{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:14:15Z","timestamp":1788304455711,"version":"build-2803163510"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish and Shellfish Immunology Reports"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.fsirep.2022.100060","type":"journal-article","created":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T09:50:29Z","timestamp":1656841829000},"page":"100060","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Device implant based on poly (lactic acid) with vitamin E for vaccine delivery system in Tilapia: Study for biocompatibility and biodegradation"],"prefix":"10.1016","volume":"3","author":[{"given":"Gabriel","family":"Conde","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6271-1252","authenticated-orcid":false,"given":"Mayumi Fernanda","family":"Aracati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Let\u00edcia Franchin","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana Luporini","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Carlino","family":"da Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ives","family":"Charlie-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thalles Fernando Rocha","family":"Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebasti\u00e3o Roberto","family":"Taboga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5845-3940","authenticated-orcid":false,"given":"Marco Antonio de Andrade","family":"Belo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsirep.2022.100060_bib0001","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.033084","article-title":"Animal models for bone tissue engineering and modelling disease","volume":"11","author":"McGovern","year":"2018","journal-title":"Dis. Model Mech."},{"key":"10.1016\/j.fsirep.2022.100060_bib0002","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.transproceed.2017.02.017","article-title":"Electrospun PHEA-PLA\/PCL Scaffold for vascular regeneration: a preliminary in vivo evaluation","volume":"49","author":"Buscemi","year":"2017","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.fsirep.2022.100060_bib0003","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.actbio.2018.09.014","article-title":"Inflammatory response and biomechanical properties of coaxial scaffolds for engineered skin in vitro and post-grafting","volume":"80","author":"Blackstone","year":"2018","journal-title":"Acta Biomater"},{"key":"10.1016\/j.fsirep.2022.100060_bib0004","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.2217\/nnm.14.156","article-title":"Poly (lactic acid) and poly (lactic-co-glycolic acid) particles as versatile carrier platforms for vaccine delivery","volume":"9","author":"Pavot","year":"2014","journal-title":"Nanomedicine"},{"key":"10.1016\/j.fsirep.2022.100060_bib0005","doi-asserted-by":"crossref","first-page":"6270","DOI":"10.1007\/s10853-014-8352-7","article-title":"Tetracycline hydrochloride (TCH)-loaded drug carrier based on PLA: PCL nanofibre mats: experimental characterisation and release kinetics modelling","volume":"49","author":"Haroosh","year":"2014","journal-title":"J. Mater. Sci."},{"key":"10.1016\/j.fsirep.2022.100060_bib0006","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.msec.2015.09.071","article-title":"Properties of PLA\/PCL particles as vehicles for oral delivery of the androgen hormone 17\u03b1-methyltestosterone","volume":"58","author":"Sacchetin","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.fsirep.2022.100060_bib0007","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1016\/j.biomaterials.2008.04.023","article-title":"On the mechanisms of biocompatibility","volume":"29","author":"Williams","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.fsirep.2022.100060_bib0008","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.addr.2016.06.014","article-title":"Poly (lactic acid) blends in biomedical applications","volume":"107","author":"Saini","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.fsirep.2022.100060_bib0009","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1002\/jbm.a.36427","article-title":"In vitro degradation and in vivo toxicity of NanoMatrix3D\u00ae polycaprolactone and poly (lactic acid) nanofibrous scaffolds","volume":"106","author":"Pogorielov","year":"2018","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"10.1016\/j.fsirep.2022.100060_bib0010","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1161\/CIRCULATIONAHA.110.971606","article-title":"Bioresorbable scaffold: the advent of a new era in percutaneous coronary and peripheral revascularization?","volume":"123","author":"Onuma","year":"2011","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.fsirep.2022.100060_bib0011","first-page":"86","article-title":"Foreign body reaction to biomaterials. In Seminars in immunology","volume":"20","author":"Anderson","year":"2008","journal-title":"Academic