{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T03:36:00Z","timestamp":1792985760234,"version":"4.5.0"},"reference-count":98,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31972777"],"award-info":[{"award-number":["31972777"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.fsi.2026.111747","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:05:14Z","timestamp":1791475514000},"page":"111747","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Immunological mechanisms of Hsp70-Tlr4 and Hsp90-Akt signaling pathways in Percocypris pingi during chronic heat stress"],"prefix":"10.1016","volume":"179","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7723-4211","authenticated-orcid":false,"given":"Chunxia","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xubin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengna","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qipeng","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7519-5277","authenticated-orcid":false,"given":"Yue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menghao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songpei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziting","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiming","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2026.111747_bib1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.scitotenv.2019.05.024","article-title":"Comparing the impacts of climate change on the responses and linkages between terrestrial and aquatic ecosystems","volume":"682","author":"H\u00e4der","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fsi.2026.111747_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecolmodel.2019.108718","article-title":"Changes in streamflow and water temperature affect fish habitat in the Athabasca River basin in the context of climate change","volume":"407","author":"Morales-Mar\u00edn","year":"2019","journal-title":"Ecol. Model."},{"issue":"4","key":"10.1016\/j.fsi.2026.111747_bib3","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Shizuo","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.fsi.2026.111747_bib4","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.theriogenology.2017.07.050","article-title":"Development, and effect of water temperature on development rate, of pikeperch Sander lucioperca embryos","volume":"104","author":"G\u00fcralp","year":"2017","journal-title":"Theriogenology"},{"key":"10.1016\/j.fsi.2026.111747_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.164834","article-title":"Climate change effects on hatching success and embryonic development of fish: assessing multiple stressor responses in a large-scale mesocosm study","volume":"893","author":"Wild","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"5","key":"10.1016\/j.fsi.2026.111747_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0217133","article-title":"The impact of acute thermal stress on the metabolome of the black rockfish (Sebastes schlegelii)","volume":"14","author":"Song","year":"2019","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.fsi.2026.111747_bib7","article-title":"Effects of temperature on metabolic scaling in black carp","volume":"8","author":"Li","year":"2020","journal-title":"PeerJ"},{"key":"10.1016\/j.fsi.2026.111747_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2024.742088","article-title":"Effects of hypoxic stress on liver metabolism, oxidative stress, and immunity in yellow catfish (Pelteobagrus fulvidraco) at different water temperatures","volume":"598","author":"Wang","year":"2025","journal-title":"Aquaculture"},{"issue":"4","key":"10.1016\/j.fsi.2026.111747_bib9","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/jfb.15163","article-title":"Temperature effects on teleost immunity in the light of climate change","volume":"101","author":"Scharsack","year":"2022","journal-title":"J. Fish. Biol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111747_bib10","doi-asserted-by":"crossref","first-page":"7150","DOI":"10.1038\/s41598-024-57731-6","article-title":"Effects of different temperatures on Leiocassis longirostris gill structure and intestinal microbial composition","volume":"14","author":"Zhao","year":"2024","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.fsi.2026.111747_bib11","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.fsi.2011.07.015","article-title":"Temperature effects on immune response and hematological parameters of channel catfish Ictalurus punctatus vaccinated with live theronts of Ichthyophthirius