{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T09:43:03Z","timestamp":1792748583572,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020818","name":"Srinakharinwirot University Strategic Wisdom and Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.fsi.2026.111771","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:58:53Z","timestamp":1792022333000},"page":"111771","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A c-Jun N-terminal kinase (JNK) homolog from Macrobrachium rosenbergii participates in immune defense against Aeromonas hydrophila"],"prefix":"10.1016","volume":"180","author":[{"given":"Kanokwan","family":"Thongfu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanitcha","family":"Choolert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phongthana","family":"Pasookhush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G.","family":"Bendena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwaporn","family":"Longyant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8326-222X","authenticated-orcid":false,"given":"Parin","family":"Chaivisuthangkura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.fsi.2026.111771_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.61885\/joa.v33.2024.290","article-title":"Global status of giant prawn, Macrobrachium rosenbergii farming with special reference to India and measures for enhancing production","volume":"33","author":"Pillai","year":"2024","journal-title":"J. Aquac."},{"key":"10.1016\/j.fsi.2026.111771_bib2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.aquaculture.2015.10.028","article-title":"Review of current disease threats for cultivated penaeid shrimp in Asia","volume":"452","author":"Thitamadee","year":"2016","journal-title":"Aquaculture"},{"issue":"16","key":"10.1016\/j.fsi.2026.111771_bib3","doi-asserted-by":"crossref","first-page":"6947","DOI":"10.1007\/s00253-016-7679-1","article-title":"Advances, challenges, and directions in shrimp disease control: the guidelines from an ecological perspective","volume":"100","author":"Xiong","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"7","key":"10.1016\/j.fsi.2026.111771_bib4","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1111\/j.1365-2109.2011.03061.x","article-title":"A review on the diseases of freshwater prawns with special focus on white tail disease of Macrobrachium rosenbergii","volume":"43","author":"Pillai","year":"2012","journal-title":"Aquac. Res."},{"issue":"2","key":"10.1016\/j.fsi.2026.111771_bib5","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1111\/raq.12754","article-title":"Diseases of the giant river prawn Macrobrachium rosenbergii: a review for a growing industry","volume":"15","author":"Hooper","year":"2023","journal-title":"Rev. Aquacult."},{"issue":"1","key":"10.1016\/j.fsi.2026.111771_bib6","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/raq.12482","article-title":"Immune responses and immunoprotection in crustaceans with special reference to shrimp","volume":"13","author":"Kulkarni","year":"2021","journal-title":"Rev. Aquacult."},{"issue":"4","key":"10.1016\/j.fsi.2026.111771_bib7","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.fsi.2012.08.008","article-title":"Pattern recognition receptors acting in innate immune system of shrimp against pathogen infections","volume":"34","author":"Wang","year":"2013","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111771_bib8","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1146\/annurev.immunol.25.022106.141615","article-title":"The host defense of Drosophila melanogaster","volume":"25","author":"Lemaitre","year":"2007","journal-title":"Annu. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2026.111771_bib9","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.fsi.2012.08.023","article-title":"Signaling pathways regulating innate immune responses in shrimp","volume":"34","author":"Li","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111771_bib10","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.dci.2017.05.009","article-title":"Shrimp humoral responses against pathogens: antimicrobial peptides and melanization","volume":"80","author":"Tassanakajon","year":"2018","journal-title":"Dev. Comp. Immunol."},{"issue":"6","key":"10.1016\/j.fsi.2026.111771_bib11","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1007\/s12192-018-0935-9","article-title":"Cloning and expression of a transcription factor activator protein-1 member identified from the swimming crab Portunus trituberculatus","volume":"23","author":"Wang","year":"2018","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.fsi.2026.111771_bib12","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.fsi.2016.04.139","article-title":"Characterization of three mitogen-activated protein kinases (MAPK) genes reveals involvement of ERK and JNK, not p38 in defense against bacterial infection in Yesso scallop Patinopecten yessoensis","volume":"54","author":"Sun","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111771_bib13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.dci.2016.11.011","article-title":"c-Jun N-terminal kinase (JNK) is involved in immune defense against bacterial infection in Crassostrea hongkongensis","volume":"67","author":"Qu","year":"2017","journal-title":"Dev. Comp. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111771_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2019.100752","article-title":"White spot syndrome virus establishes a novel IE1\/JNK\/c-Jun positive feedback loop to drive replication","volume":"23","author":"Wang","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.fsi.2026.111771_bib15","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.molimm.2021.07.011","article-title":"A novel JNK induces innate immune response by activating the expression of antimicrobial peptides in Chinese mitten crab Eriocheir sinensis","volume":"138","author":"Huang","year":"2021","journal-title":"Mol. Immunol."