{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T22:16:20Z","timestamp":1788300980802,"version":"build-2803163510"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012586","name":"Open Research Fund of State Key Laboratory of Bioelectronics","doi-asserted-by":"publisher","award":["2026SKLBC-KF01"],"award-info":[{"award-number":["2026SKLBC-KF01"]}],"id":[{"id":"10.13039\/501100012586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.fsi.2026.111656","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:43:14Z","timestamp":1786981394000},"page":"111656","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Identification and transcriptional analysis of eight C1q genes in Takifugu obscurus during bacterial infection"],"prefix":"10.1016","volume":"178","author":[{"given":"Hao","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding-Yi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Han","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2529-9064","authenticated-orcid":false,"given":"Ying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.fsi.2026.111656_bib1","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.3390\/ani13101572","article-title":"Transcriptomic analysis of Takifugu obscurus gills under acute hypoxic stress","volume":"13","author":"Zhang","year":"2023","journal-title":"Animals (Basel)."},{"issue":"3","key":"10.1016\/j.fsi.2026.111656_bib2","first-page":"200","article-title":"Evolutionary and functional relationships of B cells from fish and mammals: insights into their novel roles in phagocytosis and presentation of particulate antigen","volume":"12","author":"Sunyer","year":"2012","journal-title":"Infect. Disord.: Drug Targets"},{"issue":"2","key":"10.1016\/j.fsi.2026.111656_bib3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1574-695X.2007.00343.x","article-title":"A review on the interactions between gut microbiota and innate immunity of fish","volume":"52","author":"G\u00f3mez","year":"2008","journal-title":"FEMS Immunol. Med. Microbiol."},{"issue":"10","key":"10.1016\/j.fsi.2026.111656_bib4","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.it.2004.08.006","article-title":"C1q and tumor necrosis factor superfamily: modularity and versatility","volume":"25","author":"Kishore","year":"2004","journal-title":"Trends Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2026.111656_bib5","first-page":"405","article-title":"Arche de No\u00e9 immunologique: le syst\u00e8me immunitaire des poissons t\u00e9l\u00e9ost\u00e9ens [The immune system of teleost fish]","volume":"25","author":"Levraud","year":"2009","journal-title":"Med. Sci."},{"key":"10.1016\/j.fsi.2026.111656_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.918775","article-title":"Coagulation and complement: key innate defense participants in a seamless web","volume":"13","author":"Pryzdial","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2026.111656_bib7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1600-065X.1998.tb01251.x","article-title":"Evolution and diversity of the complement system of poikilothermic vertebrates","volume":"166","author":"Sunyer","year":"1998","journal-title":"Immunol. Rev."},{"issue":"4\u20135","key":"10.1016\/j.fsi.2026.111656_bib8","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.imbio.2006.11.009","article-title":"The phylogeny of the complement system and the origins of the classical pathway","volume":"212","author":"Dodds","year":"2007","journal-title":"Immunobiology"},{"key":"10.1016\/j.fsi.2026.111656_bib9","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/978-3-031-85340-1_7","article-title":"The complement system","volume":"1476","author":"Revel","year":"2025","journal-title":"Adv. Exp. Med. Biol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111656_bib10","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/imr.12472","article-title":"The \"ins and outs\" of complement-driven immune responses","volume":"274","author":"Freeley","year":"2016","journal-title":"Immunol. Rev."},{"issue":"1","key":"10.1016\/j.fsi.2026.111656_bib11","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.dci.2011.05.013","article-title":"Differential expression and intrachromosomal evolution of the sghC1q genes in zebrafish (Danio rerio)","volume":"36","author":"Carland","year":"2012","journal-title":"Dev. Comp. Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2026.111656_bib12","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.fsi.2007.01.019","article-title":"Extrahepatic synthesis of complement components in the rainbow trout (Oncorhynchus mykiss)","volume":"23","author":"L\u00f8voll","year":"2007","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111656_bib13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.fsi.2019.01.004","article-title":"A novel C1q domain containing protein in black rockfish (Sebastes schlegelii) serves as a pattern recognition receptor with immunoregulatory properties and possesses binding activity to heat-aggregated IgG","volume":"87","author":"Du","year":"2019","journal-title":"Fish Shellfish Immunol."