_bib6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.aquatox.2015.04.004","article-title":"Effects of ammonia exposure on apoptosis, oxidative stress and immune response in pufferfish (Takifugu obscurus)","volume":"164","author":"Cheng","year":"2015","journal-title":"Aquat. Toxicol."},{"issue":"3","key":"10.1016\/j.fsi.2026.111418_bib7","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3390\/biology4030525","article-title":"The mucosal immune system of teleost fish","volume":"4","author":"Salinas","year":"2015","journal-title":"Biology"},{"issue":"5","key":"10.1016\/j.fsi.2026.111418_bib8","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.fsi.2005.03.007","article-title":"Phylogeny and ontogeny of fish leucocytes","volume":"19","author":"Rombout","year":"2005","journal-title":"Fish Shellfish Immunol."},{"issue":"5","key":"10.1016\/j.fsi.2026.111418_bib9","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.fsi.2010.09.001","article-title":"Teleost intestinal immunology","volume":"31","author":"Rombout","year":"2010","journal-title":"Fish Shellfish Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111418_bib10","first-page":"246","article-title":"Effects of ammonia nitrogen stress on IHNV susceptibility of juvenile rainbow trout (Oncorhynchus mykiss)","volume":"32","author":"Liu","year":"2025","journal-title":"J. Fish. Sci. China"},{"key":"10.1016\/j.fsi.2026.111418_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110974","article-title":"Oxidative stress and mitochondrial dysfunction involved in ammonia-induced nephrocyte necroptosis in chickens","volume":"203","author":"Han","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"12","key":"10.1016\/j.fsi.2026.111418_bib12","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.3390\/v14122663","article-title":"Comparative study on immune function of the head and trunk kidney in rainbow trout responding to IHNV infection","volume":"14","author":"Sun","year":"2022","journal-title":"Viruses"},{"issue":"11","key":"10.1016\/j.fsi.2026.111418_bib13","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.3390\/ani11113304","article-title":"Toxic effects on bioaccumulation, hematological parameters, oxidative stress, immune responses and tissue structure in fish exposed to ammonia nitrogen: a review","volume":"11","author":"Xu","year":"2021","journal-title":"Animals"},{"key":"10.1016\/j.fsi.2026.111418_bib14","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.fsi.2020.08.039","article-title":"Sesamin attenuates histological alterations, oxidative stress and expressions of immune-related genes in liver of zebrafish (Danio rerio) exposed to fluoride","volume":"106","author":"Cao","year":"2020","journal-title":"Fish Shellfish Immunol."},{"issue":"6","key":"10.1016\/j.fsi.2026.111418_bib15","doi-asserted-by":"crossref","first-page":"620","DOI":"10.4254\/wjh.v13.i6.620","article-title":"Glutathione-S-transferases genes-promising predictors of hepatic dysfunction","volume":"13","author":"Prysyazhnyuk","year":"2021","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.fsi.2026.111418_bib16","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.fsi.2020.04.042","article-title":"Ammonia toxicity in the yellow catfish (Pelteobagrus fulvidraco): the mechanistic insight from physiological detoxification to poisoning","volume":"102","author":"Li","year":"2020","journal-title":"Fish Shellfish Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111418_bib17","first-page":"43","article-title":"Acute ammonia nitrogen stress on antioxidant capacity and non-specific immune of rainbow trout (Oncorhynchus mykiss) in an alkaline environment","volume":"49","author":"Fu","year":"2025","journal-title":"Acta Hydrobiol. Sin."},{"issue":"2","key":"10.1016\/j.fsi.2026.111418_bib18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3390\/biology5020023","article-title":"The function of fish cytokines","volume":"5","author":"Zou","year":"2016","journal-title":"Biology"},{"issue":"12","key":"10.1016\/j.fsi.2026.111418_bib19","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.tibs.2016.09.002","article-title":"Mechanism and regulation of NLRP3 inflammasome activation","volume":"41","author":"Yuan","year":"2016","journal-title":"Trends Biochem. Sci."},{"issue":"2\u20133","key":"10.1016\/j.fsi.2026.111418_bib20","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jsbmb.2010.03.058","article-title":"The role of the glucocorticoid receptor in inflammation and immunity","volume":"120","author":"Baschant","year":"2010","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"3\u20134","key":"10.1016\/j.fsi.2026.111418_bib21","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0165-2427(02)00077-6","article-title":"Neuroendocrine\u2013immune interactions in fish: a role for interleukin-1","volume":"87","author":"Engelsma","year":"2002","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111418_bib22","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.fsi.2010.10.010","article-title":"Cortisol modulates the induction of inflammatory gene expression in a rainbow trout macrophage cell line","volume":"30","author":"Castro","year":"2010","journal-title":"Fish Shellfish Immunol."},{"issue":"6","key":"10.1016\/j.fsi.2026.111418_bib23","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.3390\/ijms23063129","article-title":"Evaluation of ammonia nitrogen exposure in immune defenses present on spleen and head-kidney of Wuchang Bream (Megalobrama amblycephala)","volume":"23","author":"Guo","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.fsi.2026.111418_bib24","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.dci.2011.03.008","article-title":"Heterogeneity of macrophage activation in fish","volume":"35","author":"Forlenza","year":"2011","journal-title":"Dev. Comp. Immunol."