{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T16:22:18Z","timestamp":1783182138478,"version":"3.54.6"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD2401203"],"award-info":[{"award-number":["2022YFD2401203"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012326","name":"International Science and Technology Cooperation Programme","doi-asserted-by":"publisher","award":["GHYF2025040"],"award-info":[{"award-number":["GHYF2025040"]}],"id":[{"id":"10.13039\/501100012326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.fsi.2026.111491","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T23:52:28Z","timestamp":1780617148000},"page":"111491","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Functional divergence and epigenetic regulation of Caspase-3a and Caspase-8a in Apoptosis\u2013Inflammation crosstalk during Streptococcus iniae infection in golden pompano (Trachinotus ovatus)"],"prefix":"10.1016","volume":"176","author":[{"given":"Zemin","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoran","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2026.111491_bib1","article-title":"Development of a haplotype reference panel and analysis of genetic structure in golden pompano (Trachinotus ovatus)","volume":"38","author":"Wang","year":"2024","journal-title":"Aquac. Rep."},{"key":"10.1016\/j.fsi.2026.111491_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2025.742714","article-title":"Unraveling the genetic basis of nervous necrosis virus resistance in golden pompano: insights from genome-wide association and genomic selection","volume":"608","author":"Wang","year":"2025","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2026.111491_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2025.742174","article-title":"Integrating genomic selection and genome-wide association studies to predict Streptococcus iniae resistance traits in golden pompano (Trachinotus ovatus)","volume":"599","author":"Sun","year":"2025","journal-title":"Aquaculture"},{"issue":"4","key":"10.1016\/j.fsi.2026.111491_bib4","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a008656","article-title":"Caspase functions in cell death and disease","volume":"5","author":"McIlwain","year":"2013","journal-title":"Cold Spring Harbor Perspect. Biol."},{"issue":"4","key":"10.1016\/j.fsi.2026.111491_bib5","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.molcel.2017.01.022","article-title":"Caspase-8 acts in a non-enzymatic role as a scaffold for assembly of a pro-inflammatory \u201cFADDosome\u201d complex upon TRAIL stimulation","volume":"65","author":"Henry","year":"2017","journal-title":"Mol. Cell"},{"issue":"4","key":"10.1016\/j.fsi.2026.111491_bib6","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3390\/cells14040240","article-title":"Caspase-8: arbitrating life and death in the innate immune system","volume":"14","author":"Gupta","year":"2025","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.fsi.2026.111491_bib7","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/imr.12541","article-title":"Caspase\u20108: regulating life and death","volume":"277","author":"Tummers","year":"2017","journal-title":"Immunol. Rev."},{"issue":"10","key":"10.1016\/j.fsi.2026.111491_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2012.154","article-title":"The adaptor protein FADD and the initiator caspase-8 mediate activation of NF-\u03baB by TRAIL","volume":"3","author":"Grunert","year":"2012","journal-title":"Cell Death Dis."},{"issue":"20","key":"10.1016\/j.fsi.2026.111491_bib9","doi-asserted-by":"crossref","first-page":"7385","DOI":"10.1073\/pnas.1403252111","article-title":"Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-\u03baB and MAPK signaling","volume":"111","author":"Philip","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"8","key":"10.1016\/j.fsi.2026.111491_bib10","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/s41419-022-05156-2","article-title":"Apoptotic caspase inhibits innate immune signaling by cleaving NF-\u03baBs in both mammals and flies","volume":"13","author":"Wu","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.fsi.2026.111491_bib11","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1095-8649.2007.01665.x","article-title":"Caspases and apoptosis in fish","volume":"71","author":"Takle","year":"2007","journal-title":"J. Fish. Biol."},{"key":"10.1016\/j.fsi.2026.111491_bib12","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.fsi.2018.09.050","article-title":"Identification of Caspase-6 and Caspase-7 from miiuy croaker and evolution analysis in fish","volume":"83","author":"Bi","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111491_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2020.103987","article-title":"Identification and characterization of caspases genes in rainbow trout (Oncorhynchus mykiss) and their expression profiles after Aeromonas salmonicida and Vibrio anguillarum infection","volume":"118","author":"Zeng","year":"2021","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2026.111491_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpb.2023.110913","article-title":"Characterization of caspase gene family in Sebastes schlegelii and their expression profiles under Aeromonas salmonicida and Vibrio anguillarum infection","volume":"270","author":"Yu","year":"2024","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"10.1016\/j.fsi.2026.111491_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2023.740464","article-title":"Caspase-8 in Sebastes schlegelii: roles in regulating apoptosis and inflammation response after Vibrio anguillarum infection","volume":"581","author":"Han","year":"2024","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2026.111491_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2023.101832","article-title":"The role of caspase-8 in inflammatory signalling and pyroptotic cell death","author":"Pang","year":"2023","journal-title":"Semin. Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2026.111491_bib17","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1002\/bab.2233","article-title":"Caspase\u20103: structure, function, and biotechnological aspects","volume":"69","author":"Asadi","year":"2022","journal-title":"Biotechnol. Appl. Biochem."},{"issue":"5","key":"10.1016\/j.fsi.2026.111491_bib18","doi-asserted-by":"crossref","DOI":"10.1111\/ede.12486","article-title":"DNA methylation reprogramming in teleosts","volume":"26","author":"Matlosz","year":"2024","journal-title":"Evol. Dev."},{"issue":"3","key":"10.1016\/j.fsi.2026.111491_bib19","first-page":"411","article-title":"Epigenetic mechanisms and applications in aquaculture and fisheries, with perspectives on technology and analysis","volume":"11","author":"Lu","year":"2025","journal-title":"Aquacult. Fish."},{"issue":"1","key":"10.1016\/j.fsi.2026.111491_bib20","doi-asserted-by":"crossref","DOI":"10.1080\/15592294.2024.2392049","article-title":"Genomic context determines the effect of DNA methylation on gene expression in the gut epithelium of Atlantic salmon (Salmo salar)","volume":"19","author":"Katirtzoglou","year":"2024","journal-title":"Epigenetics"},{"key":"10.1016\/j.fsi.2026.111491_bib21","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.fsi.2021.10.007","article-title":"Immune correlates of NF-\u03baB and TNF\u03b1 promoter DNA methylation in Japanese flounder (Paralichthys olivaceus) muscle and immune parameters change response to vibrio anguillarum infection","volume":"119","author":"Yang","year":"2021","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111491_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108947","article-title":"Epigenetic reprogramming around IFN1 and IFNy2 promoters in rainbow trout cells inoculated with infectious pancreatic necrosis virus (IPNV)","volume":"140","author":"Manr\u00edquez","year":"2023","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111491_bib23","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41392-024-01757-9","article-title":"NF-\u03baB in biology and targeted therapy: new insights and translational implications","volume":"9","author":"Guo","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"1","key":"10.1016\/j.fsi.2026.111491_bib24","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.molimm.2007.05.015","article-title":"Molecular and functional characterization of gilthead seabream Sparus aurata caspase-1: the first identification of an inflammatory caspase in fish","volume":"45","author":"L\u00f3pez-Castej\u00f3n","year":"2008","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.fsi.2026.111491_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2026.111240","article-title":"Genome-wide characterization of the caspase family genes in different sturgeons: insights into lineage-specific expansion and immune responses","author":"Zhu","year":"2026","journal-title":"Fish Shellfish Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111491_bib26","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.immuni.2016.01.020","article-title":"Caspases connect cell-death signaling to organismal homeostasis","volume":"44","author":"Galluzzi","year":"2016","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.fsi.2026.111491_bib27","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nri.2015.7","article-title":"Converging roles of caspases in inflammasome activation, cell death and innate immunity","volume":"16","author":"Man","year":"2016","journal-title":"Nat. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.fsi.2026.111491_bib28","article-title":"Paradoxical roles of caspase-3 in regulating cell survival, proliferation, and tumorigenesis","volume":"221","author":"Eskandari","year":"2022","journal-title":"JCB (J. Cell Biol.)"},{"issue":"1","key":"10.1016\/j.fsi.2026.111491_bib29","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.chom.2010.06.007","article-title":"Manipulation of host cell death pathways during microbial infections","volume":"8","author":"Lamkanfi","year":"2010","journal-title":"Cell Host Microbe"},{"issue":"10","key":"10.1016\/j.fsi.2026.111491_bib30","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/s41419-019-2015-1","article-title":"Pathological alteration and therapeutic implications of sepsis-induced immune cell apoptosis","volume":"10","author":"Cao","year":"2019","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.fsi.2026.111491_bib31","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1083\/jcb.201108081","article-title":"Cell death and infection: a double-edged sword for host and pathogen survival","volume":"195","author":"Ashida","year":"2011","journal-title":"JCB (J. Cell Biol.)"},{"issue":"6","key":"10.1016\/j.fsi.2026.111491_bib32","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00851-19","article-title":"Apoptosis functions in defense against infection of mammalian cells with environmental chlamydiae","volume":"88","author":"Brokatzky","year":"2020","journal-title":"Infect. Immun."},{"key":"10.1016\/j.fsi.2026.111491_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2026.1740461","article-title":"Regulated cell death in sepsis-associated liver injury: molecular mechanisms and therapeutic implications","volume":"17","author":"Zou","year":"2026","journal-title":"Front. Immunol."},{"issue":"23","key":"10.1016\/j.fsi.2026.111491_bib34","doi-asserted-by":"crossref","first-page":"3581","DOI":"10.1016\/j.febslet.2015.10.019","article-title":"Caspase-3 cleaved p65 fragment dampens NF-\u03baB-mediated anti-apoptotic transcription by interfering with the p65\/RPS3 interaction","volume":"589","author":"Wier","year":"2015","journal-title":"FEBS Lett."},{"issue":"10","key":"10.1016\/j.fsi.2026.111491_bib35","doi-asserted-by":"crossref","first-page":"5805","DOI":"10.1007\/s12035-023-03433-5","article-title":"A review on caspases: key regulators of biological activities and apoptosis","volume":"60","author":"Sahoo","year":"2023","journal-title":"Mol. Neurobiol."