},{"issue":"9","key":"10.1016\/j.fsi.2026.111771_bib16","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nri3495","article-title":"Mitogen-activated protein kinases in innate immunity","volume":"13","author":"Arthur","year":"2013","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2026.111771_bib17","doi-asserted-by":"crossref","first-page":"857","DOI":"10.3390\/cells9040857","article-title":"The JNK signaling pathway in inflammatory skin disorders and cancer","volume":"9","author":"Hammouda","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.fsi.2026.111771_bib18","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.dci.2015.04.009","article-title":"The c-Fos and c-Jun from Litopenaeus vannamei play opposite roles in Vibrio parahaemolyticus and white spot syndrome virus infection","volume":"52","author":"Li","year":"2015","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2026.111771_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1474512","article-title":"Pattern recognition receptors in Crustacea: immunological roles under environmental stress","volume":"15","author":"Betancourt","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2026.111771_bib20","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.fsi.2022.06.007","article-title":"A C-type lectin containing two carbohydrate recognition domains participates in the antibacterial response by regulating the JNK pathway and promoting phagocytosis","volume":"127","author":"Chen","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111771_bib21","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.fsi.2016.08.036","article-title":"The receptor for activated C kinase 1 (RACK1) functions in hematopoiesis through JNK activation in Chinese mitten crab Eriocheir sinensis","volume":"57","author":"Jia","year":"2016","journal-title":"Fish Shellfish Immunol."},{"issue":"3","key":"10.1016\/j.fsi.2026.111771_bib22","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s12192-020-01085-1","article-title":"JNK signaling pathway regulates the development of ovaries and synthesis of vitellogenin (Vg) in the swimming crab Portunus trituberculatus","volume":"25","author":"Wei","year":"2020","journal-title":"Cell Stress Chaperones"},{"issue":"3\u20134","key":"10.1016\/j.fsi.2026.111771_bib23","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.dci.2012.03.002","article-title":"A novel JNK from Litopenaeus vannamei involved in white spot syndrome virus infection","volume":"37","author":"Shi","year":"2012","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2026.111771_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpb.2021.110676","article-title":"c-Jun N-terminal kinase (JNK) in Procambarus clarkii: molecular characterization and involvement in oxidative stress-induced apoptosis during molting cycle","volume":"257","author":"Tian","year":"2022","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"10.1016\/j.fsi.2026.111771_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108912","article-title":"c-Jun N-terminal kinase activation contributes to improving low temperature tolerance via regulating apoptosis in the Pacific white shrimp Penaeus vannamei","volume":"139","author":"Zheng","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111771_bib26","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.aquaculture.2012.01.019","article-title":"Infections of MrNV (Macrobrachium rosenbergii nodavirus) in cultivated whiteleg shrimp Penaeus vannamei in Asia","volume":"338","author":"Senapin","year":"2012","journal-title":"Aquaculture"},{"issue":"1","key":"10.1016\/j.fsi.2026.111771_bib27","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1186\/s12864-019-6102-6","article-title":"Transcriptomic analysis of Macrobrachium rosenbergii (giant fresh water prawn) post-larvae in response to M. rosenbergii nodavirus (MrNV) infection: De novo assembly and functional annotation","volume":"20","author":"Pasookhush","year":"2019","journal-title":"BMC Genom."},{"issue":"4","key":"10.1016\/j.fsi.2026.111771_bib32","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.fsi.2012.06.032","article-title":"Three different anti-lipopolysaccharide factors identified from giant freshwater prawn, Macrobrachium rosenbergii","volume":"33","author":"Ren","year":"2012","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111771_bib33","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.fsi.2012.10.009","article-title":"Crustin, a WAP domain containing antimicrobial peptide from freshwater prawn Macrobrachium rosenbergii: immune characterization","volume":"34","author":"Arockiaraj","year":"2013","journal-title":"Fish Shellfish Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2026.111771_bib34","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.fsi.2014.12.036","article-title":"Macrobrachium rosenbergii mannose binding lectin: synthesis of MrMBL-N20 and MrMBL-C16 peptides and their antimicrobial characterization, bioinformatics and relative gene expression analysis","volume":"43","author":"Arockiaraj","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111771_bib35","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.fsi.2022.11.002","article-title":"Bovine lactoferricin on non-specific immunity of giant freshwater prawns, Macrobrachium rosenbergii","volume":"131","author":"Zhuang","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111771_bib36","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.fsi.2020.10.003","article-title":"The regulation of immune responses against white spot syndrome virus or Vibrio alginolyticus in toll-like receptors silenced giant freshwater prawn (Macrobrachium rosenbergii)","volume":"107","author":"Li","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111771_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108945","article-title":"A novel tumor necrosis factor receptor-associated factor 6 (TRAF6) gene from Macrobrachium rosenbergii involved in antibacterial defense against Aeromonas hydrophila","volume":"140","author":"Choolert","year":"2023","journal-title":"Fish Shellfish Immunol."