multifiliis","volume":"31","author":"Martins","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111747_bib12","series-title":"Mechanism Study on Immune Response and Bacterial Susceptibility of Largemouth Bass(Micropterus salmoides)under High Temperature Stress","author":"cheng","year":"2023"},{"issue":"14","key":"10.1016\/j.fsi.2026.111747_bib13","article-title":"Decreased resistance to bacterial cold-water disease and excessive inflammatory response in ayu (Plecoglossus altivelis) reared at high water temperature","volume":"14","author":"Kato","year":"2023","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111747_bib14","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/s41590-021-01091-0","article-title":"Innate immunity: the first line of defense against SARS-CoV-2","volume":"23","author":"Diamond","year":"2022","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2026.111747_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/biology6040039","article-title":"Impacts of low temperature on the teleost immune System","volume":"6","author":"Abram","year":"2017","journal-title":"Biology"},{"issue":"4","key":"10.1016\/j.fsi.2026.111747_bib16","first-page":"1","article-title":"Effects of chronic heat stress on spleen structure, apoptosis and immune response in Siberian Sturgeon (Acipenser baerii)","volume":"76","author":"Tan","year":"2024","journal-title":"Isr. J. Aquac. Bamidgeh"},{"key":"10.1016\/j.fsi.2026.111747_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2025.105421","article-title":"Splenic tissue injury and physiological response mechanisms in juvenile yellowfin tuna (Thunnus albacares) under acute cold stress","volume":"169","author":"Huang","year":"2025","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2026.111747_bib18","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.fsi.2022.07.075","article-title":"Chronic cold exposure modulates genes related to feeding and immune system in Nile tilapia (Oreochromis niloticus)","volume":"128","author":"Dellagostin","year":"2022","journal-title":"Fish Shellfish Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111747_bib19","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3390\/antiox14020217","article-title":"Molecular response and metabolic reprogramming of the spleen coping with cold stress in the Chinese soft-shelled turtle (Pelodiscus sinensis)","volume":"14","author":"Ji","year":"2025","journal-title":"Antioxidants"},{"issue":"16","key":"10.1016\/j.fsi.2026.111747_bib20","article-title":"What's cooking? The effect of temperature on the immune response","volume":"27","author":"Old","year":"2025","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.fsi.2026.111747_bib21","doi-asserted-by":"crossref","first-page":"6378","DOI":"10.3382\/ps\/pez471","article-title":"Dietary resveratrol supplementation inhibits heat stress-induced high-activated innate immunity and inflammatory response in spleen of yellow-feather broilers","volume":"98","author":"He","year":"2019","journal-title":"Poult. Sci."},{"issue":"3","key":"10.1016\/j.fsi.2026.111747_bib22","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/14728222.2018.1439477","article-title":"The 70-kDa heat shock protein (Hsp70) as a therapeutic target for stroke","volume":"22","author":"Kim","year":"2018","journal-title":"Expert Opin. Ther. Targets"},{"issue":"17","key":"10.1016\/j.fsi.2026.111747_bib23","doi-asserted-by":"crossref","first-page":"15028","DOI":"10.1074\/jbc.M200497200","article-title":"Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4","volume":"277","author":"Asea","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.fsi.2026.111747_bib24","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1186\/s12917-024-04411-2","article-title":"Mechanism of activation of TLR4\/NF-\u03baB\/NLRP3 signaling pathway induced by heat stress disrupting the filtration barrier in broiler","volume":"20","author":"Dong","year":"2024","journal-title":"BMC Vet. Res."},{"issue":"10","key":"10.1016\/j.fsi.2026.111747_bib25","doi-asserted-by":"crossref","first-page":"13951","DOI":"10.1007\/s13277-016-5189-5","article-title":"Extracellular HSP70-peptide complexes promote the proliferation of hepatocellular carcinoma cells via TLR2\/4\/JNK1\/2MAPK pathway","volume":"37","author":"Zhe","year":"2016","journal-title":"Tumour Biol."