{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:39:44Z","timestamp":1793133584474,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":194,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institutes of Health National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["T32AI138932"],"award-info":[{"award-number":["T32AI138932"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P01CA116087"],"award-info":[{"award-number":["P01CA116087"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R41CA257262"],"award-info":[{"award-number":["R41CA257262"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["F31CA278330"],"award-info":[{"award-number":["F31CA278330"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA068485"],"award-info":[{"award-number":["P30CA068485"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["T32CA009592"],"award-info":[{"award-number":["T32CA009592"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011684","name":"Crohn's & Colitis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011684","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK128200"],"award-info":[{"award-number":["R01DK128200"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK058404"],"award-info":[{"award-number":["P30DK058404"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"US Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01CX002473"],"award-info":[{"award-number":["I01CX002473"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"US Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01CX002171"],"award-info":[{"award-number":["I01CX002171"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"US Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01BX004366"],"award-info":[{"award-number":["I01BX004366"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-21-1-0617"],"award-info":[{"award-number":["W81XWH-21-1-0617"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["703003"],"award-info":[{"award-number":["703003"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007208","name":"Vanderbilt Cancer Center","doi-asserted-by":"publisher","award":["F31CA278330"],"award-info":[{"award-number":["F31CA278330"]}],"id":[{"id":"10.13039\/100007208","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007208","name":"Vanderbilt Cancer Center","doi-asserted-by":"publisher","award":["P30CA068485"],"award-info":[{"award-number":["P30CA068485"]}],"id":[{"id":"10.13039\/100007208","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007208","name":"Vanderbilt Cancer Center","doi-asserted-by":"publisher","award":["T32CA009592"],"award-info":[{"award-number":["T32CA009592"]}],"id":[{"id":"10.13039\/100007208","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007208","name":"Vanderbilt Cancer Center","doi-asserted-by":"publisher","award":["T32AI138932"],"award-info":[{"award-number":["T32AI138932"]}],"id":[{"id":"10.13039\/100007208","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013017","name":"Vanderbilt University Medical Center","doi-asserted-by":"publisher","award":["P30DK058404"],"award-info":[{"award-number":["P30DK058404"]}],"id":[{"id":"10.13039\/100013017","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ghadvances.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastro Hep Advances"],"published-print":{"date-parts":[[2025]]},"DOI":"10.1016\/j.gastha.2025.100748","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T23:26:40Z","timestamp":1752881200000},"page":"100748","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Aconitate Decarboxylase 1 Downregulates Colitis and Maintains Homeostasis of the Gut Metabolome and Microbiome"],"prefix":"10.1016","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9347-0009","authenticated-orcid":false,"given":"Kara M.","family":"McNamara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne L.","family":"Latour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline V.","family":"Hawkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamery J.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P.","family":"Barry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret M.","family":"Allaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto G.","family":"Delgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergei V.","family":"Chetyrkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Wade","family":"Calcutt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Blanca","family":"Piazuelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Kay","family":"Washington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori A.","family":"Coburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain P.","family":"Gobert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4421-1830","authenticated-orcid":false,"given":"Keith T.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gastha.2025.100748_bib1","article-title":"Global, regional and national burden of inflammatory bowel disease in 204 countries and territories from 1990 to 2019: a systematic analysis based on the Global Burden of Disease Study 2019","volume":"13","author":"Wang","year":"2023","journal-title":"BMJ Open"},{"key":"10.1016\/j.gastha.2025.100748_bib2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41564-018-0306-4","article-title":"Gut microbiome structure and metabolic activity in inflammatory bowel disease","volume":"4","author":"Franzosa","year":"2019","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.gastha.2025.100748_bib3","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/ni.3780","article-title":"Regulation of inflammation by microbiota interactions with the host","volume":"18","author":"Blander","year":"2017","journal-title":"Nat