{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T04:33:08Z","timestamp":1792989188939,"version":"4.5.0"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007801","name":"Fundacion Seneca","doi-asserted-by":"publisher","award":["23025\/GERM\/25"],"award-info":[{"award-number":["23025\/GERM\/25"]}],"id":[{"id":"10.13039\/100007801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.fsi.2026.111717","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:56:21Z","timestamp":1789721781000},"page":"111717","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Exploring the multifaceted effects of dietary encapsulated piscidin 1 on gilthead seabream (Sparus aurata): from immunomodulation to muscle quality"],"prefix":"10.1016","volume":"179","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7969-7052","authenticated-orcid":false,"given":"Claudia","family":"Mar\u00edn-Parra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefan\u00eda","family":"Valero-Cases","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3063-1634","authenticated-orcid":false,"given":"Crist\u00f3bal","family":"Espinosa-Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3375-3901","authenticated-orcid":false,"given":"Christopher R.","family":"Coxon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6264-1458","authenticated-orcid":false,"given":"Mar\u00eda \u00c1ngeles","family":"Esteban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.fsi.2026.111717_bib1","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/s41579-021-00585-w","article-title":"Antibiofilm activity of host defence peptides: complexity provides opportunities","volume":"19","author":"Hancock","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"issue":"20","key":"10.1016\/j.fsi.2026.111717_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222011172","article-title":"Host defense peptides: dual antimicrobial and immunomodulatory action","volume":"22","author":"Drayton","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.fsi.2026.111717_bib3","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.it.2014.07.004","article-title":"Host defense peptides: front-line immunomodulators","volume":"35","author":"Mansour","year":"2014","journal-title":"Trends Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111717_bib4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1159\/000092305","article-title":"Human cathelicidin LL-37 is a chemoattractant for eosinophils and neutrophils that acts via formyl-peptide receptors","volume":"140","author":"Tjabringa","year":"2006","journal-title":"Int. Arch. Allergy Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111717_bib5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1042\/BJ20140778","article-title":"The antimicrobial peptide LL-37 facilitates the formation of neutrophil extracellular traps","volume":"464","author":"Neumann","year":"2014","journal-title":"Biochem. J."},{"issue":"2","key":"10.1016\/j.fsi.2026.111717_bib6","doi-asserted-by":"crossref","first-page":"225","DOI":"10.5114\/ceji.2015.51359","article-title":"Cathelicidin impact on inflammatory cells","volume":"40","author":"Agier","year":"2015","journal-title":"Cent. Eur. J. Immunol."},{"issue":"3","key":"10.1016\/j.fsi.2026.111717_bib7","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1074\/jbc.M504327200","article-title":"Endotoxin (lipopolysaccharide) neutralization by innate immunity host-defense peptides","volume":"281","author":"Rosenfeld","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"6861","key":"10.1016\/j.fsi.2026.111717_bib8","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/35104690","article-title":"Peptide antibiotics in mast cells of fish","volume":"414","author":"Silphaduang","year":"2001","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.fsi.2026.111717_bib9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s10989-020-10068-w","article-title":"Piscidin, fish antimicrobial peptide: structure, classification, properties, mechanism, gene regulation and therapeutical importance","volume":"27","author":"Raju","year":"2021","journal-title":"Int. J. Pept. Res. Therapeut."},{"key":"10.1016\/j.fsi.2026.111717_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.lwt.2024.117189","article-title":"Fish-derived cationic antimicrobial peptide piscidin 1 exerts broad-spectrum bactericidal activities against multidrug-resistant Gram-negative pathogens","volume":"215","author":"Sun","year":"2025","journal-title":"LWT"},{"issue":"9","key":"10.1016\/j.fsi.2026.111717_bib11","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.bbamem.2006.03.034","article-title":"Investigating molecular recognition and biological function at interfaces using piscidins, antimicrobial peptides from fish","volume":"1758","author":"Chekmenev","year":"2006","journal-title":"Biochim. Biophys. Acta Biomembr."