{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:43:09Z","timestamp":1786120989239,"version":"build-2736575974"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.fsi.2026.111568","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:29:36Z","timestamp":1783034976000},"page":"111568","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Cyprinid herpesvirus 3 ORF24 facilitates viral replication via RLR signaling pathway-mediated innate immune evasion"],"prefix":"10.1016","volume":"177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4722-0552","authenticated-orcid":false,"given":"Chi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqian","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2019-7798","authenticated-orcid":false,"given":"Xianqin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9956-3879","authenticated-orcid":false,"given":"Yong-An","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.fsi.2026.111568_bib1","first-page":"783","article-title":"Cyprinid herpesvirus 3 (Cyhv-3), koi herpesvirus (Khv) disease and their current status in Iran","volume":"23","author":"Bavarsad","year":"2024","journal-title":"A Review"},{"issue":"1","key":"10.1016\/j.fsi.2026.111568_bib2","first-page":"44","article-title":"A herpesvirus associated with mass mortality of juvenile and adult koi","volume":"12","author":"H","year":"2000","journal-title":"a Strain of Common Carp"},{"key":"10.1016\/j.fsi.2026.111568_bib3","author":"Molla"},{"issue":"7164","key":"10.1016\/j.fsi.2026.111568_bib4","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/nature06246","article-title":"Recognition of microorganisms and activation of the immune response","volume":"449","author":"Medzhitov","year":"2007","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.fsi.2026.111568_bib5","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/ni.3123","article-title":"Control of adaptive immunity by the innate immune system","volume":"16","author":"Iwasaki","year":"2015","journal-title":"Nature. Immunol."},{"key":"10.1016\/j.fsi.2026.111568_bib6","author":"Zhu"},{"issue":"2","key":"10.1016\/j.fsi.2026.111568_bib7","first-page":"840","article-title":"Nlrc3 attenuates antiviral innate immune response by targeting Irf7 in grass carp","volume":"26","author":"Zhang","year":"2025","journal-title":"(Ctenopharyngodon Idelus)"},{"issue":"3","key":"10.1016\/j.fsi.2026.111568_bib8","first-page":"107","article-title":"Cyprinid herpesvirus 2 Orf41 protein degrades pyruvate dehydrogenase (Pdh)-E1\u03b2 to promote viral replication in gibel carp brain (gicb)","volume":"10","author":"Xue","year":"2025","journal-title":"Cells"},{"issue":"12","key":"10.1016\/j.fsi.2026.111568_bib9","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.dci.2011.07.001","article-title":"Teleost fish interferons and their role in immunity","volume":"35","author":"Zou","year":"2011","journal-title":"Dev. Comp. Immunol."},{"issue":"10","key":"10.1016\/j.fsi.2026.111568_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2022.103161","article-title":"Friend or foe: rig- I like receptors and diseases","volume":"21","author":"Song","year":"2022","journal-title":"Autoimmun Rev."},{"issue":"1","key":"10.1016\/j.fsi.2026.111568_bib11","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/s00018-025-05864-w","article-title":"Regulation of antiviral and antimicrobial innate immunity and immune evasion","volume":"82","author":"Wang","year":"2025","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.fsi.2026.111568_bib12","first-page":"155","article-title":"Herpesviruses: overview of systematics","volume":"22","author":"Dotto-Maurel","year":"2025","journal-title":"Genomic Complexity and Life Cycle"},{"key":"10.1016\/j.fsi.2026.111568_bib13","article-title":"Viral oncogenes","volume":"13","author":"Ye","year":"2023","journal-title":"Viruses, and Cancer: A Third-Generation Sequencing Perspective on Viral Integration into the Human Genome"},{"issue":"5","key":"10.1016\/j.fsi.2026.111568_bib14","first-page":"657","article-title":"Attempts to detect virus-specific DNA in human tumors. Ii","volume":"13","author":"Hausen","year":"1974","journal-title":"Nucleic Acid Hybridizations with Complementary Rna of Human Herpes Group Viruses"},{"issue":"40","key":"10.1016\/j.fsi.2026.111568_bib15","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adi6586","article-title":"Human cytomegalovirus Ul36 inhibits Irf3-Dependent immune signaling to counterbalance its immunoenhancement as apoptotic inhibitor","volume":"9","author":"Ren","year":"2023","journal-title":"Sci Adv."},{"key":"10.1016\/j.fsi.2026.111568_bib16","author":"Lu"},{"issue":"8","key":"10.1016\/j.fsi.2026.111568_bib17","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1080\/15548627.2025.2479671","article-title":"The alpha-coronavirus E protein inhibits the jak-stat pathway signaling by triggering Stat2 degradation through Optn- and Nbr1-Mediated selective","volume":"21","author":"Huang","year":"2024","journal-title":"Autophagy"},{"key":"10.1016\/j.fsi.2026.111568_bib18","unstructured":"(!!! INVALID CITATION !!! [13]) ."