{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T22:16:01Z","timestamp":1788300961561,"version":"build-2803163510"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2812102"],"award-info":[{"award-number":["2023YFC2812102"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.fsi.2026.111638","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:59:35Z","timestamp":1787241575000},"page":"111638","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Comparative transcriptomics of wild-type and LAAO-knockout zebrafish challenged with Streptococcus agalactiae"],"prefix":"10.1016","volume":"178","author":[{"given":"Wenxu","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.fsi.2026.111638_bib1","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jmb.2006.11.071","article-title":"The structure of a bacterial L-amino acid oxidase from Rhodococcus opacus gives new evidence for the hydride mechanism for dehydrogenation","volume":"367","author":"Faust","year":"2007","journal-title":"J. Mol. Biol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111638_bib2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1742-4658.2006.05570.x","article-title":"Identification of an antibacterial protein as L-amino acid oxidase in the skin mucus of rockfish Sebastes schlegelii","volume":"274","author":"Kitani","year":"2007","journal-title":"FEBS J."},{"issue":"1","key":"10.1016\/j.fsi.2026.111638_bib3","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S1532-0456(03)00174-1","article-title":"Purification and characterization of an antibacterial protein in the skin secretion of rockfish Sebastes schlegelii","volume":"136","author":"Nagashima","year":"2003","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111638_bib4","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.fsi.2010.01.006","article-title":"A novel protein isolated from the serum of rabbitfish (Siganus oramin) is lethal to Cryptocaryon irritans","volume":"29","author":"Wang","year":"2010","journal-title":"Fish Shellfish Immunol."},{"issue":"4\u20135","key":"10.1016\/j.fsi.2026.111638_bib5","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.fsi.2011.02.004","article-title":"The serum of rabbitfish (Siganus oramin) has antimicrobial activity to some pathogenic organisms and a novel serum L-amino acid oxidase is isolated","volume":"30","author":"Wang","year":"2011","journal-title":"Fish Shellfish Immunol."},{"issue":"3","key":"10.1016\/j.fsi.2026.111638_bib6","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/sj.cdd.4400811","article-title":"Apoptosis-inducing protein, AIP, from parasite-infected fish induces apoptosis in mammalian cells by two different molecular mechanisms","volume":"8","author":"Murakawa","year":"2001","journal-title":"Cell Death Differ."},{"issue":"11","key":"10.1016\/j.fsi.2026.111638_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142979","article-title":"IL4I1 is a novel regulator of M2 macrophage polarization that can inhibit T cell activation via L-tryptophan and arginine depletion and IL-10 production","volume":"10","author":"Yue","year":"2015","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.fsi.2026.111638_bib8","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1002\/eji.201445000","article-title":"The immunosuppressive enzyme IL4I1 promotes FoxP3+ regulatory T lymphocyte differentiation","volume":"45","author":"Cousin","year":"2015","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.fsi.2026.111638_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2021.104040","article-title":"Expression profile of the fish immune enzyme L-amino acid oxidase (LAAO) after Streptococcus agalactiae infection in zebrafish (Danio rerio)","volume":"119","author":"Huang","year":"2021","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2026.111638_bib10","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/623789","article-title":"Intraperitoneal exposure to nano\/microparticles of fullerene (C60) increases acetylcholinesterase activity and lipid peroxidation in adult zebrafish (Danio rerio) brain","author":"Dal Forno","year":"2013","journal-title":"Biomed Res. Int."},{"issue":"11","key":"10.1016\/j.fsi.2026.111638_bib11","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.3390\/cells9112367","article-title":"The role of PPARs in disease","volume":"9","author":"Wagner","year":"2020","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.fsi.2026.111638_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2021.166097","article-title":"PPARs in liver physiology","volume":"1867","author":"Berthier","year":"2021","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"issue":"6","key":"10.1016\/j.fsi.2026.111638_bib13","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.3390\/ijms18061126","article-title":"The peroxisome-mitochondria connection: how and why?","volume":"18","author":"Fransen","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.fsi.2026.111638_bib14","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1159\/000450912","article-title":"Regulation of liver energy balance by the nuclear receptors farnesoid X receptor and peroxisome proliferator activated receptor \u03b1","volume":"35","author":"Kim","year":"2017","journal-title":"Dig. Dis."