},{"issue":"5","key":"10.1016\/j.fsi.2026.111717_bib12","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2108\/zsj.29.327","article-title":"Piscidin-1, an antimicrobial peptide from fish (Hybrid striped bass Morone saxatilis x M. chrysops), induces apoptotic and necrotic activity in HT1080 cells","volume":"29","author":"Lin","year":"2012","journal-title":"Zool. Sci."},{"key":"10.1016\/j.fsi.2026.111717_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2024.1379192","article-title":"Antiviral activity of the host defense peptide piscidin 1: investigating a membrane-mediated mode of action","volume":"12","author":"Bepler","year":"2024","journal-title":"Front. Chem."},{"issue":"9","key":"10.1016\/j.fsi.2026.111717_bib14","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1021\/ja411119m","article-title":"High-resolution structures and orientations of antimicrobial peptides Piscidin 1 and Piscidin 3 in fluid bilayers reveal tilting, kinking, and bilayer immersion","volume":"136","author":"Perrin","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.fsi.2026.111717_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2025.110501","article-title":"Piscidin 1 and 2 of gilthead seabream (Sparus aurata): new insights into their role as host defense peptides","volume":"165","author":"Mar\u00edn-Parra","year":"2025","journal-title":"Fish Shellfish Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111717_bib16","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3390\/molecules23020311","article-title":"The Road from host-defense peptides to a new generation of antimicrobial drugs","volume":"23","author":"Boto","year":"2018","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.fsi.2026.111717_bib17","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s00726-005-0289-3","article-title":"Strategies to improve plasma half life time of peptide and protein drugs","volume":"30","author":"Werle","year":"2006","journal-title":"Amino Acids"},{"key":"10.1016\/j.fsi.2026.111717_bib18","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.euprot.2014.05.003","article-title":"The emergence of peptides in the pharmaceutical business: from exploration to exploitation","volume":"4","author":"Uhlig","year":"2014","journal-title":"EuPA Open Proteom."},{"issue":"6","key":"10.1016\/j.fsi.2026.111717_bib19","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/psc.2885","article-title":"Cyclization of a cell-penetrating peptide via click-chemistry increases proteolytic resistance and improves drug delivery","volume":"22","author":"Reichart","year":"2016","journal-title":"J. Pept. Sci."},{"issue":"1","key":"10.1016\/j.fsi.2026.111717_bib20","doi-asserted-by":"crossref","DOI":"10.1080\/15384047.2025.2486141","article-title":"\u03b2-amino acid substitution in the SIINFEKL antigen alters immunological recognition","volume":"26","author":"Rastogi","year":"2025","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.fsi.2026.111717_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2022.107962","article-title":"Strategies employed in the design of antimicrobial peptides with enhanced proteolytic stability","volume":"59","author":"Lai","year":"2022","journal-title":"Biotechnol. Adv."},{"issue":"97","key":"10.1016\/j.fsi.2026.111717_bib22","doi-asserted-by":"crossref","first-page":"79270","DOI":"10.1039\/C5RA13419F","article-title":"Encapsulation of food protein hydrolysates and peptides: a review","volume":"5","author":"Mohan","year":"2015","journal-title":"RSC Adv."},{"issue":"1","key":"10.1016\/j.fsi.2026.111717_bib23","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jfutfo.2024.01.003","article-title":"Polymer-based encapsulation in food products: a comprehensive review of applications and advancements","volume":"5","author":"Barbosa-Nu\u00f1ez","year":"2025","journal-title":"J. Future Foods"},{"issue":"5","key":"10.1016\/j.fsi.2026.111717_bib24","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1039\/D4FO04447A","article-title":"Recent advances in the effect of simulated gastrointestinal digestion and encapsulation on peptide bioactivity and stability","volume":"16","author":"Chen","year":"2025","journal-title":"Food Funct."},{"key":"10.1016\/j.fsi.2026.111717_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.tcsw.2023.100097","article-title":"Carrageenan biosynthesis in red algae: a review","volume":"9","author":"Chevenier","year":"2023","journal-title":"Cell Surf."},{"key":"10.1016\/j.fsi.2026.111717_bib26","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/B978-0-323-95367-2.00028-4","article-title":"Carrageenan in drug delivery","author":"Askari","year":"2025","journal-title":"Natural Biopolym. Drug Deliv."