{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T03:35:38Z","timestamp":1792985738920,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","award":["BK20190698"],"award-info":[{"award-number":["BK20190698"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013156","name":"Startup Foundation for Introducing Talent of Nanjing University of Information Science and Technology","doi-asserted-by":"publisher","award":["JSTJ-2024-167"],"award-info":[{"award-number":["JSTJ-2024-167"]}],"id":[{"id":"10.13039\/501100013156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31902397"],"award-info":[{"award-number":["31902397"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.fsi.2026.111674","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:40:09Z","timestamp":1787614809000},"page":"111674","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Identification and functional characterization of an Ig domain-containing C-type lectin involved in antibacterial innate immunity in Eriocheir sinensis"],"prefix":"10.1016","volume":"179","author":[{"given":"Yongchun","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2026.111674_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2025.108251","article-title":"Pathogenicity of Vibrio parahaemolyticus associated with mass mortality events in juvenile Chinese mitten crab (Eriocheir sinensis)","volume":"211","author":"Zhou","year":"2026","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.fsi.2026.111674_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.138604","article-title":"Overlooked risk of dissemination and mobility of antibiotic resistance genes in freshwater aquaculture of the Micropterus salmoides in Zhejiang, China","volume":"494","author":"Ding","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.fsi.2026.111674_bib3","doi-asserted-by":"crossref","first-page":"6179","DOI":"10.1111\/j.1742-4658.2005.05031.x","article-title":"The C-type lectin-like domain superfamily","volume":"272","author":"Zelensky","year":"2005","journal-title":"FEBS J."},{"key":"10.1016\/j.fsi.2026.111674_bib4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.dci.2012.04.009","article-title":"Diversity and multiple functions of lectins in shrimp immunity","volume":"39","author":"Wang","year":"2013","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2026.111674_bib5","article-title":"A C-type lectin with an immunoglobulin-like domain promotes phagocytosis of hemocytes in crayfish Procambarus clarkii","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fsi.2026.111674_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109361","article-title":"LDLa containing C-type lectin mediates phagocytosis of V.anguillarum and regulates immune effector genes in shrimp","volume":"145","author":"Wang","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111674_bib7","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.dci.2013.10.004","article-title":"An LDLa domain-containing C-type lectin is involved in the innate immunity of Eriocheir sinensis","volume":"42","author":"Huang","year":"2014","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2026.111674_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2024.741620","article-title":"C-type lectins containing an immunoglobulin domain have an anti-WSSV function in Procambarus clarkii","volume":"595","author":"Ren","year":"2025","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2026.111674_bib9","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.4049\/jimmunol.2101027","article-title":"A novel Ig domain-containing C-type lectin triggers the intestine-hemocyte axis to regulate antibacterial immunity in crab","volume":"208","author":"Zhou","year":"2022","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2026.111674_bib10","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.fsi.2015.10.025","article-title":"Antimicrobial activity of a novel hypervariable immunoglobulin domain-containing receptor Dscam in Cherax quadricarinatus","volume":"47","author":"Li","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111674_bib11","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.dci.2011.05.006","article-title":"Heterogeneous nuclear ribonucleoprotein hrp36 acts as an alternative splicing repressor in Litopenaeus vannamei Dscam","volume":"36","author":"Lee","year":"2012","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2026.111674_bib12","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.dci.2009.07.006","article-title":"The putative invertebrate adaptive immune protein Litopenaeus vannamei Dscam (LvDscam) is the first reported Dscam to lack a transmembrane domain and cytoplasmic tail","volume":"33","author":"Chou","year":"2009","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2026.111674_bib13","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.dci.2017.11.008","article-title":"Beyond immunity: the Imd pathway as a coordinator of host defense, organismal physiology and behavior","volume":"83","author":"Zhai","year":"2018","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2026.111674_bib14","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1038\/s44318-026-00761-9","article-title":"FADD is recruited to activated STING oligomers to initiate caspase-mediated NF-\u03baB activation in Drosophila melanogaster","volume":"45","author":"Winther","year":"2026","journal-title":"EMBO J."},{"key":"10.1016\/j.fsi.2026.111674_bib15","doi-asserted-by":"crossref","first-page":"756","DOI":"10.3390\/md20080501","article-title":"Marine arthropods as a source of antimicrobial peptides","volume":"20","author":"Saucedo-V\u00e1zquez","year":"2022","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.fsi.2026.111674_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108714","article-title":"Caspar negatively regulates anti-bacterial immunity by controlling the nuclear translocation of Relish in Chinese mitten crab (Eriocheir sinensis)","volume":"136","author":"Luo","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111674_bib17","doi-asserted-by":"crossref","first-page":"15942","DOI":"10.1074\/jbc.M500814200","article-title":"NF-\u03baB is transported into the nucleus byimportin \u03b13 and importin \u03b14","volume":"280","author":"Fagerlund","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fsi.2026.111674_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2019.103451","article-title":"A novel nuclear factor Akirin regulating the expression of antimicrobial peptides in