},{"issue":"7","key":"10.1016\/j.fsi.2026.111418_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112793","article-title":"Cross-organ single-cell transcriptome profiling reveals macrophage and dendritic cell heterogeneity in zebrafish","volume":"42","author":"Zhou","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.fsi.2026.111418_bib26","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.fsi.2017.02.021","article-title":"Expression analysis of nine toll-like receptors in yellow catfish (Pelteobagrus fulvidraco) responding to Aeromonas hydrophila challenge","volume":"63","author":"Zhang","year":"2017","journal-title":"Fish Shellfish Immunol."},{"issue":"6","key":"10.1016\/j.fsi.2026.111418_bib27","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1016\/j.ajpath.2013.09.001","article-title":"TNF-\u03b1 modulation of intestinal epithelial tight junction barrier is regulated by ERK1\/2 activation of Elk-1","volume":"183","author":"Al-Sadi","year":"2013","journal-title":"Am. J. Pathol."},{"issue":"5","key":"10.1016\/j.fsi.2026.111418_bib28","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.2353\/ajpath.2010.100371","article-title":"IL-1beta-induced increase in intestinal epithelial tight junction permeability is mediated by MEKK-1 activation of canonical NF-kappaB pathway","volume":"177","author":"Al-Sadi","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.fsi.2026.111418_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1279051","article-title":"Ammonia nitrogen stress damages the intestinal mucosal barrier of yellow catfish (Pelteobagrus fulvidraco) and induces intestinal inflammation","volume":"14","author":"Liu","year":"2023","journal-title":"Front. Physiol."},{"issue":"6","key":"10.1016\/j.fsi.2026.111418_bib30","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1373\/clinchem.2018.292391","article-title":"Interferon-inducible myxovirus resistance proteins: potential biomarkers for differentiating viral from bacterial infections","volume":"65","author":"Zav'yalov","year":"2019","journal-title":"Clin. Chem."},{"key":"10.1016\/j.fsi.2026.111418_bib31","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.fsi.2019.04.297","article-title":"Fish species-specific TRIM gene FTRCA1 negatively regulates interferon response through attenuating IRF7 transcription","volume":"90","author":"Wu","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111418_bib32","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.fsi.2018.12.013","article-title":"The immune evasion strategies of fish viruses","volume":"86","author":"Guo","year":"2018","journal-title":"Fish Shellfish Immunol."},{"issue":"5","key":"10.1016\/j.fsi.2026.111418_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2006.10.004","article-title":"Type I interferon gene induction by the interferon regulatory factor family of transcription factors","volume":"25","author":"Honda","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.fsi.2026.111418_bib34","series-title":"Veterinary Molecular Immunology","article-title":"Mucosal immunity and immune tolerance","author":"Zheng","year":"2024"},{"issue":"Pt 10","key":"10.1016\/j.fsi.2026.111418_bib35","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1099\/0022-1317-81-10-2341","article-title":"Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures","volume":"81","author":"Goodbourn","year":"2000","journal-title":"J. Gen. Virol."},{"issue":"10","key":"10.1016\/j.fsi.2026.111418_bib36","doi-asserted-by":"crossref","first-page":"27092","DOI":"10.1007\/s11356-022-24072-8","article-title":"Ammonium induces oxidative stress, endoplasmic reticulum stress, and apoptosis of hepatocytes in the liver cell line of grass carp (Ctenopharyngodon idella)","volume":"30","author":"Hu","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.fsi.2026.111418_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2021.105903","article-title":"Ammonia exposure induces endoplasmic reticulum stress and apoptosis in Chinese striped-necked turtles (Mauremys sinensis)","volume":"237","author":"Huang","year":"2021","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.fsi.2026.111418_bib38","doi-asserted-by":"crossref","first-page":"513","DOI":"10.3389\/fimmu.2020.00513","article-title":"Virus-induced T cell-mediated heterologous immunity and vaccine development","volume":"11","author":"Balz","year":"2020","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2026.111418_bib39","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1007\/s10499-021-00724-3","article-title":"Ammonia stress\u2013induced apoptosis by p53\u2013BAX\/BCL-2 signal pathway in hepatopancreas of common carp (Cyprinus carpio)","volume":"29","author":"Xue","year":"2021","journal-title":"Aquac. Int."},{"key":"10.1016\/j.fsi.2026.111418_bib40","article-title":"The effects of ammonia-N stress on immune parameters, antioxidant capacity, digestive function, and intestinal microflora of Chinese mitten crab, Eriocheir sinensis, and the protective effect of dietary supplement of melatonin","volume":"240","author":"Yang","year":"2021","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111418_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102843","article-title":"TGF-\u03b21 suppresses the T-cell response in teleost fish by initiating Smad3- and Foxp3-mediated transcriptional networks","volume":"299","author":"Zhang","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fsi.2026.111418_bib42","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.copbio.2020.10.004","article-title":"Virus-induced metabolic reprogramming and innate sensing hereof by the infected host","volume":"68","author":"Thyrsted","year":"2021","journal-title":"Curr. Opin. Biotechnol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111418_bib43","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.fsi.2014.08.020","article-title":"Adaptive immune responses at mucosal surfaces of teleost fish","volume":"40","author":"Rombout","year":"2014","journal-title":"Fish Shellfish Immunol."