},{"issue":"5","key":"10.1016\/j.fsi.2026.111747_bib26","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.3390\/ijms21051646","article-title":"Hsp90 relieves heat stress-induced damage in mouse kidneys: involvement of antiapoptotic PKM2-AKT and Autophagic HIF-1\u03b1 signaling","volume":"21","author":"Chen","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.fsi.2026.111747_bib27","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s12192-011-0255-9","article-title":"Heat-shock protein 90 alpha (HSP90\u03b1) modulates signaling pathways towards tolerance of oxidative stress and enhanced survival of hepatocytes of Mugil cephalus","volume":"16","author":"Rani","year":"2011","journal-title":"Cell Stress Chaperones"},{"issue":"20","key":"10.1016\/j.fsi.2026.111747_bib28","doi-asserted-by":"crossref","first-page":"10832","DOI":"10.1073\/pnas.170276797","article-title":"Modulation of Akt kinase activity by binding to Hsp90","volume":"97","author":"Sato","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.fsi.2026.111747_bib29","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1755-1536-3-21","article-title":"Toll-like receptor 4 signaling in liver injury and hepatic fibrogenesis","volume":"3","author":"Guo","year":"2010","journal-title":"Fibrogenesis Tissue Repair"},{"issue":"42","key":"10.1016\/j.fsi.2026.111747_bib30","doi-asserted-by":"crossref","first-page":"39858","DOI":"10.1074\/jbc.M206322200","article-title":"Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function","volume":"277","author":"Basso","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.fsi.2026.111747_bib31","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3389\/fvets.2020.00016","article-title":"Floods, hurricanes, and other catastrophes: a challenge for the immune system of livestock and other animals","volume":"7","author":"Filipe","year":"2020","journal-title":"Front. Vet. Sci."},{"issue":"6","key":"10.1016\/j.fsi.2026.111747_bib32","article-title":"Molecular phylogeny and biogeography of percocypris (Cyprinidae, Teleostei)","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.fsi.2026.111747_bib33","article-title":"Genetic diversity and structure analysis of Percocypris pingi (Cypriniformes: Cyprinidae): implications for conservation and hatchery release in the Yalong River","volume":"11","author":"Li","year":"2016","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.fsi.2026.111747_bib34","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s12864-025-12500-1","article-title":"Population structure based on whole-genome resequencing and adaptive evolutionary mechanisms of circadian entrainment in the endangered fish Percocypris pingi","volume":"27","author":"Yan","year":"2026","journal-title":"BMC Genom."},{"issue":"3","key":"10.1016\/j.fsi.2026.111747_bib35","first-page":"88","article-title":"Study on the morphological development and growth characteristics of Percocypris pingi pingi (Tchang) larva in the middle rea-ches of Jinsha River","volume":"52","author":"Xiang","year":"2024","journal-title":"J. Anhui Agric. Sci."},{"issue":"1","key":"10.1016\/j.fsi.2026.111747_bib36","first-page":"9","article-title":"Observation of embryonic development and early growth of F1 hybrid between Schizothorax prenanti and Percocypris pingi","volume":"43","author":"Xialin","year":"2025","journal-title":"J. Sichuan Agricult. Univ."},{"issue":"4","key":"10.1016\/j.fsi.2026.111747_bib37","first-page":"84","article-title":"Artificial propagation of Percocypris pingi","volume":"37","author":"xiang","year":"2016","journal-title":"J. Hydroecol."},{"key":"10.1016\/j.fsi.2026.111747_bib38","series-title":"Comparative Mitochondrial Genomics and Phylogeny of Schizothoracinae and Barbinae","first-page":"1","author":"Rusitanmu","year":"2021"},{"key":"10.1016\/j.fsi.2026.111747_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2022.738805","article-title":"Hybridization with Percocypris pingi male can improve the cultivation characteristics of snow trout (Schizothorax wangchiachii), especially the resistance to white spot disease (Ichthyophthirius multifiliis)","volume":"562","author":"Gu","year":"2023","journal-title":"Aquaculture"},{"issue":"10","key":"10.1016\/j.fsi.2026.111747_bib40","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1002\/jez.2742","article-title":"Continuous flow stimulation had no significant effect on the growth rate but was conducive to the swimming performance, spontaneous behavior, and nonspecific immune parameter of juvenile Percocypris pingi","volume":"339","author":"Li","year":"2023","journal-title":"J. Exp. Zool. A Ecol. Integr Physiol."