{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T16:16:45Z","timestamp":1782836205250,"version":"3.54.5"},"reference-count":23,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:00:00Z","timestamp":1584403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gaceta Sanitaria"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.gaceta.2020.02.008","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T17:39:23Z","timestamp":1587490763000},"page":"339-344","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Efectividad de la vacuna de la gripe para prevenir casos graves. Temporada 2018\/2019"],"prefix":"10.1016","volume":"35","author":[{"given":"Paula","family":"Gras-Valent\u00ed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Chico-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natividad","family":"Algado-Sell\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Adelina","family":"Gimeno-Gasc\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Gabriel","family":"Mora-Muriel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"S\u00e1nchez-Pay\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gaceta.2020.02.008_bib0120","unstructured":"World Health Organization (WHO). Influenza (seasonal). Ask the expert: Influenza Q&A. Geneva: WHO. (Consultado el 12\/09\/2019.) Disponible en: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/influenza-.(seasonal)."},{"key":"10.1016\/j.gaceta.2020.02.008_bib0125","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1750-2659.2009.00073.x","article-title":"Estimates of US influenza-associated deaths made using four different methods","volume":"3","author":"Thompson","year":"2009","journal-title":"Influenza Other Respi Viruses."},{"key":"10.1016\/j.gaceta.2020.02.008_bib0130","unstructured":"Informe Semanal de Vigilancia de la Gripe en Espa\u00f1a: Sistema de Vigilancia de la Gripe en Espa\u00f1a. Instituto de Salud Carlos III. (Consultado el 19\/09\/2019.) Disponible en: http:\/\/vgripe.isciii.es\/documentos\/20182019\/boletines\/grn202019.pdf."},{"key":"10.1016\/j.gaceta.2020.02.008_bib0135","unstructured":"Boletin Vigil\u00e0ncia Casos Greus de Grip, Comunitat Valenciana. Setmana 40 (any 2018) a setmana 20 (any 2019). \u00daltima setmana temporada 2018-2019. Direcci\u00f3 General d\u2019Epidemiologia, Vigil\u00e0ncia de la Salut i Sanitat ambiental; 2019."},{"key":"10.1016\/j.gaceta.2020.02.008_bib0140","unstructured":"World Health Organization. Vaccines against influenza. WHO position paper - November 2012. Relev Epidemiol Hebd. 2012;87:461-76."},{"key":"10.1016\/j.gaceta.2020.02.008_bib0145","unstructured":"Recomendaciones de vacunaci\u00f3n frente a la gripe. Temporada 2018-2019. Ministerio de Sanidad, Servicios Sociales e Igualdad. (Consultado el 12\/04\/2019.) Disponible en: https:\/\/www.mscbs.gob.es\/profesionales\/saludPublica\/prevPromocion\/vacunaciones\/docs\/Recomendaciones_vacunacion_gripe.pdf."},{"key":"10.1016\/j.gaceta.2020.02.008_bib0150","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1089\/vim.2017.0141","article-title":"Influenza virus: dealing with a drifting and shifting pathogen","volume":"31","author":"Kim","year":"2018","journal-title":"Viral Immunol."},{"key":"10.1016\/j.gaceta.2020.02.008_bib0155","unstructured":"World Health Organization. Recommended composition of influenza virus vaccines for use in the 2018-2019 northern hemisphere influenza season. Geneva: WHO. (Consultado el 12\/04\/2019.) Disponible en: https:\/\/www.who.int\/influenza\/vaccines\/virus\/recommendations\/201802_recommendation.pdf?ua=1."},{"key":"10.1016\/j.gaceta.2020.02.008_bib0160","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.vaccine.2013.11.060","article-title":"Influenza vaccination and risk of hospitalization among adults with laboratory confirmed influenza illness","volume":"32","author":"McLean","year":"2014","journal-title":"Vaccine."},{"key":"10.1016\/j.gaceta.2020.02.008_bib0165","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/ije\/dyi274","article-title":"Evidence of bias in estimates of influenza vaccine effectiveness in seniors","volume":"35","author":"Jackson","year":"2006","journal-title":"Int J Epidemiol."},{"key":"10.1016\/j.gaceta.2020.02.008_bib0170","doi-asserted-by":"crossref","first-page":"e76318","DOI":"10.1371\/journal.pone.0076318","article-title":"Effectiveness of inactivated influenza vaccines in preventing influenza-associated deaths and hospitalizations among Ontario residents aged>\/=65 years: estimates with generalized linear models accounting for healthy vaccinee effects","volume":"8","author":"Ridenhour","year":"2013","journal-title":"PLoS One."},{"key":"10.1016\/j.gaceta.2020.02.008_bib0175","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/S1473-3099(07)70236-0","article-title":"Mortality benefits of influenza vaccination in elderly people: an ongoing controversy","volume":"7","author":"Simonsen","year":"2007","journal-title":"Lancet Infect Dis."