{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T22:16:39Z","timestamp":1788300999353,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","award":["2026GXNSFBA00640146"],"award-info":[{"award-number":["2026GXNSFBA00640146"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017691","name":"Guangxi Key Research and Development Program","doi-asserted-by":"publisher","award":["Guike Nong AB2506910047"],"award-info":[{"award-number":["Guike Nong AB2506910047"]}],"id":[{"id":"10.13039\/501100017691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012253","name":"Guangxi University","doi-asserted-by":"publisher","award":["ZX01080033425005"],"award-info":[{"award-number":["ZX01080033425005"]}],"id":[{"id":"10.13039\/501100012253","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.fsi.2026.111659","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:11:05Z","timestamp":1787008265000},"page":"111659","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Genomic characterization of a hypervirulent Aeromonas veronii NN0115 from Nile tilapia and head kidney transcriptome of infected fish reveals B-cell-dominated immune response with specific immunoglobulin downregulation"],"prefix":"10.1016","volume":"178","author":[{"given":"Zulin","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengshuang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuhao","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jifeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youchuan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9676-3077","authenticated-orcid":false,"given":"Qi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.fsi.2026.111659_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/femsre\/fuac048","article-title":"Origins of symbiosis: shared mechanisms underlying microbial pathogenesis, commensalism and mutualism of plants and animals","volume":"47","author":"Wiesmann","year":"2023","journal-title":"FEMS Microbiol. Rev."},{"issue":"3","key":"10.1016\/j.fsi.2026.111659_bib2","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1111\/brv.13047","article-title":"Sensing for survival: specialised regulatory mechanisms of Type III secretion systems in Gram-negative pathogens","volume":"99","author":"Manisha","year":"2024","journal-title":"Biol. Rev."},{"key":"10.1016\/j.fsi.2026.111659_bib3","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.cell.2006.01.034","article-title":"Anti-Immunology: evasion of the host immune system by bacterial and viral pathogens","author":"Finlay","year":"2006","journal-title":"Cell 124(4)"},{"issue":"1","key":"10.1016\/j.fsi.2026.111659_bib4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3390\/microorganisms8010129","article-title":"An update on the genus Aeromonas: Taxonomy, epidemiology, and pathogenicity","volume":"8","author":"Fern\u00e1ndez-Bravo","year":"2020","journal-title":"Microorganisms"},{"issue":"6","key":"10.1016\/j.fsi.2026.111659_bib5","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41576-020-0212-5","article-title":"A systems approach to infectious disease","volume":"21","author":"Eckhardt","year":"2020","journal-title":"Nat. Rev. Genet."},{"issue":"1","key":"10.1016\/j.fsi.2026.111659_bib6","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1600-065X.2010.00998.x","article-title":"A systems biological view of intracellular pathogens","volume":"240","author":"Beiting","year":"2011","journal-title":"Immunol. Rev."},{"issue":"4","key":"10.1016\/j.fsi.2026.111659_bib7","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.01804-25","article-title":"Heterogeneity of bacterial host-pathogen interactions across biological scales","volume":"11","author":"Redondo","year":"2026","journal-title":"mSystems"},{"issue":"1","key":"10.1016\/j.fsi.2026.111659_bib8","doi-asserted-by":"crossref","DOI":"10.1111\/raq.70097","article-title":"The genus Aeromonas in aquaculture: a comprehensive review of prevalence, virulence, and antibiotic resistance with an emphasis on key pathogenic species","volume":"18","author":"Tao","year":"2026","journal-title":"Rev. Aquacult."},{"issue":"6","key":"10.1016\/j.fsi.2026.111659_bib9","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41576-021-00326-y","article-title":"Cross-species RNA-seq for deciphering host-microbe interactions","volume":"22","author":"Westermann","year":"2021","journal-title":"Nat. Rev. Genet."},{"issue":"4","key":"10.1016\/j.fsi.2026.111659_bib10","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/jfd.12025","article-title":"Aeromonas spp. whole genomes and virulence factors implicated in fish disease","volume":"36","author":"Beaz-Hidalgo","year":"2013","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2026.111659_bib11","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.3389\/fmicb.2016.01337","article-title":"Virulence factors of Aeromonas hydrophila: in the wake of reclassification","volume":"7","author":"Rasmussen-Ivey","year":"2016","journal-title":"Front. Microbiol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111659_bib12","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1038\/s41467-026-68712-w","article-title":"Aeromonas in South Asia: genomic insights into an environmental pathogen and reservoir of antimicrobial resistance","volume":"17","author":"Singh","year":"2026","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.fsi.2026.111659_bib13","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s11259-024-10594-8","article-title":"Isolation, characterization, and whole genome sequencing analysis of Aeromonas veronii from Channa argus in China","volume":"49","author":"Sun","year":"2025","journal-title":"Vet. Res. Commun."