Press"},{"key":"10.1016\/j.fsirep.2022.100060_bib0012","doi-asserted-by":"crossref","unstructured":"Ramot, Y., Haim-Zada, M., Domb, A.J., Nyska, A., 2016. Biocompatibility and safety of PLA and its copolymers. Advanced drug delivery reviews, 107, 153\u2013162. https:\/\/doi.org\/10.1016\/j.addr.2016.03.012.","DOI":"10.1016\/j.addr.2016.03.012"},{"key":"10.1016\/j.fsirep.2022.100060_bib0013","doi-asserted-by":"crossref","first-page":"6692","DOI":"10.1016\/j.biomaterials.2011.05.078","article-title":"Immune responses to implants\u2013a review of the implications for the design of immunomodulatory biomaterials","volume":"32","author":"Franz","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.fsirep.2022.100060_bib0014","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.aquaculture.2018.10.045","article-title":"Immunoglobulin Y in the diagnosis of Aeromonas hydrophila infection in Nile tilapia (Oreochromis niloticus)","volume":"500","author":"Fernandes","year":"2019","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsirep.2022.100060_bib0015","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.prevetmed.2018.12.003","article-title":"Economic appraisal of vaccination against Streptoccocus agalactiae in Nile tilapia farms in Brazil","volume":"162","author":"Delphino","year":"2019","journal-title":"Prevent. Vet. Med."},{"key":"10.1016\/j.fsirep.2022.100060_bib0016","doi-asserted-by":"crossref","unstructured":"Delphino, M.K., Leal, C.A., Gardner, I.A., Assis, G.B., Roriz, G.D., Ferreira, F., Gon\u00e7alves, V.S., 2019b. Seasonal dynamics of bacterial pathogens of Nile tilapia farmed in a Brazilian reservoir. Aquaculture. 498, 100\u2013108. https:\/\/doi.org\/10.1016\/j.aquaculture.2018.08.023.","DOI":"10.1016\/j.aquaculture.2018.08.023"},{"issue":"02","key":"10.1016\/j.fsirep.2022.100060_bib0017","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0378-5173(02)00342-3","article-title":"Improved immune response from biodegradable polymer particles entrapping tetanus toxoid by use of different immunization protocol and adjuvants","volume":"245","author":"Raghuvanshi","year":"2002","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.fsirep.2022.100060_bib0018","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.fsi.2009.11.009","article-title":"Parenteral immunization of fish, Labeo rohita with Poly D, l-lactide-co-glycolic acid (PLGA) encapsulated antigen microparticles promotes innate and adaptive immune responses","volume":"28","author":"Behera","year":"2010","journal-title":"Fish Shellfish Immunol."},{"issue":"02","key":"10.1016\/j.fsirep.2022.100060_bib0019","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0928-4931(02)00017-6","article-title":"Polymeric nanospheres fabricated with natural emulsifiers for clinical administration of an anticancer drug paclitaxel (Taxol\u00ae)","volume":"20","author":"Feng","year":"2002","journal-title":"Mater. Sci. Eng. C"},{"issue":"02","key":"10.1016\/j.fsirep.2022.100060_bib0020","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0168-3659(02)00025-1","article-title":"Vitamin E TPGS used as emulsifier in the solvent evaporation\/extraction technique for fabrication of polymeric nanospheres for controlled release of paclitaxel (Taxol\u00ae)","volume":"80","author":"Mu","year":"2002","journal-title":"J. Controlled Release"},{"key":"10.1016\/j.fsirep.2022.100060_sbref0021","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/(SICI)1097-4636(199612)32:4<493::AID-JBM1>3.0.CO;2-M","article-title":"Vitamin E as an antioxidant for poly (etherurethane urea): in vivo studies","volume":"32","author":"Schubert","year":"1996","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.fsirep.2022.100060_bib0022","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0002-9440(10)63474-8","article-title":"Foreign body-type multinucleated giant cell formation is potently induced by \u03b1-tocopherol and prevented by the diacylglycerol kinase inhibitor R59022","volume":"163","author":"McNally","year":"2003","journal-title":"American J. Pathol."},{"issue":"02","key":"10.1016\/j.fsirep.2022.100060_bib0023","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1096-4959(02)00256-7","article-title":"Dietary vitamin E supplementation affects tissue lipid peroxidation of hybrid tilapia, Oreochromis niloticus\u00d7 O. aureus","volume":"134","author":"Huang","year":"2003","journal-title":"Comparative Biochem. Physiol. Part B"},{"key":"10.1016\/j.fsirep.2022.100060_bib0024","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jcpa.2005.04.004","article-title":"Effect of dietary supplementation with vitamin E and stocking density on macrophage recruitment and giant cell formation in the teleost fish, Piaractus mesopotamicus","volume":"133","author":"Belo","year":"2005","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.fsirep.2022.100060_bib0025","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.aquaculture.2013.12.013","article-title":"Deleterious