},{"issue":"41","key":"10.1016\/j.fsi.2026.111491_bib36","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2207240119","article-title":"Caspase-8 and FADD prevent spontaneous ZBP1 expression and necroptosis","volume":"119","author":"Rodriguez","year":"2022","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.fsi.2026.111491_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111434","article-title":"Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation","volume":"41","author":"Wang","year":"2022","journal-title":"Cell Rep."},{"issue":"12","key":"10.1016\/j.fsi.2026.111491_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113476","article-title":"cFLIPL acts as a suppressor of TRAIL-and Fas-initiated inflammation by inhibiting assembly of caspase-8\/FADD\/RIPK1 NF-\u03baB-activating complexes","volume":"42","author":"Davidovich","year":"2023","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.fsi.2026.111491_bib39","doi-asserted-by":"crossref","first-page":"9822","DOI":"10.1038\/s41467-025-65098-z","article-title":"Non-apoptotic caspase-8 is critical for orchestrating exaggerated inflammation during severe SARS-CoV-2 infection","volume":"16","author":"Bader","year":"2025","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.fsi.2026.111491_bib40","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1038\/cdd.2017.67","article-title":"The small molecule that packs a punch: ubiquitin-mediated regulation of RIPK1\/FADD\/caspase-8 complexes","volume":"24","author":"Feltham","year":"2017","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.fsi.2026.111491_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.110110","article-title":"FADD cooperates with Caspase-8 to positively regulate the innate immune response and promote apoptosis following bacterial infection in Japanese eel","volume":"157","author":"Wang","year":"2025","journal-title":"Fish Shellfish Immunol."},{"issue":"3","key":"10.1016\/j.fsi.2026.111491_bib42","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.dci.2009.11.007","article-title":"Expression of zebrafish cxcl8 (interleukin-8) and its receptors during development and in response to immune stimulation","volume":"34","author":"Oehlers","year":"2010","journal-title":"Dev. Comp. Immunol."},{"issue":"12","key":"10.1016\/j.fsi.2026.111491_bib43","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.4049\/jimmunol.1901496","article-title":"Genome-wide DNA methylation and RNA analysis reveal potential mechanism of resistance to Streptococcus agalactiae in GIFT strain of nile tilapia (Oreochromis niloticus)","volume":"204","author":"Hu","year":"2020","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2026.111491_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.109144","article-title":"Genome-wide DNA methylation mediates the resistance to vibriosis in Cynoglossus semilaevis","volume":"142","author":"Ma","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111491_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2024.741530","article-title":"Genome-wide identification of DNA methylation marks associated with resistance to Streptococcus agalactiae in the GIFT strain of Nile Tilapia (Oreochromis niloticus)","volume":"595","author":"Qiao","year":"2025","journal-title":"Aquaculture"},{"issue":"10","key":"10.1016\/j.fsi.2026.111491_bib46","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.jmb.2017.02.008","article-title":"Dynamics and context-dependent roles of DNA methylation","volume":"429","author":"Ambrosi","year":"2017","journal-title":"J. Mol. Biol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111491_bib47","doi-asserted-by":"crossref","first-page":"7173","DOI":"10.1038\/s41598-026-39352-3","article-title":"The DNA methylation landscape of naturally short-lived killifish","volume":"16","author":"Steiger","year":"2026","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.fsi.2026.111491_bib48","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1038\/s41588-022-01241-6","article-title":"Evidence that direct inhibition of transcription factor binding is the prevailing mode of gene and repeat repression by DNA methylation","volume":"54","author":"Kaluscha","year":"2022","journal-title":"Nat. Genet."},{"issue":"9","key":"10.1016\/j.fsi.2026.111491_bib49","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.cels.2024.08.007","article-title":"Promoter DNA methylation and transcription factor condensation are linked to transcriptional memory in mammalian cells","volume":"15","author":"Fan","year":"2024","journal-title":"Cell Syst."},{"issue":"2","key":"10.1016\/j.fsi.2026.111491_bib50","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1042\/bj3560353","article-title":"Heat shock stimulation of a tilapia heat shock protein 70 promoter is mediated by a distal element","volume":"356","author":"Molina","year":"2001","journal-title":"Biochem. J."},{"issue":"7","key":"10.1016\/j.fsi.2026.111491_bib51","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1093\/molbev\/msaa062","article-title":"Tbx2a modulates switching of RH2 and LWS opsin gene expression","volume":"37","author":"Sandkam","year":"2020","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.fsi.2026.111491_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpb.2021.110675","article-title":"Promoter analysis of TLR5M and TLR5S revealed NF-\u03baB might be a conserved cis-element in TLR5S promoter of large yellow croaker","volume":"257","author":"Sun","year":"2022","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826003955?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826003955?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T16:05:32Z","timestamp":1783181132000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464826003955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":52,"alternative-id":["S1050464826003955"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111491","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional divergence and epigenetic regulation of Caspase-3a and Caspase-8a in Apoptosis\u2013Inflammation crosstalk during Streptococcus iniae infection in golden pompano (Trachinotus ovatus)","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111491","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"111491"}}