Chinese mitten crab Eriocheir sinensis","volume":"101","author":"Yang","year":"2019","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2026.111674_bib19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0044-8486(00)00411-7","article-title":"The proPO and clotting system in crustaceans","volume":"191","author":"Sritunyalucksana","year":"2000","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2026.111674_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2021.104098","article-title":"Immune properties of invertebrate phenoloxidases","volume":"122","author":"Cerenius","year":"2021","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2026.111674_bib21","first-page":"510","article-title":"Expression profiles of antimicrobial peptides (AMPs) and their regulation by Relish","volume":"33","author":"Wang","year":"2012","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111674_bib22","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.fsi.2010.10.012","article-title":"Characterization of a C-type lectin (PcLec2) as an upstream detector in the prophenoloxidase activating system of red swamp crayfish","volume":"30","author":"Wang","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111674_bib23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.fsi.2016.01.031","article-title":"A single CRD C-type lectin from Eriocheir sinensis (EsLecB) with microbial-binding, antibacterial prophenoloxidase activation and hem-encapsulation activities","volume":"50","author":"Fang","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111674_bib24","article-title":"The antibacterial activity and antibacterial mechanism analyses of an LRR-IG protein in the Chinese mitten crab","volume":"234","author":"Zhang","year":"2023","journal-title":"Eriocheir sinensis. Int. J. Biol. Macromol."},{"key":"10.1016\/j.fsi.2026.111674_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jip.2026.108671","article-title":"C-type lectins in arthropods: evolutionary diversification and prospects for pathogen defense","volume":"218","author":"Li","year":"2026","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.fsi.2026.111674_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076132","article-title":"Association of a hepatopancreas-specific C-type lectin with the antibacterial response of Eriocheir sinensis","volume":"8","author":"Jin","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2026.111674_bib27","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.dci.2018.11.016","article-title":"A comparative global proteomic analysis of the hematopoietic lineages in the crustacean Pacifastacus leniusculus","volume":"92","author":"S\u00f6derh\u00e4ll","year":"2019","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2026.111674_bib28","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3389\/fimmu.2020.00268","article-title":"Hemocyte-mediated phagocytosis in crustaceans","volume":"11","author":"Liu","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2026.111674_bib29","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.foodchem.2018.03.110","article-title":"Two types of phenoloxidases contribute to hemocytes PO activity in spiny lobster","volume":"260","author":"Masuda","year":"2018","journal-title":"Food Chem."},{"key":"10.1016\/j.fsi.2026.111674_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2026.111290","article-title":"TRIM37 promotes antibacterial defense by regulating antimicrobial peptides in Chinese mitten crab (Eriocheir sinensis)","volume":"173","author":"Shen","year":"2026","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111674_bib31","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2216574120","article-title":"Scavenger receptor B2, a type III membrane pattern recognition receptor, senses LPS and activates the IMD pathway in crustaceans","volume":"120","author":"Shi","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.fsi.2026.111674_bib32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3390\/cells13010071","article-title":"Viral targeting of importin alpha-mediated nuclear import to block innate immunity","volume":"13","author":"Vogel","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.fsi.2026.111674_bib33","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.15252\/embj.201488456","article-title":"Akirin specifies NF-\u03baB selectivity of Drosophila innate immune response via chromatin remodeling","volume":"33","author":"Bonnay","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.fsi.2026.111674_bib34","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1369\/jhc.4A6564.2005","article-title":"Mosquito phenoloxidase and defensin colocalize in melanization innate immune responses","volume":"53","author":"Hillyer","year":"2005","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.fsi.2026.111674_bib35","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.0105-2896.2004.00116.x","article-title":"The prophenoloxidase-activating system in invertebrates","volume":"198","author":"Cerenius","year":"2004","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.fsi.2026.111674_bib36","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/glycob\/cwq193","article-title":"Survey of immune-related, mannose\/fucose-binding C-type lectin receptors reveals widely divergent sugar-binding specificities","volume":"21","author":"Lee","year":"2011","journal-title":"Glycobiology"},{"key":"10.1016\/j.fsi.2026.111674_bib37","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.fsi.2018.05.021","article-title":"A novel C-type lectin from the sea cucumber Apostichopus japonicus (AjCTL-2) with preferential binding of D-galactose","volume":"79","author":"Wang","year":"2018","journal-title":"Fish Shellfish Immunol."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826005784?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826005784?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T03:28:30Z","timestamp":1792985310000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464826005784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":37,"alternative-id":["S1050464826005784"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111674","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification and functional characterization of an Ig domain-containing C-type lectin involved in antibacterial innate immunity in Eriocheir sinensis","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111674","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111674"}}