},{"issue":"1\u20132","key":"10.1016\/j.fsi.2026.111656_bib14","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.vetimm.2008.05.004","article-title":"Molecular cloning of two C1q-like cDNAs in mandarin fish Siniperca chuatsi","volume":"125","author":"Lao","year":"2008","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.fsi.2026.111656_bib15","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.dci.2018.05.023","article-title":"The complement component 1 q (C1q) in Nile tilapia (Oreochromis niloticus): functional characterization in host defense against bacterial infection and effect on cytokine response in macrophages","volume":"87","author":"Chen","year":"2018","journal-title":"Dev. Comp. Immunol."},{"issue":"8","key":"10.1016\/j.fsi.2026.111656_bib16","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.1128\/IAI.66.8.3825-3831.1998","article-title":"Activation of the complement classical pathway (C1q binding) by mesophilic Aeromonas hydrophila outer membrane protein","volume":"66","author":"Merino","year":"1998","journal-title":"Infect. Immun."},{"issue":"37","key":"10.1016\/j.fsi.2026.111656_bib17","doi-asserted-by":"crossref","first-page":"28777","DOI":"10.1074\/jbc.M110.131318","article-title":"Characterization of C1q in teleosts: insight into the molecular and functional evolution of C1q family and classical pathway","volume":"285","author":"Hu","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"27","key":"10.1016\/j.fsi.2026.111656_bib18","doi-asserted-by":"crossref","first-page":"10127","DOI":"10.1073\/pnas.0402180101","article-title":"Origin of the classical complement pathway: Lamprey orthologue of mammalian C1q acts as a lectin","volume":"101","author":"Matsushita","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.fsi.2026.111656_bib19","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.dci.2011.01.018","article-title":"The C1q domain containing proteins of the Mediterranean mussel Mytilus galloprovincialis: a widespread and diverse family of immune-related molecules","volume":"35","author":"Gerdol","year":"2011","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2026.111656_bib20","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.fsi.2016.10.010","article-title":"Identification and function of a novel C1q domain-containing (C1qDC) protein in triangle-shell pearl mussel (Hyriopsis cumingii)","volume":"58","author":"Huang","year":"2016","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111656_bib21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/cmi.2008.2","article-title":"The classical and regulatory functions of C1q in immunity and autoimmunity","volume":"5","author":"Lu","year":"2008","journal-title":"Cell. Mol. Immunol."},{"issue":"1\u20133","key":"10.1016\/j.fsi.2026.111656_bib22","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s12026-015-8705-6","article-title":"Fundamental role of C1q in autoimmunity and inflammation","volume":"63","author":"Son","year":"2015","journal-title":"Immunol. Res."},{"issue":"Pt 1","key":"10.1016\/j.fsi.2026.111656_bib23","article-title":"Complement C1q is involved in the activation of membrane attack complexes, regulation of bacterial infectious inflammation, and apoptosis through overexpression in primary cells of silver pomfret (Pampus argenteus) in vitro","volume":"268","author":"Li","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"8","key":"10.1016\/j.fsi.2026.111656_bib24","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1111\/jfd.13374","article-title":"Toll protein family structure, evolution and response of the whiteleg shrimp (Litopenaeus vannamei) to exogenous iridescent virus","volume":"44","author":"Liu","year":"2021","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2026.111656_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2020.736192","article-title":"Characterization of five caspase genes and their transcriptional changes in response to exogenous iridescent virus challenge in the whiteleg shrimp (Litopenaeus vannamei)","volume":"534","author":"Guo","year":"2021","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2026.111656_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1481696","article-title":"Genome-wide characterization and comparative expression profiling of dual-specificity phosphatase genes in yellow catfish (Pelteobagrus fulvidraco) after infection with exogenous Aeromonas hydrophila","volume":"15","author":"Guo","year":"2024","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2026.111656_bib27","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"2","key":"10.1016\/j.fsi.2026.111656_bib28","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.imlet.2004.06.015","article-title":"Structural and functional anatomy of the globular domain of complement protein C1q","volume":"95","author":"Kishore","year":"2004","journal-title":"Immunol. Lett."