{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T22:16:02Z","timestamp":1788300962906,"version":"build-2803163510"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["202212012"],"award-info":[{"award-number":["202212012"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004195","name":"Ocean University of China","doi-asserted-by":"publisher","award":["2022010042"],"award-info":[{"award-number":["2022010042"]}],"id":[{"id":"10.13039\/501100004195","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32373160"],"award-info":[{"award-number":["32373160"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.fsi.2026.111669","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T15:23:08Z","timestamp":1787325788000},"page":"111669","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Effects of single and double deletion of Vibrio anguillarum histone-like protein HU subunits on biofilm formation and pathogenicity in flounder (Paralichthys olivaceus)"],"prefix":"10.1016","volume":"178","author":[{"given":"Jiahui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiwei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqian","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3365-1259","authenticated-orcid":false,"given":"Xiuzhen","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1931-9842","authenticated-orcid":false,"given":"Zhihai","family":"Sui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.fsi.2026.111669_bib1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/raq.12188","article-title":"A comprehensive review of Vibrio (Listonella) anguillarum: ecology, pathology and prevention","volume":"10","author":"Hickey","year":"2018","journal-title":"Rev. Aquacult."},{"issue":"9","key":"10.1016\/j.fsi.2026.111669_bib2","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/j.1365-2761.2011.01279.x","article-title":"Vibrio anguillarum as a fish pathogen: virulence factors, diagnosis and prevention","volume":"34","author":"Frans","year":"2011","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2026.111669_bib3","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3389\/fcimb.2017.00342","article-title":"Iron acquisition strategies of Vibrio anguillarum","volume":"7","author":"Li","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.fsi.2026.111669_bib4","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.3389\/fmicb.2019.02335","article-title":"The expression of virulence factors in Vibrio anguillarum is dually regulated by iron levels and temperature","volume":"10","author":"Lages","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.fsi.2026.111669_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2025.107331","article-title":"Biological studies reveal the role of trpA gene in biofilm formation, motility, hemolysis and virulence in Vibrio anguillarum","volume":"200","author":"Che","year":"2025","journal-title":"Microb. Pathog."},{"issue":"10","key":"10.1016\/j.fsi.2026.111669_bib6","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/s41579-022-00767-0","article-title":"The biofilm life cycle: expanding the conceptual model of biofilm formation","volume":"20","author":"Sauer","year":"2022","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.fsi.2026.111669_bib7","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev.mi.41.100187.002251","article-title":"Bacterial biofilms in nature and disease","volume":"41","author":"Costerton","year":"1987","journal-title":"Annu. Rev. Microbiol."},{"issue":"4","key":"10.1016\/j.fsi.2026.111669_bib8","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1007\/s42770-021-00624-x","article-title":"Microbial biofilm: formation, architecture, antibiotic resistance, and control strategies","volume":"52","author":"Rather","year":"2021","journal-title":"Braz. J. Microbiol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111669_bib9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3390\/biology14020165","article-title":"Biofilm resilience: molecular mechanisms driving antibiotic resistance in clinical contexts","volume":"14","author":"Almatroudi","year":"2025","journal-title":"Biology"},{"issue":"23","key":"10.1016\/j.fsi.2026.111669_bib10","doi-asserted-by":"crossref","first-page":"5740","DOI":"10.1016\/j.cell.2021.10.010","article-title":"Z-form extracellular DNA is a structural component of the bacterial biofilm matrix","volume":"184","author":"Buzzo","year":"2021","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.fsi.2026.111669_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/mbo3.563","article-title":"The DNABII family of proteins is comprised of the only nucleoid associated proteins required for nontypeable Haemophilus influenzae biofilm structure","volume":"7","author":"Devaraj","year":"2018","journal-title":"Microbiologyopen"},{"issue":"6","key":"10.1016\/j.fsi.2026.111669_bib12","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1111\/mmi.12994","article-title":"DNABII proteins play a central role in UPEC biofilm structure","volume":"96","author":"Devaraj","year":"2015","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.fsi.2026.111669_bib13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ebiom.2016.06.022","article-title":"Monoclonal antibodies against DNA-binding tips of DNABII proteins disrupt biofilms in vitro and induce bacterial clearance in vivo","volume":"10","author":"Novotny","year":"2016","journal-title":"EBioMedicine"},{"issue":"9","key":"10.1016\/j.fsi.2026.111669_bib14","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1073\/pnas.72.9.3428","article-title":"Characterization of a novel, low-molecular-weight DNA-binding protein from Escherichia coli","volume":"72","author":"Rouvi\u00e8re-Yaniv","year":"1975","journal-title":"Proc. Natl. Acad. Sci. USA."