{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T17:26:53Z","timestamp":1770830813897,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterolog\u00eda y Hepatolog\u00eda"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.gastrohep.2015.10.004","type":"journal-article","created":{"date-parts":[[2015,11,15]],"date-time":"2015-11-15T04:30:18Z","timestamp":1447561818000},"page":"560-565","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["\u00bfTiene alg\u00fan papel la pentoxifilina en el tratamiento de la hepatitis alcoh\u00f3lica?"],"prefix":"10.1016","volume":"39","author":[{"given":"Juan","family":"Caballeria","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.gastrohep.2015.10.004_bib0155","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1056\/NEJMra0805786","article-title":"Alcoholic hepatitis","volume":"360","author":"Lucey","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.gastrohep.2015.10.004_bib0160","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/hep.23258","article-title":"Alcoholic liver disease","volume":"51","author":"O'Shea","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.gastrohep.2015.10.004_bib0165","doi-asserted-by":"crossref","unstructured":"European Association for the Study of the Liver. EASL Clinical Practical Guidelines: Management of alcoholic liver disease. J Hepatol. 2012;57:399-420.","DOI":"10.1016\/j.jhep.2012.04.004"},{"key":"10.1016\/j.gastrohep.2015.10.004_bib0170","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1053\/j.gastro.2009.04.062","article-title":"Infection in patients with severe alcoholic hepatitis treated with steroid: Early response to therapy is the key factor","volume":"137","author":"Louvet","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gastrohep.2015.10.004_bib0175","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.gtc.2011.06.008","article-title":"Alcoholic hepatitis: Prognostic models and treatment","volume":"40","author":"Singal","year":"2011","journal-title":"Gastroenterol Clin North Am"},{"key":"10.1016\/j.gastrohep.2015.10.004_bib0180","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1053\/j.gastro.2014.01.018","article-title":"A histologic scoring system for prognosis of patients with alcoholic hepatitis","volume":"146","author":"Altamirano","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gastrohep.2015.10.004_bib0185","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11901-012-0158-y","article-title":"Alcoholic hepatitis: Steroids vs. pentoxifylline","volume":"12","author":"Smart","year":"2013","journal-title":"Curr Hepat Rep"},{"key":"10.1016\/j.gastrohep.2015.10.004_bib0190","first-page":"96A","article-title":"Pentoxifylline may prevent renal impairment (hepatorenal syndrome) in severe acute alcoholic hepatitis","volume":"14","author":"McHutchison","year":"1991","journal-title":"Hepatology"},{"key":"10.1016\/j.gastrohep.2015.10.004_bib0195","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1053\/gast.2000.20189","article-title":"Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: A double-blind placebo-controlled trial","volume":"119","author":"Akriviadis","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gastrohep.2015.10.004_bib0200","first-page":"CD007339","article-title":"Pentoxifylline for alcoholic hepatitis","author":"Whitfield","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1016\/j.gastrohep.2015.10.004_bib0205","first-page":"961A","article-title":"No additional effect of adding pentoxifylline to corticosteroids in severe alcoholic hepatitis: Meta-analyses of randomized controlled trials","volume":"56","author":"Thiele","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.gastrohep.2015.10.004_bib0210","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1111\/apt.12279","article-title":"Systematic review: Pentoxifylline for the treatment of severe alcoholic hepatitis","volume":"37","author":"Parker","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.gastrohep.2015.10.004_bib0215","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1001\/jama.2013.276301","article-title":"Treatment of severe alcoholic hepatitis with corticosteroids and pentoxifylline","volume":"310","author":"Halegoua-De Marzio","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.gastrohep.2015.10.004_bib0220","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.jhep.2014.07.001","article-title":"Prednisolone vs. pentoxifylline for severe alcoholic hepatitis","volume":"61","author":"Louvet","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.gastrohep.2015.10.004_bib0225","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1002\/hep.27657","article-title":"Is pentoxifylline still an option in severe alcoholic hepatitis","volume":"61","author":"Caballeria","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.gastrohep.2015.10.004_bib0230","first-page":"A459","article-title":"Role of pentoxifylline in treatment of severe acute alcoholic hepatitis \u2014a randomized controlled