},{"key":"10.1016\/j.gaceta.2020.02.008_bib0180","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1093\/aje\/kwp173","article-title":"Influenza vaccination and mortality: differentiating vaccine effects from bias","volume":"170","author":"Fireman","year":"2009","journal-title":"Am J Epidemiol."},{"key":"10.1016\/j.gaceta.2020.02.008_bib0185","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/cid\/cit194","article-title":"Influenza vaccine effectiveness in preventing outpatient, inpatient, and severe cases of laboratory-confirmed influenza","volume":"57","author":"Castilla","year":"2013","journal-title":"Clin Infect Dis."},{"key":"10.1016\/j.gaceta.2020.02.008_bib0190","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2018.23.43.1700732","article-title":"Influenza vaccine effectiveness in reducing severe outcomes over six influenza seasons, a case-case analysis, Spain, 2010\/11 to 2015\/16","volume":"23","author":"Godoy","year":"2018","journal-title":"Eurosurveillance."},{"key":"10.1016\/j.gaceta.2020.02.008_bib0195","unstructured":"Gu\u00eda de procedimientos para la vigilancia de gripe en Espa\u00f1a. Marzo 2019. Red Nacional de Vigilancia Epidemiol\u00f3gica. Instituto de Salud Carlos III. (Consultado el 19\/09\/2019.) Disponible en: https:\/\/www.isciii.es\/QueHacemos\/Servicios\/VigilanciaSaludPublicaRENAVE\/EnfermedadesTransmisibles\/Documents\/GRIPE\/GUIAS\/Gu%C3%ADa%20de%20procedimientos%20para%20la%20vigilancia%20de%20gripe%20en%20Espa%C3%B1a_marzo%202019.pdf."},{"key":"10.1016\/j.gaceta.2020.02.008_bib0200","unstructured":"European Commission. Commission Regulation (EC) No. 2018\/945 of 22 June 2018 on the communicable diseases and related special health issues to be covered by epidemiological surveillance as well as relevant case definitions. Official Journal of the European Union. 6.7.2018: L 170\/1. (Consultado el 12\/04\/2019.) Disponible en: https:\/\/eur-lex.europa.eu\/legal-content\/EN\/TXT\/PDF\/?uri=CELEX: 32018D0945&from=EN#page=24."},{"key":"10.1016\/j.gaceta.2020.02.008_bib0205","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1080\/14760584.2019.1622419","article-title":"Challenges in estimating influenza vaccine effectiveness","volume":"18","author":"Ainslie","year":"2019","journal-title":"Expert Rev Vaccines."},{"key":"10.1016\/j.gaceta.2020.02.008_bib0210","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3201\/eid1201.051237","article-title":"Cell-mediated protection in influenza infection","volume":"12","author":"Thomas","year":"2006","journal-title":"Emerg Infect Dis."},{"key":"10.1016\/j.gaceta.2020.02.008_bib0215","doi-asserted-by":"crossref","first-page":"6527","DOI":"10.1128\/JVI.00519-10","article-title":"lymphocytes established by seasonal human influenza cross-react against 2009 pandemic H1N1 influenza virus","volume":"84","author":"Tu","year":"2010","journal-title":"J Virol."},{"key":"10.1016\/j.gaceta.2020.02.008_bib0220","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1586\/14760584.2016.1134328","article-title":"Effect of influenza vaccination on the prognosis of hospitalized influenza patients","volume":"15","author":"Casado","year":"2016","journal-title":"Expert Rev Vaccines."},{"key":"10.1016\/j.gaceta.2020.02.008_bib0225","unstructured":"Coberturas de vacunaci\u00f3n frente a gripe en \u226565 a\u00f1os, personas de 60-64 a\u00f1os, embarazadas y personal sanitario. Comunidades aut\u00f3nomas. Campa\u00f1a 2018-2019. Secretar\u00eda General de Sanidad y Consumo. Direcci\u00f3n General de Salud P\u00fablica, Calidad e Innovaci\u00f3n. Subdirecci\u00f3n General de Promoci\u00f3n de la Salud y Vigilancia en Salud P\u00fablica. (Consultado el 12\/10\/2019.) Disponible en: http:\/\/www.mscbs.gob.es\/profesionales\/saludPublica\/prevPromocion\/vacunaciones\/docs\/CoberturasVacunacion\/Tabla13.pdf."},{"key":"10.1016\/j.gaceta.2020.02.008_bib0230","unstructured":"World Health Organization. Methods for assessing influenza vaccination coverage in target groups. Geneva: WHO. (Consultado el 12\/09\/2019.) Disponible en: http:\/\/www.euro.who.int\/__data\/assets\/pdf_file\/0004\/317344\/Methods-assessing-influenza-vaccination-coverage-target-groups.pdf?ua=1."}],"container-title":["Gaceta Sanitaria"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0213911120300716?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0213911120300716?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T13:21:53Z","timestamp":1759324913000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0213911120300716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S0213911120300716"],"URL":"https:\/\/doi.org\/10.1016\/j.gaceta.2020.02.008","relation":{},"ISSN":["0213-9111"],"issn-type":[{"value":"0213-9111","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efectividad de la vacuna de la gripe para prevenir casos graves. Temporada 2018\/2019","name":"articletitle","label":"Article Title"},{"value":"Gaceta Sanitaria","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gaceta.2020.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 SESPAS. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}]}}