},{"issue":"6","key":"10.1016\/j.fsi.2026.111669_bib15","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.mib.2010.09.013","article-title":"Effects of nucleoid-associated proteins on bacterial chromosome structure and gene expression","volume":"13","author":"Browning","year":"2010","journal-title":"Curr. Opin. Microbiol."},{"issue":"Pt 4","key":"10.1016\/j.fsi.2026.111669_bib16","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1099\/mic.0.046359-0","article-title":"Nucleoid-associated protein HU controls three regulons that coordinate virulence, response to stress and general physiology in Salmonella enterica serovar Typhimurium","volume":"157","author":"Mangan","year":"2011","journal-title":"Microbiology"},{"issue":"18","key":"10.1016\/j.fsi.2026.111669_bib17","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1128\/JB.00306-15","article-title":"DNA-binding protein HU coordinates pathogenicity in Vibrio parahaemolyticus","volume":"197","author":"Phan","year":"2015","journal-title":"J. Bacteriol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111669_bib18","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1006\/jmbi.1997.1310","article-title":"Variation in HU composition during growth of Escherichia coli: the heterodimer is required for long term survival","volume":"273","author":"Claret","year":"1997","journal-title":"J. Mol. Biol."},{"issue":"3","key":"10.1016\/j.fsi.2026.111669_bib19","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1432-1033.1980.tb05968.x","article-title":"Complete amino-acid sequences of DNA-binding proteins HU-1 and HU-2 from Escherichia coli","volume":"103","author":"Laine","year":"1980","journal-title":"Eur. J. Biochem."},{"issue":"1","key":"10.1016\/j.fsi.2026.111669_bib20","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1046\/j.1365-2958.2002.02868.x","article-title":"Selective expression of the beta-subunit of nucleoid-associated protein HU during cold shock in Escherichia coli","volume":"44","author":"Giangrossi","year":"2002","journal-title":"Mol. Microbiol."},{"issue":"3","key":"10.1016\/j.fsi.2026.111669_bib21","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s11802-008-0343-3","article-title":"Isolation and characterization of pathogenic Listonella anguillarum of diseased half-smooth tongue sole (Cynoglossus semilaevis G\u00fcnther)","volume":"7","author":"Tang","year":"2008","journal-title":"J. Ocean Univ. China"},{"key":"10.1016\/j.fsi.2026.111669_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2019.103492","article-title":"The effects of CCL3, CCL4, CCL19 and CCL21 as molecular adjuvants on the immune response to VAA DNA vaccine in flounder (Paralichthys olivaceus)","volume":"103","author":"Xu","year":"2020","journal-title":"Dev. Comp. Immunol."},{"issue":"Pt 2","key":"10.1016\/j.fsi.2026.111669_bib23","article-title":"The role and molecular mechanism of flgK gene in biological properties, pathogenicity and virulence genes expression of Aeromonas hydrophila","volume":"258","author":"Lu","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"Pt 2","key":"10.1016\/j.fsi.2026.111669_bib24","article-title":"Effects of the histone-like protein on biofilm formation and pathogenicity of Listeria monocytogenes","volume":"304","author":"Li","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.fsi.2026.111669_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.133950","article-title":"Polystyrene nanoparticles induce biofilm formation in Pseudomonas aeruginosa","volume":"469","author":"Huang","year":"2024","journal-title":"J. Hazard. Mater."