{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T04:32:45Z","timestamp":1792989165154,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M763483"],"award-info":[{"award-number":["2024M763483"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDB0730300"],"award-info":[{"award-number":["XDB0730300"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD2401800"],"award-info":[{"award-number":["2022YFD2401800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFF1000300"],"award-info":[{"award-number":["2022YFF1000300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.fsi.2026.111762","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:43:43Z","timestamp":1791243823000},"page":"111762","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The E3 ubiquitin ligase Fancl negatively regulates zebrafish antiviral immunity against spring viremia of carp virus"],"prefix":"10.1016","volume":"179","author":[{"given":"Yonglin","family":"Ruan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinli","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyong","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangyan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.fsi.2026.111762_bib1","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.molimm.2004.11.008","article-title":"Type I interferons and the innate immune response--more than just antiviral cytokines","volume":"42","author":"Smith","year":"2005","journal-title":"Mol. Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2026.111762_bib2","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.fsi.2026.111762_bib3","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.fsi.2026.111762_bib4","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat. Immunol."},{"issue":"7","key":"10.1016\/j.fsi.2026.111762_bib5","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/ni1087","article-title":"The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses","volume":"5","author":"Yoneyama","year":"2004","journal-title":"Nat. Immunol."},{"issue":"5801","key":"10.1016\/j.fsi.2026.111762_bib6","doi-asserted-by":"crossref","DOI":"10.1126\/science.1132998","article-title":"RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates","volume":"314","author":"Pichlmair","year":"2006","journal-title":"Science"},{"issue":"7089","key":"10.1016\/j.fsi.2026.111762_bib7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature04734","article-title":"Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses","volume":"441","author":"Kato","year":"2006","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.fsi.2026.111762_bib8","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.cell.2011.06.041","article-title":"MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response","volume":"146","author":"Hou","year":"2011","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.fsi.2026.111762_bib9","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/ni.2549","article-title":"Fishing for mammalian paradigms in the teleost immune system","volume":"14","author":"Sunyer","year":"2013","journal-title":"Nat. Immunol."},{"issue":"16","key":"10.1016\/j.fsi.2026.111762_bib10","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1093\/hmg\/ddg219","article-title":"Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia","volume":"12","author":"Wong","year":"2003","journal-title":"Hum. Mol. Genet."},{"issue":"1\u20132","key":"10.1016\/j.fsi.2026.111762_bib11","article-title":"Fanconi anemia and its diagnosis","volume":"668","author":"Auerbach","year":"2009","journal-title":"Mutat. Res."},{"issue":"16","key":"10.1016\/j.fsi.2026.111762_bib12","doi-asserted-by":"crossref","first-page":"10896","DOI":"10.1074\/jbc.M511411200","article-title":"The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly","volume":"281","author":"Gurtan","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.fsi.2026.111762_bib13","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/ng1241","article-title":"A novel ubiquitin ligase is deficient in Fanconi anemia","volume":"35","author":"Meetei","year":"2003","journal-title":"Nat. Genet."},{"issue":"7","key":"10.1016\/j.fsi.2026.111762_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001034","article-title":"Sex reversal in zebrafish fancl mutants is caused by Tp53-mediated germ cell apoptosis","volume":"6","author":"Rodr\u00edguez-Mar\u00ed","year":"2010","journal-title":"PLoS Genet."},{"issue":"3","key":"10.1016\/j.fsi.2026.111762_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1011170","article-title":"New insights into the all-testis differentiation in zebrafish with compromised endogenous androgen and estrogen synthesis","volume":"20","author":"Ruan","year":"2024","journal-title":"PLoS Genet."