{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T09:42:59Z","timestamp":1792748579049,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32573564"],"award-info":[{"award-number":["32573564"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.fsi.2026.111773","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:22:14Z","timestamp":1791645734000},"page":"111773","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Functional characterization of grass carp OXR1 in response to GCRV infection"],"prefix":"10.1016","volume":"180","author":[{"given":"Yanxia","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2845-3617","authenticated-orcid":false,"given":"Li","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2914-4564","authenticated-orcid":false,"given":"Zhen","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6209-7184","authenticated-orcid":false,"given":"Junhua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2026.111773_bib1","series-title":"China Fishery Statistical Yearbook 2026","author":"Zeng","year":"2026"},{"key":"10.1016\/j.fsi.2026.111773_bib2","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/1743-422X-11-178","article-title":"Pathogenicity and tissue distribution of grass carp reovirus after intraperitoneal administration","volume":"11","author":"Liang","year":"2014","journal-title":"Virol. J."},{"key":"10.1016\/j.fsi.2026.111773_bib3","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70268","article-title":"Oxidative stress: signaling pathways, biological functions, and disease","volume":"6","author":"Liu","year":"2025","journal-title":"MedComm"},{"key":"10.1016\/j.fsi.2026.111773_bib4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12964-023-01398-5","article-title":"Interplay of oxidative stress, cellular communication and signaling pathways in cancer","volume":"22","author":"Iqbal","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.fsi.2026.111773_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101759","article-title":"Innate-adaptive immunity interplay and redox regulation in immune response","volume":"37","author":"Sun","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.fsi.2026.111773_bib6","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1038\/s41467-018-04686-8","article-title":"Mitochondrial reactive oxygen species regulate the induction of CD8+ T cells by plasmacytoid dendritic cells","volume":"9","author":"Oberkampf","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.fsi.2026.111773_bib7","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.cmet.2015.06.006","article-title":"Redox homeostasis and mitochondrial dynamics","volume":"22","author":"Willems","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.fsi.2026.111773_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232213880","article-title":"Mitochondrial respiratory chain supercomplexes: from structure to function","volume":"23","author":"Guan","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fsi.2026.111773_bib9","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.immuni.2012.10.020","article-title":"Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling","volume":"38","author":"Sena","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.fsi.2026.111773_bib10","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nri3423","article-title":"Beyond oxidative stress: an immunologist's guide to reactive oxygen species","volume":"13","author":"Nathan","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.fsi.2026.111773_bib11","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/2149812","article-title":"Oxidative DNA damage signalling in neural stem cells in Alzheimer's disease","volume":"2019","author":"Kiero\u0144","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.fsi.2026.111773_bib12","first-page":"1","article-title":"Oxidative damage to DNA: formation, measurement, and biological significance","volume":"131","author":"Cadet","year":"1997","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.fsi.2026.111773_bib13","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.3390\/biom13091291","article-title":"Lipid peroxidation and antioxidant protection","volume":"13","author":"Valgimigli","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.fsi.2026.111773_bib14","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.bbrc.2016.10.086","article-title":"Lipid peroxidation in cell death","volume":"482","author":"Gaschler","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.fsi.2026.111773_bib15","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.tcm.2018.05.010","article-title":"Oxidized LDL and anti-oxidized LDL antibodies in atherosclerosis: novel insights and future directions in diagnosis and therapy","volume":"29","author":"Hartley","year":"2019","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.fsi.2026.111773_bib16","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.freeradbiomed.2010.12.005","article-title":"Oxidative stress and the etiology of insulin resistance and type 2 diabetes","volume":"51","author":"Henriksen","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.fsi.2026.111773_bib17","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3390\/antiox14030297","article-title":"Oxidative stress in brain function","volume":"14","author":"Trofin","year":"2025","journal-title":"Antioxidants"},{"key":"10.1016\/j.fsi.2026.111773_bib18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/bs.acc.2014.11.001","article-title":"Manganese superoxide dismutase and oxidative stress modulation","volume":"68","author":"Bresciani","year":"2015","journal-title":"Adv. Clin. Chem."},{"key":"10.1016\/j.fsi.2026.111773_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2025.105447","article-title":"Molecular delineation, immune modulation analysis, and antioxidant functional assessment of catalase (CAT) from chub mackerel (Scomber japonicus)","volume":"170","author":"Dilshan","year":"2025","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2026.111773_bib20","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.mce.2005.12.027","article-title":"The antioxidant glutathione peroxidase family and spermatozoa: a complex story","volume":"250","author":"Drevet","year":"2006","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.fsi.2026.111773_bib21","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0166-6851(01)00252-3","article-title":"Antioxidant enzyme families in parasitic nematodes","volume":"114","author":"Henkle-D\u00fchrsen","year":"2001","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.fsi.2026.111773_bib22","doi-asserted-by":"crossref","first-page":"14530","DOI":"10.1073\/pnas.260495897","article-title":"Functional genomics reveals a family of eukaryotic oxidation protection genes","volume":"97","author":"Volkert","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.fsi.2026.111773_bib23","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.1128\/MCB.24.8.3180-3187.2004","article-title":"Stress induction and mitochondrial localization of Oxr1 proteins in yeast and humans","volume":"24","author":"Elliott","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.fsi.2026.111773_bib24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2121-8-13","article-title":"The OXR domain defines a conserved family of eukaryotic oxidation resistance proteins","volume":"8","author":"Durand","year":"2007","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.fsi.2026.111773_bib25","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1471-2199-13-26","article-title":"Structural\/functional analysis of the human OXR1 protein: identification of exon 8 as the anti-oxidant encoding function","volume":"13","author":"Murphy","year":"2012","journal-title":"BMC Mol. Biol."