{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T20:15:50Z","timestamp":1793650550303,"version":"4.5.1"},"reference-count":57,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T00:00:00Z","timestamp":1722556800000},"content-version":"vor","delay-in-days":214,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007313","name":"The University of Texas MD Anderson Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020046","name":"Khalifa Bin Zayed Al Nahyan Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ghadvances.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastro Hep Advances"],"published-print":{"date-parts":[[2024]]},"DOI":"10.1016\/j.gastha.2024.08.002","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T16:19:20Z","timestamp":1722961160000},"page":"1098-1115","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Blood-Based microRNA Biomarker Signature of Early-Stage Pancreatic Ductal Adenocarcinoma With Lead-Time Trajectory in Prediagnostic Samples"],"prefix":"10.1016","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7542-5201","authenticated-orcid":false,"given":"Warapen","family":"Treekitkarnmongkol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianliang","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deivendran","family":"Sankaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristian","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seetharaman","family":"Balasenthil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W.","family":"Hurd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Katayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinchita","family":"Roy-Chowdhuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George A.","family":"Calin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall E.","family":"Brand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Lampe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony Y.","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anirban","family":"Maitra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene J.","family":"Koay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann M.","family":"Killary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6884-6246","authenticated-orcid":false,"given":"Subrata","family":"Sen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gastha.2024.08.002_bib1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3322\/caac.21820","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.gastha.2024.08.002_bib2","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0140-6736(16)30583-9","article-title":"Adjuvant chemotherapy of S-1 versus gemcitabine for resected pancreatic cancer: a phase 3, open-label, randomised, non-inferiority trial (JASPAC 01)","volume":"388","author":"Uesaka","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.gastha.2024.08.002_bib3","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1056\/NEJMoa1809775","article-title":"FOLFIRINOX or gemcitabine as adjuvant therapy for pancreatic cancer","volume":"379","author":"Conroy","year":"2018","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.gastha.2024.08.002_bib4","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1200\/JCO.22.00298","article-title":"The multicenter cancer of pancreas screening study: impact on stage and survival","volume":"40","author":"Dbouk","year":"2022","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.gastha.2024.08.002_bib5","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1056\/NEJMoa1304369","article-title":"Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine","volume":"369","author":"Von Hoff","year":"2013","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.gastha.2024.08.002_bib6","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1056\/NEJMoa1903387","article-title":"Maintenance Olaparib for Germline BRCA-mutated metastatic pancreatic cancer","volume":"381","author":"Golan","year":"2019","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.gastha.2024.08.002_bib7","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0016-5085(86)90930-3","article-title":"Comparison of the sensitivity and specificity of the CA19-9 and carcinoembryonic antigen assays in detecting cancer of the pancreas","volume":"90","author":"Steinberg","year":"1986","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gastha.2024.08.002_bib8","first-page":"5501","article-title":"Relationship of carbohydrate antigen 19-9 and Lewis antigens in pancreatic cancer","volume":"47","author":"Tempero","year":"1987","journal-title":"Cancer Res"},{"key":"10.1016\/j.gastha.2024.08.002_bib9","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1006\/bbrc.1993.2295","article-title":"Alpha (1,3\/1,4)fucosyltransferase (FucT-III) gene is inactivated by a single amino acid substitution in Lewis histo-blood type negative individuals","volume":"196","author":"Nishihara","year":"1993","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.gastha.2024.08.002_bib10","doi-asserted-by":"crossref","first-page":"8820","DOI":"10.1038\/s41598-020-65720-8","article-title":"Carbohydrate