},{"issue":"12","key":"10.1016\/j.fsi.2026.111762_bib16","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nri.2016.99","article-title":"Emerging roles of p53 and other tumour-suppressor genes in immune regulation","volume":"16","author":"Mu\u00f1oz-Fontela","year":"2016","journal-title":"Nat. Rev. Immunol."},{"issue":"20","key":"10.1016\/j.fsi.2026.111762_bib17","doi-asserted-by":"crossref","first-page":"10770","DOI":"10.1128\/JVI.01030-09","article-title":"Activation of tumor suppressor protein p53 is required for Theiler's murine encephalomyelitis virus-induced apoptosis in M1-D macrophages","volume":"83","author":"Son","year":"2009","journal-title":"J. Virol."},{"issue":"3","key":"10.1016\/j.fsi.2026.111762_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007695","article-title":"Spring viraemia of carp virus modulates p53 expression using two distinct mechanisms","volume":"15","author":"Li","year":"2019","journal-title":"PLoS Pathog."},{"issue":"18","key":"10.1016\/j.fsi.2026.111762_bib19","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1038\/sj.onc.1208477","article-title":"Resistance to viral infection of super p53 mice","volume":"24","author":"Munoz-Fontela","year":"2005","journal-title":"Oncogene"},{"issue":"23","key":"10.1016\/j.fsi.2026.111762_bib20","doi-asserted-by":"crossref","first-page":"12985","DOI":"10.1128\/JVI.01485-07","article-title":"p53 and hTERT determine sensitivity to viral apoptosis","volume":"81","author":"Nguyen","year":"2007","journal-title":"J. Virol."},{"issue":"8","key":"10.1016\/j.fsi.2026.111762_bib21","doi-asserted-by":"crossref","first-page":"4113","DOI":"10.1021\/acs.jproteome.1c00434","article-title":"Quantitative Proteomics Reveals a Novel Role of the E3 Ubiquitin-Protein Ligase FANCL in the Activation of the Innate Immune Response through Regulation of TBK1 Phosphorylation during Peste des Petits Ruminants Virus Infection","volume":"20","author":"Chen","year":"2021","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.fsi.2026.111762_bib22","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3354\/dao052261","article-title":"Spring viremia of carp","volume":"52","author":"Ahne","year":"2002","journal-title":"Dis. Aquat. Org."},{"issue":"6","key":"10.1016\/j.fsi.2026.111762_bib23","doi-asserted-by":"crossref","first-page":"3924","DOI":"10.4049\/jimmunol.0901495","article-title":"The two groups of zebrafish virus-induced interferons signal via distinct receptors with specific and shared chains","volume":"183","author":"Aggad","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2026.111762_bib24","doi-asserted-by":"crossref","unstructured":"C. Chiale, Chapter Four - IFN response regulation upon viral infections, in: M.S. de la Cruz (Ed.), Advances in Genetics, Academic Press2026, pp. 189-228. .","DOI":"10.1016\/bs.adgen.2025.11.007"},{"issue":"1","key":"10.1016\/j.fsi.2026.111762_bib25","first-page":"133","article-title":"Mouse models of Fanconi anemia, mutation research - fundamental and molecular mechanisms of mutagenesis","volume":"668","author":"Parmar","year":"2009"},{"issue":"1","key":"10.1016\/j.fsi.2026.111762_bib26","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0379-4172(06)60008-5","article-title":"Generation of mouse FANCL antibody and analysis of FANCL protein expression profile in mouse tissues","volume":"33","author":"Zhao","year":"2006","journal-title":"Acta Genetica Sin."},{"key":"10.1016\/j.fsi.2026.111762_bib27","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.fsi.2018.12.063","article-title":"SVCV infection triggers fish IFN response through RLR signaling pathway","volume":"86","author":"Gong","year":"2019","journal-title":"Fish Shellfish Immunol."},{"issue":"22","key":"10.1016\/j.fsi.2026.111762_bib28","doi-asserted-by":"crossref","first-page":"8459","DOI":"10.1073\/pnas.0603082103","article-title":"Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus","volume":"103","author":"Gitlin","year":"2006","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"15","key":"10.1016\/j.fsi.2026.111762_bib29","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1016\/j.vaccine.2011.01.097","article-title":"A comparative review on European-farmed finfish RNA viruses and their vaccines","volume":"29","author":"Gomez-Casado","year":"2011","journal-title":"Vaccine"}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826006662?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826006662?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T03:33:42Z","timestamp":1792985622000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464826006662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":29,"alternative-id":["S1050464826006662"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111762","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The E3 ubiquitin ligase Fancl negatively regulates zebrafish antiviral immunity against spring viremia of carp virus","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111762","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"111762"}}