{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T03:35:21Z","timestamp":1792985721611,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"publisher","award":["335990"],"award-info":[{"award-number":["335990"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"publisher","award":["MABIT"],"award-info":[{"award-number":["MABIT"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.fsi.2026.111767","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:29:15Z","timestamp":1791473355000},"page":"111767","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Immune responses in the olfactory organ and brain of Atlantic cod (Gadus morhua) following nasal vaccination against Francisella noatunensis"],"prefix":"10.1016","volume":"179","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2363-7963","authenticated-orcid":false,"given":"Christian P.","family":"Cordero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne","family":"Brenne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Ytteborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslava","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3364-8247","authenticated-orcid":false,"given":"Lill-Heidi","family":"Johansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy","family":"Vanrompay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne C.","family":"Winther-Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2823-2669","authenticated-orcid":false,"given":"Carlo C.","family":"Lazado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.fsi.2026.111767_bib1","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/jwas.12811","article-title":"Atlantic cod aquaculture: boom, bust, and rebirth?","volume":"52","author":"Nardi","year":"2021","journal-title":"J. World Aquacult. Soc."},{"issue":"6","key":"10.1016\/j.fsi.2026.111767_bib2","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.fsi.2011.08.020","article-title":"Intracellular localisation and innate immune responses following Francisella noatunensis infection of Atlantic cod (Gadus morhua) macrophages","volume":"31","author":"Bakkemo","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111767_bib3","series-title":"Francisella Infections in Farmed and Wild Aquatic Organisms","author":"Colquhoun","year":"2011"},{"issue":"52","key":"10.1016\/j.fsi.2026.111767_bib4","doi-asserted-by":"crossref","first-page":"7264","DOI":"10.1016\/j.vaccine.2017.11.009","article-title":"Francisella noatunensis subspecies noatunensis clpB deletion mutant impairs development of francisellosis in a zebrafish model","volume":"35","author":"Lampe","year":"2017","journal-title":"Vaccine"},{"issue":"3\u20134","key":"10.1016\/j.fsi.2026.111767_bib5","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.vetmic.2011.07.030","article-title":"Genetic analysis and antimicrobial susceptibility of Francisella noatunensis subsp. orientalis (syn. F. asiatica) isolates from fish","volume":"154","author":"Soto","year":"2012","journal-title":"Vet. Microbiol."},{"issue":"3","key":"10.1016\/j.fsi.2026.111767_bib24","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.vaccine.2010.06.040","article-title":"Attenuated Francisella asiatica iglC mutant induces protective immunity to francisellosis in tilapia","volume":"29","author":"Soto","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2026.111767_bib6","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.fsi.2021.11.026","article-title":"Brain immunity response of fish Eleginops maclovinus to infection with Francisella noatunensis: the brain's immunity response","volume":"120","author":"Quilapi","year":"2022","journal-title":"Fish Shellfish Immunol."},{"issue":"6","key":"10.1016\/j.fsi.2026.111767_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ygeno.2023.110735","article-title":"Nasal responses to elevated temperature and Francisella noatunensis infection in Atlantic cod (Gadus morhua)","volume":"115","author":"Lazado","year":"2023","journal-title":"Genomics"},{"issue":"6","key":"10.1016\/j.fsi.2026.111767_bib8","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.4049\/jimmunol.1900157","article-title":"Nasal vaccination drives modifications of nasal and systemic antibody repertoires in Rainbow Trout","volume":"203","author":"Magadan","year":"2019","journal-title":"J. Immunol."},{"issue":"Oct","key":"10.1016\/j.fsi.2026.111767_bib9","article-title":"Nasal immunity is an ancient arm of the mucosal immune system of vertebrates","volume":"5","author":"Tacchi","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.fsi.2026.111767_bib10","series-title":"Mucosal Immunity and Probiotics in Fish","author":"Lazado","year":"2014"},{"key":"10.1016\/j.fsi.2026.111767_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2026.111120","article-title":"The Atlantic salmon tongue mucosa functions as an active mucosal immune site capable of responding to a pathogen","volume":"170","author":"Lazado","year":"2026","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111767_bib12","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.fsi.2020.05.076","article-title":"Fish nasal immunity: from mucosal vaccines to neuroimmunology","volume":"104","author":"Das","year":"2020","journal-title":"Fish Shellfish Immunol."