{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T22:59:57Z","timestamp":1784588397575,"version":"3.55.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012411","name":"NIHR School of Social Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["101873"],"award-info":[{"award-number":["101873"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["215599"],"award-info":[{"award-number":["215599"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["200208"],"award-info":[{"award-number":["200208"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["224323"],"award-info":[{"award-number":["224323"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/N006364\/2"],"award-info":[{"award-number":["MR\/N006364\/2"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/M026663\/2"],"award-info":[{"award-number":["MR\/M026663\/2"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013342","name":"NIHR Imperial Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013342","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020013","name":"NIHR Leicester Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020013","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fungal Biology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.funbio.2024.08.011","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T20:48:59Z","timestamp":1725310139000},"page":"2148-2156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hyphal swelling induced in the phagosome of macrophages"],"prefix":"10.1016","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6973-2849","authenticated-orcid":false,"given":"Mar\u00eda Fernanda","family":"Alonso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1060-0419","authenticated-orcid":false,"given":"Judith M.","family":"Bain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1847-5819","authenticated-orcid":false,"given":"Lars P.","family":"Erwig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1406-4251","authenticated-orcid":false,"given":"Alistair J.P.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2776-5850","authenticated-orcid":false,"given":"Neil A.R.","family":"Gow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.funbio.2024.08.011_bib1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1099\/13500872-140-2-271","article-title":"The role of the cytoskeleton in the polarized growth of the germ tube in Candida albicans","volume":"140","author":"Akashi","year":"1994","journal-title":"Microbiology (Reading, England)"},{"issue":"15","key":"10.1016\/j.funbio.2024.08.011_bib2","article-title":"Immune cells fold and damage fungal hyphae","volume":"118","author":"Bain","year":"2021","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"9","key":"10.1016\/j.funbio.2024.08.011_bib3","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.fgb.2012.01.008","article-title":"Non-lytic expulsion\/exocytosis of Candida albicans from macrophages","volume":"49","author":"Bain","year":"2012","journal-title":"Fungal Genet. Biol."},{"issue":"4","key":"10.1016\/j.funbio.2024.08.011_bib4","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/yea.1099","article-title":"GFP as a quantitative reporter of gene regulation in Candida albicans","volume":"21","author":"Barelle","year":"2004","journal-title":"Yeast"},{"issue":"1\u20132","key":"10.1016\/j.funbio.2024.08.011_bib5","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/BF00436698","article-title":"A characterization of pH-regulated dimorphism in Candida albicans","volume":"85","author":"Buffo","year":"1984","journal-title":"Mycopathologia"},{"issue":"8","key":"10.1016\/j.funbio.2024.08.011_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109584","article-title":"The macrophage-derived protein PTMA induces filamentation of the human fungal pathogen Candida albicans","volume":"36","author":"Case","year":"2021","journal-title":"Cell Rep."},{"issue":"2","key":"10.1016\/j.funbio.2024.08.011_bib7","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1128\/EC.00240-07","article-title":"CTA4 transcription factor mediates induction of nitrosative stress response in Candida albicans","volume":"7","author":"Chiranand","year":"2008","journal-title":"Eukaryot. Cell"},{"issue":"1","key":"10.1016\/j.funbio.2024.08.011_bib8","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1080\/21505594.2020.1748930","article-title":"The regulation of hyphae growth in Candida albicans","volume":"11","author":"Chen","year":"2020","journal-title":"Virulence"},{"issue":"13","key":"10.1016\/j.funbio.2024.08.011_bib9","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1242\/jcs.02414","article-title":"Candida albicans hyphae have a Spitzer that is distinct from the polarisome found in yeast and pseudohyphae","volume":"118","author":"Crampin","year":"2005","journal-title":"J. Cell Sci."},{"issue":"11","key":"10.1016\/j.funbio.2024.08.011_bib10","doi-asserted-by":"crossref","first-page":"4416","DOI":"10.1128\/IAI.00984-15","article-title":"The Candida albicans ATO gene family promotes neutralization of the macrophage phagolysosome","volume":"83","author":"Danhof","year":"2015","journal-title":"Infect. Immun."