},{"key":"10.1016\/j.fsi.2026.111773_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011168","article-title":"The Anopheles gambiae oxidation resistance 1 gene regulates expression of enzymes that detoxify reactive oxygen species","volume":"5","author":"Jaramillo-Gutierrez","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2026.111773_bib27","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.freeradbiomed.2014.09.003","article-title":"Human OXR1 maintains mitochondrial DNA integrity and counteracts hydrogen peroxide-induced oxidative stress by regulating antioxidant pathways involving p21","volume":"77","author":"Yang","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.fsi.2026.111773_bib28","article-title":"Transcriptome analysis of human OXR1-depleted cells reveals its role in regulating the p53 signaling pathway","volume":"5","author":"Yang","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fsi.2026.111773_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002338","article-title":"Oxr1 is essential for protection against oxidative stress-induced neurodegeneration","volume":"7","author":"Oliver","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.fsi.2026.111773_bib30","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.freeradbiomed.2016.03.029","article-title":"The antioxidant protein Oxr1 influences aspects of mitochondrial morphology","volume":"95","author":"Wu","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.fsi.2026.111773_bib31","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.3390\/antiox11101952","article-title":"Grass carp Prx 3 elevates host antioxidant activity and induces autophagy to inhibit GCRV replication in fish cells","volume":"11","author":"Liang","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.fsi.2026.111773_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109419","article-title":"Grass carp peroxiredoxin 5 and 6-mediated autophagy inhibit grass carp reovirus replication and mitigate oxidative stress","volume":"146","author":"Wang","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111773_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2021.104213","article-title":"Molecular characterization and functional analysis of peroxiredoxin 4 in grass carp (Ctenopharyngodon idella)","volume":"125","author":"Liang","year":"2021","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2026.111773_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.128454","article-title":"Grass carp superoxide dismutases exert antioxidant function and inhibit autophagy to promote grass carp reovirus (GCRV) replication","volume":"256","author":"Liang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.fsi.2026.111773_bib35","doi-asserted-by":"crossref","DOI":"10.1080\/21505594.2026.2678043","article-title":"Grass carp catalase inhibits GCRV replication through ROS scavenging-mediated immune suppression and autophagy","volume":"17","author":"Wang","year":"2026","journal-title":"Virulence"},{"key":"10.1016\/j.fsi.2026.111773_bib36","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/670437","article-title":"Insights into the antiviral immunity against grass carp (Ctenopharyngodon idella) reovirus (GCRV) in grass carp","volume":"2015","author":"Rao","year":"2015","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.fsi.2026.111773_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.694965","article-title":"Multi-omics sequencing provides insights into age-dependent susceptibility of grass carp (Ctenopharyngodon idellus) to reovirus","volume":"12","author":"He","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2026.111773_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.545302","article-title":"Grass carp reovirus (GCRV) giving its all to suppress IFN production by countering MAVS signaling transduction","volume":"11","author":"Lu","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2026.111773_bib39","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.fsi.2019.08.005","article-title":"GCRV hijacks TBK1 to evade IRF7-mediated antiviral immune responses in grass carp Ctenopharyngodon idella","volume":"93","author":"Rao","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111773_bib40","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.fsi.2020.02.004","article-title":"Grass carp reovirus VP56 represses interferon production by degrading phosphorylated IRF7","volume":"99","author":"Zhang","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2026.111773_bib41","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.cell.2018.02.033","article-title":"Transcriptome engineering with RNA-targeting type VI-D CRISPR effectors","volume":"173","author":"Konermann","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.fsi.2026.111773_bib42","article-title":"Transcriptome-wide Cas13 guide RNA design for model organisms and viral RNA pathogens","volume":"1","author":"Guo","year":"2021","journal-title":"Cell Genom."},{"key":"10.1016\/j.fsi.2026.111773_bib43","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.15252\/embj.201488658","article-title":"Parkin-independent mitophagy requires Drp 1 and maintains the integrity of mammalian heart and brain","volume":"33","author":"Kageyama","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.fsi.2026.111773_bib44","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.virs.2023.04.006","article-title":"Temperature-regulated type II grass carp reovirus establishes latent infection in Ctenopharyngodon idella brain","volume":"38","author":"Jiang","year":"2023","journal-title":"Virol. Sin."},{"key":"10.1016\/j.fsi.2026.111773_bib45","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00344-25","article-title":"ATG5 negatively regulates grass carp reovirus-induced immune-inflammatory response by degrading RIG-I and MDA5","volume":"99","author":"Chu","year":"2025","journal-title":"J. Virol."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826006777?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464826006777?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T09:15:35Z","timestamp":1792746935000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464826006777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":45,"alternative-id":["S1050464826006777"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111773","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional characterization of grass carp OXR1 in response to GCRV infection","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2026.111773","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"111773"}}