{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T22:16:12Z","timestamp":1788300972823,"version":"build-2803163510"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515012924"],"award-info":[{"award-number":["2023A1515012924"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515010962"],"award-info":[{"award-number":["2021A1515010962"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.fsi.2026.111637","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T15:12:48Z","timestamp":1786201968000},"page":"111637","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["PmFREP1 exhibits antibacterial activity and bacterial agglutination in Pinctada fucata martensii"],"prefix":"10.1016","volume":"178","author":[{"given":"Qiyuan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanjie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1635-2892","authenticated-orcid":false,"given":"Junqin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lining","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiling","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2026.111637_bib1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ympev.2009.09.019","article-title":"The long way to diversity: phylogeny and evolution of the heterobranchia (Mollusca: astropoda)","volume":"55","author":"Dinapoli","year":"2010","journal-title":"Mol. Phylogenet. Evol."},{"key":"10.1016\/j.fsi.2026.111637_bib2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF02338828","article-title":"Phylogenetic relationships of annelids, molluscs, and arthropods evidenced from molecules and morphology","volume":"43","author":"Kim","year":"1996","journal-title":"J. Mol. Evol."},{"key":"10.1016\/j.fsi.2026.111637_bib3","doi-asserted-by":"crossref","first-page":"R510","DOI":"10.1016\/j.cub.2012.05.039","article-title":"Molluscs","volume":"22","author":"Haszprunar","year":"2012","journal-title":"Curr. Biol."},{"key":"10.1016\/j.fsi.2026.111637_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fendo.2022.792589","article-title":"Physiological roles of serotonin in bivalves: possible interference by environmental chemicals resulting in neuroendocrine disruption","volume":"13","author":"Canesi","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.fsi.2026.111637_bib5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1146\/annurev-ecolsys-110617-062703","article-title":"Bivalve impacts in freshwater and marine ecosystems","volume":"49","author":"Vaughn","year":"2018","journal-title":"Annu. Rev. Ecol. Evol. Syst."},{"key":"10.1016\/j.fsi.2026.111637_bib6","article-title":"The occurrence and prevention and control strategies of mollusc diseases in marine aquaculture of China","volume":"47","author":"Song","year":"2023","journal-title":"J. Fish. China"},{"key":"10.1016\/j.fsi.2026.111637_bib7","first-page":"1","article-title":"An early warning system for diseases during mollusc mariculture: exploration and utilization","volume":"35","author":"Song","year":"2020","journal-title":"J. Dalian Ocean Univ."},{"key":"10.1016\/j.fsi.2026.111637_bib8","doi-asserted-by":"crossref","first-page":"616","DOI":"10.3389\/fimmu.2020.00616","article-title":"A signaling pathway to mediate the combined immunomodulation of acetylcholine and enkephalin in oyster Crassostrea gigas","volume":"11","author":"Liu","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2026.111637_bib9","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3390\/ijms19030721","article-title":"Pathogen-derived carbohydrate recognition in molluscs immune defense","volume":"19","author":"Wang","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fsi.2026.111637_bib10","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1126\/science.1068883","article-title":"Decoding the patterns of self and nonself by the innate immune system","volume":"296","author":"Medzhitov","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.fsi.2026.111637_bib11","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nature06617","article-title":"The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans","volume":"451","author":"King","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2026.111637_bib12","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1002\/pro.2177","article-title":"Correlating structure and function during the evolution of fibrinogen-related domains","volume":"21","author":"Doolittle","year":"2012","journal-title":"Protein Sci."