effects of low level of vitamin E and high stocking density on the hematology response of pacus, during chronic inflammatory reaction","volume":"422","author":"Belo","year":"2014","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsirep.2022.100060_bib0026","first-page":"1","article-title":"Synergistic effects of selenium nanoparticles and vitamin E on growth, immune-related gene expression, and regulation of antioxidant status of Nile tilapia (Oreochromis niloticus)","author":"Dawood","year":"2019","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.fsirep.2022.100060_bib0027","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.fsi.2019.06.026","article-title":"Dietary vitamin E deficiency inhibits fat metabolism, antioxidant capacity, and immune regulation of inflammatory response in genetically improved farmed tilapia (GIFT, Oreochromis niloticus) fingerlings following Streptococcus iniae infection","volume":"92","author":"Qiang","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsirep.2022.100060_bib0028","series-title":"Water Quality in Ponds for Aquaculture, Alabama Agricultural Experiment 416 Station","author":"Boyd","year":"1990"},{"key":"10.1016\/j.fsirep.2022.100060_bib0029","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1590\/S1516-14392012005000146","article-title":"Characterization of poly (L-co-D, L Lactic Acid) and a study of polymer-tissue interaction in subcutaneous implants in wistar rats","volume":"16","author":"Ciambelli","year":"2013","journal-title":"Mater. Res."},{"key":"10.1016\/j.fsirep.2022.100060_bib0030","doi-asserted-by":"crossref","unstructured":"Miszuk, J.M., Xu, T., Yao, Q., Fang, F., Childs, J.D., Hong, Z., Sun, H., 2018. Functionalization of PCL-3D electrospun nanofibrous scaffolds for improved BMP2-induced bone formation. Applied materials today. 10, 194\u2013202. https:\/\/doi.org\/10.1016\/j.apmt.2017.12.004.","DOI":"10.1016\/j.apmt.2017.12.004"},{"key":"10.1016\/j.fsirep.2022.100060_bib0031","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1111\/jfb.12060","article-title":"Haematological response of curimbas Prochilodus lineatus, naturally infected with Neoechinorhynchus curemai","volume":"82","author":"Belo","year":"2013","journal-title":"J. Fish Biol."},{"key":"10.1016\/j.fsirep.2022.100060_bib0032","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.anifeedsci.2015.11.004","article-title":"Probiotic feeding improves the immunity of pacus, Piaractus mesopotamicus, during Aeromonas hydrophila infection","volume":"211","author":"Farias","year":"2016","journal-title":"Anim. Feed Sci. Technol."},{"key":"10.1016\/j.fsirep.2022.100060_bib0033","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.etp.2010.08.001","article-title":"Hepatoprotective treatment attenuates oxidative damages induced by carbon tetrachloride in rats","volume":"64","author":"Belo","year":"2012","journal-title":"Exper. Toxicol. Pathol."},{"key":"10.1016\/j.fsirep.2022.100060_bib0034","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.biomaterials.2004.06.026","article-title":"Tissue response to partially in vitro predegraded poly-L-lactide implants","volume":"26","author":"De Jong","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.fsirep.2022.100060_bib0035","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.fsirep.2022.100060_bib0036","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.fsi.2019.10.071","article-title":"Spleen melanomacrophage centers response of Nile tilapia during Aeromanas hydrophila and Mycobacterium marinum infections","volume":"95","author":"Manrique","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsirep.2022.100060_bib0037","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.fsi.2005.01.012","article-title":"Inflammatory cells of teleostean fish: a review focusing on mast cells\/eosinophilic granule cells and rodlet cells","volume":"20","author":"Reite","year":"2006","journal-title":"Fish Shellfish Immunol."},{"issue":"99","key":"10.1016\/j.fsirep.2022.100060_bib0038","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0145-305X(99)00027-0","article-title":"Degranulation of eosinophilic granular cells with possible involvement in neutrophil migration to site of inflammation in tilapia","volume":"23","author":"Matsuyama","year":"1999","journal-title":"Develop. Comparative Immunol."