{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T21:47:18Z","timestamp":1785880038460,"version":"3.56.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD2400602"],"award-info":[{"award-number":["2023YFD2400602"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017055","name":"National Natural Science Foundation of China-Shandong Joint Fund","doi-asserted-by":"publisher","award":["U2106232"],"award-info":[{"award-number":["U2106232"]}],"id":[{"id":"10.13039\/100017055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.fsi.2026.111470","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T16:31:30Z","timestamp":1780417890000},"page":"111470","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["G protein-coupled receptor 119 exerts anti-inflammatory effects on the liver of zebrafish (Danio rerio) via mediating Gs\/cAMP-dependent pathway"],"prefix":"10.1016","volume":"176","author":[{"given":"Changxu","family":"Sui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiliang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangsen","family":"Mai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3958-474X","authenticated-orcid":false,"given":"Qinghui","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.fsi.2026.111470_bib1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10695-011-9518-8","article-title":"Behavioural indicators of welfare in farmed fish","volume":"38","author":"Martins","year":"2012","journal-title":"Fish Physiol. Biochem."},{"issue":"1","key":"10.1016\/j.fsi.2026.111470_bib2","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/raq.12492","article-title":"Nutritional immunity of fish intestines: important insights for sustainable aquaculture","volume":"13","author":"Dawood","year":"2021","journal-title":"Rev. Aquacult."},{"issue":"7851","key":"10.1016\/j.fsi.2026.111470_bib3","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/s41586-021-03308-6","article-title":"A 20-year retrospective review of global aquaculture","volume":"591","author":"Naylor","year":"2021","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.fsi.2026.111470_bib4","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/j.1751-0813.2001.tb10753.x","article-title":"Immune responses of teleost fish","volume":"79","author":"Watts","year":"2001","journal-title":"Aust. Vet. J."},{"key":"10.1016\/j.fsi.2026.111470_bib5","first-page":"431","volume":"vol. 9","author":"Insel","year":"2018"},{"issue":"5721","key":"10.1016\/j.fsi.2026.111470_bib6","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1126\/science.1109237","article-title":"Transduction of receptor signals by \u03b2-arrestins","volume":"308","author":"Lefkowitz","year":"2005","journal-title":"science"},{"issue":"9","key":"10.1016\/j.fsi.2026.111470_bib7","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nrm908","article-title":"Seven-transmembrane receptors","volume":"3","author":"Pierce","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"7","key":"10.1016\/j.fsi.2026.111470_bib8","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/s41401-023-01215-2","article-title":"GPCRs involved in metabolic diseases: pharmacotherapeutic development updates","volume":"45","author":"Jin","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"issue":"1","key":"10.1016\/j.fsi.2026.111470_bib9","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1463-1326.2010.01315.x","article-title":"The role of small molecule GPR119 agonist, AS1535907, in glucose\u2010stimulated insulin secretion and pancreatic \u03b2\u2010cell function, diabetes","volume":"13","author":"Yoshida","year":"2011","journal-title":"Obes. Metabol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111470_bib10","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1210\/me.2009-0239","article-title":"N-oleoyldopamine enhances glucose homeostasis through the activation of GPR119","volume":"24","author":"Chu","year":"2010","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.fsi.2026.111470_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115345","article-title":"GPR119 activation by DA-1241 alleviates hepatic and systemic inflammation in MASH mice through inhibition of NF\u03baB signaling","volume":"166","author":"Lee","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.fsi.2026.111470_bib12","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/B978-0-12-381517-0.00016-3","article-title":"GPR119 agonists for the potential treatment of type 2 diabetes and related metabolic disorders","volume":"84","author":"Shah","year":"2010","journal-title":"Vitam. Horm."},{"issue":"3","key":"10.1016\/j.fsi.2026.111470_bib13","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1242\/jcs.115.3.455","article-title":"The role of \u03b2-arrestins in the termination and transduction of G-protein-coupled receptor signals","volume":"115","author":"Luttrell","year":"2002","journal-title":"J. Cell Sci."},{"issue":"8","key":"10.1016\/j.fsi.2026.111470_bib14","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock vina 1.2. 0: new docking methods, expanded force field, and python bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model."},{"issue":"1","key":"10.1016\/j.fsi.2026.111470_bib15","first-page":"82","article-title":"Pymol: an open-source molecular graphics tool, CCP4 newsl","volume":"40","author":"DeLano","year":"2002","journal-title":"protein crystallogr"},{"issue":"12","key":"10.1016\/j.fsi.2026.111470_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1004586","article-title":"AutoDockFR: advances in protein-ligand docking with explicitly specified binding site flexibility","volume":"11","author":"Ravindranath","year":"2015","journal-title":"PLoS Comput. Biol."},{"issue":"4","key":"10.1016\/j.fsi.2026.111470_bib17","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"methods"},{"issue":"12","key":"10.1016\/j.fsi.2026.111470_bib18","article-title":"Tip60-mediated Rheb acetylation links palmitic acid with mTORC1 activation and insulin resistance","volume":"223","author":"Zhao","year":"2024","journal-title":"JCB (J. Cell Biol.)"