},{"issue":"10","key":"10.1016\/j.fsi.2026.111767_bib13","first-page":"1","article-title":"Vaccination route determines the kinetics and magnitude of nasal innate immune responses in rainbow trout (Oncorhynchus mykiss)","volume":"9","author":"Dong","year":"2020","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.fsi.2026.111767_bib14","series-title":"Adaptive Immune Responses at Mucosal Surfaces of Teleost Fish","author":"Rombout","year":"2014"},{"issue":"6","key":"10.1016\/j.fsi.2026.111767_bib15","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/j.fsi.2013.09.032","article-title":"The mucosal immune system of fish: the evolution of tolerating commensals while fighting pathogens","volume":"35","author":"Gomez","year":"2013","journal-title":"Fish Shellfish Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111767_bib16","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3354\/dao03087","article-title":"Francisella noatunensis ssp. noatunensis iglC deletion mutant protects adult zebrafish challenged with acute mortality dose of wild-type strain","volume":"123","author":"Lampe","year":"2017","journal-title":"Dis. Aquat. Org."},{"issue":"3","key":"10.1016\/j.fsi.2026.111767_bib17","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s10499-012-9591-8","article-title":"Expression of genes involved in the early immune response at the distal segment of the gut in Atlantic cod, Gadus morhua L. after vaccination with a bacterial antigen","volume":"21","author":"Caipang","year":"2013","journal-title":"Aquac. Int."},{"issue":"3","key":"10.1016\/j.fsi.2026.111767_bib18","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.cbpb.2009.03.005","article-title":"Profiling gene expression in the spleen of Atlantic cod, Gadus morhua upon vaccination with Vibrio anguillarum antigen","volume":"153","author":"Caipang","year":"2009","journal-title":"Compar. Biochem. Physiol. - B Biochem. Mol. Biol."},{"issue":"3","key":"10.1016\/j.fsi.2026.111767_bib19","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.fsi.2007.11.018","article-title":"Intraperitoneal vaccination of Atlantic cod, Gadus morhua with heat-killed Listonella anguillarum enhances serum antibacterial activity and expression of immune response genes","volume":"24","author":"Caipang","year":"2008","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111767_bib20","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.fsi.2012.10.010","article-title":"Response to vaccination of Atlantic cod (Gadus morhua L.) progenies from families with different estimated family breeding values for vibriosis resistance","volume":"34","author":"Mikkelsen","year":"2013","journal-title":"Fish Shellfish Immunol."},{"issue":"7363","key":"10.1016\/j.fsi.2026.111767_bib21","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature10342","article-title":"The genome sequence of Atlantic cod reveals a unique immune system","volume":"477","author":"Star","year":"2011","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.fsi.2026.111767_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-29745-4","article-title":"ClpB mutants of Francisella tularensis subspecies holarctica and tularensis are defective for type VI secretion and intracellular replication","volume":"8","author":"Alam","year":"2018","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.fsi.2026.111767_bib26","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1111\/j.1365-2672.2008.04092.x","volume":"106","author":"Ottem","year":"2009","journal-title":"J. Appl. Microbiol."},{"issue":"7","key":"10.1016\/j.fsi.2026.111767_bib27","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/j.1365-2761.2008.00930.x","article-title":"Occurrence of Francisella piscicida in farmed and wild Atlantic cod, Gadus morhua L., in Norway","volume":"31","author":"Ottem","year":"2008","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2026.111767_bib29","unstructured":"S. Xijin Ge, D. Jung, and R. Yao, \u2018Shinygo: a Graphical gene-set Enrichment Tool for Animals and Plants\u2019, doi: 10.5281\/zenodo.1451847."},{"key":"10.1016\/j.fsi.2026.111767_bib30","series-title":"Enrichr: Interactive and Collaborative HTML5 Gene List Enrichment Analysis Tool","author":"Chen","year":"2013"},{"issue":"1","key":"10.1016\/j.fsi.2026.111767_bib31","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.fsi.2026.111767_bib32","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.fsi.2011.05.021","article-title":"Francisella noatunensis in Atlantic cod (Gadus morhua L.); waterborne transmission and immune responses","volume":"31","author":"Ellingsen","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111767_bib33","series-title":"G\u20ac Unter Weiss Macrophage Defense Mechanisms Against Intracellular Bacteria","author":"Schaible","year":"2015"},{"issue":"5","key":"10.1016\/j.fsi.2026.111767_bib34","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1365-2761.2006.00714.x","article-title":"A novel systemic granulomatous inflammatory disease in farmed Atlantic cod, Gadus morhua L., associated with a bacterium belonging to the genus francisella","volume":"29","author":"Olsen","year":"2006","journal-title":"J. Fish. Dis."