},{"key":"10.1016\/j.fsi.2026.111717_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.125366","article-title":"Application of polysaccharides for the encapsulation of beneficial microorganisms for agricultural purposes: a review","volume":"244","author":"Ali","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111717_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/psc.3539","article-title":"The development and optimisation of an HPLC-based in vitro serum stability assay for a calcitonin gene-related peptide receptor antagonist peptide","volume":"30","author":"D'Aloisio","year":"2024","journal-title":"J. Pept. Sci."},{"issue":"8","key":"10.1016\/j.fsi.2026.111717_bib29","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1021\/acschembio.6b00386","article-title":"Protease-resistant and cell-permeable double-stapled peptides targeting the Rab8a GTPase","volume":"11","author":"Cromm","year":"2016","journal-title":"ACS Chem. Biol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111717_bib30","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"issue":"5","key":"10.1016\/j.fsi.2026.111717_bib31","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.fsi.2004.04.013","article-title":"Maternal transfer of humoral specific and non-specific immune parameters to sea bream (Sparus aurata) larvae","volume":"17","author":"Hanif","year":"2004","journal-title":"Fish Shellfish Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111717_bib32","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3181\/00379727-119-30188","article-title":"A rapid and sensitive assay of muramidase","volume":"119","author":"Parry","year":"1965","journal-title":"Proc. Soc. Exp. Biol. Med."},{"issue":"3","key":"10.1016\/j.fsi.2026.111717_bib33","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0165-2427(97)00048-2","article-title":"A rapid, direct assay to measure degranulation of bovine neutrophil primary granules","volume":"58","author":"Quade","year":"1997","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"6","key":"10.1016\/j.fsi.2026.111717_bib34","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/jlb.50.6.554","article-title":"Modulation of the oxidative burst in trout myeloid cells by adrenocorticotropic hormone and catecholamines: mechanisms of action","volume":"50","author":"Bayne","year":"1991","journal-title":"J. Leukoc. Biol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111717_bib35","first-page":"415","article-title":"Phagocytosis and peroxidase release by seabream (Sparus aurata L.) leucocytes in response to yeast cells, the anatomical record part A: discoveries in molecular","volume":"272A","author":"Rodr\u00edguez","year":"2003","journal-title":"Cell., Evolution. Biol."},{"issue":"4","key":"10.1016\/j.fsi.2026.111717_bib36","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.fsi.2026.111717_bib37","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.fsi.2016.02.008","article-title":"Effects of Shewanella putrefaciens on innate immunity and cytokine expression profile upon high stocking density of gilthead seabream specimens","volume":"51","author":"Cordero","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111717_bib38","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.chemosphere.2017.02.009","article-title":"Head kidney, liver and skin histopathology and gene expression in gilthead seabream (Sparus aurata L.) exposed to highly polluted marine sediments from portman Bay (Spain)","volume":"174","author":"Ben Hamed","year":"2017","journal-title":"Chemosphere"},{"issue":"2","key":"10.1016\/j.fsi.2026.111717_bib39","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3390\/antiox11020319","article-title":"Interaction between the effects of sustained swimming activity and dietary macronutrient proportions on the redox status of gilthead Sea bream juveniles (Sparus aurata L.)","volume":"11","author":"S\u00e1nchez-Moya","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.fsi.2026.111717_bib40","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.fsi.2017.07.006","article-title":"Effects of dietary polyvinylchloride microparticles on general health, immune status and expression of several genes related to stress in gilthead seabream (Sparus aurata L.)","volume":"68","author":"Espinosa","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111717_bib41","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.fsi.2021.10.009","article-title":"Acute inflammatory response in the skin of gilthead seabream (Sparus aurata) caused by carrageenin","volume":"119","author":"Campos-S\u00e1nchez","year":"2021","journal-title":"Fish Shellfish Immunol."