},{"issue":"6","key":"10.1016\/j.fsi.2026.111747_bib41","doi-asserted-by":"crossref","first-page":"374","DOI":"10.3390\/fishes7060374","article-title":"Effects of water temperature on the growth, antioxidant capacity, and gut microbiota of Percocypris pingi juveniles","volume":"7","author":"Wu","year":"2022","journal-title":"Fishes"},{"key":"10.1016\/j.fsi.2026.111747_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtherbio.2025.104233","article-title":"A comprehensive understanding of thermal tolerance in Percocypris pingi (Tchang, 1930) under different acclimation temperatures supported by behavioral assessments","volume":"132","author":"Guo","year":"2025","journal-title":"J. Therm. Biol."},{"issue":"8","key":"10.1016\/j.fsi.2026.111747_bib43","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat. Biotechnol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111747_bib44","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/s41392-025-02124-y","article-title":"Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets","volume":"10","author":"Guan","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"11","key":"10.1016\/j.fsi.2026.111747_bib45","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat. Rev. Immunol."},{"issue":"11","key":"10.1016\/j.fsi.2026.111747_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0080908","article-title":"Macrophage polarisation: an immunohistochemical approach for identifying M1 and M2 macrophages","volume":"8","author":"Barros","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2026.111747_bib47","article-title":"A global regulatory network for dysregulated gene expression and abnormal metabolic signaling in immune cells in the microenvironment of graves' disease and Hashimoto's thyroiditis","volume":"13","author":"Zheng","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2026.111747_bib48","first-page":"2321","article-title":"Heat shock proteins, importance and expression in fishes","volume":"4","author":"Wali","year":"2016","journal-title":"Eur. J. Biotechnol. Biosci."},{"issue":"10","key":"10.1016\/j.fsi.2026.111747_bib49","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00568-24","article-title":"Dissecting the heat stress altering immune responses and skin microbiota in fish in a recirculating aquaculture system in Singapore","volume":"13","author":"Ng","year":"2024","journal-title":"Microbiol. Spectr."},{"issue":"2","key":"10.1016\/j.fsi.2026.111747_bib50","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3390\/fishes8020093","article-title":"Main components of fish immunity: an overview of the fish immune system","volume":"8","author":"Mokhtar","year":"2023","journal-title":"Fishes"},{"issue":"1","key":"10.1016\/j.fsi.2026.111747_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00251-020-01198-y","article-title":"Immunogenetics special issue 2021: fish immunology","volume":"73","author":"Dijkstra","year":"2021","journal-title":"Immunogenetics"},{"key":"10.1016\/j.fsi.2026.111747_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.109280","article-title":"The fish spleen","volume":"144","author":"Zapata","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111747_bib53","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3389\/fimmu.2017.00827","article-title":"Melanomacrophage centers as a histological indicator of immune function in fish and other poikilotherms","volume":"8","author":"Steinel","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2026.111747_bib54","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev-physiol-022516-034339","article-title":"Macrophage polarization","volume":"79","author":"Murray","year":"2017","journal-title":"Annu. Rev. Physiol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111747_bib55","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41413-025-00471-8","article-title":"Biomaterial-mediated macrophage polarization remodeling and sequential regulation: a potential strategy in bone infections treatment","volume":"13","author":"Shi","year":"2025","journal-title":"Bone Res."},{"key":"10.1016\/j.fsi.2026.111747_bib56","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/6979117","article-title":"lnc-MRGPRF-6:1 promotes M1 polarization of macrophage and inflammatory response through the TLR4-MyD88-MAPK pathway","volume":"2022","author":"Hu","year":"2022","journal-title":"Mediat. Inflamm."},{"issue":"5","key":"10.1016\/j.fsi.2026.111747_bib57","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.102","article-title":"Ubiquitylation of MFHAS1 by the ubiquitin ligase praja2 promotes M1 macrophage polarization by activating JNK and p38 pathways","volume":"8","author":"Zhong","year":"2017","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.fsi.2026.111747_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109955","article-title":"Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors","volume":"37","author":"He","year":"2021","journal-title":"Cell Rep."