},{"issue":"2","key":"10.1016\/j.fsi.2026.111656_bib29","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1177\/1753425910396252","article-title":"Complement and non-complement activating functions of C1q: a prototypical innate immune molecule","volume":"18","author":"Nayak","year":"2012","journal-title":"Innate Immun."},{"issue":"44","key":"10.1016\/j.fsi.2026.111656_bib30","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2406192121","article-title":"Complement activation by IgG subclasses is governed by their ability to oligomerize upon antigen binding","volume":"121","author":"Frischauf","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.fsi.2026.111656_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2020.736313","article-title":"Identification and immune functional analysis of a novel C1q domain-containing protein in Yellow River carp (Cyprinus carpio L.)","volume":"534","author":"Zhu","year":"2021","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2026.111656_bib32","article-title":"Characterization and functional analysis of a novel C1q domain-containing protein from grass carp (Ctenopharyngodon idella) in response to bacterial challenge","volume":"35","author":"Zhang","year":"2024","journal-title":"Aquac. Rep."},{"issue":"1","key":"10.1016\/j.fsi.2026.111656_bib33","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/1749-4877.12100","article-title":"Functional C1q is present in the skin mucus of Siberian sturgeon (Acipenser baerii)","volume":"10","author":"Fan","year":"2015","journal-title":"Integr. Zool."},{"issue":"1","key":"10.1016\/j.fsi.2026.111656_bib34","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.dci.2014.09.010","article-title":"sghC1q, a novel C1q family member from half-smooth tongue sole (Cynoglossus semilaevis): identification, expression and analysis of antibacterial and antiviral activities","volume":"48","author":"Zeng","year":"2015","journal-title":"Dev. Comp. Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111656_bib35","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.fsi.2015.05.021","article-title":"A C1q domain containing protein from Crassostrea gigas serves as pattern recognition receptor and opsonin with high binding affinity to LPS","volume":"45","author":"Jiang","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111656_bib36","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.fsi.2019.01.014","article-title":"Identification of a novel C1q complement component in razor clam Sinonovacula constricta and its role in antibacterial activity","volume":"87","author":"Li","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111656_bib37","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.fsi.2022.10.031","article-title":"A C1q domain-containing protein in Pinctada fucata contributes to the innate immune response and elimination of the pathogen","volume":"131","author":"Wang","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111656_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109477","article-title":"Identification of the C1qDC gene family in grass carp (Ctenopharyngodon idellus) and the response of C1qA, C1qB, and C1qC to GCRV infection in vivo and in vitro","volume":"148","author":"Yang","year":"2024","journal-title":"Fish Shellfish Immunol."},{"issue":"5","key":"10.1016\/j.fsi.2026.111656_bib39","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.fsi.2013.08.013","article-title":"Three complement component 1q genes from rock bream, Oplegnathus fasciatus: genome characterization and potential role in immune response against bacterial and viral infections","volume":"35","author":"Bathige","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111656_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2022.108472","article-title":"A novel C1qDC (PoC1qDC) with a collagen domain in Paralichthys olivaceus mediates complement activation and against bacterial infection","volume":"132","author":"Li","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111656_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2025.105389","article-title":"A novel complement C1q A chain from marbled flounder, Pseudopleuronectes yokohamae: genome characterization, expression and potential role in antibacterial immunity","volume":"167","author":"Wang","year":"2025","journal-title":"Dev. Comp. Immunol."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826005607?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826005607?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T21:58:37Z","timestamp":1788299917000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464826005607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":41,"alternative-id":["S1050464826005607"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111656","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification and transcriptional analysis of eight C1q genes in Takifugu obscurus during bacterial infection","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111656","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111656"}}