{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T04:32:46Z","timestamp":1792989166115,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFD2401502"],"award-info":[{"award-number":["2024YFD2401502"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.fsi.2026.111754","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:14:38Z","timestamp":1790810078000},"page":"111754","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The response mechanism of mandarin fish (Siniperca chuatsi) astrocyte\u2010like cells to SCRV infection: Insights from Transcriptome Sequencing"],"prefix":"10.1016","volume":"179","author":[{"given":"Pengfei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunjian","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinxuan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GanXiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2026.111754_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.671650","article-title":"A chromosome-level genome assembly of the mandarin fish (Siniperca chuatsi)","volume":"12","author":"Ding","year":"2021","journal-title":"Front. Genet."},{"key":"10.1016\/j.fsi.2026.111754_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2022.738894","article-title":"Isolation, genomic and biological characterizations of a rhabdovirus from mandarin fish (Siniperca chuatsi)","volume":"563","author":"Liu","year":"2023","journal-title":"Aquaculture"},{"issue":"1","key":"10.1016\/j.fsi.2026.111754_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aquaculture.2006.09.030","article-title":"Isolation and characterization of a rhabdovirus from co-infection of two viruses in mandarin fish","volume":"262","author":"Tao","year":"2007","journal-title":"Aquaculture"},{"issue":"6","key":"10.1016\/j.fsi.2026.111754_bib4","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/jfd.13329","article-title":"Transcriptome analysis of immune response against Siniperca chuatsi rhabdovirus infection in mandarin fish Siniperca chuatsi","volume":"44","author":"Huang","year":"2021","journal-title":"J. Fish. Dis."},{"issue":"6","key":"10.1016\/j.fsi.2026.111754_bib5","doi-asserted-by":"crossref","DOI":"10.1099\/jgv.0.001689","article-title":"ICTV Virus Taxonomy Profile: rhabdoviridae 2022","volume":"103","author":"Walker","year":"2022","journal-title":"J. Gen. Virol."},{"issue":"11","key":"10.1016\/j.fsi.2026.111754_bib6","article-title":"Revised taxonomy of rhabdoviruses infecting fish and marine mammals","volume":"12","author":"Walker","year":"2022","journal-title":"Animals (Basel)"},{"issue":"5","key":"10.1016\/j.fsi.2026.111754_bib7","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/BF02977883","article-title":"Three different viruses observed from the tissues of diseased mandarin fish Siniperca chuatsi","volume":"44","author":"Zhang","year":"1999","journal-title":"Chin. Sci. Bull."},{"issue":"7","key":"10.1016\/j.fsi.2026.111754_bib8","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1007\/s11427-020-1789-5","article-title":"Long noncoding RNA AANCR modulates innate antiviral responses by blocking miR-210-dependent MITA downregulation in teleost fish, Miichthys miiuy","volume":"64","author":"Chu","year":"2021","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.fsi.2026.111754_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2023.739684","article-title":"Infection tracing and organ tropism of Siniperca chuatsi rhabdovirus expressing enhanced green fluorescent protein","volume":"574","author":"Liu","year":"2023","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2026.111754_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2026.111109","article-title":"Transcriptome analysis reveals the response mechanism of largemouth bass (Micropterus salmoides) brain to MSRV infection","volume":"170","author":"Guo","year":"2026","journal-title":"Fish Shellfish Immunol."},{"issue":"3","key":"10.1016\/j.fsi.2026.111754_bib11","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/08997659.2013.799613","article-title":"A strain of Siniperca chuatsi rhabdovirus causes high mortality among cultured Largemouth Bass in South China","volume":"25","author":"Ma","year":"2013","journal-title":"J. Aquat. Anim. Health"},{"issue":"1","key":"10.1016\/j.fsi.2026.111754_bib12","doi-asserted-by":"crossref","DOI":"10.1080\/21688370.2020.1840913","article-title":"Basic physiology of the blood-brain barrier in health and disease: a brief overview","volume":"9","author":"Kaya","year":"2021","journal-title":"Tissue Barriers"},{"issue":"1","key":"10.1016\/j.fsi.2026.111754_bib13","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00441-008-0658-9","article-title":"Brain endothelial cells and the glio-vascular complex","volume":"335","author":"Wolburg","year":"2009","journal-title":"Cell Tissue Res."