},{"key":"10.1016\/j.fsi.2026.111659_bib14","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jgar.2021.08.007","article-title":"Whole-genome sequencing and antimicrobial resistance analysis of multidrug-resistant Aeromonas veronii strain JC529 from a common carp","volume":"27","author":"Sheng","year":"2021","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"10.1016\/j.fsi.2026.111659_bib15","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.3389\/fmicb.2019.02742","article-title":"Isolation, identification and characteristics of Aeromonas veronii from diseased Crucian Carp (Carassius auratus gibelio)","volume":"10","author":"Chen","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.fsi.2026.111659_bib16","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3390\/fishes9050188","article-title":"Isolation, characterization, and pathogenicity of an Aeromonas veronii strain causing disease in Rhinogobio ventralis","volume":"9","author":"Wu","year":"2024","journal-title":"Fishes"},{"issue":"6","key":"10.1016\/j.fsi.2026.111659_bib17","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3390\/fishes7060394","article-title":"Isolation, identification, and pathogenicity of Aeromonas veronii, the causal agent of hemorrhagic septicemia in Channel Catfish (Ictalurus punctatus) in China","volume":"7","author":"Qin","year":"2022","journal-title":"Fishes"},{"key":"10.1016\/j.fsi.2026.111659_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2024.741150","article-title":"Genetic diversity, antibiotic resistance, and pathogenicity of Aeromonas veronii isolated from farmed largemouth bass (Micropterus salmoides) in the main aquaculture regions of China","volume":"592","author":"Chen","year":"2024","journal-title":"Aquaculture"},{"issue":"10","key":"10.1016\/j.fsi.2026.111659_bib19","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1111\/jfd.12617","article-title":"Aeromonas jandaei and Aeromonas veronii caused disease and mortality in Nile tilapia, Oreochromis niloticus (L)","volume":"40","author":"Dong","year":"2017","journal-title":"J. Fish. Dis."},{"issue":"4","key":"10.1016\/j.fsi.2026.111659_bib20","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.01934-17","article-title":"CLSI methods development and standardization working group best practices for evaluation of antimicrobial susceptibility tests","volume":"56","author":"Humphries","year":"2018","journal-title":"J. Clin. Microbiol."},{"issue":"6","key":"10.1016\/j.fsi.2026.111659_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1005595","article-title":"Unicycler: resolving bacterial genome assemblies from short and long sequencing reads","volume":"13","author":"Wick","year":"2017","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.fsi.2026.111659_bib22","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1093\/bioinformatics\/btu153","article-title":"Prokka: rapid prokaryotic genome annotation","author":"Seemann","year":"2014","journal-title":"Bioinformatics 30(14)"},{"issue":"9","key":"10.1016\/j.fsi.2026.111659_bib23","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1101\/gr.092759.109","article-title":"Circos: an information aesthetic for comparative genomics","volume":"19","author":"Krzywinski","year":"2009","journal-title":"Genome Res."},{"key":"10.1016\/j.fsi.2026.111659_bib24","doi-asserted-by":"crossref","first-page":"W182","DOI":"10.1093\/nar\/gkm321","article-title":"KAAS: an automatic genome annotation and pathway reconstruction server","volume":"35","author":"Moriya","year":"2007","journal-title":"Nucleic Acids Res."},{"issue":"20","key":"10.1016\/j.fsi.2026.111659_bib25","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.3390\/ani15202951","article-title":"RNA-Seq and single-cell RNA-Seq analyses of tilapia head kidney in response to Streptococcus agalactiae and Aeromonas hydrophila","volume":"15","author":"Li","year":"2025","journal-title":"Animals"},{"issue":"1","key":"10.1016\/j.fsi.2026.111659_bib26","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.gene.2013.06.013","article-title":"Evaluation of reference genes for quantitative real-time RT-PCR analysis of gene expression in Nile tilapia (Oreochromis niloticus)","volume":"527","author":"Yang","year":"2013","journal-title":"Gene"},{"key":"10.1016\/j.fsi.2026.111659_bib27","first-page":"11","article-title":"Selection and evaluation of stable reference genes for quantitative real-time PCR in the head kidney leukocyte of Oreochromis niloticus","volume":"31","author":"Jiang","year":"2023","journal-title":"Aquac. Rep."},{"issue":"45","key":"10.1016\/j.fsi.2026.111659_bib28","doi-asserted-by":"crossref","first-page":"19126","DOI":"10.1073\/pnas.0906412106","article-title":"Shifting the genomic gold standard for the prokaryotic species definition","volume":"106","author":"Richter","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.fsi.2026.111659_bib29","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02136-14","article-title":"Bioinformatic genome comparisons for taxonomic and phylogenetic assignments using Aeromonas as a test case","volume":"5","author":"Colston","year":"2014","journal-title":"mBio"},{"issue":"4","key":"10.1016\/j.fsi.2026.111659_bib30","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s10499-025-01960-7","article-title":"Aeromonas veronii infection in cultured Oreochromis niloticus: prevalence, molecular and histopathological characterization correlated to water physicochemical characteristics, with the protective autochthonous probiotic","volume":"33","author":"Fadel","year":"2025","journal-title":"Aquac. Int."},{"issue":"1","key":"10.1016\/j.fsi.2026.111659_bib31","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s11033-023-09033-9","article-title":"Long-term exposure to lead nitrate and zinc sulfate Nile tilapia impact the Aeromonas hydrophila treatment","volume":"51","author":"Sherif","year":"2024","journal-title":"Mol. Biol. Rep."