{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T02:46:34Z","timestamp":1785897994024,"version":"3.56.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024A1515011419"],"award-info":[{"award-number":["2024A1515011419"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Guangxi Natural Science Foundation","doi-asserted-by":"publisher","award":["2024GXNSFAA010480"],"award-info":[{"award-number":["2024GXNSFAA010480"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32573552"],"award-info":[{"award-number":["32573552"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009047","name":"Shantou University","doi-asserted-by":"publisher","award":["NTF24022T"],"award-info":[{"award-number":["NTF24022T"]}],"id":[{"id":"10.13039\/100009047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.fsi.2026.111501","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T15:33:02Z","timestamp":1781537582000},"page":"111501","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Hemocyanin modulates ferroptosis through a HSP90-dependent antioxidant function in shrimp"],"prefix":"10.1016","volume":"176","author":[{"given":"Zeyan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diqian","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jude Juventus","family":"Aweya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianliang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7954-4649","authenticated-orcid":false,"given":"Zhihong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"21","key":"10.1016\/j.fsi.2026.111501_bib1","doi-asserted-by":"crossref","first-page":"R1292","DOI":"10.1016\/j.cub.2020.09.068","article-title":"Ferroptosis","volume":"30","author":"Tang","year":"2020","journal-title":"Curr. Biol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111501_bib2","first-page":"273","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism","volume":"171","author":"Stockwell","year":"2017","journal-title":"Redox Biology, and Disease, Cell"},{"issue":"7","key":"10.1016\/j.fsi.2026.111501_bib3","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.7150\/thno.54113","article-title":"Ferroptosis as a novel therapeutic target for cardiovascular disease","volume":"11","author":"Wu","year":"2021","journal-title":"Theranostics"},{"issue":"6","key":"10.1016\/j.fsi.2026.111501_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/cells9061505","article-title":"Ferroptosis and cancer: Mitochondria meet the \"Iron Maiden\" cell death","volume":"9","author":"Battaglia","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.fsi.2026.111501_bib5","doi-asserted-by":"crossref","DOI":"10.1111\/raq.12976","article-title":"Cell death in crustacean immune defense","volume":"17","author":"Chen","year":"2024","journal-title":"Rev. Aquacult."},{"key":"10.1016\/j.fsi.2026.111501_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biochi.2022.03.010","article-title":"p53 knock-down and hypoxia affects glutathione peroxidase 4 antioxidant response in hepatopancreas of the white shrimp litopenaeus vannamei","volume":"199","author":"Estrada-C\u00e1rdenas","year":"2022","journal-title":"Biochimie"},{"issue":"12","key":"10.1016\/j.fsi.2026.111501_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105463","article-title":"Exosomes drive ferroptosis by stimulating iron accumulation to inhibit bacterial infection in crustaceans","volume":"299","author":"Sun","year":"2023","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.fsi.2026.111501_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/v14030585","article-title":"Viral shrimp diseases listed by the OIE: a review","volume":"14","author":"Lee","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.fsi.2026.111501_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2022.105545","article-title":"Shrimp bacterial and parasitic disease listed in the OIE: a review","volume":"166","author":"Yu","year":"2022","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.fsi.2026.111501_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.110059","article-title":"The benefits of astaxanthin-rich microalgal powder on growth, health, and disease resistance against Fusarium solani in Pacific white shrimp","volume":"156","author":"Eissa","year":"2025","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111501_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jip.2020.107369","article-title":"How do abiotic environmental conditions influence shrimp susceptibility to disease? A critical analysis focussed on white spot disease","volume":"186","author":"Millard","year":"2021","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.fsi.2026.111501_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2025.105361","article-title":"An integrated investigation of major environmental stressors on the Pacific white shrimp litopenaeus vannamei","volume":"166","author":"Han","year":"2025","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2026.111501_bib13","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jip.2016.11.006","article-title":"Potential of RNAi applications to control viral diseases of farmed shrimp","volume":"147","author":"Itsathitphaisarn","year":"2017","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.fsi.2026.111501_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.109347","article-title":"The evolutionary adaptation of shrimp hemocyanin subtypes and the consequences on their structure and functions","volume":"145","author":"Li","year":"2024","journal-title":"Fish Shellfish Immunol."