},{"key":"10.1016\/j.fsi.2026.111568_bib19","author":"Xu"},{"key":"10.1016\/j.fsi.2026.111568_bib20","author":"Wang"},{"issue":"6","key":"10.1016\/j.fsi.2026.111568_bib21","first-page":"679","article-title":"Disease ecology and host range of cyprinid herpesvirus 3 (Cyhv-3) in Cyhv-3 endemic Lakes of","volume":"46","author":"Tolo","year":"2023","journal-title":"North America"},{"key":"10.1016\/j.fsi.2026.111568_bib22","author":"Gui"},{"key":"10.1016\/j.fsi.2026.111568_bib23","author":"Shpiler"},{"key":"10.1016\/j.fsi.2026.111568_bib24","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jviromet.2015.02.021","article-title":"Rapid detection of cyprinid Herpesvirus-3 (Cyhv-3) using a gold nanoparticle-based hybridization assay","volume":"217","author":"Saleh","year":"2015","journal-title":"J Virol Methods."},{"issue":"3","key":"10.1016\/j.fsi.2026.111568_bib25","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.fsi.2019.03.048","article-title":"Molecular characterization of cyprinid herpesvirus 3 encoded viral Interleukin10","volume":"89","author":"Ouyang","year":"2019","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111568_bib26","series-title":"Comparison the Function of Cyprinid Herpesvirus 3 Encoded Two Viral Tumor Necrosis Factor Receptors[M]","author":"Zhou","year":"2021"},{"key":"10.1016\/j.fsi.2026.111568_bib27","author":"Wang"},{"issue":"6","key":"10.1016\/j.fsi.2026.111568_bib28","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1002\/cbin.11565","article-title":"Host\u2013virus interaction and viral evasion","volume":"45","author":"Strumillo","year":"2021","journal-title":"Cell. Biol. Int."},{"key":"10.1016\/j.fsi.2026.111568_bib29","article-title":"Advances in the evasion of innate immunity by fish viruses","volume":"579","author":"Liu","year":"2024","journal-title":"A Glance at Rlrs and Cgas-Sting Signaling Pathways"},{"key":"10.1016\/j.fsi.2026.111568_bib30","article-title":"Cyprinid herpesvirus 2 (Cyhv-2","volume":"vol. 163","author":"Cui","year":"2025"},{"key":"10.1016\/j.fsi.2026.111568_bib31","author":"Zhou"},{"issue":"4","key":"10.1016\/j.fsi.2026.111568_bib32","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s12250-020-00330-2","article-title":"Herpesviruses and the type iii interferon system","volume":"36","author":"Yin","year":"2021","journal-title":"Virol. Sin"},{"issue":"16","key":"10.1016\/j.fsi.2026.111568_bib33","doi-asserted-by":"crossref","first-page":"8383","DOI":"10.1128\/JVI.00468-15","article-title":"Herpes simplex virus 1 reactivates from autonomic ciliary ganglia independently from sensory trigeminal ganglia to cause recurrent ocular disease","volume":"89","author":"Lee","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.fsi.2026.111568_bib34","author":"Wang"},{"key":"10.1016\/j.fsi.2026.111568_bib35","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/bs.aivir.2015.03.001","article-title":"Cyprinid herpesvirus 3: an archetype of fish alloherpesviruses","author":"Boutier","year":"2015","journal-title":"Adv. Virus Res."},{"issue":"10","key":"10.1016\/j.fsi.2026.111568_bib36","first-page":"1918","article-title":"Microrna Mir-722 inhibits cyprinid herpesvirus 3 replication via targeting the viral immune evasion protein Orf89","volume":"209","author":"Zhang","year":"2022","journal-title":"Which Negatively Regulates Ifn by Degrading Irf3"},{"issue":"5","key":"10.1016\/j.fsi.2026.111568_bib37","first-page":"1223","article-title":"Molecular characterization of cyprinid herpesvirus 3 (Cyhv-3) major capsid protein (Mcp) and its impact on immune gene expression in vitro","volume":"24","author":"Li","year":"2025","journal-title":"Commun. Collect"},{"issue":"1","key":"10.1016\/j.fsi.2026.111568_bib38","first-page":"53","article-title":"The Il-10 homologue encoded by cyprinid herpesvirus 3 is essential neither for viral replication in vitro nor for","volume":"44","author":"Ouyang","year":"2013","journal-title":"Virulence in Vivo"},{"issue":"6","key":"10.1016\/j.fsi.2026.111568_bib39","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00705-024-06045-z","article-title":"Characterization of the ictalurid herpesvirus 1 immediate-early gene Orf24 and its potential role in transcriptional regulation in yeast","volume":"169","author":"Xu","year":"2024","journal-title":"Arch. Virol."},{"issue":"11","key":"10.1016\/j.fsi.2026.111568_bib40","doi-asserted-by":"crossref","first-page":"6148","DOI":"10.1128\/JVI.00272-15","article-title":"Association of kaposi's sarcoma-associated herpesvirus Orf31 with Orf34 and Orf24 is critical for late gene expression","volume":"89","author":"Brulois","year":"2015","journal-title":"J. Virol."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826004729?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826004729?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T02:18:52Z","timestamp":1786069132000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464826004729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":40,"alternative-id":["S1050464826004729"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111568","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cyprinid herpesvirus 3 ORF24 facilitates viral replication via RLR signaling pathway-mediated innate immune evasion","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111568","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111568"}}