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Transplant."},{"key":"10.1016\/j.gastrohep.2010.11.007_bib0430","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.transproceed.2005.12.108","article-title":"Human leukocyte antigen-G, a new parameter in the follow-up of liver transplantation","volume":"38","author":"Ba\u015ft\u00fcrk","year":"2006","journal-title":"Transplant Proc."},{"key":"10.1016\/j.gastrohep.2010.11.007_bib0435","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/MOT.0b013e328334269a","article-title":"Monitoring the operationally liver allograft recipient","volume":"15","author":"Castellaneta","year":"2010","journal-title":"Curr Opin Organ Transplant."},{"key":"10.1016\/j.gastrohep.2010.11.007_bib0440","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1097\/TP.0b013e31816a8a6d","article-title":"Alemtuzumab preconditioning with tacrolimus monotherapy-the impact of serial monitoring for donor-specific 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