{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T05:45:22Z","timestamp":1769147122341,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2003,11,1]],"date-time":"2003-11-01T00:00:00Z","timestamp":1067644800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2003,11]]},"DOI":"10.1016\/j.gastro.2003.08.021","type":"journal-article","created":{"date-parts":[[2003,11,3]],"date-time":"2003-11-03T17:23:16Z","timestamp":1067880196000},"page":"1428-1440","source":"Crossref","is-referenced-by-count":27,"title":["Genetic background modifies intestinal pseudo-obstruction and the expression of a reporter gene in Hox11L1\u2212\/\u2212 mice1 1The authors thank Carmen Booth for technical assistance and Kristy Seidel for statistical analysis."],"prefix":"10.1016","volume":"125","author":[{"given":"Melissa A","family":"Parisi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey E","family":"Baldessari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malissa H.K","family":"Iida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine M","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Doggett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senji","family":"Shirasawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raj P","family":"Kapur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.gastro.2003.08.021_BIB1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/00005176-199701000-00021","article-title":"Diagnosis and treatment of chronic intestinal pseudo-obstruction in children","volume":"24","author":"Rudolph","year":"1997","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.gastro.2003.08.021_BIB2","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/path.885","article-title":"Neuropathology of paediatric chronic intestinal pseudo-obstruction and related animal models","volume":"194","author":"Kapur","year":"2001","journal-title":"J Pathol"},{"key":"10.1016\/j.gastro.2003.08.021_BIB3","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1097\/00008480-200012000-00017","article-title":"The genetics of Hirschsprung disease","volume":"12","author":"Parisi","year":"2000","journal-title":"Curr Opin Pediatr"},{"key":"10.1016\/j.gastro.2003.08.021_BIB4","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1172\/JCI119593","article-title":"A novel pathogenesis of megacolon in Ncx\/Hox11L.1 deficient mice","volume":"100","author":"Hatano","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.gastro.2003.08.021_BIB5","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/nm0697-646","article-title":"Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia and megacolon","volume":"3","author":"Shirasawa","year":"1997","journal-title":"Nat Med"},{"key":"10.1016\/j.gastro.2003.08.021_BIB6","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1242\/dev.125.10.1877","article-title":"The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development","volume":"125","author":"Tang","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.gastro.2003.08.021_BIB7","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.1073\/pnas.90.10.4431","article-title":"The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes","volume":"90","author":"Dear","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.gastro.2003.08.021_BIB8","first-page":"1089","article-title":"Developmental expression of Hox11 and specification of splenic cell fate","volume":"146","author":"Roberts","year":"1995","journal-title":"Am J Pathol"},{"key":"10.1016\/j.gastro.2003.08.021_BIB9","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0014-5793(00)01651-3","article-title":"Identification of an optimal Ncx binding sequence required for transcriptional activation","volume":"475","author":"Shimizu","year":"2000","journal-title":"FEBS Lett"},{"key":"10.1016\/j.gastro.2003.08.021_BIB10","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s004290050061","article-title":"Ncx, a Hox11 related gene, is expressed in a variety of tissues derived from neural crest cells","volume":"195","author":"Hatano","year":"1997","journal-title":"Anat Embryol"},{"key":"10.1016\/j.gastro.2003.08.021_BIB11","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1053\/jpsu.2001.25797","article-title":"Intestinal neuronal dysplasia-like pathology in Ncx\/Hox11L.1 gene-deficient mice","volume":"36","author":"Yamataka","year":"2001","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.gastro.2003.08.021_BIB12","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/S0022-5347(05)66590-1","article-title":"Vesicourethral sphincter dysfunction in Ncx deficient mice with an increased neuronal cell number in vesical ganglia","volume":"165","author":"Jusuf","year":"2000","journal-title":"J Urol"},{"key":"10.1016\/j.gastro.2003.08.021_BIB13","doi-asserted-by":"crossref","first-page":"24401","DOI":"10.1074\/jbc.274.34.24401","article-title":"An enhancer element for expression of the Ncx (Enx, Hox11L1) gene in neural crest-derived cells","volume":"274","author":"Iitsuka","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.gastro.2003.08.021_BIB14","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/sj.cgt.7700408","article-title":"Tissue-specific expression of a suicide gene for selective killing of neuroblastoma cells using a promoter region of the NCX gene","volume":"8","author":"Narita","year":"2001","journal-title":"Cancer Gene Ther"},{"key":"10.1016\/j.gastro.2003.08.021_BIB15","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/0896-6273(91)90274-4","article-title":"The dopamine \u03b2-hydroxylase gene promoter directs expression of E. coli lacZ to sympathetic and other neurons in adult transgenic mice","volume":"7","author":"Mercer","year":"1991","journal-title":"Neuron"},{"key":"10.1016\/j.gastro.2003.08.021_BIB16","series-title":"Mouse genetics","first-page":"46","author":"Silver","year":"1995"},{"key":"10.1016\/j.gastro.2003.08.021_BIB17","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/(SICI)1097-0177(200001)217:1<120::AID-DVDY11>3.0.CO;2-U","article-title":"Transgenic rescue of aganglionosis and piebaldism in lethal spotted mice","volume":"217","author":"Rice","year":"2000","journal-title":"Dev Dyn"},{"key":"10.1016\/j.gastro.2003.08.021_BIB18","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/0896-6273(91)90275-5","article-title":"Some neuronal cell populations