antigen 19-9 elevation without evidence of malignant or pancreatobiliary diseases","volume":"10","author":"Kim","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.gastha.2024.08.002_bib11","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1093\/annonc\/mdr561","article-title":"The prognostic and predictive value of serum CA19.9 in pancreatic cancer","volume":"23","author":"Humphris","year":"2012","journal-title":"Ann Oncol"},{"key":"10.1016\/j.gastha.2024.08.002_bib12","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1053\/ejso.1999.0925","article-title":"Elevated tumour marker CA19-9: clinical interpretation and influence of obstructive jaundice","volume":"26","author":"Mann","year":"2000","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.gastha.2024.08.002_bib13","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1158\/1078-0432.CCR-20-0235","article-title":"High detection rates of pancreatic cancer across stages by plasma assay of novel methylated DNA markers and CA19-9","volume":"27","author":"Majumder","year":"2021","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.gastha.2024.08.002_bib14","first-page":"105","article-title":"The clinical utility of serum CA 19-9 in the diagnosis, prognosis and management of pancreatic adenocarcinoma: an evidence based appraisal","volume":"3","author":"Ballehaninna","year":"2012","journal-title":"J\u00a0Gastrointest Oncol"},{"key":"10.1016\/j.gastha.2024.08.002_bib15","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1056\/NEJM199305203282001","article-title":"Pancreatitis and the risk of pancreatic cancer. International pancreatitis study group","volume":"328","author":"Lowenfels","year":"1993","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.gastha.2024.08.002_bib16","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/ajg.2017.218","article-title":"Chronic pancreatitis and pancreatic cancer risk: a systematic review and meta-analysis","volume":"112","author":"Kirkegard","year":"2017","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.gastha.2024.08.002_bib17","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1126\/science.aar3247","article-title":"Detection and localization of surgically resectable cancers with a multi-analyte blood test","volume":"359","author":"Cohen","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.gastha.2024.08.002_bib18","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1001\/jama.2013.284664","article-title":"MicroRNA biomarkers in whole blood for detection of pancreatic cancer","volume":"311","author":"Schultz","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.gastha.2024.08.002_bib19","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1093\/jnci\/djy126","article-title":"A\u00a0plasma-derived protein-metabolite multiplexed panel for early-stage pancreatic cancer","volume":"111","author":"Fahrmann","year":"2019","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.gastha.2024.08.002_bib20","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.3390\/cancers12051147","article-title":"Plasma-derived extracellular vesicles convey protein signatures that reflect pathophysiology in lung and pancreatic adenocarcinomas","volume":"12","author":"Fahrmann","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.gastha.2024.08.002_bib21","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.cell.2020.07.009","article-title":"Extracellular vesicle and particle biomarkers define multiple human cancers","volume":"182","author":"Hoshino","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.gastha.2024.08.002_bib22","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1158\/2159-8290.CD-20-1311","article-title":"Liquid biopsy: from discovery to clinical application","volume":"11","author":"Alix-Panabieres","year":"2021","journal-title":"Cancer Discov"},{"key":"10.1016\/j.gastha.2024.08.002_bib23","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1158\/1078-0432.CCR-16-1676","article-title":"Emerging role of MicroRNAs as liquid biopsy biomarkers in gastrointestinal cancers","volume":"23","author":"Shigeyasu","year":"2017","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.gastha.2024.08.002_bib24","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.cell.2019.03.023","article-title":"The extracellular RNA communication consortium: establishing foundational knowledge and technologies for extracellular RNA research","volume":"177","author":"Das","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.gastha.2024.08.002_bib25","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1158\/1940-6207.CAPR-20-0303","article-title":"Plasma miRNA biomarkers in limited volume samples for detection of early-stage pancreatic cancer","volume":"14","author":"Dittmar","year":"2021","journal-title":"Cancer Prev Res (Phila)"},{"key":"10.1016\/j.gastha.2024.08.002_bib26","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1158\/1940-6207.CAPR-09-0094","article-title":"MicroRNAs