},{"issue":"7","key":"10.1016\/j.fsi.2026.111638_bib15","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/gutjnl-2015-310798","article-title":"Liver PPAR\u03b1 is crucial for whole-body fatty acid homeostasis and is protective against NAFLD","volume":"65","author":"Montagner","year":"2016","journal-title":"Gut"},{"issue":"6294","key":"10.1016\/j.fsi.2026.111638_bib16","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/347645a0","article-title":"Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators","volume":"347","author":"Issemann","year":"1990","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.fsi.2026.111638_bib17","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1128\/IAI.00023-12","article-title":"Genome-wide mapping of cystitis due to Streptococcus agalactiae and Escherichia coli in mice identifies a unique bladder transcriptome that signifies pathogen-specific antimicrobial defense against urinary tract infection","volume":"80","author":"Tan","year":"2012","journal-title":"Infect. Immun."},{"issue":"10","key":"10.1016\/j.fsi.2026.111638_bib18","doi-asserted-by":"crossref","first-page":"5657","DOI":"10.1007\/s11033-013-2667-3","article-title":"Transcriptome profiling and digital gene expression analysis of Nile tilapia (Oreochromis niloticus) infected by Streptococcus agalactiae","volume":"40","author":"Zhang","year":"2013","journal-title":"Mol. Biol. Rep."},{"issue":"6904","key":"10.1016\/j.fsi.2026.111638_bib19","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature01036","article-title":"Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress","volume":"419","author":"Kops","year":"2002","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.fsi.2026.111638_bib20","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1093\/jmcb\/mjr013","article-title":"Applications of post-translational modifications of FoxO family proteins in biological functions","volume":"3","author":"Zhao","year":"2011","journal-title":"J. Mol. Cell Biol."},{"issue":"29","key":"10.1016\/j.fsi.2026.111638_bib21","doi-asserted-by":"crossref","first-page":"19881","DOI":"10.1074\/jbc.M600320200","article-title":"FOXO1 represses peroxisome proliferator-activated receptor-gamma1 and -gamma2 gene promoters in primary adipocytes: a novel paradigm to increase insulin sensitivity","volume":"281","author":"Armoni","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"46","key":"10.1016\/j.fsi.2026.111638_bib22","doi-asserted-by":"crossref","first-page":"45485","DOI":"10.1074\/jbc.M309069200","article-title":"Convergence of peroxisome proliferator-activated receptor gamma and Foxo1 signaling pathways","volume":"278","author":"Dowell","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.fsi.2026.111638_bib23","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41577-020-00478-8","article-title":"Redox regulation of immunometabolism","volume":"21","author":"Muri","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.fsi.2026.111638_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.694152","article-title":"Glutathione metabolism is a regulator of the acute inflammatory response of monocytes to (1\u21923)-\u03b2-D-glucan","volume":"12","author":"Ramendra","year":"2021","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.fsi.2026.111638_bib25","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/iub.1756","article-title":"The glutathione cycle: glutathione metabolism beyond the \u03b3-glutamyl cycle","volume":"70","author":"Bachhawat","year":"2018","journal-title":"IUBMB Life"},{"key":"10.1016\/j.fsi.2026.111638_bib26","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.fsi.2017.08.041","article-title":"Transcriptome analysis of hybrid tilapia (Oreochromis spp.) with Streptococcus agalactiae infection identifies toll-like receptor pathway-mediated induction of NADPH oxidase complex and piscidins as primary immune-related responses","volume":"70","author":"Ken","year":"2017","journal-title":"Fish Shellfish Immunol."},{"issue":"3","key":"10.1016\/j.fsi.2026.111638_bib27","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1017\/S0022029919000451","article-title":"Isolated perfused udder model for transcriptome analysis in response to Streptococcus agalactiae","volume":"86","author":"Weller","year":"2019","journal-title":"J. Dairy Res."},{"key":"10.1016\/j.fsi.2026.111638_bib28","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.fsi.2019.10.007","article-title":"Multiomics analyses reveal that NOD-like signaling pathway plays an important role against Streptococcus agalactiae in the spleen of tilapia","volume":"95","author":"Wu","year":"2019","journal-title":"Fish Shellfish Immunol."}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826005425?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826005425?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T21:54:04Z","timestamp":1788299644000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464826005425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":28,"alternative-id":["S1050464826005425"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111638","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative transcriptomics of wild-type and LAAO-knockout zebrafish challenged with Streptococcus agalactiae","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111638","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"111638"}}