},{"issue":"12","key":"10.1016\/j.fsi.2026.111717_bib42","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1111\/jfd.12481","article-title":"Characterization of the gilthead seabream (Sparus aurata L.) immune response under a natural lymphocystis disease virus outbreak","volume":"39","author":"Cordero","year":"2016","journal-title":"J. Fish. Dis."},{"issue":"12","key":"10.1016\/j.fsi.2026.111717_bib43","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.21273\/HORTSCI.27.12.1254","article-title":"Reporting of objective color measurements","volume":"27","author":"McGuire","year":"1992","journal-title":"Hortscience"},{"key":"10.1016\/j.fsi.2026.111717_bib44","series-title":"Official Methods of Analysis of AOAC International","article-title":"Official methods of analysis","year":"2023"},{"issue":"4","key":"10.1016\/j.fsi.2026.111717_bib45","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1080\/10408347.2012.751787","article-title":"An overview of the kjeldahl method of nitrogen determination. Part II. Sample Preparation, working scale, instrumental finish, and quality control","volume":"43","author":"S\u00e1ez-Plaza","year":"2013","journal-title":"Crit. Rev. Anal. Chem."},{"key":"10.1016\/j.fsi.2026.111717_bib46","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3389\/fmicb.2020.00168","article-title":"Backbone cyclization and dimerization of LL-37-derived peptides enhance antimicrobial activity and proteolytic stability","volume":"11","author":"Gunasekera","year":"2020","journal-title":"Front. Microbiol."},{"issue":"9","key":"10.1016\/j.fsi.2026.111717_bib47","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.biochi.2010.02.023","article-title":"Structural determinants of host defense peptides for antimicrobial activity and target cell selectivity","volume":"92","author":"Takahashi","year":"2010","journal-title":"Biochimie"},{"issue":"20","key":"10.1016\/j.fsi.2026.111717_bib48","doi-asserted-by":"crossref","first-page":"5565","DOI":"10.1021\/bi702036s","article-title":"NMR structure of the cathelicidin-derived human antimicrobial peptide LL-37 in dodecylphosphocholine micelles","volume":"47","author":"Porcelli","year":"2008","journal-title":"Biochemistry"},{"issue":"12","key":"10.1016\/j.fsi.2026.111717_bib49","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.1021\/bi062233u","article-title":"Solution structure and cell selectivity of Piscidin 1 and its analogues","volume":"46","author":"Lee","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.fsi.2026.111717_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2022.120209","article-title":"Trifluoroethanol direct interactions with protein backbones destabilize \u03b1-helices","volume":"365","author":"Pereira","year":"2022","journal-title":"J. Mol. Liq."},{"issue":"10","key":"10.1016\/j.fsi.2026.111717_bib51","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.3390\/life15101568","article-title":"Design, structural stability, membrane binding, and antibacterial activity of novel antimicrobial peptides derived from Wuchuanin-A1","volume":"15","author":"Putri","year":"2025","journal-title":"Life"},{"key":"10.1016\/j.fsi.2026.111717_bib52","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41579-025-01200-y","article-title":"Antimicrobial peptides: structure, functions and translational applications","volume":"23","author":"Oliveira J\u00fanior","year":"2025","journal-title":"Nat. Rev. Microbiol."},{"issue":"6","key":"10.1016\/j.fsi.2026.111717_bib53","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/BF00004453","article-title":"The effect of dietary vitamin A on the immunocompetence of Atlantic salmon (Salmo salar L.)","volume":"12","author":"Thompson","year":"1994","journal-title":"Fish Physiol. Biochem."},{"issue":"8","key":"10.1016\/j.fsi.2026.111717_bib54","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0145-305X(01)00038-6","article-title":"Innate host defense mechanisms of fish against viruses and bacteria","volume":"25","author":"Ellis","year":"2001","journal-title":"Dev. Comp. Immunol."},{"issue":"10","key":"10.1016\/j.fsi.2026.111717_bib55","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.3390\/biology14101333","article-title":"Differential immunostimulatory effects of hydrophilic and hydrophobic Solanum trilobatum fractions in tilapia","volume":"14","author":"Gnaneswari","year":"2025","journal-title":"Biology"},{"issue":"1","key":"10.1016\/j.fsi.2026.111717_bib56","doi-asserted-by":"crossref","first-page":"3210","DOI":"10.1038\/s41598-020-60131-1","article-title":"Fecal bacteria and metabolite responses to dietary lysozyme in a sow model from late gestation until lactation","volume":"10","author":"Xu","year":"2020","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.fsi.2026.111717_bib57","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/anu.13031","article-title":"Effects of antimicrobial peptide APSH-07 on the growth performance, anti-oxidation responses, stress resistance and intestine microbiota in large yellow croaker Larimichthys crocea","volume":"26","author":"Ge","year":"2020","journal-title":"Aquac. Nutr."