Immunol"},{"key":"10.1016\/j.gastha.2025.100748_bib4","doi-asserted-by":"crossref","first-page":"7820","DOI":"10.1073\/pnas.1218599110","article-title":"Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production","volume":"110","author":"Michelucci","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.gastha.2025.100748_bib5","doi-asserted-by":"crossref","first-page":"16386","DOI":"10.1021\/ja2070889","article-title":"Itaconic acid is a mammalian metabolite induced during macrophage activation","volume":"133","author":"Strelko","year":"2011","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.gastha.2025.100748_bib6","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1021\/acs.jproteome.8b00139","article-title":"Identification of immune-responsive gene 1 (IRG1) as a target of A20","volume":"17","author":"Van Quickelberghe","year":"2018","journal-title":"J Proteome Res"},{"key":"10.1016\/j.gastha.2025.100748_bib7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1089\/jir.2008.0013","article-title":"The proinflammatory cytokine-induced IRG1 protein associates with mitochondria","volume":"29","author":"Degrandi","year":"2009","journal-title":"J Interferon Cytokine Res"},{"key":"10.1016\/j.gastha.2025.100748_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108510","article-title":"Hypusination orchestrates the antimicrobial response of macrophages","volume":"33","author":"Gobert","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.gastha.2025.100748_bib9","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1016\/j.molcel.2022.05.009","article-title":"Itaconate is a lysosomal inducer that promotes antibacterial innate immunity","volume":"82","author":"Zhang","year":"2022","journal-title":"Mol Cell"},{"key":"10.1016\/j.gastha.2025.100748_bib10","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02629-19","article-title":"IRG1 and inducible nitric oxide synthase act redundantly with other interferon-gamma-induced factors to restrict intracellular replication of Legionella pneumophila","volume":"10","author":"Price","year":"2019","journal-title":"mBio"},{"key":"10.1016\/j.gastha.2025.100748_bib11","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1084\/jem.20180118","article-title":"Irg1 expression in myeloid cells prevents immunopathology during M. tuberculosis infection","volume":"215","author":"Nair","year":"2018","journal-title":"J Exp Med"},{"key":"10.1016\/j.gastha.2025.100748_bib12","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/s41385-021-00462-y","article-title":"Irg1\/itaconate metabolic pathway is a crucial determinant of dendritic cells immune-priming function and contributes to resolute allergen-induced airway inflammation","volume":"15","author":"Jaiswal","year":"2022","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.gastha.2025.100748_bib13","doi-asserted-by":"crossref","first-page":"4392","DOI":"10.3390\/ijms23084392","article-title":"Aconitate decarboxylase 1 deficiency exacerbates mouse colitis induced by dextran sodium sulfate","volume":"23","author":"Kim","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.gastha.2025.100748_bib14","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1002\/oby.23509","article-title":"Aconitate decarboxylase 1 regulates glucose homeostasis and obesity in mice","volume":"30","author":"Frieler","year":"2022","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.gastha.2025.100748_bib15","article-title":"STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages","volume":"26","author":"Liu","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.gastha.2025.100748_bib16","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1007\/s00109-020-01963-2","article-title":"The anti-inflammatory drug dimethyl itaconate protects against colitis-associated colorectal cancer","volume":"98","author":"Wang","year":"2020","journal-title":"J Mol Med (Berl)"},{"key":"10.1016\/j.gastha.2025.100748_bib17","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1097\/MIB.0000000000001246","article-title":"Genetic and transcriptomic bases of intestinal epithelial barrier dysfunction in inflammatory bowel disease","volume":"23","author":"Vancamelbeke","year":"2017","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.gastha.2025.100748_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0116117","article-title":"Integrated miRNA and mRNA expression profiling in inflamed colon of patients with ulcerative colitis","volume":"9","author":"Van der Goten","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.gastha.2025.100748_bib19","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1097\/MIB.0000000000000790","article-title":"L-arginine availability and metabolism is altered in ulcerative colitis","volume":"22","author":"Coburn","year":"2016","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.gastha.2025.100748_bib20","article-title":"Immunoresponsive gene 1 facilitates TLR4-agonist-induced augmentation of innate antimicrobial immunity","volume":"117","author":"McBride","year":"2024","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.gastha.2025.100748_bib21","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2192623","article-title":"Epithelial talin-1 protects mice from Citrobacter rodentium-induced colitis by restricting bacterial crypt intrusion and enhancing T cell immunity","volume":"15","author":"Latour","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.gastha.2025.100748_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-49614-z","article-title":"Myeloid deletion of talin-1 reduces mucosal macrophages and protects mice from colonic inflammation","volume":"13","author":"Latour","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.gastha.2025.100748_bib23","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.1172\/JCI83585","article-title":"EGFR regulates macrophage activation and function in bacterial infection","volume":"126","author":"Hardbower","year":"2016","journal-title":"J Clin