},{"key":"10.1016\/j.fsi.2026.111637_bib13","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.fsi.2008.07.019","article-title":"A fibrinogen-related protein from bay scallop Argopecten irradians involved in innate immunity as pattern recognition receptor","volume":"26","author":"Zhang","year":"2009","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111637_bib14","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.fsi.2012.08.008","article-title":"Pattern recognition receptors acting in innate immune system of shrimp against pathogen infections","volume":"34","author":"Wang","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111637_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2025.110204","article-title":"Evolutionary and functional insights into fibrinogen-related protein (FREP) dynamics in sea cucumbers","volume":"160","author":"Li","year":"2025","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111637_bib16","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.fsi.2021.10.041","article-title":"Identification and diversity of fibrinogen-related protein (FREP) gene family in haliotis discus hannai, H. rufescens, and H. laevigata and their responses to Vibrio parahaemolyticus infection","volume":"119","author":"Zou","year":"2021","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111637_bib17","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.dci.2009.12.007","article-title":"In search of the origin of FREPs: characterization of Aplysia californica fibrinogen-related proteins","volume":"34","author":"Gorbushin","year":"2010","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2026.111637_bib18","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.gene.2004.07.003","article-title":"Representation of an immune responsive gene family encoding fibrinogen-related proteins in the freshwater mollusc Biomphalaria glabrata, an intermediate host for Schistosoma mansoni","volume":"341","author":"Zhang","year":"2004","journal-title":"Gene"},{"key":"10.1016\/j.fsi.2026.111637_bib19","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.fsi.2016.05.017","article-title":"Characterization of the gene encoding a fibrinogen-related protein expressed in Crassostrea gigas hemocytes","volume":"54","author":"Skazina","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111637_bib20","doi-asserted-by":"crossref","first-page":"36739","DOI":"10.1074\/jbc.M111.245944","article-title":"Functional characterization of a ficolin-mediated complement pathway in amphioxus","volume":"286","author":"Huang","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fsi.2026.111637_bib21","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0145-305X(99)00020-8","article-title":"C-type lectins and galectins mediate innate and adaptive immune functions: their roles in the complement activation pathway","volume":"23","author":"Vasta","year":"1999","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2026.111637_bib22","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/3205072","article-title":"Ficolins and the recognition of pathogenic microorganisms: an overview of the innate immune response and contribution of single nucleotide polymorphisms","volume":"2019","author":"Bidula","year":"2019","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.fsi.2026.111637_bib23","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.fsi.2014.08.006","article-title":"Characteristic and functional analysis of a ficolin-like protein from the oyster Crassostrea hongkongensis","volume":"40","author":"Xiang","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111637_bib24","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.fsi.2014.03.025","article-title":"A new fibrinogen-related protein from Argopecten irradians (AiFREP-2) with broad recognition spectrum and bacteria agglutination activity","volume":"38","author":"Yang","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111637_bib25","doi-asserted-by":"crossref","first-page":"3312","DOI":"10.1007\/s11434-012-5155-6","article-title":"Sequence variability of fibrinogen-related proteins (FREPs) in Crassostrea gigas","volume":"57","author":"Zhang","year":"2012","journal-title":"Chin. Sci. Bull."},{"key":"10.1016\/j.fsi.2026.111637_bib26","doi-asserted-by":"crossref","first-page":"8691","DOI":"10.1073\/pnas.94.16.8691","article-title":"A family of fibrinogen-related proteins that precipitates parasite-derived molecules is produced by an invertebrate after infection","volume":"94","author":"Adema","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.fsi.2026.111637_bib27","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.fsi.2018.05.007","article-title":"A fibrinogen-related protein, LvFREP2, from Litopenaeus vannamei facilitates the clearance of Vibrio harveyi","volume":"78","author":"Tian","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111637_bib28","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.dci.2010.10.007","article-title":"Individual sequence variability and functional activities of fibrinogen-related proteins (FREPs) in the Mediterranean mussel (Mytilus galloprovincialis) suggest ancient and complex immune recognition models in invertebrates","volume":"35","author":"Romero","year":"2011","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2026.111637_bib29","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.fsi.2021.04.022","article-title":"A fibrinogen-related protein mediates the recognition of various bacteria and haemocyte phagocytosis in oyster Crassostrea gigas","volume":"114","author":"Yang","year":"2021","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111637_bib30","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.fsi.2014.05.005","article-title":"A fibrinogen-related protein (FREP) is involved in the antibacterial immunity of Marsupenaeus japonicus","volume":"39","author":"Sun","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111637_bib31","first-page":"111","article-title":"Fibrinogen-related proteins (FREPs) in mollusks, results probl","volume":"57","author":"Adema","year":"2015","journal-title":"Cell Differ."