},{"issue":"2","key":"10.1016\/j.fsi.2026.111767_bib35","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3354\/dao03043","article-title":"Francisella noatunensis subsp. noatunensis invades, survives and replicates in Atlantic cod cells","volume":"121","author":"Bakkemo","year":"2016","journal-title":"Dis. Aquat. Org."},{"key":"10.1016\/j.fsi.2026.111767_bib36","unstructured":"K. Buchmann and C. J. Secombes, \u2018Principles of Fish Immunology from Cells and Molecules to Host Protection\u2019."},{"key":"10.1016\/j.fsi.2026.111767_bib37","series-title":"Mucosal Barrier Functions of Fish Under Changing Environmental Conditions'","author":"Cabillon","year":"2019"},{"issue":"Oct","key":"10.1016\/j.fsi.2026.111767_bib38","article-title":"In Atlantic salmon skin infested with salmon lice, elevated seawater temperatures change gene expression and mucus glycosylation, which promotes pathogen binding","volume":"165","author":"Thomsson","year":"2025","journal-title":"Fish Shellfish Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111767_bib39","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.fsi.2012.05.012","article-title":"Pigment-producing granulomatous myopathy in Atlantic salmon: a novel inflammatory response","volume":"33","author":"Larsen","year":"2012","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111767_bib40","series-title":"The Immunology and Inflammatory Responses of Human Melanocytes in Infectious Diseases","author":"Gasque","year":"2015"},{"key":"10.1016\/j.fsi.2026.111767_bib41","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jconrel.2021.03.027","article-title":"Delivery of nanoparticle antigens to antigen-presenting cells: from extracellular specific targeting to intracellular responsive presentation","volume":"333","author":"Wang","year":"2021","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.fsi.2026.111767_bib42","series-title":"The Role of Immune Activation and Antigen Persistence in Acute and Long COVID","author":"Opsteen","year":"2023"},{"issue":"4","key":"10.1016\/j.fsi.2026.111767_bib43","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.cbpb.2010.04.009","article-title":"Infection-induced changes in expression of antibacterial and cytokine genes in the gill epithelial cells of Atlantic cod, Gadus morhua during incubation with bacterial pathogens","volume":"156","author":"Caipang","year":"2010","journal-title":"Compar. Biochem. Physiol. - B Biochem. Mol. Biol."},{"issue":"JUN","key":"10.1016\/j.fsi.2026.111767_bib44","article-title":"Aeromonas salmonicidasubsp. SalmonicidaEarly infection and immune response of atlantic cod (Gadus morhuaL.) primary macrophages","volume":"10","author":"Soto-D\u00e1vila","year":"2019","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.fsi.2026.111767_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0079743","article-title":"Analysis of two lysozyme genes and antimicrobial functions of their recombinant proteins in Asian seabass","volume":"8","author":"Fu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2026.111767_bib46","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.dci.2016.09.011","article-title":"Molecular characterization of a bactericidal permeability-increasing protein\/lipopolysaccharide-binding protein from black rockfish (sebastes schlegelii): deciphering its putative antibacterial role","volume":"67","author":"Lee","year":"2017","journal-title":"Dev. Comp. Immunol."},{"issue":"5\u20136","key":"10.1016\/j.fsi.2026.111767_bib47","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.fsi.2010.02.006","article-title":"Antimicrobial activity in the tissues of Atlantic cod (Gadus morhua L.)","volume":"28","author":"Ruangsri","year":"2010","journal-title":"Fish Shellfish Immunol."},{"issue":"5","key":"10.1016\/j.fsi.2026.111767_bib48","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00203-006-0109-5","article-title":"Francisella sp. (Family Francisellaceae) causing mortality in Norwegian cod (Gadus morhua) farming","volume":"185","author":"Nylund","year":"2006","journal-title":"Arch. Microbiol."},{"issue":"1\u20132","key":"10.1016\/j.fsi.2026.111767_bib49","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.gep.2015.06.001","article-title":"Dynamic remodeling of the extra cellular matrix during zebrafish fin regeneration","volume":"19","author":"Govindan","year":"2015","journal-title":"Gene Expr. Patterns"},{"key":"10.1016\/j.fsi.2026.111767_bib50","series-title":"Acellular Fish Skin for Wound Healing","author":"Esmaeili","year":"2023"}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826006716?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826006716?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T03:26:17Z","timestamp":1792985177000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464826006716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":47,"alternative-id":["S1050464826006716"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111767","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immune responses in the olfactory organ and brain of Atlantic cod (Gadus morhua) following nasal vaccination against Francisella noatunensis","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111767","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"111767"}}