},{"issue":"19","key":"10.1016\/j.funbio.2024.08.011_bib11","doi-asserted-by":"crossref","first-page":"4550","DOI":"10.1128\/MCB.00313-10","article-title":"Thioredoxin regulates multiple hydrogen peroxide-induced signaling pathways in Candida albicans","volume":"30","author":"da Silva Dantas","year":"2010","journal-title":"Molecular and cellular biology"},{"issue":"2","key":"10.1016\/j.funbio.2024.08.011_bib12","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1091\/mbc.e05-06-0501","article-title":"Role of the Hog 1 stress-activated protein kinase in the global transcriptional response to stress in the fungal pathogen Candida albicans","volume":"17","author":"Enjalbert","year":"2006","journal-title":"Mol. Biol. Cell"},{"issue":"3","key":"10.1016\/j.funbio.2024.08.011_bib13","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/nrmicro.2015.21","article-title":"Interactions of fungal pathogens with phagocytes","volume":"14","author":"Erwig","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.funbio.2024.08.011_bib14","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev-pathol-011811-132445","article-title":"The cell biology of phagocytosis","volume":"7","author":"Flannagan","year":"2012","journal-title":"Annual Review of Pathology"},{"issue":"1","key":"10.1016\/j.funbio.2024.08.011_bib15","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1152\/physrev.00009.2022","article-title":"Determinants, maintenance, and function of organellar pH","volume":"103","author":"Freeman","year":"2023","journal-title":"Physiol. Rev."},{"issue":"4","key":"10.1016\/j.funbio.2024.08.011_bib16","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/s41579-022-00796-9","article-title":"Architecture of the dynamic fungal cell wall","volume":"21","author":"Gow","year":"2022","journal-title":"Nat. Rev. Microbiol."},{"issue":"8","key":"10.1016\/j.funbio.2024.08.011_bib17","first-page":"1145","article-title":"Microbe profile: Candida albicans: a shape-changing, opportunistic pathogenic fungus of humans","volume":"163","author":"Gow","year":"2017","journal-title":"Microbiology (United Kingdom)"},{"issue":"1\u20132","key":"10.1016\/j.funbio.2024.08.011_bib43","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jim.2006.05.013","article-title":"Soluble Dectin-1 as a tool to detect beta-glucans","volume":"314","author":"Graham","year":"2006","journal-title":"J. Immunol. Methods"},{"issue":"1","key":"10.1016\/j.funbio.2024.08.011_bib18","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1006\/fgbi.1997.0957","article-title":"Actin disruption by latrunculin B causes turgor-related changes in tip growth of saprolegnia ferax hyphae","volume":"21","author":"Gupta","year":"1997","journal-title":"Fungal Genet. Biol."},{"issue":"6","key":"10.1016\/j.funbio.2024.08.011_bib19","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1128\/EC.1.6.856-864.2002","article-title":"Hyphal tip-associated localization of Cdc 42 is F-actin dependent in Candida albicans","volume":"1","author":"Hazan","year":"2002","journal-title":"Eukaryot. Cell"},{"issue":"4","key":"10.1016\/j.funbio.2024.08.011_bib20","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01334-14","article-title":"Mechanisms underlying the exquisite sensitivity of Candida albicans to combinatorial cationic and oxidative stress that enhances the potent fungicidal activity of phagocytes","volume":"5","author":"Kaloriti","year":"2014","journal-title":"mBio"},{"issue":"6","key":"10.1016\/j.funbio.2024.08.011_bib21","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/0955-0674(95)80069-7","article-title":"Budding yeast morphogenesis: signalling, cytoskeleton and cell cycle","volume":"7","author":"Kron","year":"1995","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.funbio.2024.08.011_bib22","article-title":"Live-cell video microscopy of fungal pathogen phagocytosis","volume":"71","author":"Lewis","year":"2013","journal-title":"J. Vis. Exp."},{"issue":"5","key":"10.1016\/j.funbio.2024.08.011_bib23","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1128\/EC.3.5.1076-1087.2004","article-title":"Transcriptional response of Candida albicans upon internalization by macrophages","volume":"3","author":"Lorenz","year":"2004","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.funbio.2024.08.011_bib24","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34798","article-title":"Integrin-based diffusion barrier separates membrane domains enabling the formation of microbiostatic frustrated phagosomes","volume":"7","author":"Maxson","year":"2018","journal-title":"Elife"},{"issue":"7597","key":"10.1016\/j.funbio.2024.08.011_bib25","first-page":"64","article-title":"Candidalysin is a fungal peptide toxin critical for mucosal infection","volume":"532","author":"Moyes","year":"2016","journal-title":"Nature 2016"},{"issue":"JUN","key":"10.1016\/j.funbio.2024.08.011_bib26","article-title":"Candida albicans yeast, pseudohyphal, and hyphal morphogenesis differentially affects immune recognition","volume":"8","author":"Mukaremera","year":"2017","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.funbio.2024.08.011_bib27","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1128\/MCB.15.4.2197","article-title":"Functional characterization of the MKC1 gene of Candida albicans, which encodes a mitogen-activated protein kinase homolog related to cell integrity","volume":"15","author":"Navarro-Garc\u00eda","year":"1995","journal-title":"Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.funbio.2024.08.011_bib28","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1128\/IAI.02917-14","article-title":"Rab14 regulates maturation of macrophage phagosomes Containing the fungal pathogen Candida albicans and outcome of the host-pathogen interaction","volume":"83","author":"Okai","year":"2015","journal-title":"Infect. Immun."