},{"issue":"3","key":"10.1016\/j.fsi.2026.111717_bib58","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.phytochem.2003.10.022","article-title":"Horseradish peroxidase: a modern view of a classic enzyme","volume":"65","author":"Veitch","year":"2004","journal-title":"Phytochemistry"},{"issue":"6","key":"10.1016\/j.fsi.2026.111717_bib59","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1189\/jlb.0513304","article-title":"Antimicrobial peptide LL-37 promotes bacterial phagocytosis by human macrophages","volume":"95","author":"Wan","year":"2014","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.fsi.2026.111717_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2024.105144","article-title":"The effects of four paralogous piscidin antimicrobial peptides on the chemotaxis, macrophage respiratory burst, phagocytosis and expression of immune-related genes in orange-spotted grouper (Epinephelus coicodes)","volume":"154","author":"Huang","year":"2024","journal-title":"Dev. Comp. Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2026.111717_bib61","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0062302","article-title":"A novel beta-defensin antimicrobial peptide in atlantic cod with stimulatory effect on phagocytic activity","volume":"8","author":"Ruangsri","year":"2013","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.fsi.2026.111717_bib62","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.3390\/biology10121247","article-title":"The functions of \u03b2-defensin in flounder (Paralichthys olivaceus): antibiosis, chemotaxis and modulation of phagocytosis","volume":"10","author":"Hao","year":"2021","journal-title":"Biology"},{"issue":"8","key":"10.1016\/j.fsi.2026.111717_bib63","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S0145-305X(01)00037-4","article-title":"Antimicrobial mechanisms of fish phagocytes and their role in host defense","volume":"25","author":"Neumann","year":"2001","journal-title":"Dev. Comp. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111717_bib64","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41420-024-02278-8","article-title":"Free radicals and their impact on health and antioxidant defenses: a review","volume":"11","author":"Chandimali","year":"2025","journal-title":"Cell Death Discov."},{"issue":"4","key":"10.1016\/j.fsi.2026.111717_bib65","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10126-025-10488-z","article-title":"Analysis of in silico properties and in vitro immunomodulatory effects of seven synthetic host defence peptides in gilthead seabream (Sparus aurata) leucocytes","volume":"27","author":"Mar\u00edn-Parra","year":"2025","journal-title":"Mar. Biotechnol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111717_bib66","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.bbrc.2008.04.176","article-title":"Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression","volume":"372","author":"Hasegawa","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"7","key":"10.1016\/j.fsi.2026.111717_bib67","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1039\/D4TB02200A","article-title":"Tyrosine-modified tilapia skin antioxidant peptides and their hydroxyl radical quenching activities","volume":"13","author":"Wang","year":"2025","journal-title":"J. Mater. Chem. B"},{"issue":"1","key":"10.1016\/j.fsi.2026.111717_bib68","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008808","article-title":"MHC Class II molecules enhance toll-like receptor mediated innate immune responses","volume":"5","author":"Frei","year":"2010","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.fsi.2026.111717_bib69","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/ni.2015","article-title":"Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk","volume":"12","author":"Liu","year":"2011","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2026.111717_bib70","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nri3818","article-title":"The ins and outs of MHC class II-mediated antigen processing and presentation","volume":"15","author":"Roche","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.fsi.2026.111717_bib71","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.semcdb.2018.02.002","article-title":"Modulation of toll-like receptor signaling by antimicrobial