in plasma of pancreatic ductal adenocarcinoma patients as novel blood-based biomarkers of disease","volume":"2","author":"Wang","year":"2009","journal-title":"Cancer Prev Res (Phila)"},{"key":"10.1016\/j.gastha.2024.08.002_bib27","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/ijc.24687","article-title":"Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival","volume":"126","author":"Greither","year":"2010","journal-title":"Int J Cancer"},{"key":"10.1016\/j.gastha.2024.08.002_bib28","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/MPA.0b013e3182592ba7","article-title":"Expression of microRNAs in patients with pancreatic cancer and its prognostic significance","volume":"42","author":"Papaconstantinou","year":"2013","journal-title":"Pancreas"},{"key":"10.1016\/j.gastha.2024.08.002_bib29","doi-asserted-by":"crossref","first-page":"5311","DOI":"10.1158\/1078-0432.CCR-17-0577","article-title":"Evaluation of tumor-derived exosomal miRNA as potential diagnostic biomarkers for early-stage non-small cell lung cancer using next-generation sequencing","volume":"23","author":"Jin","year":"2017","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.gastha.2024.08.002_bib30","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.annonc.2021.01.074","article-title":"Exosome-based liquid biopsies in cancer: opportunities and challenges","volume":"32","author":"Yu","year":"2021","journal-title":"Ann Oncol"},{"key":"10.1016\/j.gastha.2024.08.002_bib31","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1053\/j.gastro.2022.06.090","article-title":"An exosome-based transcriptomic signature for noninvasive, early detection of patients with pancreatic ductal adenocarcinoma: a multicenter cohort study","volume":"163","author":"Nakamura","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gastha.2024.08.002_bib32","doi-asserted-by":"crossref","first-page":"4212","DOI":"10.1016\/j.celrep.2019.11.078","article-title":"Comparison of reproducibility, accuracy, sensitivity, and specificity of miRNA quantification platforms","volume":"29","author":"Godoy","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.gastha.2024.08.002_bib33","doi-asserted-by":"crossref","first-page":"273S","DOI":"10.1016\/S0197-2456(00)00098-2","article-title":"Design of the prostate, lung, colorectal and ovarian (PLCO) cancer screening trial","volume":"21","author":"Prorok","year":"2000","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.gastha.2024.08.002_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.596931","article-title":"Imaging-based subtypes of pancreatic ductal adenocarcinoma exhibit differential growth and metabolic patterns in the pre-diagnostic period: implications for early detection","volume":"10","author":"Zaid","year":"2020","journal-title":"Front Oncol"},{"key":"10.1016\/j.gastha.2024.08.002_bib35","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng1180","article-title":"PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes","volume":"34","author":"Mootha","year":"2003","journal-title":"Nat Genet"},{"key":"10.1016\/j.gastha.2024.08.002_bib36","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.gastha.2024.08.002_bib37","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate - a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J\u00a0Roy Stat Soc B Stat Methodol"},{"key":"10.1016\/j.gastha.2024.08.002_bib38","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1053\/j.gastro.2018.09.022","article-title":"Circulating nucleic acids are associated with outcomes of patients with pancreatic cancer","volume":"156","author":"Bernard","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gastha.2024.08.002_bib39","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3007094","article-title":"Detection of circulating tumor DNA in early- and late-stage human malignancies","volume":"6","author":"Bettegowda","year":"2014","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.gastha.2024.08.002_bib40","doi-asserted-by":"crossref","first-page":"5883","DOI":"10.1158\/1078-0432.CCR-17-3668","article-title":"A\u00a0visually apparent and quantifiable CT imaging feature identifies biophysical subtypes of pancreatic ductal adenocarcinoma","volume":"24","author":"Koay","year":"2018","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.gastha.2024.08.002_bib41","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1126\/science.aaw3145","article-title":"The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice","volume":"364","author":"Engle","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.gastha.2024.08.002_bib42","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature14581","article-title":"Glypican-1 identifies cancer exosomes and detects early pancreatic cancer","volume":"523","author":"Melo","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.gastha.2024.08.002_bib43","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41571-018-0035-x","article-title":"Clinical