},{"issue":"19","key":"10.1016\/j.fsi.2026.111501_bib15","doi-asserted-by":"crossref","first-page":"3592","DOI":"10.1002\/pmic.200700281","article-title":"Proteomic analysis of differentially expressed proteins in Penaeus vannamei hemocytes upon taura syndrome virus infection","volume":"7","author":"Chongsatja","year":"2007","journal-title":"Proteomics"},{"issue":"3","key":"10.1016\/j.fsi.2026.111501_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/md21030164","article-title":"Modulation of SREBP expression and fatty acid levels by bacteria-induced ER stress is mediated by hemocyanin in penaeid shrimp","volume":"21","author":"Huang","year":"2023","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.fsi.2026.111501_bib17","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.dci.2017.10.015","article-title":"Trypsin of litopenaeus vannamei is required for the generation of hemocyanin-derived peptides","volume":"79","author":"Li","year":"2018","journal-title":"Dev. Comp. Immunol."},{"issue":"12","key":"10.1016\/j.fsi.2026.111501_bib18","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.4049\/jimmunol.2400493","article-title":"Ubiquitination of hemocyanin mediated by a mitochondrial E3 ubiquitin ligase regulates immune response in Penaeus vannamei","volume":"213","author":"Zhang","year":"2024","journal-title":"J. Immunol."},{"issue":"9","key":"10.1016\/j.fsi.2026.111501_bib19","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.4049\/jimmunol.2200598","article-title":"Dephosphorylation of T517 on hemocyanin is required for antibacterial activity in Penaeus vannamei","volume":"210","author":"Feng","year":"2023","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.fsi.2026.111501_bib20","doi-asserted-by":"crossref","first-page":"476","DOI":"10.4049\/jimmunol.2200078","article-title":"Deacetylation of K481 and K484 on penaeid shrimp hemocyanin is critical for antibacterial activity","volume":"209","author":"Nie","year":"2022","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.fsi.2026.111501_bib21","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.4049\/jimmunol.2100746","article-title":"The microbial composition of penaeid shrimps' hepatopancreas is modulated by hemocyanin","volume":"207","author":"Zheng","year":"2021","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2026.111501_bib22","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"1","key":"10.1016\/j.fsi.2026.111501_bib23","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/s41598-018-19213-4","article-title":"The ferroptosis inducer erastin irreversibly inhibits system xc\u2212 and synergizes with cisplatin to increase cisplatin's cytotoxicity in cancer cells","volume":"8","author":"Sato","year":"2018","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.fsi.2026.111501_bib24","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.7150\/ijbs.77979","article-title":"Timosaponin AIII promotes non-small-cell lung cancer ferroptosis through targeting and facilitating HSP90 mediated GPX4 ubiquitination and degradation","volume":"19","author":"Zhou","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.fsi.2026.111501_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2020.103875","article-title":"Structure, gene expression, and putative functions of crustacean heat shock proteins in innate immunity","volume":"115","author":"Junprung","year":"2021","journal-title":"Dev. Comp. Immunol."},{"issue":"9","key":"10.1016\/j.fsi.2026.111501_bib26","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.2174\/1381612053507585","article-title":"Hsp 90 inhibitor geldanamycin and its derivatives as novel cancer chemotherapeutic agents","volume":"11","author":"Miyata","year":"2005","journal-title":"Curr. Pharm. Des."},{"issue":"4","key":"10.1016\/j.fsi.2026.111501_bib27","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111501_bib28","doi-asserted-by":"crossref","DOI":"10.1111\/raq.12976","article-title":"Cell death in crustacean immune defense","volume":"17","author":"Chen","year":"2024","journal-title":"Rev. Aquacult."},{"key":"10.1016\/j.fsi.2026.111501_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.772091","article-title":"Protein diversity and immune specificity of hemocyanin from shrimp litopenaeus vannamei","volume":"12","author":"Zhao","year":"2021","journal-title":"Front. Immunol."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826004055?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826004055?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T02:05:01Z","timestamp":1785895501000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464826004055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":29,"alternative-id":["S1050464826004055"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111501","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hemocyanin modulates ferroptosis through a HSP90-dependent antioxidant function in shrimp","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111501","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111501"}}