},{"issue":"Pt 10","key":"10.1016\/j.fsi.2026.111669_bib26","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1099\/00221287-146-10-2395","article-title":"Quantification of biofilm structures by the novel computer program COMSTAT","volume":"146","author":"Heydorn","year":"2000","journal-title":"Microbiology"},{"issue":"Pt 1","key":"10.1016\/j.fsi.2026.111669_bib27","article-title":"Teleost Muc2 and Muc5ac: key guardians of mucosal immunity in flounder (Paralichthys olivaceus)","volume":"277","author":"Wang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"11","key":"10.1016\/j.fsi.2026.111669_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms10112175","article-title":"The early peritoneal cavity immune response to Vibrio anguillarum infection and to inactivated bacterium in olive flounder (Paralichthys olivaceus)","volume":"10","author":"Shi","year":"2022","journal-title":"Microorganisms"},{"issue":"1","key":"10.1016\/j.fsi.2026.111669_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004593","article-title":"DNA is an antimicrobial component of neutrophil extracellular traps","volume":"11","author":"Halverson","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.fsi.2026.111669_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2025.110486","article-title":"Decreased pathogenicity of triple-mutant of Aeromonas hydrophila flgK, flgL, flgE suggests its potential as a live attenuated vaccine for Carassius auratus","volume":"165","author":"Xiong","year":"2025","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111669_bib31","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3389\/fcimb.2019.00159","article-title":"Nucleoid-associated protein HU: a lilliputian in gene regulation of bacterial virulence","volume":"9","author":"Stojkova","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"1\u20132","key":"10.1016\/j.fsi.2026.111669_bib32","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.vetmic.2014.03.030","article-title":"HU-induced polymorphous filamentation in fish pathogen Edwardsiella tarda leading to reduced invasion and virulence in zebrafish","volume":"171","author":"Wang","year":"2014","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.fsi.2026.111669_bib33","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.3389\/fmicb.2018.01780","article-title":"HU-lacking mutants of Salmonella enterica Enteritidis are highly attenuated and can induce protection in murine model of infection","volume":"9","author":"Milanez","year":"2018","journal-title":"Front. Microbiol."},{"issue":"4","key":"10.1016\/j.fsi.2026.111669_bib34","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/mpp.12777","article-title":"The histone-like protein HupB influences biofilm formation and virulence in Xanthomonas citri ssp. citri through the regulation of flagellar biosynthesis","volume":"20","author":"Conforte","year":"2019","journal-title":"Mol. Plant Pathol."},{"key":"10.1016\/j.fsi.2026.111669_bib35","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41522-017-0029-y","article-title":"Ecological strategies and metabolic trade-offs of complex environmental biofilms","volume":"3","author":"Niederdorfer","year":"2017","journal-title":"npj Biofilms Microbiomes"},{"issue":"7","key":"10.1016\/j.fsi.2026.111669_bib36","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1111\/1462-2920.16356","article-title":"Strain-specific quorum-sensing responses determine virulence properties in Vibrio anguillarum","volume":"25","author":"Mauritzen","year":"2023","journal-title":"Environ. Microbiol."},{"issue":"7","key":"10.1016\/j.fsi.2026.111669_bib37","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1600650","article-title":"HU multimerization shift controls nucleoid compaction","volume":"2","author":"Hammel","year":"2016","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.fsi.2026.111669_bib38","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3934\/microbiol.2018.1.140","article-title":"Bacterial autoaggregation","volume":"4","author":"Trunk","year":"2018","journal-title":"AIMS Microbiol"},{"key":"10.1016\/j.fsi.2026.111669_bib39","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3389\/fmicb.2017.00301","article-title":"Cronobacter sakazakii ATCC 29544 autoaggregation requires FliC flagellation, not motility","volume":"8","author":"Hoeflinger","year":"2017","journal-title":"Front. Microbiol."},{"issue":"6","key":"10.1016\/j.fsi.2026.111669_bib40","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.00831-25","article-title":"Flagellar motility and the mucus environment influence aggregation-mediated antibiotic tolerance of Pseudomonas aeruginosa in chronic lung infection","volume":"16","author":"Higgs","year":"2025","journal-title":"mBio"},{"key":"10.1016\/j.fsi.2026.111669_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2024.108505","article-title":"The role of the proteosurfaceome and exoproteome in bacterial coaggregation","volume":"79","author":"Afonso","year":"2025","journal-title":"Biotechnol. Adv."},{"issue":"2","key":"10.1016\/j.fsi.2026.111669_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0004367","article-title":"The HU regulon is composed of genes responding to anaerobiosis, acid stress, high osmolarity and SOS induction","volume":"4","author":"Oberto","year":"2009","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.fsi.2026.111669_bib43","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/0022-2836(88)90357-9","article-title":"Construction and characterization of the deletion mutant of hupA and hupB genes in Escherichia coli","volume":"204","author":"Wada","year":"1988","journal-title":"J. Mol. Biol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111669_bib44","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/s12934-024-02549-0","article-title":"The role of two major nucleoid-associated proteins in Streptomyces, HupA and HupS, in stress survival and gene expression regulation","volume":"23","author":"Strza\u0142ka","year":"2024","journal-title":"Microb. Cell Fact."