},{"issue":"10","key":"10.1016\/j.fsi.2026.111754_bib14","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1111\/jfd.13674","article-title":"Establishment of an astrocyte-like cell line from the brain of tilapia (Oreochromis niloticus) for virus pathogenesis and a vitro model of the blood-brain barrier","volume":"45","author":"Li","year":"2022","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2026.111754_bib15","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.104772.4","article-title":"Myosin light chain 3 serves as a receptor for nervous necrosis virus entry into host cells via the macropinocytosis pathway","volume":"13","author":"Yao","year":"2025","journal-title":"eLife"},{"key":"10.1016\/j.fsi.2026.111754_bib16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.fsi.2017.07.055","article-title":"Comparative transcriptome analysis of zebrafish (Danio rerio) brain and spleen infected with spring viremia of carp virus (SVCV)","volume":"69","author":"Wang","year":"2017","journal-title":"Fish Shellfish Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111754_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/cells13020150","article-title":"Involvement of astrocytes in the Formation, maintenance, and function of the blood-brain barrier","volume":"13","author":"Schiera","year":"2024","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.fsi.2026.111754_bib18","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00281-015-0515-3","article-title":"Control of autoimmune CNS inflammation by astrocytes","volume":"37","author":"Rothhammer","year":"2015","journal-title":"Semin. Immunopathol."},{"issue":"5","key":"10.1016\/j.fsi.2026.111754_bib19","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/nrn3898","article-title":"Astrocyte barriers to neurotoxic inflammation","volume":"16","author":"Sofroniew","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"issue":"3","key":"10.1016\/j.fsi.2026.111754_bib20","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/ni1439","article-title":"The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease","volume":"8","author":"Qian","year":"2007","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.fsi.2026.111754_bib21","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1172\/JCI88720","article-title":"Regional astrocyte IFN signaling restricts pathogenesis during neurotropic viral infection","volume":"127","author":"Daniels","year":"2017","journal-title":"J. Clin. Investig."},{"issue":"12","key":"10.1016\/j.fsi.2026.111754_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms10122464","article-title":"Siniperca chuatsi rhabdovirus (SCRV)-induced key pathways and major antiviral genes in fish cells","volume":"10","author":"Ke","year":"2022","journal-title":"Microorganisms"},{"issue":"1","key":"10.1016\/j.fsi.2026.111754_bib23","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01176-23","article-title":"EFHD2 cooperates with E3 ubiquitin ligase Smurf1 to facilitate virus infection by promoting the degradation of TRAF6 in teleost fish","volume":"98","author":"Wang","year":"2024","journal-title":"J. Virol."},{"issue":"11","key":"10.1016\/j.fsi.2026.111754_bib24","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01226-23","article-title":"Eukaryotic translation elongation factor 1 alpha (eEF1A) inhibits Siniperca chuatsi rhabdovirus (SCRV) infection through two distinct mechanisms","volume":"97","author":"Meng","year":"2023","journal-title":"J. Virol."},{"key":"10.1016\/j.fsi.2026.111754_bib25","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.fsi.2018.11.020","article-title":"MicroRNAs profiles of Chinese Perch Brain (CPB) cells infected with Siniperca chuatsi rhabdovirus (SCRV)","volume":"84","author":"Zhao","year":"2019","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111754_bib26","article-title":"MicroRNA regulation of toll-like receptor, RIG-I-like receptor and Nod-like receptor pathways in teleost fish: fish miRNAs in innate immune","author":"Chu","year":"2020","journal-title":"Rev. Aquacult."},{"issue":"7","key":"10.1016\/j.fsi.2026.111754_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008670","article-title":"Long noncoding RNA MARL regulates antiviral responses through suppression miR-122-dependent MAVS downregulation in lower vertebrates","volume":"16","author":"Chu","year":"2020","journal-title":"PLoS Pathog."},{"issue":"12","key":"10.1016\/j.fsi.2026.111754_bib28","article-title":"A novel protein NLRP12-119aa that prevents rhabdovirus replication by disrupting the RNP complex formation","volume":"12","author":"Zheng","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"D1","key":"10.1016\/j.fsi.2026.111754_bib29","doi-asserted-by":"crossref","first-page":"D279","DOI":"10.1093\/nar\/gkv1344","article-title":"The Pfam protein families database: towards a more sustainable future","volume":"44","author":"Finn","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"17","key":"10.1016\/j.fsi.2026.111754_bib30","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkt646","article-title":"Utilizing sequence intrinsic composition to classify protein-coding and long non-coding transcripts","volume":"41","author":"Sun","year":"2013","journal-title":"Nucleic Acids Res."