peptides","volume":"88","author":"Lee","year":"2019","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.fsi.2026.111717_bib72","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.fsi.2016.06.028","article-title":"The response of fish to immunostimulant diets","volume":"56","author":"Vallejos-Vidal","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111717_bib73","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1161067","article-title":"The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions","volume":"14","author":"Carlini","year":"2023","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111717_bib74","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.molcel.2009.09.023","article-title":"A small molecule inhibitor of inducible heat shock protein 70","volume":"36","author":"Leu","year":"2009","journal-title":"Mol. Cell"},{"issue":"24","key":"10.1016\/j.fsi.2026.111717_bib75","doi-asserted-by":"crossref","first-page":"19376","DOI":"10.1039\/D5RA03137K","article-title":"Disrupting the Hsp90\u2013Cdc37 axis: a selective strategy for targeting oncogenic kinases in cancer","volume":"15","author":"Kamel","year":"2025","journal-title":"RSC Adv."},{"key":"10.1016\/j.fsi.2026.111717_bib76","series-title":"Improving Farmed Fish Quality and Safety","first-page":"241","article-title":"9 - understanding factors affecting flesh quality in farmed fish","author":"Espe","year":"2008"},{"issue":"4","key":"10.1016\/j.fsi.2026.111717_bib77","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1089\/zeb.2008.0551","article-title":"Pigments, patterns, and fish behavior","volume":"5","author":"Price","year":"2008","journal-title":"Zebrafish"},{"issue":"1","key":"10.1016\/j.fsi.2026.111717_bib78","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s11160-009-9121-6","article-title":"Genetics of salmonid skin pigmentation: clues and prospects for improving the external appearance of farmed salmonids","volume":"20","author":"Colihueque","year":"2010","journal-title":"Rev. Fish Biol. Fish."},{"key":"10.1016\/j.fsi.2026.111717_bib79","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cbpa.2017.06.001","article-title":"Fish pigmentation and the melanocortin system","volume":"211","author":"Cal","year":"2017","journal-title":"Comp. Biochem. Physiol. Mol. Integr. Physiol."},{"issue":"3","key":"10.1016\/j.fsi.2026.111717_bib80","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.aquaculture.2011.09.022","article-title":"Soy peptide inclusion levels influence the growth performance, proteolytic enzyme activities, blood biochemical parameters and body composition of Japanese flounder, Paralichthys olivaceus","volume":"321","author":"Mamauag","year":"2011","journal-title":"Aquaculture"},{"issue":"11","key":"10.1016\/j.fsi.2026.111717_bib81","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.3390\/ani10112138","article-title":"Skin pigmentation in gilthead seabream (Sparus aurata L.) fed conventional and novel protein sources in diets deprived of fish meal","volume":"10","author":"Pulcini","year":"2020","journal-title":"Animals"},{"issue":"1","key":"10.1016\/j.fsi.2026.111717_bib82","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/raq.12849","article-title":"The flesh texture of teleost fish: characteristics and interventional strategies","volume":"16","author":"Wang","year":"2024","journal-title":"Rev. Aquacult."},{"key":"10.1016\/j.fsi.2026.111717_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2022.738701","article-title":"Applications of recombinant proteins in aquaculture","volume":"561","author":"Mohammadzadeh","year":"2022","journal-title":"Aquaculture"},{"issue":"1","key":"10.1016\/j.fsi.2026.111717_bib84","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00253-025-13667-z","article-title":"Optimized expression and antimicrobial activity of rainbow trout defensin 3 in Komagataella phaffii","volume":"110","author":"Cai","year":"2026","journal-title":"Appl. Microbiol. Biotechnol."}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826006212?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826006212?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T03:43:50Z","timestamp":1792986230000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464826006212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":84,"alternative-id":["S1050464826006212"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111717","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the multifaceted effects of dietary encapsulated piscidin 1 on gilthead seabream (Sparus aurata): from immunomodulation to muscle quality","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111717","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"111717"}}