},{"issue":"5663","key":"10.1016\/j.fsi.2026.111669_bib45","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.fsi.2026.111669_bib46","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.dci.2015.11.005","article-title":"Neutrophils of Scophthalmus maximus produce extracellular traps that capture bacteria and inhibit bacterial infection","volume":"56","author":"Chi","year":"2016","journal-title":"Dev. Comp. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111669_bib47","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12866-024-03222-7","article-title":"RpoS role in antibiotic resistance, tolerance and persistence in E. coli natural isolates","volume":"24","author":"Valencia","year":"2024","journal-title":"BMC Microbiol."},{"issue":"9","key":"10.1016\/j.fsi.2026.111669_bib48","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.dnarep.2012.06.006","article-title":"A histone-like protein of Helicobacter pylori protects DNA from stress damage and aids host colonization","volume":"11","author":"Wang","year":"2012","journal-title":"DNA Repair"},{"issue":"13","key":"10.1016\/j.fsi.2026.111669_bib49","doi-asserted-by":"crossref","first-page":"6712","DOI":"10.1073\/pnas.94.13.6712","article-title":"Alterations of the outer membrane composition in Escherichia coli lacking the histone-like protein HU","volume":"94","author":"Painbeni","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA."},{"issue":"4","key":"10.1016\/j.fsi.2026.111669_bib50","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1165\/rcmb.2017-0321TR","article-title":"Pseudomonas aeruginosa biofilms: host response and clinical implications in lung infections","volume":"58","author":"Maurice","year":"2018","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"8","key":"10.1016\/j.fsi.2026.111669_bib51","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1016\/j.cell.2024.03.001","article-title":"Biofilm exopolysaccharides alter sensory-neuron-mediated sickness during lung infection","volume":"187","author":"Granton","year":"2024","journal-title":"Cell"},{"issue":"28","key":"10.1016\/j.fsi.2026.111669_bib52","doi-asserted-by":"crossref","first-page":"7416","DOI":"10.1073\/pnas.1721949115","article-title":"Staphylococcus aureus biofilms release leukocidins to elicit extracellular trap formation and evade neutrophil-mediated killing","volume":"115","author":"Bhattacharya","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA."},{"issue":"10","key":"10.1016\/j.fsi.2026.111669_bib53","doi-asserted-by":"crossref","DOI":"10.1128\/iai.00304-25","article-title":"Biofilm-associated molecular patterns: BAMPs","volume":"93","author":"\u00d8strup Jensen","year":"2025","journal-title":"Infect. Immun."},{"issue":"2","key":"10.1016\/j.fsi.2026.111669_bib54","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.it.2023.12.004","article-title":"DNA at the center of mammalian innate immune recognition of bacterial biofilms","volume":"45","author":"Gallucci","year":"2024","journal-title":"Trends Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111669_bib55","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00631-20","article-title":"The extracellular polysaccharide matrix of Pseudomonas aeruginosa biofilms is a determinant of polymorphonuclear leukocyte responses","volume":"89","author":"Rybtke","year":"2020","journal-title":"Infect. Immun."},{"issue":"11","key":"10.1016\/j.fsi.2026.111669_bib56","doi-asserted-by":"crossref","first-page":"6386","DOI":"10.4049\/jimmunol.0901640","article-title":"Extracellular DNA: a major proinflammatory component of Pseudomonas aeruginosa biofilms","volume":"184","author":"Fuxman Bass","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2026.111669_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2025.110361","article-title":"\u0394FleQ of Aeromonas hydrophila generated as a live attenuated vaccine in common carp (Cyprinus carpio)","volume":"162","author":"Fang","year":"2025","journal-title":"Fish Shellfish Immunol."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826005735?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826005735?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T21:56:16Z","timestamp":1788299776000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464826005735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":57,"alternative-id":["S1050464826005735"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111669","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of single and double deletion of Vibrio anguillarum histone-like protein HU subunits on biofilm formation and pathogenicity in flounder (Paralichthys olivaceus)","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111669","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111669"}}