express human dopamine \u03b2-hydroxylase-lacZ transgenes transiently during embryonic development","volume":"7","author":"Kapur","year":"1991","journal-title":"Neuron"},{"key":"10.1016\/j.gastro.2003.08.021_BIB19","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1679\/aohc.56.459","article-title":"Immunohistochemical analysis of neurons and their projections in the proximal colon of the guinea pig","volume":"56","author":"Messenger","year":"1993","journal-title":"Arch Histol Cytol"},{"key":"10.1016\/j.gastro.2003.08.021_BIB20","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0165-0270(87)90101-4","article-title":"Specific, selective, and complete staining of neurons of the myenteric plexus, using cuprolinic blue","volume":"21","author":"Heinicke","year":"1987","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.gastro.2003.08.021_BIB21","doi-asserted-by":"crossref","first-page":"6795","DOI":"10.1073\/pnas.84.19.6795","article-title":"A \u03b2-galactosidase hybrid protein targeted to nuclei as a marker for developmental studies","volume":"84","author":"Bonnerot","year":"1987","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.gastro.2003.08.021_BIB22","first-page":"789","article-title":"Time of origin of neurons in the murine enteric nervous system","volume":"314","author":"Pham","year":"1991","journal-title":"J Comp Med"},{"key":"10.1016\/j.gastro.2003.08.021_BIB23","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s004410050565","article-title":"Chemical coding of neurons in the myenteric plexus and external muscle of the small and large intestine of the mouse","volume":"284","author":"Sang","year":"1996","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.gastro.2003.08.021_BIB24","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s10024-001-0142-y","article-title":"Enteric nervous system","volume":"5","author":"Newgreen","year":"2002","journal-title":"Pediatr Dev Pathol"},{"key":"10.1016\/j.gastro.2003.08.021_BIB25","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s10024-002-0002-4","article-title":"Enteric nervous system","volume":"5","author":"Newgreen","year":"2002","journal-title":"Pediatr Dev Pathol"},{"key":"10.1016\/j.gastro.2003.08.021_BIB26","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1016\/S0002-9440(10)63082-9","article-title":"Embryonic gut anomalies in a mouse model of retinoic acid-induced caudal regression syndrome","volume":"159","author":"Pitera","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1016\/j.gastro.2003.08.021_BIB27","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0165-1838(00)00127-2","article-title":"Types of neurons in the enteric nervous system","volume":"81","author":"Furness","year":"2000","journal-title":"J Autonomic Nerv Sys"},{"key":"10.1016\/j.gastro.2003.08.021_BIB28","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1146\/annurev.physiol.61.1.117","article-title":"The enteric nervous system and regulation of intestinal motility","volume":"61","author":"Kunze","year":"1999","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.gastro.2003.08.021_BIB29","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0092-8674(00)80561-9","article-title":"Progression from extrinsic to intrinsic signaling in cell fate specification","volume":"96","author":"Edlund","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.gastro.2003.08.021_BIB30","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1242\/dev.122.1.309","article-title":"Distinct subpopulations of enteric neuronal progenitors defined by time and place of development, sympathoadrenal lineage markers and Mash-1-dependence","volume":"122","author":"Blaugrund","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.gastro.2003.08.021_BIB31","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3109\/15513819309048209","article-title":"Intestinal neuronal density in childhood","volume":"13","author":"Smith","year":"1993","journal-title":"Pediatr Pathol"},{"key":"10.1016\/j.gastro.2003.08.021_BIB32","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/BF00192108","article-title":"Histopathological criteria for intestinal neuronal dysplasia of the submucosal plexus (type B)","volume":"426","author":"Meier-Ruge","year":"1995","journal-title":"Virchows Arch"},{"key":"10.1016\/j.gastro.2003.08.021_BIB33","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1136\/jmg.37.7.e9","article-title":"Evaluation of the Hox11L1 gene as a candidate for congenital disorders of intestinal innervation","volume":"37","author":"Costa","year":"2000","journal-title":"J Med Genet"},{"key":"10.1016\/j.gastro.2003.08.021_BIB34","first-page":"101","article-title":"HOX11L1","volume":"10","author":"Fava","year":"2002","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.gastro.2003.08.021_BIB35","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1055\/s-2008-1072218","article-title":"Chronic intestinal pseudo-obstruction syndrome in pediatric patients","volume":"9","author":"Goulet","year":"1999","journal-title":"Eur J Pediatr Surg"},{"key":"10.1016\/j.gastro.2003.08.021_BIB36","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1101\/gr.9.3.215","article-title":"The Sox10Dom mouse","volume":"9","author":"Southard-Smith","year":"1999","journal-title":"Genome Res"},{"key":"10.1016\/j.gastro.2003.08.021_BIB37","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1101\/gr.5.1.29","article-title":"Quantitative trait loci that modify the severity of spotting in piebald mice","volume":"5","author":"Pavan","year":"1995","journal-title":"Genome Res"},{"key":"10.1016\/j.gastro.2003.08.021_BIB38","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1073\/pnas.0337540100","article-title":"Phenotypic variation in two-locus mouse models of Hirschsprung disease","volume":"100","author":"McCallion","year":"2003","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508503013507?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508503013507?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T11:30:12Z","timestamp":1682595012000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508503013507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2003,11]]}},"alternative-id":["S0016508503013507"],"URL":"https:\/\/doi.org\/10.1016\/j.gastro.2003.08.021","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2003,11]]}}}