utility of circulating non-coding RNAs - an update","volume":"15","author":"Anfossi","year":"2018","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.gastha.2024.08.002_bib44","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1158\/1940-6207.CAPR-15-0094","article-title":"Plasma MicroRNAs as novel biomarkers for patients with intraductal papillary mucinous neoplasms of the pancreas","volume":"8","author":"Permuth-Wey","year":"2015","journal-title":"Cancer Prev Res (Phila)"},{"key":"10.1016\/j.gastha.2024.08.002_bib45","first-page":"277","article-title":"Significance of microRNA-based biomarkers for pancreatic cancer","volume":"3","author":"Kaur","year":"2015","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.gastha.2024.08.002_bib46","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nature16965","article-title":"Genomic analyses identify molecular subtypes of pancreatic cancer","volume":"531","author":"Bailey","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.gastha.2024.08.002_bib47","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s41575-019-0109-y","article-title":"Molecular subtypes of pancreatic cancer","volume":"16","author":"Collisson","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.gastha.2024.08.002_bib48","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/s41588-019-0566-9","article-title":"Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution","volume":"52","author":"Chan-Seng-Yue","year":"2020","journal-title":"Nat Genet"},{"key":"10.1016\/j.gastha.2024.08.002_bib49","doi-asserted-by":"crossref","first-page":"6744","DOI":"10.1038\/ncomms7744","article-title":"Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets","volume":"6","author":"Witkiewicz","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.gastha.2024.08.002_bib50","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1053\/j.gastro.2023.02.012","article-title":"Pancreatic cancer: changing epidemiology and new approaches to risk assessment, early detection, and prevention","volume":"164","author":"Stoffel","year":"2023","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gastha.2024.08.002_bib51","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aay1984","article-title":"Applications of liquid biopsies for cancer","volume":"11","author":"Mattox","year":"2019","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.gastha.2024.08.002_bib52","first-page":"900","article-title":"Lewis antigen-negative pancreatic cancer: an aggressive subgroup","volume":"56","author":"Liu","year":"2020","journal-title":"Int J Oncol"},{"key":"10.1016\/j.gastha.2024.08.002_bib53","first-page":"639","article-title":"Protein biomarkers and alternatively methylated cell-free DNA detect early stage pancreatic cancer","volume":"73","author":"Ben-Ami","year":"2024","journal-title":"Gut"},{"key":"10.1016\/j.gastha.2024.08.002_bib54","doi-asserted-by":"crossref","DOI":"10.1126\/science.abb9601","article-title":"Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention","volume":"369","author":"Lennon","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.gastha.2024.08.002_bib55","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1053\/j.gastro.2019.01.259","article-title":"Early detection of pancreatic cancer: opportunities and challenges","volume":"156","author":"Singhi","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gastha.2024.08.002_bib56","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/s43018-022-00349-2","article-title":"Translational advances in pancreatic ductal adenocarcinoma therapy","volume":"3","author":"Hosein","year":"2022","journal-title":"Nat Cancer"},{"key":"10.1016\/j.gastha.2024.08.002_bib57","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41575-021-00470-0","article-title":"Early detection of pancreatic cancer using DNA-based molecular approaches","volume":"18","author":"Singhi","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"}],"container-title":["Gastro Hep Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S277257232400116X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S277257232400116X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:37:12Z","timestamp":1733013432000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S277257232400116X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":57,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024]]}},"alternative-id":["S277257232400116X"],"URL":"https:\/\/doi.org\/10.1016\/j.gastha.2024.08.002","relation":{},"ISSN":["2772-5723"],"issn-type":[{"value":"2772-5723","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Blood-Based microRNA Biomarker Signature of Early-Stage Pancreatic Ductal Adenocarcinoma With Lead-Time Trajectory in Prediagnostic Samples","name":"articletitle","label":"Article Title"},{"value":"Gastro Hep Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gastha.2024.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.","name":"copyright","label":"Copyright"}]}}