},{"issue":"5","key":"10.1016\/j.fsi.2026.111747_bib59","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.349","article-title":"Signaling pathways in macrophages: molecular mechanisms and therapeutic targets","volume":"4","author":"Li","year":"2023","journal-title":"MedComm"},{"issue":"20","key":"10.1016\/j.fsi.2026.111747_bib60","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1097\/CM9.0000000000002426","article-title":"Metabolic reprogramming in the immunosuppression of tumor-associated macrophages","volume":"135","author":"Wang","year":"2022","journal-title":"Chin. Med. J."},{"issue":"4","key":"10.1016\/j.fsi.2026.111747_bib61","first-page":"880","article-title":"Substrate stiffness modulates bone marrow-derived macrophage polarization through NF-\u03baB signaling pathway","volume":"5","author":"Chen","year":"2020","journal-title":"Bioact. Mater."},{"issue":"7","key":"10.1016\/j.fsi.2026.111747_bib62","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1039\/D2FO02191A","article-title":"The anti-hepatocellular carcinoma effects of polysaccharides from Ganoderma lucidum by regulating macrophage polarization via the MAPK\/NF-\u03baB signaling pathway","volume":"14","author":"Li","year":"2023","journal-title":"Food Funct."},{"issue":"6","key":"10.1016\/j.fsi.2026.111747_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e17116","article-title":"Exploring the potential of treating chronic liver disease targeting the PI3K\/Akt pathway and polarization mechanism of macrophages","volume":"9","author":"Yang","year":"2023","journal-title":"Heliyon"},{"issue":"1","key":"10.1016\/j.fsi.2026.111747_bib64","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1038\/s41467-024-46210-1","article-title":"Proinflammatory polarization of engineered heat-inducible macrophages reprogram the tumor immune microenvironment during cancer immunotherapy","volume":"15","author":"Xue","year":"2024","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.fsi.2026.111747_bib65","doi-asserted-by":"crossref","first-page":"5999","DOI":"10.4049\/jimmunol.1402719","article-title":"Cryptococcal heat shock protein 70 homolog Ssa1 contributes to pulmonary expansion of cryptococcus neoformans during the afferent phase of the immune response by promoting macrophage M2 polarization","volume":"194","author":"Eastman","year":"2015","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111747_bib66","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-73394-9","article-title":"HSP90 promotes tumor associated macrophage differentiation during triple-negative breast cancer progression","volume":"14","author":"Hong","year":"2024","journal-title":"Sci. Rep."},{"issue":"24","key":"10.1016\/j.fsi.2026.111747_bib67","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242417574","article-title":"Fever-range hyperthermia promotes macrophage polarization towards regulatory phenotype M2b","volume":"24","author":"Koz\u0142owski","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.fsi.2026.111747_bib68","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030077","article-title":"Elevation in body temperature to fever range enhances and prolongs subsequent responsiveness of macrophages to endotoxin challenge","volume":"7","author":"Lee","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2026.111747_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109631","article-title":"Fibrinogen-like protein 2 promotes proinflammatory macrophage polarization and mitochondrial dysfunction in liver fibrosis","volume":"117","author":"Tao","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"10.1016\/j.fsi.2026.111747_bib70","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/jfd.13287","article-title":"Genome-wide analysis of toll-like receptors in zebrafish and the effect of rearing temperature on the receptors in response to stimulated pathogen infection","volume":"44","author":"Chen","year":"2021","journal-title":"J. Fish. Dis."},{"issue":"6","key":"10.1016\/j.fsi.2026.111747_bib71","first-page":"1021","article-title":"Modulation of TLR2, TLR4, TLR5, NOD1 and NOD2 receptor gene expressions and their downstream signaling molecules following thermal stress in the Indian major carp catla (Catla catla)","volume":"5","author":"Basu","year":"2015","journal-title":"Biotech"},{"issue":"7","key":"10.1016\/j.fsi.2026.111747_bib72","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3390\/vetsci11070293","article-title":"Chronic heat stress induces oxidative stress and induces inflammatory injury in broiler spleen via TLRs\/MyD88\/NF-\u03baB signaling pathway in broilers","volume":"11","author":"Chen","year":"2024","journal-title":"Vet. Sci."