Invest"},{"key":"10.1016\/j.gastha.2025.100748_bib24","doi-asserted-by":"crossref","first-page":"6540","DOI":"10.1038\/s41388-021-02046-3","article-title":"CCL11 exacerbates colitis and inflammation-associated colon tumorigenesis","volume":"40","author":"Polosukhina","year":"2021","journal-title":"Oncogene"},{"key":"10.1016\/j.gastha.2025.100748_bib25","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1053\/j.gastro.2021.11.005","article-title":"Protective role of spermidine in colitis and colon carcinogenesis","volume":"162","author":"Gobert","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gastha.2025.100748_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e33838","article-title":"Analysis of the effect of hypusination in myeloid cells on colitis and colitis-associated cancer","volume":"10","author":"Gobert","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.gastha.2025.100748_bib27","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1053\/j.gastro.2023.05.041","article-title":"Hypusination maintains intestinal homeostasis and prevents colitis and carcinogenesis by enhancing aldehyde detoxification","volume":"165","author":"Gobert","year":"2023","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gastha.2025.100748_bib28","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.155338","article-title":"Cystathionine \u03b3-lyase exacerbates Helicobacter pylori immunopathogenesis by promoting macrophage metabolic remodeling and activation","volume":"7","author":"Latour","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.gastha.2025.100748_bib29","doi-asserted-by":"crossref","first-page":"796","DOI":"10.4049\/jimmunol.2100795","article-title":"Ornithine decarboxylase in gastric epithelial cells promotes the immunopathogenesis of Helicobacter pylori infection","volume":"209","author":"Latour","year":"2022","journal-title":"J Immunol"},{"key":"10.1016\/j.gastha.2025.100748_bib30","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3389\/fcimb.2019.00066","article-title":"Dietary arginine regulates severity of experimental colitis and affects the colonic microbiome","volume":"9","author":"Singh","year":"2019","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.gastha.2025.100748_bib31","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1038\/s41388-023-02691-w","article-title":"Electrophilic reactive aldehydes as a therapeutic target in colorectal cancer prevention and treatment","volume":"42","author":"Gobert","year":"2023","journal-title":"Oncogene"},{"key":"10.1016\/j.gastha.2025.100748_bib32","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00726-024-03423-4","article-title":"The reverse transsulfuration pathway affects the colonic microbiota and contributes to colitis in mice","volume":"56","author":"Gobert","year":"2024","journal-title":"Amino Acids"},{"key":"10.1016\/j.gastha.2025.100748_bib33","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.3389\/fimmu.2018.01242","article-title":"Distinct immunomodulatory effects of spermine oxidase in colitis induced by epithelial injury or infection","volume":"9","author":"Gobert","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.gastha.2025.100748_bib34","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3389\/fmicb.2015.00171","article-title":"Biomarker-based classification of bacterial and fungal whole-blood infections in a genome-wide expression study","volume":"6","author":"Dix","year":"2015","journal-title":"Front Microbiol"},{"key":"10.1016\/j.gastha.2025.100748_bib35","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.mucimm.2024.06.004","article-title":"Cell type-specific modulation of metabolic, immune-regulatory, and anti-microbial pathways by CD101","volume":"17","author":"Wrage","year":"2024","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.gastha.2025.100748_bib36","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/j.gendis.2022.05.039","article-title":"Protective effects of IRG1\/itaconate on acute colitis through the inhibition of gasdermins-mediated pyroptosis and inflammation response","volume":"10","author":"Yang","year":"2023","journal-title":"Genes Dis"},{"key":"10.1016\/j.gastha.2025.100748_bib37","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1111\/imcb.12167","article-title":"Purine metabolism controls innate lymphoid cell function and protects against intestinal injury","volume":"96","author":"Crittenden","year":"2018","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.gastha.2025.100748_bib38","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.3390\/molecules28031060","article-title":"Cepharanthine alleviates DSS-induced ulcerative colitis via regulating aconitate decarboxylase 1 expression and macrophage infiltration","volume":"28","author":"Zhang","year":"2023","journal-title":"Molecules"}],"container-title":["Gastro Hep Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772572325001359?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772572325001359?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T12:05:15Z","timestamp":1778933115000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772572325001359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":38,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025]]}},"alternative-id":["S2772572325001359"],"URL":"https:\/\/doi.org\/10.1016\/j.gastha.2025.100748","relation":{},"ISSN":["2772-5723"],"issn-type":[{"value":"2772-5723","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aconitate Decarboxylase 1 Downregulates Colitis and Maintains Homeostasis of the Gut Metabolome and Microbiome","name":"articletitle","label":"Article Title"},{"value":"Gastro Hep Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gastha.2025.100748","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc. on behalf of the AGA Institute.","name":"copyright","label":"Copyright"}],"article-number":"100748"}}