},{"issue":"Web Server issue","key":"10.1016\/j.fsi.2026.111754_bib31","doi-asserted-by":"crossref","first-page":"W345","DOI":"10.1093\/nar\/gkm391","article-title":"CPC: assess the protein-coding potential of transcripts using sequence features and support vector machine","volume":"35","author":"Kong","year":"2007","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.fsi.2026.111754_bib32","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"1","key":"10.1016\/j.fsi.2026.111754_bib33","doi-asserted-by":"crossref","DOI":"10.1242\/dev.185595","article-title":"Single cell sequencing of radial glia progeny reveals the diversity of newborn neurons in the adult zebrafish brain","volume":"147","author":"Lange","year":"2020","journal-title":"Development"},{"issue":"35","key":"10.1016\/j.fsi.2026.111754_bib34","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ado0519","article-title":"The embryonic zebrafish brain is exclusively colonized by pu.1-dependent and lymphatic-independent population of microglia","volume":"10","author":"Yu","year":"2024","journal-title":"Sci. Adv."},{"issue":"3","key":"10.1016\/j.fsi.2026.111754_bib35","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s12264-022-00938-2","article-title":"Immunological markers for central nervous system glia","volume":"39","author":"Huang","year":"2023","journal-title":"Neurosci. Bull."},{"issue":"19","key":"10.1016\/j.fsi.2026.111754_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231911734","article-title":"Experimental and clinical biomarkers for progressive evaluation of neuropathology and therapeutic interventions for acute and chronic neurological disorders","volume":"23","author":"Reddy","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fsi.2026.111754_bib37","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.fsi.2018.11.024","article-title":"European sea bass brain DLB-1 cell line is susceptible to nodavirus: a transcriptomic study","volume":"86","author":"Chaves-Pozo","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111754_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2026.1819983","article-title":"Temporal transcriptomic analysis of scale drop disease virus in Asian seabass kidney cells reveals host immune and signaling changes","volume":"17","author":"Xin","year":"2026","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.fsi.2026.111754_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1013652","article-title":"ZNFX1 functions as a compensatory dsRNA recognition receptor to exert antiviral effect in orange-spotted grouper","volume":"21","author":"Zheng","year":"2025","journal-title":"PLoS Pathog."},{"issue":"43","key":"10.1016\/j.fsi.2026.111754_bib40","doi-asserted-by":"crossref","first-page":"16743","DOI":"10.1073\/pnas.0804947105","article-title":"Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction","volume":"105","author":"Gack","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7138","key":"10.1016\/j.fsi.2026.111754_bib41","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/nature05732","article-title":"TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity","volume":"446","author":"Gack","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2026.111754_bib42","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.3389\/fimmu.2019.02805","article-title":"Zebrafish TRIM25 promotes innate immune response to RGNNV infection by targeting 2CARD and RD regions of RIG-I for K63-Linked ubiquitination","volume":"10","author":"Jin","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2026.111754_bib43","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.fsi.2022.06.033","article-title":"TRIM25 inhibits spring viraemia of carp virus replication by positively regulating RIG-I signaling pathway in common carp (Cyprinus carpio L.)","volume":"127","author":"Liu","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111754_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.109095","article-title":"TRIM25 negatively regulates IKKepsilon-mediated interferon signaling in black carp","volume":"142","author":"Yang","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111754_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.aaf.2026.03.005","article-title":"The long non-coding RNA LTCONS32135 mediates dual antiviral and antibacterial immunity in the Miichthys miiuy","author":"He","year":"2026","journal-title":"Aquaculture and Fisheries"}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826006583?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826006583?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T03:32:51Z","timestamp":1792985571000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464826006583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":45,"alternative-id":["S1050464826006583"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111754","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The response mechanism of mandarin fish (Siniperca chuatsi) astrocyte\u2010like cells to SCRV infection: Insights from Transcriptome Sequencing","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111754","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111754"}}