{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:35:19Z","timestamp":1792204519013,"version":"4.4.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:00:00Z","timestamp":1709856000000},"content-version":"vor","delay-in-days":67,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008723","name":"Finnish Medical Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013500","name":"Diabetestutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013500","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015738","name":"Mary and Georg C Ehrnrooth Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018870","name":"Swedish Heart and Lung Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018870","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020948","name":"AstraZeneca Gothenburg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020948","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut and Alice Wallenberg Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsradet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004092","name":"Kuopio University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004092","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ghadvances.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastro Hep Advances"],"published-print":{"date-parts":[[2024]]},"DOI":"10.1016\/j.gastha.2024.03.005","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T17:42:18Z","timestamp":1710265338000},"page":"594-601","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Protein Phosphatase 1 Regulatory Subunit 3 Beta rs4240624 Genotype Is Associated With Gallstones and With Significant Changes in Bile Lipidome"],"prefix":"10.1016","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0735-400X","authenticated-orcid":false,"given":"Ville T.","family":"M\u00e4nnist\u00f6","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Kaminska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylke","family":"Haal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juho","family":"Asteljoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panu K.","family":"Luukkonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pirjo","family":"K\u00e4kel\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Tavaglione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"van Weeghel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Neuvonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Niemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Romeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Nieuwdorp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jussi","family":"Pihlajam\u00e4ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert K.","family":"Groen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gastha.2024.03.005_bib1","doi-asserted-by":"crossref","DOI":"10.1111\/eci.12935","article-title":"Genetics of gallstone disease","volume":"48","author":"Rebholz","year":"2018","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.gastha.2024.03.005_bib2","doi-asserted-by":"crossref","first-page":"g2669","DOI":"10.1136\/bmj.g2669","article-title":"Gallstones","volume":"348","author":"Gurusamy","year":"2014","journal-title":"BMJ"},{"key":"10.1016\/j.gastha.2024.03.005_bib3","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.24","article-title":"Gallstones","volume":"2","author":"Lammert","year":"2016","journal-title":"Nat Rev Dis Primers"},{"issue":"Suppl","key":"10.1016\/j.gastha.2024.03.005_bib4","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1194\/jlr.R800075-JLR200","article-title":"Biliary lipids and cholesterol gallstone disease","volume":"50","author":"Wang","year":"2009","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.gastha.2024.03.005_bib5","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1002\/hep.20654","article-title":"Genetic and environmental influences on symptomatic gallstone disease: a Swedish study of 43,141 twin pairs","volume":"41","author":"Katsika","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.gastha.2024.03.005_bib6","doi-asserted-by":"crossref","first-page":"5101","DOI":"10.1038\/s41467-018-07460-y","article-title":"Genome-wide association meta-analysis yields 20 loci associated with gallstone disease","volume":"9","author":"Ferkingstad","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.gastha.2024.03.005_bib7","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/hep4.1630","article-title":"Protein phosphatase 1 regulatory subunit 3B genotype at rs4240624 has a major effect on gallbladder bile composition","volume":"5","author":"M\u00e4nnist\u00f6","year":"2020","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.gastha.2024.03.005_bib8","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1172\/JCI105794","article-title":"The physicochemical basis of cholesterol gallstone formation in man","volume":"47","author":"Admirand","year":"1968","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.gastha.2024.03.005_bib9","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1194\/jlr.S091199","article-title":"Gallbladder bile supersaturated with cholesterol in gallstone patients preferentially develops from shortage of bile acids","volume":"60","author":"Rudling","year":"2019","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.gastha.2024.03.005_bib10","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1194\/jlr.P054387","article-title":"Lipoprotein subclass metabolism in non-alcoholic steatohepatitis","volume":"55","author":"M\u00e4nnist\u00f6","year":"2014","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.gastha.2024.03.005_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Med"},{"key":"10.1016\/j.gastha.2024.03.005_bib12","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/hep4.1192","article-title":"Protein phosphatase 1 regulatory subunit 3B gene variation protects against hepatic fat accumulation and fibrosis in individuals at high risk of nonalcoholic fatty liver disease","volume":"2","author":"Dongiovanni","year":"2018","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.gastha.2024.03.005_bib13","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.metabol.2009.10.004","article-title":"Cholesterol absorption decreases after Roux-en-Y gastric bypass but not after gastric banding","volume":"59","author":"Pihlajam\u00e4ki","year":"2010","journal-title":"Metabolism"},{"key":"10.1016\/j.gastha.2024.03.005_bib14","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jchromb.2009.11.019","article-title":"High performance liquid chromatography-tandem mass spectrometry for the determination of bile acid concentrations in human plasma","volume":"878","author":"Xiang","year":"2010","journal-title":"J\u00a0Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1016\/j.gastha.2024.03.005_bib15","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jhep.2019.03.021","article-title":"Liver-directed gene therapy results in long-term correction of progressive familial intrahepatic cholestasis type 3 in mice","volume":"71","author":"Aronson","year":"2019","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.gastha.2024.03.005_bib16","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1172\/JCI109025","article-title":"The physical chemistry of cholesterol solubility in bile. Relationship to gallstone formation and dissolution in man","volume":"61","author":"Carey","year":"1978","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.gastha.2024.03.005_bib17","doi-asserted-by":"crossref","first-page":"682","DOI":"10.3390\/metabo11100682","article-title":"Gallstone Formation follows a different trajectory in bariatric patients compared to nonbariatric patients","volume":"11","author":"Haal","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.gastha.2024.03.005_bib18","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J\u00a0Roy Stat Soc B"},{"key":"10.1016\/j.gastha.2024.03.005_bib19","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s12944-021-01527-4","article-title":"Free fatty acids and triglyceride change in the gallbladder bile of gallstone patients with pancreaticobiliary reflux","volume":"20","author":"Xiang","year":"2021","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.gastha.2024.03.005_bib20","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/sj.ijo.0800634","article-title":"Gallbladder motility and gallstone formation in obese patients following very low calorie diets. Use it (fat) to lose it (well)","volume":"22","author":"Festi","year":"1998","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.gastha.2024.03.005_bib21","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/hep.510240313","article-title":"The role of gallbladder emptying in gallstone formation during diet-induced rapid weight loss","volume":"24","author":"Gebhard","year":"1996","journal-title":"Hepatology"}],"container-title":["Gastro Hep Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772572324000360?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772572324000360?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T08:25:41Z","timestamp":1721118341000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772572324000360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024]]}},"alternative-id":["S2772572324000360"],"URL":"https:\/\/doi.org\/10.1016\/j.gastha.2024.03.005","relation":{},"ISSN":["2772-5723"],"issn-type":[{"value":"2772-5723","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protein Phosphatase 1 Regulatory Subunit 3 Beta rs4240624 Genotype Is Associated With Gallstones and With Significant Changes in Bile Lipidome","name":"articletitle","label":"Article Title"},{"value":"Gastro Hep Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gastha.2024.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.","name":"copyright","label":"Copyright"}]}}