},{"key":"10.1016\/j.fsirep.2022.100060_bib0039","doi-asserted-by":"crossref","first-page":"19434","DOI":"10.1073\/pnas.0704535104","article-title":"Histamine is stored in mast cells of most evolutionarily advanced fish and regulates the fish inflammatory response","volume":"104","author":"Mulero","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.fsirep.2022.100060_bib0040","doi-asserted-by":"crossref","first-page":"4253","DOI":"10.1016\/j.actbio.2012.08.011","article-title":"Pro-angiogenic CD14++ CD16+ CD163+ monocytes accelerate the in vitro endothelialization of soft hydrophobic poly (n-butyl acrylate) networks","volume":"8","author":"Mayer","year":"2012","journal-title":"Acta Biomater"},{"key":"10.1016\/j.fsirep.2022.100060_bib0041","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1590\/S0100-204X2013000300010","article-title":"Kinetics of chronic inflammation in Nile tilapia fed n3 and n6 essential fatty acids","volume":"48","author":"Sakabe","year":"2013","journal-title":"Pesquisa Agropecu\u00e1ria Brasileira"},{"key":"10.1016\/j.fsirep.2022.100060_bib0042","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00441-010-1034-0","article-title":"The complement system","volume":"343","author":"Sarma","year":"2011","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.fsirep.2022.100060_bib0043","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/jbm.a.30907","article-title":"iNOS-mediated generation of reactive oxygen and nitrogen species by biomaterial-adherent neutrophils","volume":"80","author":"Patel","year":"2007","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"10.1016\/j.fsirep.2022.100060_bib0044","doi-asserted-by":"crossref","unstructured":"K\u00f6llner, B., Fischer, U., Rombout, J.H.W.M., Taverne-Thiele, J.J., Hansen, J.D., 2004. Potential involvement of rainbow trout thrombocytes in immune functions: a study using a panel of monoclonal antibodies and RT-PCR. Developmental & Comparative Immunology. 28, 1049\u20131062. https:\/\/doi.org\/10.1016\/j.dci.2004.03.005.","DOI":"10.1016\/j.dci.2004.03.005"},{"key":"10.1016\/j.fsirep.2022.100060_bib0045","doi-asserted-by":"crossref","unstructured":"Jaros, J., Korytar, T., Huong, D.T., Weiss, M., K\u00f6llner, B., 2013. Rainbow trout (Oncorhynchus mykiss) thrombocytes are involved in MHC II dependent antigen presentation. Fish and Shellfish Immunology. 6, 1657. https:\/\/doi.org\/10.1016\/j.fsi.2013.03.072.","DOI":"10.1016\/j.fsi.2013.03.072"},{"key":"10.1016\/j.fsirep.2022.100060_bib0046","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s10499-019-00342-0","article-title":"Effects of water flow rates on growth and welfare of Nile tilapia (Oreochromis niloticus) reared in a recirculating aquaculture system","volume":"27","author":"Obirikorang","year":"2019","journal-title":"Aquacul. Int."},{"key":"10.1016\/j.fsirep.2022.100060_bib0047","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.aquaculture.2009.12.014","article-title":"Inflammation induced by inactivated Aeromonas hydrophila in Nile tilapia fed diets supplemented with Saccharomyces cerevisiae","volume":"300","author":"Reque","year":"2010","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsirep.2022.100060_bib0048","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.fsi.2013.01.006","article-title":"Acute aerocystitis in Piaractus mesopotamicus: participation of eicosanoids and pro-inflammatory cytokines","volume":"34","author":"Claudiano","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsirep.2022.100060_bib0049","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.aquaculture.2014.04.036","article-title":"Chromium carbochelate dietary supplementation favored the glucocorticoid response during acute inflammation of Piaractus mesopotamicus","volume":"432","author":"Castro","year":"2014","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsirep.2022.100060_bib0050","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1590\/1678-5150-pvb-5533","article-title":"Hepatic steatosis alters cellular recruitment during induced aerocystitis in Nile tilapia","author":"Moraes","year":"2018","journal-title":"Pesquisa Veterinaria Brasileira"},{"key":"10.1016\/j.fsirep.2022.100060_bib0051","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1590\/1678-5150-pvb-5532","article-title":"Insulin favors acute inflammatory reaction in alloxan-diabetic tilapia during infectious aerocystitis","volume":"38","author":"Prado","year":"2018","journal-title":"Pesq. Vet. Bras."},{"issue":"23","key":"10.1016\/j.fsirep.2022.100060_bib0052","article-title":"The function of fish cytokines","volume":"5","author":"Zou","year":"2016","journal-title":"Biology (Basel)"},{"issue":"96","key":"10.1016\/j.fsirep.2022.100060_bib0053","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0142-9612(96)85565-7","article-title":"Time course of membrane microarchitecture-driven neovascularization","volume":"17","author":"Padera","year":"1996","journal-title":"Biomaterials"},{"key":"10.1016\/j.fsirep.2022.100060_bib0054","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1002\/jbm.a.35958","article-title":"The pathology of the foreign body reaction against biomaterials","volume":"105","author":"Klopfleisch","year":"2017","journal-title":"J. Biomed. Mater. Res. Part A"},{"issue":"12","key":"10.1016\/j.fsirep.2022.100060_bib0055","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1002\/2211-5463.12734","article-title":"Inhibition of sodium-glucose cotransporter 2 ameliorates renal injury in a novel medaka model of nonalcoholic steatohepatitis-related kidney disease","volume":"9","author":"Nagoya","year":"2019","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.fsirep.2022.100060_bib0056","doi-asserted-by":"crossref","unstructured":"Nair, L.S., Laurencin, C.T., 2007. Biodegradable polymers as biomaterials. Progress in polymer science. 