},{"issue":"3","key":"10.1016\/j.fsi.2026.111747_bib73","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3390\/ani14030497","article-title":"The role of the TLR4-MyD88 signaling pathway in the immune response of the selected scallop strain \"Hongmo No. 1\" to heat stress","volume":"14","author":"Yue","year":"2024","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.fsi.2026.111747_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2025.110294","article-title":"Heat stress induces oxidative stress and weakens the immune system in catfish Clarias magur: evidence from physiological, histological, and transcriptomic analyses","volume":"161","author":"Singh","year":"2025","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111747_bib75","article-title":"Exposure to heat stress causes downregulation of immune response genes and weakens the disease resistance of Micropterus salmoides. Comparative biochemistry and physiology Part D","volume":"43","author":"Yang","year":"2022","journal-title":"Genom. Proteonomics"},{"key":"10.1016\/j.fsi.2026.111747_bib76","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.redox.2014.10.003","article-title":"Natural thermal adaptation increases heat shock protein levels and decreases oxidative stress","volume":"3","author":"Oksala","year":"2014","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111747_bib77","doi-asserted-by":"crossref","DOI":"10.1007\/s10695-026-01666-4","article-title":"Chronic thermal stress during early zebrafish (Danio rerio) development induces morphological, molecular, and liver histopathological changes","volume":"52","author":"Adzijovski","year":"2026","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.fsi.2026.111747_bib78","article-title":"Temperature acclimation alters the thermal tolerance and intestinal heat stress response in a Tibetan fish Oxygymnocypris stewarti","volume":"13","author":"Zhu","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.fsi.2026.111747_bib79","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.31668","article-title":"Hsf1 and Hsp70 constitute a two-component feedback loop that regulates the yeast heat shock response","volume":"7","author":"Krakowiak","year":"2018","journal-title":"eLife"},{"issue":"14","key":"10.1016\/j.fsi.2026.111747_bib80","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2019104096","article-title":"Feedback regulation of heat shock factor 1 (Hsf1) activity by Hsp70\u2010mediated trimer unzipping and dissociation from DNA","volume":"39","author":"Kmiecik","year":"2020","journal-title":"EMBO J."},{"issue":"21","key":"10.1016\/j.fsi.2026.111747_bib81","article-title":"Long-Term heat stress triggers immune activation and cell death remodeling in the brain of largemouth bass (Micropterus salmoides)","volume":"15","author":"Meng","year":"2025","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.fsi.2026.111747_bib82","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.redox.2014.10.003","article-title":"Natural thermal adaptation increases heat shock protein levels and decreases oxidative stress","volume":"3","author":"Oksala","year":"2014","journal-title":"Redox Biol."},{"issue":"24","key":"10.1016\/j.fsi.2026.111747_bib83","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252413372","article-title":"Integrated analysis of transcriptome and metabolome in the brain after cold stress of Red Tilapia during overwintering","volume":"25","author":"Zhu","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.fsi.2026.111747_bib84","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.3390\/ijms22063028","article-title":"Characterization of biological pathways regulating acute cold resistance of Zebrafish","volume":"22","author":"Ren","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.fsi.2026.111747_bib85","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1186\/s12864-020-06946-8","article-title":"Transcriptomic profiling revealed key signaling pathways for cold tolerance and acclimation of two carp species","volume":"21","author":"Ge","year":"2020","journal-title":"BMC Genom."