},{"issue":"1\u20134","key":"10.1016\/j.fsi.2026.111771_bib37","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.aquaculture.2007.02.026","article-title":"Outbreaks of infectious myonecrosis virus (IMNV) in Indonesia confirmed by genome sequencing and use of an alternative RT-PCR detection method","volume":"266","author":"Senapin","year":"2007","journal-title":"Aquaculture"},{"issue":"3","key":"10.1016\/j.fsi.2026.111771_bib38","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1128\/JCM.41.3.1048-1054.2003","article-title":"Detection and characterization of the hemolysin genes in Aeromonas hydrophila and Aeromonas sobria by multiplex PCR","volume":"41","author":"Wang","year":"2003","journal-title":"J. Clin. Microbiol."},{"issue":"4","key":"10.1016\/j.fsi.2026.111771_bib28","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394Ct method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"2","key":"10.1016\/j.fsi.2026.111771_bib29","first-page":"107","article-title":"Identification of Aeromonas hydrophila infection with specific monoclonal antibodies","volume":"1","author":"Longyant","year":"2007","journal-title":"Maejo Int. J. Sci. Technol."},{"key":"10.1016\/j.fsi.2026.111771_bib30","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.fsi.2018.10.015","article-title":"Molecular isolation and characterization of a sp\u00e4tzle gene from Macrobrachium rosenbergii","volume":"84","author":"Vaniksampanna","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111771_bib39","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.fsi.2016.12.025","article-title":"The immune response of the C-Jun in the black tiger shrimp (Penaeus monodon) after bacterial infection","volume":"61","author":"Shi","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111771_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109804","article-title":"Characterization of c-Jun N-terminal kinase (JNK) gene reveals involvement of immune defense against Vibrio splendidus infection in Apostichopus japonicus","volume":"153","author":"Tao","year":"2024","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2026.111771_bib41","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1146\/annurev.immunol.20.091301.131133","article-title":"MAP kinases in the immune response","volume":"20","author":"Dong","year":"2002","journal-title":"Annu. Rev. Immunol."},{"issue":"13","key":"10.1016\/j.fsi.2026.111771_bib42","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1038\/sj.emboj.7601182","article-title":"Cooperative control of Drosophila immune responses by the JNK and NF\u2010\u03baB signaling pathways","volume":"25","author":"Delaney","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.fsi.2026.111771_bib43","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.fsi.2018.05.017","article-title":"A novel JNK is involved in immune response by regulating IL expression in oyster Crassostrea gigas","volume":"79","author":"Sun","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111771_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2020.735431","article-title":"Altered intestinal microbiota induced by chronic hypoxia drives the effects on lipid metabolism and the immune response of oriental river prawn Macrobrachium nipponense","volume":"526","author":"Sun","year":"2020","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2026.111771_bib45","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.fsi.2020.07.014","article-title":"Characterization of a gill-abundant crustin with microbiota modulating function in Litopenaeus vannamei","volume":"105","author":"Lv","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111771_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2026.111369","article-title":"Identification of Cdc42 in the red swamp crayfish (Procambarus clarkii) and its roles in phagocytosis and apoptosis","author":"Du","year":"2026","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111771_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2026.120543","article-title":"Acute low-salinity stress induces gill injury, oxidative stress, and apoptosis via the JNK-JUN\/MAPK axis in the swimming crab (Portunus trituberculatus)","volume":"322","author":"Lu","year":"2026","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"4","key":"10.1016\/j.fsi.2026.111771_bib48","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.fsi.2012.09.021","article-title":"Discovery of immune molecules and their crucial functions in shrimp immunity","volume":"34","author":"Tassanakajon","year":"2013","journal-title":"Fish Shellfish Immunol."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826006753?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826006753?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T09:16:21Z","timestamp":1792746981000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464826006753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":48,"alternative-id":["S1050464826006753"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111771","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A c-Jun N-terminal kinase (JNK) homolog from Macrobrachium rosenbergii participates in immune defense against Aeromonas hydrophila","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111771","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"111771"}}