},{"issue":"1","key":"10.1016\/j.fsi.2026.111659_bib32","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41598-023-43270-z","article-title":"Silymarin enhances the response to oxytetracycline treatment in Oreochromis niloticus experimentally infected with Aeromonas hydrophila","volume":"13","author":"Sherif","year":"2023","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.fsi.2026.111659_bib33","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/j.1574-6976.2008.00136.x","article-title":"Genomic islands: tools of bacterial horizontal gene transfer and evolution","volume":"33","author":"Juhas","year":"2009","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.fsi.2026.111659_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2025.743410","article-title":"Whole-genome sequencing reveals the genetic diversity of Aeromonas from freshwater fish and the presence of novel genomic islands carrying clinically important antimicrobial resistance genes","volume":"613","author":"Wang","year":"2026","journal-title":"Aquaculture"},{"issue":"4","key":"10.1016\/j.fsi.2026.111659_bib35","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00088-17","article-title":"Mobile genetic elements associated with antimicrobial resistance","volume":"31","author":"Partridge","year":"2018","journal-title":"Clin. Microbiol. Rev."},{"issue":"10014","key":"10.1016\/j.fsi.2026.111659_bib36","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0140-6736(15)00473-0","article-title":"Understanding the mechanisms and drivers of antimicrobial resistance","volume":"387","author":"Holmes","year":"2016","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.fsi.2026.111659_bib37","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1111\/1462-2920.12134","article-title":"Antimicrobial use in aquaculture re-examined: its relevance to antimicrobial resistance and to animal and human health","volume":"15","author":"Cabello","year":"2013","journal-title":"Environ. Microbiol."},{"issue":"7","key":"10.1016\/j.fsi.2026.111659_bib38","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrmicro3270","article-title":"Microbiological effects of sublethal levels of antibiotics","volume":"12","author":"Andersson","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.fsi.2026.111659_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.jip.2026.108612","article-title":"Whole-genome characteristics, antimicrobial resistance and virulence of pathogenic Aeromonas veronii from diseased Macrobrachium rosenbergii","volume":"217","author":"Zhou","year":"2026","journal-title":"J. Invertebr. Pathol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111659_bib40","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1128\/CMR.00117-14","article-title":"The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria","volume":"28","author":"Li","year":"2015","journal-title":"Clin. Microbiol. Rev."},{"issue":"5","key":"10.1016\/j.fsi.2026.111659_bib41","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41579-022-00820-y","article-title":"Molecular mechanisms of antibiotic resistance revisited","volume":"21","author":"Darby","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"issue":"3","key":"10.1016\/j.fsi.2026.111659_bib42","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S1473-3099(13)70001-X","article-title":"Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach","volume":"13","author":"Hotchkiss","year":"2013","journal-title":"Lancet Infect. Dis."},{"issue":"12","key":"10.1016\/j.fsi.2026.111659_bib43","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nri3552","article-title":"Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy","volume":"13","author":"Hotchkiss","year":"2013","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.fsi.2026.111659_bib44","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.cell.2019.03.016","article-title":"B cell responses: cell interaction dynamics and decisions","volume":"177","author":"Cyster","year":"2019","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.fsi.2026.111659_bib45","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/ni1454","article-title":"Pax5: the guardian of B cell identity and function","volume":"8","author":"Cobaleda","year":"2007","journal-title":"Nat. Immunol."},{"issue":"6","key":"10.1016\/j.fsi.2026.111659_bib46","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.immuni.2007.05.010","article-title":"The transcriptional regulation of B cell lineage commitment","volume":"26","author":"Nutt","year":"2007","journal-title":"Immunity"},{"issue":"11","key":"10.1016\/j.fsi.2026.111659_bib47","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.4049\/jimmunol.2200497","article-title":"Maintenance of lineage identity: lessons from a B cell","volume":"209","author":"Belcheva","year":"2022","journal-title":"J. Immunol."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826005632?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826005632?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T22:00:58Z","timestamp":1788300058000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464826005632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":47,"alternative-id":["S1050464826005632"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111659","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genomic characterization of a hypervirulent Aeromonas veronii NN0115 from Nile tilapia and head kidney transcriptome of infected fish reveals B-cell-dominated immune response with specific immunoglobulin downregulation","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111659","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111659"}}