{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:49:09Z","timestamp":1786121349591,"version":"build-2736575974"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32560901"],"award-info":[{"award-number":["32560901"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Jiangxi Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["20252BAC240707"],"award-info":[{"award-number":["20252BAC240707"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Jiangxi Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["20242BAB20319"],"award-info":[{"award-number":["20242BAB20319"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.fsi.2026.111608","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T15:09:33Z","timestamp":1784732973000},"page":"111608","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Zebrafish RNF128a positively regulates innate immunity by promoting the K63-linked ubiquitination of TBK1"],"prefix":"10.1016","volume":"177","author":[{"given":"Zeyin","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2987-9453","authenticated-orcid":false,"given":"Chengyu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.fsi.2026.111608_bib1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.immuni.2024.03.007","article-title":"The conceptual foundations of innate immunity: taking stock 30 years later","volume":"57","author":"Pradeu","year":"2024","journal-title":"Immunity"},{"issue":"13","key":"10.1016\/j.fsi.2026.111608_bib2","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1016\/j.molcel.2024.06.004","article-title":"Phase separation as a new form of regulation in innate immunity","volume":"84","author":"Wang","year":"2024","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.fsi.2026.111608_bib3","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/s41392-023-01543-z","article-title":"Extracellular RNAs-TLR3 signaling contributes to cognitive impairment after chronic neuropathic pain in mice","volume":"8","author":"Zhang","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"3","key":"10.1016\/j.fsi.2026.111608_bib4","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/s41423-020-00602-7","article-title":"Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors","volume":"18","author":"Onomoto","year":"2021","journal-title":"Cell. Mol. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111608_bib5","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41584-023-01054-9","article-title":"Anti-MDA5 antibody-positive dermatomyositis: pathogenesis and clinical progress","volume":"20","author":"Lu","year":"2024","journal-title":"Nat. Rev. Rheumatol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111608_bib6","doi-asserted-by":"crossref","first-page":"5246","DOI":"10.1038\/s41467-023-40952-0","article-title":"DNAJA2 deficiency activates cGAS-STING pathway via the induction of aberrant mitosis and chromosome instability","volume":"14","author":"Huang","year":"2023","journal-title":"Nat. Commun."},{"issue":"21","key":"10.1016\/j.fsi.2026.111608_bib7","doi-asserted-by":"crossref","first-page":"12765","DOI":"10.1128\/JVI.02037-14","article-title":"Lysine 63-linked TANK-binding kinase 1 ubiquitination by mindbomb E3 ubiquitin protein ligase 2 is mediated by the mitochondrial antiviral signaling protein","volume":"88","author":"Ye","year":"2014","journal-title":"J. Virol."},{"issue":"7","key":"10.1016\/j.fsi.2026.111608_bib8","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/abbs\/gmaa051","article-title":"TBK1, a central kinase in innate immune sensing of nucleic acids and beyond","volume":"52","author":"Zhou","year":"2020","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"issue":"12","key":"10.1016\/j.fsi.2026.111608_bib9","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1038\/s41556-018-0229-6","article-title":"TBK1 and IKK\u03b5 prevent TNF-induced cell death by RIPK1 phosphorylation","volume":"20","author":"Lafont","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.fsi.2026.111608_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.virol.2025.110574","article-title":"IFIT3 inhibits transmissible gastroenteritis virus (TGEV) infection by promoting the phosphorylation of TBK1 and STAT1, which enhances the innate immune response","volume":"609","author":"Chen","year":"2025","journal-title":"Virology"},{"issue":"19","key":"10.1016\/j.fsi.2026.111608_bib11","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01118-18","article-title":"Phosphatase Cdc25A negatively regulates the antiviral immune response by inhibiting TBK1 activity","volume":"92","author":"Qi","year":"2018","journal-title":"J. Virol."},{"issue":"4","key":"10.1016\/j.fsi.2026.111608_bib12","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s13238-020-00751-5","article-title":"Histone deacetylase 3 promotes innate antiviral immunity through deacetylation of TBK1","volume":"12","author":"Tang","year":"2021","journal-title":"Protein Cell"},{"issue":"1","key":"10.1016\/j.fsi.2026.111608_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-65081-8","article-title":"Palmitoylation of TBK1 enhances the type I interferon signaling and strengthens anti-malarial immunity in mice","volume":"16","author":"Han","year":"2025","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.fsi.2026.111608_bib14","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.bbamcr.2014.10.008","article-title":"SUMO modification of TBK1 at the adaptor-binding C-terminal coiled-coil domain contributes to its antiviral activity","volume":"1853","author":"Saul","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"10.1016\/j.fsi.2026.111608_bib15","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.immuni.2011.06.014","article-title":"Mapping a dynamic innate immunity protein interaction network regulating type I interferon production","volume":"35","author":"Li","year":"2011","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.fsi.2026.111608_bib16","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/ni.1742","article-title":"The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon","volume":"10","author":"Wang","year":"2009","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2026.111608_bib17","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/ni.2239","article-title":"NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4","volume":"13","author":"Cui","year":"2012","journal-title":"Nat. Immunol."},{"issue":"10","key":"10.1016\/j.fsi.2026.111608_bib18","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1084\/jem.20120024","article-title":"TRAF-interacting protein (TRIP) negatively regulates IFN-\u03b2 production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1","volume":"209","author":"Zhang","year":"2012","journal-title":"J. Exp. Med."