},{"issue":"22","key":"10.1016\/j.fsi.2026.111470_bib19","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202501468R","article-title":"FFAR4 functions as a DHA receptor to attenuate LPS\u2010Induced inflammation via the cAMP\/I\u03baB\u03b1 pathway in large yellow croaker (Larimichthys crocea)","volume":"39","author":"Wu","year":"2025","journal-title":"FASEB J."},{"key":"10.1016\/j.fsi.2026.111470_bib20","article-title":"Existence and functions of a kisspeptin neuropeptide signaling system in a non-chordate deuterostome species","volume":"9","author":"Wang","year":"2020","journal-title":"eLife"},{"issue":"9","key":"10.1016\/j.fsi.2026.111470_bib21","doi-asserted-by":"crossref","first-page":"937","DOI":"10.3390\/nu9090937","article-title":"Eicosapentaenoic acid (EPA) induced macrophages activation through GPR120-mediated Raf-ERK1\/2-IKK\u03b2-NF-\u03baB p65 signaling pathways","volume":"9","author":"Han","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.fsi.2026.111470_bib22","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.toxlet.2022.01.012","article-title":"Adenosine receptor A2B mediates alcoholic hepatitis by regulating cAMP levels and the NF-KB pathway","volume":"359","author":"Zhao","year":"2022","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fsi.2026.111470_bib23","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.neulet.2016.05.066","article-title":"The reciprocal interaction of sympathetic nervous system and cAMP-PKA-NF-kB pathway in immune suppression after experimental stroke","volume":"627","author":"Zuo","year":"2016","journal-title":"Neurosci. Lett."},{"issue":"9","key":"10.1016\/j.fsi.2026.111470_bib24","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.tips.2011.05.002","article-title":"\u03b2-Arrestin-mediated receptor trafficking and signal transduction","volume":"32","author":"Shenoy","year":"2011","journal-title":"Trends Pharmacol. Sci."},{"issue":"3\u20134","key":"10.1016\/j.fsi.2026.111470_bib25","doi-asserted-by":"crossref","first-page":"222","DOI":"10.2119\/2007-00119.Tilg","article-title":"Inflammatory mechanisms in the regulation of insulin resistance","volume":"14","author":"Tilg","year":"2008","journal-title":"Mol. Med."},{"issue":"4","key":"10.1016\/j.fsi.2026.111470_bib26","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/nrd2518","article-title":"Structural diversity of G protein-coupled receptors and significance for drug discovery","volume":"7","author":"Lagerstr\u00f6m","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"issue":"6","key":"10.1016\/j.fsi.2026.111470_bib27","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1124\/mol.63.6.1256","article-title":"The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints","volume":"63","author":"Fredriksson","year":"2003","journal-title":"Mol. Pharmacol."},{"issue":"7436","key":"10.1016\/j.fsi.2026.111470_bib28","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nature11896","article-title":"Molecular signatures of G-protein-coupled receptors","volume":"494","author":"Venkatakrishnan","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2026.111470_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114660","article-title":"Oleoylethanolamide ameliorates collagen-induced rheumatoid arthritis via activation of GPR119","volume":"155","author":"Lee","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"26","key":"10.1016\/j.fsi.2026.111470_bib30","doi-asserted-by":"crossref","first-page":"8525","DOI":"10.3748\/wjg.v20.i26.8525","article-title":"High fat diet feeding results in gender specific steatohepatitis and inflammasome activation","volume":"20","author":"Ganz","year":"2014","journal-title":"World J. Gastroenterol.: WJG"},{"issue":"3","key":"10.1016\/j.fsi.2026.111470_bib31","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/hep.21752","article-title":"Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes","volume":"46","author":"Joshi-Barve","year":"2007","journal-title":"Hepatology"},{"issue":"11","key":"10.1016\/j.fsi.2026.111470_bib32","doi-asserted-by":"crossref","first-page":"6413","DOI":"10.4049\/jimmunol.1001829","article-title":"The role of the transcription factor CREB in immune function","volume":"185","author":"Wen","year":"2010","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111470_bib33","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-35184-y","article-title":"Unique, intersecting, and overlapping roles of C\/EBP \u03b2 and CREB in cells of the innate immune system","volume":"8","author":"Larabee","year":"2018","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.fsi.2026.111470_bib34","article-title":"The interplay between cyclic AMP, MAPK, and NF\u2010\u03baB pathways in response to proinflammatory signals in microglia","volume":"2015","author":"Ghosh","year":"2015","journal-title":"BioMed Res. Int."},{"issue":"2","key":"10.1016\/j.fsi.2026.111470_bib35","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1124\/pr.109.002436","article-title":"Beyond desensitization: physiological relevance of arrestin-dependent signaling","volume":"62","author":"Luttrell","year":"2010","journal-title":"Pharmacol. Rev."},{"issue":"4","key":"10.1016\/j.fsi.2026.111470_bib36","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0896-6273(00)80602-9","article-title":"Cross talk between ERK and PKA is required for Ca2+ stimulation of CREB-dependent transcription and ERK nuclear translocation","volume":"21","author":"Impey","year":"1998","journal-title":"Neuron"}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826003748?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826003748?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T21:05:54Z","timestamp":1785877554000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464826003748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":36,"alternative-id":["S1050464826003748"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111470","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"G protein-coupled receptor 119 exerts anti-inflammatory effects on the liver of zebrafish (Danio rerio) via mediating Gs\/cAMP-dependent pathway","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111470","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"111470"}}