},{"issue":"1513","key":"10.1016\/j.fsi.2026.111418_bib44","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1098\/rstb.2008.0151","article-title":"Inflammation and oxidative stress in vertebrate host-parasite systems","volume":"364","author":"Sorci","year":"2009","journal-title":"Phil. Trans. Biol. Sci."},{"key":"10.1016\/j.fsi.2026.111418_bib45","article-title":"Integrated analysis of immune parameters, miRNA-mRNA interaction, and immune genes expression in the liver of rainbow trout following infectious hematopoietic necrosis virus infection","volume":"13","author":"Wu","year":"2022","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111418_bib46","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/jimmun\/vkae012","article-title":"Ammonium chloride mitigates the amplification of fish virus by blocking autophagy-dependent replication","volume":"214","author":"Chen","year":"2025","journal-title":"J. Immunol."},{"issue":"P4","key":"10.1016\/j.fsi.2026.111418_bib47","article-title":"Transcription factor GATA5 enhances autophagy by modulating miR-2765 in Penaeus vannamei under ammonia nitrogen stress","volume":"318","author":"Wang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"6","key":"10.1016\/j.fsi.2026.111418_bib48","doi-asserted-by":"crossref","first-page":"7671","DOI":"10.1007\/s10499-024-01535-y","article-title":"Aquaculture and Aeromonas hydrophila: a complex interplay of environmental factors and virulence","volume":"32","author":"Abdella","year":"2024","journal-title":"Aquac. Int."},{"issue":"12","key":"10.1016\/j.fsi.2026.111418_bib49","doi-asserted-by":"crossref","first-page":"980","DOI":"10.3390\/biology13120980","article-title":"Navigating fish immunity: focus on mucosal immunity and the evolving landscape of mucosal vaccines","volume":"13","author":"Hopo","year":"2024","journal-title":"Biology"},{"key":"10.1016\/j.fsi.2026.111418_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2022.738934","article-title":"Ammonia nitrogen stress increases susceptibility to bacterial infection via blocking IL-1R\u2013Relish axis mediated antimicrobial peptides expression in shrimp","volume":"563","author":"Li","year":"2023","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2026.111418_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122990","article-title":"Effects of nanoplastics on antioxidant and immune enzyme activities and related gene expression in juvenile Macrobrachium nipponense","volume":"398","author":"Li","year":"2020","journal-title":"J. Hazard Mater."},{"issue":"4","key":"10.1016\/j.fsi.2026.111418_bib52","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41580-019-0199-y","article-title":"mTOR at the nexus of nutrition, growth, ageing and disease","volume":"21","author":"Liu","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111418_bib53","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3390\/v11020141","article-title":"Metabolic reprogramming of the host cell by human adenovirus infection","volume":"11","author":"Prusinkiewicz","year":"2019","journal-title":"Viruses"},{"issue":"1","key":"10.1016\/j.fsi.2026.111418_bib54","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.pharmthera.2012.12.007","article-title":"Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation","volume":"138","author":"Zanger","year":"2013","journal-title":"Pharmacol. Therapeut."},{"issue":"3","key":"10.1016\/j.fsi.2026.111418_bib55","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1083\/jcb.200205044","article-title":"Hijacking the translation apparatus by RNA viruses","volume":"158","author":"Martin","year":"2002","journal-title":"JCB (J. Cell Biol.)"},{"issue":"1","key":"10.1016\/j.fsi.2026.111418_bib56","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1471-2180-11-48","article-title":"Hepatitis B virus X protein impedes the DNA repair via its association with transcription factor, TFIIH","volume":"11","author":"Abdel-Hafiz","year":"2011","journal-title":"BMC Microbiol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111418_bib57","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.fsi.2026.111418_bib58","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.fsi.2026.111418_bib59","article-title":"Effect of ammonia stress on transcriptome and endoplasmic reticulum stress pathway for common carp (Cyprinus carpio) hepatopancreas","volume":"20","author":"Xue","year":"2021","journal-title":"Aquac. Rep."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826003220?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826003220?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T08:17:26Z","timestamp":1783153046000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464826003220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":59,"alternative-id":["S1050464826003220"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111418","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The synergistic toxic effects of ammonia nitrogen and IHNV co-stress on the immune and intestinal health of rainbow trout","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111418","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111418"}}