},{"issue":"4","key":"10.1016\/j.fsi.2026.111608_bib19","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S1074-7613(03)00084-0","article-title":"GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells","volume":"18","author":"Anandasabapathy","year":"2003","journal-title":"Immunity"},{"issue":"39","key":"10.1016\/j.fsi.2026.111608_bib20","doi-asserted-by":"crossref","first-page":"16770","DOI":"10.1073\/pnas.0908957106","article-title":"E3 ubiquitin ligase GRAIL controls primary T cell activation and oral tolerance","volume":"106","author":"Kriegel","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.fsi.2026.111608_bib21","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1038\/s41467-025-57404-6","article-title":"E3 ubiquitin ligase RNF128 promotes Lys63-linked polyubiquitination on SRB1 in macrophages and aggravates atherosclerosis","volume":"16","author":"Liu","year":"2025","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.fsi.2026.111608_bib22","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/s41420-025-02488-8","article-title":"RNF128 promotes gastric cancer progression by inhibiting autophagy-dependent ferroptosis through Beclin1 ubiquitination","volume":"11","author":"Zhu","year":"2025","journal-title":"Cell Death Discov."},{"issue":"12","key":"10.1016\/j.fsi.2026.111608_bib23","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1038\/ni.3588","article-title":"E3 ubiquitin ligase RNF128 promotes innate antiviral immunity through K63-linked ubiquitination of TBK1","volume":"17","author":"Song","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.fsi.2026.111608_bib24","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/j.ijbiomac.2020.07.293","article-title":"Structure of fish Toll-like receptors (TLR) and NOD-like receptors (NLR)","volume":"161","author":"Sahoo","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"issue":"24","key":"10.1016\/j.fsi.2026.111608_bib25","doi-asserted-by":"crossref","first-page":"4904","DOI":"10.1016\/j.jmb.2013.09.033","article-title":"The antiviral innate immune response in fish: evolution and conservation of the IFN system","volume":"425","author":"Langevin","year":"2013","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.fsi.2026.111608_bib26","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.98357","article-title":"Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response","volume":"13","author":"Lu","year":"2026","journal-title":"eLife"},{"issue":"1","key":"10.1016\/j.fsi.2026.111608_bib27","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01792-22","article-title":"Cytokine receptor-like factor 3 negatively regulates antiviral immunity by promoting the degradation of TBK1 in teleost fish","volume":"97","author":"Yan","year":"2023","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111608_bib28","doi-asserted-by":"crossref","first-page":"559","DOI":"10.4049\/jimmunol.1801325","article-title":"Zebrafish MVP recruits and degrades TBK1 to suppress IFN production","volume":"202","author":"Li","year":"2019","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2026.111608_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.109023","article-title":"Grass carp (Ctenopharyngodon idella) Mex3B positively regulates innate immunity by promoting the K63-linked ubiquitination of TLR3","volume":"141","author":"Hu","year":"2023","journal-title":"Fish Shellfish Immunol."},{"issue":"44","key":"10.1016\/j.fsi.2026.111608_bib30","article-title":"Accurate site-specific folding via conditional diffusion based on Alphafold3","volume":"122","author":"Tang","year":"2025","journal-title":"bioRxiv"},{"issue":"1","key":"10.1016\/j.fsi.2026.111608_bib31","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/bioinformatics\/19.1.163","article-title":"ConSurf: identification of functional regions in proteins by surface-mapping of phylogenetic information","volume":"19","author":"Glaser","year":"2003","journal-title":"Bioinformatics"},{"issue":"W1","key":"10.1016\/j.fsi.2026.111608_bib32","doi-asserted-by":"crossref","first-page":"W159","DOI":"10.1093\/nar\/gkac394","article-title":"CB-Dock2: improved protein-ligand blind docking by integrating cavity detection, docking and homologous template fitting","volume":"50","author":"Liu","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"10","key":"10.1016\/j.fsi.2026.111608_bib33","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1110\/ps.9.10.1930","article-title":"The PA domain: a protease-associated domain","volume":"9","author":"Mahon","year":"2000","journal-title":"Protein Sci."},{"issue":"32","key":"10.1016\/j.fsi.2026.111608_bib34","article-title":"E3 ubiquitin ligase RNF13 suppresses TLR Lysosomal degradation by promoting LAMP-1 proteasomal degradation","volume":"11","author":"Liu","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"16","key":"10.1016\/j.fsi.2026.111608_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25168664","article-title":"Post-translational variants of major proteins in amyotrophic lateral sclerosis provide new insights into the pathophysiology of the disease","volume":"25","author":"Bedja-Iacona","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"7237","key":"10.1016\/j.fsi.2026.111608_bib36","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/nature07959","article-title":"Ubiquitylation in innate and adaptive immunity","volume":"458","author":"Bhoj","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2026.111608_bib37","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev.biochem.78.101807.093809","article-title":"RING domain E3 ubiquitin ligases","volume":"78","author":"Deshaies","year":"2009","journal-title":"Annu. Rev. Biochem."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826005127?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826005127?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T04:32:34Z","timestamp":1786077154000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464826005127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":37,"alternative-id":["S1050464826005127"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111608","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zebrafish RNF128a positively regulates innate immunity by promoting the K63-linked ubiquitination of TBK1","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111608","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111608"}}