},{"key":"10.1016\/j.fsi.2026.111747_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.126404","article-title":"FoxO signaling and mitochondria-related apoptosis pathways mediate tsinling lenok trout (Brachymystax lenok tsinlingensis) liver injury under high temperature stress","volume":"251","author":"Ma","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"10","key":"10.1016\/j.fsi.2026.111747_bib87","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.3390\/genes15101345","article-title":"Transcriptomic analysis of hippocampus abdominalis larvae under high temperature stress","volume":"15","author":"Xiao","year":"2024","journal-title":"Genes"},{"issue":"8","key":"10.1016\/j.fsi.2026.111747_bib88","doi-asserted-by":"crossref","first-page":"926","DOI":"10.3390\/antiox14080926","article-title":"Chronic heat stress caused lipid metabolism disorder and tissue injury in the liver of Huso dauricus via oxidative-stress-mediated ferroptosis","volume":"14","author":"Zhang","year":"2025","journal-title":"Antioxidants"},{"key":"10.1016\/j.fsi.2026.111747_bib89","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1294729","article-title":"Transcriptome analysis in hepatopancreases reveals the response of domesticated common carp to a high-temperature environment in the agricultural heritage rice-fish system","volume":"14","author":"Cheng","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.fsi.2026.111747_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116835","article-title":"Transcriptional dynamic changes in energy metabolism, protein synthesis and cell cycle regulation reveal the biological adaptation mechanisms of juvenile Acrossocheilus wenchowensis under acute temperature changes","volume":"283","author":"He","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fsi.2026.111747_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2023.740037","article-title":"Comparative transcriptome analysis of hybrid Jinhu grouper (Epinephelus fuscoguttatus \u2640 \u00d7 Epinephelus tukula \u2642) and Epinephelus fuscoguttatus under temperature stress","volume":"578","author":"Duan","year":"2024","journal-title":"Aquaculture"},{"issue":"11","key":"10.1016\/j.fsi.2026.111747_bib92","first-page":"1673","article-title":"Transcriptome analysis of high-temperature adaptation in large yellow croaker (Larimichthys crocea)","volume":"42","author":"zhen","year":"2018","journal-title":"J. Fish. China"},{"issue":"2","key":"10.1016\/j.fsi.2026.111747_bib93","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2174\/1874104501105010093","article-title":"Medicinal chemistry and actions of dual and pan PPAR modulators","volume":"5","author":"Adeghate","year":"2011","journal-title":"Open Med. Chem. J."},{"issue":"10","key":"10.1016\/j.fsi.2026.111747_bib94","doi-asserted-by":"crossref","first-page":"8569","DOI":"10.3390\/ijms24108569","article-title":"Comprehensive analysis of microbiome, metabolome, and transcriptome revealed the mechanisms of intestinal injury in Rainbow Trout under heat stress","volume":"24","author":"Zhou","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.fsi.2026.111747_bib95","first-page":"808","article-title":"Research progress on the systematic evolution and plateau adaptation of schizothoracine fishes","volume":"35","author":"Baoshan","year":"2023","journal-title":"J. Lake Sci."},{"key":"10.1016\/j.fsi.2026.111747_bib96","first-page":"203","article-title":"Study on artificial breeding technology of Percocypris pingi in a full recirculating aquaculture system","volume":"23","author":"zhang","year":"2019","journal-title":"Mod. Agric. Sci. Technol."},{"key":"10.1016\/j.fsi.2026.111747_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtherbio.2025.104233","article-title":"A comprehensive understanding of thermal tolerance in Percocypris pingi (Tchang, 1930) under different acclimation temperatures supported by behavioral assessments","volume":"132","author":"Guo","year":"2025","journal-title":"J. Therm. Biol."},{"issue":"17","key":"10.1016\/j.fsi.2026.111747_bib98","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25179629","article-title":"Environmental temperature variation affects brain lipid composition in adult zebrafish (Danio rerio)","volume":"25","author":"Maffioli","year":"2024","journal-title":"Int. J. Mol. Sci."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826006510?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826006510?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T03:28:11Z","timestamp":1792985291000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464826006510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":98,"alternative-id":["S1050464826006510"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111747","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunological mechanisms of Hsp70-Tlr4 and Hsp90-Akt signaling pathways in Percocypris pingi during chronic heat stress","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111747","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111747"}}