},{"key":"10.1016\/j.fsi.2026.111637_bib32","first-page":"99","article-title":"Progress in fibrinogen-related proteins of invertebrates","volume":"23","author":"Liu","year":"2011","journal-title":"Chin. J. Schistosomiasis Control."},{"key":"10.1016\/j.fsi.2026.111637_bib33","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/1471-2164-6-114","article-title":"Identification and characterization of the fibrinogen-like domain of fibrinogen-related proteins in the mosquito, Anopheles gambiae, and the fruitfly, Drosophila melanogaster, genomes","volume":"6","author":"Wan","year":"2005","journal-title":"BMC Genom."},{"key":"10.1016\/j.fsi.2026.111637_bib34","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.1016\/j.molimm.2008.04.019","article-title":"Fibrinogen-related protein from amphioxus Branchiostoma belcheri is a multivalent pattern recognition receptor with a bacteriolytic activity","volume":"45","author":"Fan","year":"2008","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.fsi.2026.111637_bib35","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ijbiomac.2019.05.133","article-title":"A feedback loop involving FREP and NF-\u03baB regulates the immune response of sea cucumber Apostichopus japonicus","volume":"135","author":"Jiang","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.fsi.2026.111637_bib36","article-title":"Advances in Pinctada martensii","volume":"2","author":"Deng","year":"2009","journal-title":"Mod. Agric. Sci. Technol."},{"key":"10.1016\/j.fsi.2026.111637_bib37","first-page":"480","article-title":"Outbreaks of vibriosis in mariculture shellfish and its research progress","volume":"39","author":"Zhang","year":"2020","journal-title":"Mar. Environ. Sci."},{"key":"10.1016\/j.fsi.2026.111637_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.110079","article-title":"Expression and antimicrobial characterization of rhamnose-binding lectin in Pinctada fucata martensii","volume":"157","author":"Zhang","year":"2025","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111637_bib39","article-title":"Acetylation inhibition of key lysine residue enhances antibacterial activity of rhamnose-binding lectin in pearl oyster, Pinctada fucata martensii","volume":"41","author":"Chen","year":"2025","journal-title":"Aquac. Rep."},{"key":"10.1016\/j.fsi.2026.111637_bib40","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s11010-007-9603-6","article-title":"Production of active eukaryotic proteins through bacterial expression systems: a review of the existing biotechnology strategies","volume":"307","author":"Sahdev","year":"2008","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.fsi.2026.111637_bib41","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.fsi.2019.07.001","article-title":"A single-CRD C-type lectin (CgCLec-3) with novel DIN motif exhibits versatile immune functions in Crassostrea gigas","volume":"92","author":"Song","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111637_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1530732","article-title":"A C-type lectin HcLec1 with dual function of immunology and mineralization from the freshwater oyster (Hyriopsis cumingii Lea)","volume":"15","author":"Chen","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2026.111637_bib43","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.fsi.2022.10.007","article-title":"A fibrinogen-related lectin from Echinometra lucunter represents a new FReP family in echinodermata phylum","volume":"131","author":"Duarte","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111637_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109451","article-title":"Zebrafish ANGPT4, member of fibrinogen-related proteins, is an LTA-, LPS- and PGN-binding protein with a bacteriolytic activity","volume":"147","author":"Zhou","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111637_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2021.104075","article-title":"Two fibrinogen-related proteins (FREPs) in the razor clam (Sinonovacula constricta) with a broad recognition spectrum and bacteria agglutination activity","volume":"121","author":"Wu","year":"2021","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2026.111637_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2019.108672","article-title":"Molecular characterization and expression analysis of fibrinogen related protein (FREP) genes of manila clam (Ruditapes philippinarum) after lipopolysaccharides challenge","volume":"228","author":"Li","year":"2020","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.fsi.2026.111637_bib47","doi-asserted-by":"crossref","first-page":"21087","DOI":"10.1073\/pnas.1011242107","article-title":"Role for a somatically diversified lectin in resistance of an invertebrate to parasite infection","volume":"107","author":"Hanington","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.fsi.2026.111637_bib48","doi-asserted-by":"crossref","first-page":"13519","DOI":"10.1073\/pnas.201523798","article-title":"The 2.0-A