},{"issue":"12","key":"10.1016\/j.funbio.2024.08.011_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111374","article-title":"The escape of Candida albicans from macrophages is enabled by the fungal toxin candidalysin and two host cell death pathways","volume":"40","author":"Olivier","year":"2022","journal-title":"Cell Rep."},{"issue":"18","key":"10.1016\/j.funbio.2024.08.011_bib30","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1089\/ars.2013.5199","article-title":"Ybp1 and Gpx3 signaling in Candida albicans Govern hydrogen peroxide-induced oxidation of the Cap1 transcription factor and macrophage escape","volume":"19","author":"Patterson","year":"2013","journal-title":"Antioxidants Redox Signal."},{"issue":"6","key":"10.1016\/j.funbio.2024.08.011_bib31","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01318-18","article-title":"Hypoxia promotes immune evasion by triggering \u03b2-glucan masking on the Candida albicans cell surface via mitochondrial and cAMP-protein kinase A signaling","volume":"9","author":"Pradhan","year":"2018","journal-title":"mBio"},{"issue":"86","key":"10.1016\/j.funbio.2024.08.011_bib32","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/oxfordjournals.aob.a083602","article-title":"Observations of the effect of water on the hyphal apices of Fusarium oxysporum","volume":"22","author":"Robertson","year":"1958","journal-title":"Ann. Bot."},{"issue":"5","key":"10.1016\/j.funbio.2024.08.011_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006403","article-title":"Adaptation of Candida albicans to environmental pH induces cell wall remodelling and enhances innate immune recognition","volume":"13","author":"Sherrington","year":"2017","journal-title":"PLoS Pathog."},{"issue":"7","key":"10.1016\/j.funbio.2024.08.011_bib34","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.tim.2004.05.008","article-title":"The distinct morphogenic states of Candida albicans","volume":"12","author":"Sudbery","year":"2004","journal-title":"Trends Microbiol."},{"issue":"1","key":"10.1016\/j.funbio.2024.08.011_bib35","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1099\/00221287-144-1-45","article-title":"Effect of cytochalasin A on apical growth, actin cytoskeleton organization and enzyme secretion in Aspergillus nidulans","volume":"144","author":"Torralba","year":"1998","journal-title":"Microbiology (Reading, England)"},{"issue":"3","key":"10.1016\/j.funbio.2024.08.011_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003995","article-title":"Modulation of phagosomal pH by Candida albicans promotes hyphal morphogenesis and requires Stp2p, a regulator of amino acid transport","volume":"10","author":"Vylkova","year":"2014","journal-title":"PLoS Pathog."},{"issue":"1","key":"10.1016\/j.funbio.2024.08.011_bib37","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01820-16","article-title":"Candida albicans chitin increases arginase-1 activity in human macrophages, with an impact on macrophage antimicrobial functions","volume":"8","author":"Wagener","year":"2017","journal-title":"mBio"},{"key":"10.1016\/j.funbio.2024.08.011_bib38","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.85114","article-title":"Intravital imaging-based genetic screen reveals the transcriptional network governing Candida albicans filamentation during mammalian infection","volume":"12","author":"Wakade","year":"2023","journal-title":"Elife"},{"issue":"2","key":"10.1016\/j.funbio.2024.08.011_bib39","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1128\/EC.00336-13","article-title":"Candida albicans triggers NLRP3-mediated pyroptosis in macrophages","volume":"13","author":"Wellington","year":"2014","journal-title":"Eukaryot. Cell"},{"issue":"5","key":"10.1016\/j.funbio.2024.08.011_bib40","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01226-18","article-title":"Candida albicans hyphal expansion causes phagosomal membrane damage and luminal alkalinization","volume":"9","author":"Westman","year":"2018","journal-title":"mBio"},{"issue":"3","key":"10.1016\/j.funbio.2024.08.011_bib41","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1046\/j.1365-2958.2000.01877.x","article-title":"Analysis of the oxidative stress regulation of the Candida albicans transcription factor, Cap1p","volume":"36","author":"Zhang","year":"2000","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.funbio.2024.08.011_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.1029966","article-title":"The advances in the regulation of immune microenvironment by Candida albicans and macrophage cross-talk","volume":"13","author":"Zhao","year":"2022","journal-title":"Front. Microbiol."}],"container-title":["Fungal Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878614624001211?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878614624001211?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T07:44:56Z","timestamp":1778831096000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878614624001211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":43,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S1878614624001211"],"URL":"https:\/\/doi.org\/10.1016\/j.funbio.2024.08.011","relation":{},"ISSN":["1878-6146"],"issn-type":[{"value":"1878-6146","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hyphal swelling induced in the phagosome of macrophages","name":"articletitle","label":"Article Title"},{"value":"Fungal Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.funbio.2024.08.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd on behalf of British Mycological Society.","name":"copyright","label":"Copyright"}]}}