32, 762\u2013798. https:\/\/doi.org\/10.1016\/j.progpolymsci.2007.05.017.","DOI":"10.1016\/j.progpolymsci.2007.05.017"},{"key":"10.1016\/j.fsirep.2022.100060_bib0057","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1046\/j.1365-2761.2003.00485.x","article-title":"Melano-macrophage centres and their role in fish pathology","volume":"26","author":"Agius","year":"2003","journal-title":"J. Fish Dis."},{"key":"10.1016\/j.fsirep.2022.100060_bib0058","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1111\/jai.12445","article-title":"Response of splenic melanomacrophage centers of Oreochromis niloticus (Linnaeus, 1758) to inflammatory stimuli by BCG and foreign bodies","volume":"30","author":"Manrique","year":"2014","journal-title":"J. Appl. Ichthyol."},{"key":"10.1016\/j.fsirep.2022.100060_bib0059","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3389\/fimmu.2017.00827","article-title":"Melanomacrophage centers as a histological indicator of immune function in fish and other poikilotherms","volume":"8","author":"Steinel","year":"2017","journal-title":"Front Immunol."},{"key":"10.1016\/j.fsirep.2022.100060_bib0060","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1600-0749.1989.tb00168.x","article-title":"Occurrence of melanin granules and melanosynthesis in the kidney of Sparus auratus","volume":"2","author":"Zuasti","year":"1989","journal-title":"Pigm. Cell Res."},{"key":"10.1016\/j.fsirep.2022.100060_bib0061","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1095-8649.1984.tb04818.x","article-title":"An electron microscopical study on the genesis of lipofuscin, melanin and haemosiderin in the haemopoietic tissues of fish","volume":"24","author":"Agius","year":"1984","journal-title":"J. Fish Biol."},{"key":"10.1016\/j.fsirep.2022.100060_bib0062","first-page":"5","article-title":"A study of the hypophysectomized male killifish, Fundulus heteroclitus (Linn","volume":"14","author":"Pickford","year":"1953","journal-title":"Bull. Bingham Oceanogra. Coll."},{"issue":"92","key":"10.1016\/j.fsirep.2022.100060_bib0063","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0959-8030(92)90058-6","article-title":"Piscine macrophage aggregates: a review","volume":"2","author":"Wolke","year":"1992","journal-title":"Annu. Rev. Fish Dis."},{"key":"10.1016\/j.fsirep.2022.100060_bib0064","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1046\/j.1365-2109.2003.00908.x","article-title":"No synergistic effects by the dietary supplementation of ascorbic acid, \u03b1-tocopheryl acetate and selenium on the growth performance and challenge test of Edwardsiella tarda in fingerling Nile tilapia, Oreochromis niloticus L","volume":"34","author":"Kim","year":"2003","journal-title":"Aquacult. Res."},{"key":"10.1016\/j.fsirep.2022.100060_bib0065","first-page":"76","volume":"16","author":"Tavares-Dias","year":"2000"},{"key":"10.1016\/j.fsirep.2022.100060_bib0066","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1590\/S1519-69842011000400017","article-title":"Seasonal influence on the hematological parameters in cultured Nile tilapia from southern Brazil","volume":"71","author":"Jer\u00f4nimo","year":"2011","journal-title":"Brazilian J. Biol."},{"issue":"03","key":"10.1016\/j.fsirep.2022.100060_bib0067","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1016\/S0142-9612(03)00161-3","article-title":"Biocompatibility of implantable synthetic polymeric drug carriers: focus on brain biocompatibility","volume":"24","author":"Fournier","year":"2003","journal-title":"Biomaterials"}],"container-title":["Fish and Shellfish Immunology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667011922000111?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667011922000111?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:54:01Z","timestamp":1763020441000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667011922000111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":67,"alternative-id":["S2667011922000111"],"URL":"https:\/\/doi.org\/10.1016\/j.fsirep.2022.100060","relation":{},"ISSN":["2667-0119"],"issn-type":[{"value":"2667-0119","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Device implant based on poly (lactic acid) with vitamin E for vaccine delivery system in Tilapia: Study for biocompatibility and biodegradation","name":"articletitle","label":"Article Title"},{"value":"Fish and Shellfish Immunology Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsirep.2022.100060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100060"}}