crystal structure of tachylectin 5A provides evidence for the common origin of the innate immunity and the blood coagulation systems","volume":"98","author":"Kairies","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.fsi.2026.111637_bib49","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.imbio.2006.11.014","article-title":"Role of ficolin in innate immunity and its molecular basis","volume":"212","author":"Endo","year":"2007","journal-title":"Immunobiology"},{"key":"10.1016\/j.fsi.2026.111637_bib50","doi-asserted-by":"crossref","first-page":"10086","DOI":"10.1073\/pnas.96.18.10086","article-title":"Horseshoe crab acetyl group-recognizing lectins involved in innate immunity are structurally related to fibrinogen","volume":"96","author":"Gokudan","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.fsi.2026.111637_bib51","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.dci.2014.01.009","article-title":"Cloning and characterization of two different ficolins from the giant freshwater prawn Macrobrachium rosenbergii","volume":"44","author":"Zhang","year":"2014","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2026.111637_bib52","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.fsi.2016.09.032","article-title":"Identification of 10 transcripts of FREP in penaeid shrimp Litopenaeus vannamei","volume":"58","author":"Hou","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111637_bib53","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1016\/j.molimm.2007.03.008","article-title":"Molecular cloning and characterization of a thioester-containing protein from zhikong scallop Chlamys farreri","volume":"44","author":"Zhang","year":"2007","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.fsi.2026.111637_bib54","doi-asserted-by":"crossref","DOI":"10.3389\/fmars.2023.1156831","article-title":"Secretory and transcriptomic responses of mantle cells to low pH in the Pacific oyster (Crassostrea gigas)","volume":"10","author":"Z\u00fa\u00f1iga-Soto","year":"2023","journal-title":"Front. Mar. Sci."},{"key":"10.1016\/j.fsi.2026.111637_bib55","article-title":"Transcriptome and biomineralization responses of the pearl oyster Pinctada fucata to elevated CO2 and temperature","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fsi.2026.111637_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108691","article-title":"Preliminary investigation of the immune activity of PmH2A-derived antimicrobial peptides from the pearl oyster Pinctada fucata martensii","volume":"135","author":"Shen","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111637_bib57","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.fsi.2020.12.012","article-title":"Characterization and functional analysis of fibrinogen-related protein (FreP) in the black tiger shrimp, Penaeus monodon","volume":"109","author":"Oangkhana","year":"2021","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111637_bib58","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1016\/j.csbj.2023.03.031","article-title":"Immune diversity in lophotrochozoans, with a focus on recognition and effector systems","volume":"21","author":"Li","year":"2023","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.fsi.2026.111637_bib59","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1046\/j.1469-7580.2002.00099.x","article-title":"Structure, function and evolution of the gas exchangers: comparative perspectives","volume":"201","author":"Maina","year":"2002","journal-title":"J. Anat."},{"key":"10.1016\/j.fsi.2026.111637_bib60","doi-asserted-by":"crossref","first-page":"911","DOI":"10.3389\/fimmu.2020.00911","article-title":"Transcriptomic evidence reveals the molecular basis for functional differentiation of hemocytes in a marine invertebrate, Crassostrea gigas","volume":"11","author":"Mao","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2026.111637_bib61","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2023.0065","article-title":"Cross-talk and mutual shaping between the immune system and the microbiota during an oyster's life","volume":"379","author":"Destoumieux-Garz\u00f3n","year":"2024","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"10.1016\/j.fsi.2026.111637_bib62","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3390\/md15060182","article-title":"Microbial diseases of bivalve mollusks: infections, immunology and antimicrobial defense","volume":"15","author":"Zannella","year":"2017","journal-title":"Mar. Drugs"}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826005413?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826005413?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T21:55:58Z","timestamp":1788299758000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464826005413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":62,"alternative-id":["S1050464826005413"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111637","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PmFREP1 exhibits antibacterial activity and bacterial agglutination in Pinctada fucata martensii","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111637","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111637"}}