trial","volume":"21","author":"Paladugu","year":"2006","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.gastrohep.2015.10.004_bib0235","first-page":"373A","article-title":"Pentoxifylline reduces disease severity and prevents renal impairment in severe acute alcoholic hepatitis: A double-blind, placebo-controlled trial","volume":"44","author":"Sidhu","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.gastrohep.2015.10.004_bib0240","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.3748\/wjg.15.1613","article-title":"Pentoxifylline vs prednisolone for severe alcoholic hepatitis: a randomized controlled trial","volume":"15","author":"De","year":"2009","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.gastrohep.2015.10.004_bib0245","first-page":"227","article-title":"Pentoxiflina versus esteroides en la sobrevivencia a corto plazo en hepatitis aguda alcoh\u00f3lica severa","volume":"28","author":"Garrido Garc\u00eda","year":"2012","journal-title":"Med Int Mex"},{"key":"10.1016\/j.gastrohep.2015.10.004_bib0250","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.jhep.2014.05.014","article-title":"Pentoxifylline vs. corticosteroid to treat severe alcoholic hepatitis: A randomized, non-inferiority, open trial","volume":"61","author":"Park","year":"2014","journal-title":"J Hepatol."},{"key":"10.1016\/j.gastrohep.2015.10.004_bib0255","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1053\/j.gastro.2010.01.040","article-title":"Pentoxifylline does not decrease short-term mortality but does reduce complications in patients with advanced cirrhosis","volume":"138","author":"Lebrec","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gastrohep.2015.10.004_bib0260","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1007\/s10620-012-2097-4","article-title":"Corticosteroid plus pentoxifylline is not better than corticosteroid alone for improving survival in severe alcoholic hepatitis (COPE trial)","volume":"57","author":"Sidhu","year":"2012","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.gastrohep.2015.10.004_bib0265","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1001\/jama.2013.276300","article-title":"Prednisolone with vs without pentoxifylline and survival of patients with severe alcoholic hepatitis: A randomized clinical trial","volume":"310","author":"Mathurin","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.gastrohep.2015.10.004_bib0270","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jhep.2007.10.010","article-title":"Early switch to pentoxifylline in patients with severe alcoholic hepatitis is inefficient in non-responders to corticosteroids","volume":"48","author":"Louvet","year":"2008","journal-title":"J Hepatol"},{"key":"10.1016\/j.gastrohep.2015.10.004_bib0275","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1056\/NEJMoa1412278","article-title":"Prednisolone or pentoxifylline for alcoholic hepatitis","volume":"372","author":"Thursz","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.gastrohep.2015.10.004_bib0280","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1053\/j.gastro.2015.06.006","article-title":"Comparative effectiveness of pharmacological interventions for severe alcoholic hepatitis: A systematic review and network meta-analysis","volume":"149","author":"Singh","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gastrohep.2015.10.004_bib0285","doi-asserted-by":"crossref","first-page":"130","DOI":"10.7326\/0003-4819-159-2-201307160-00008","article-title":"Conceptual and technical challenges in network meta-analysis","volume":"159","author":"Cipriani","year":"2013","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.gastrohep.2015.10.004_bib0290","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1053\/j.gastro.2015.08.027","article-title":"Comparative effectiveness of medical therapies for severe alcoholic hepatitis: Guidance at last","volume":"149","author":"Parikh","year":"2015","journal-title":"Gastroenterology"},{"issue":"Suppl 1","key":"10.1016\/j.gastrohep.2015.10.004_bib0295","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1016\/j.jhep.2015.03.006","article-title":"Trends in the management and burden of alcoholic liver disease","volume":"62","author":"Mathurin","year":"2015","journal-title":"J Hepatol"},{"issue":"Suppl 1","key":"10.1016\/j.gastrohep.2015.10.004_bib0300","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/jgh.12030","article-title":"Alcoholic liver disease: Pathogenesis, management ant novel targets for therapy","volume":"28","author":"Oman","year":"2013","journal-title":"J Gastroenterol Hepatol"}],"container-title":["Gastroenterolog\u00eda y Hepatolog\u00eda"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0210570515002460?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0210570515002460?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T17:56:36Z","timestamp":1537206996000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0210570515002460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S0210570515002460"],"URL":"https:\/\/doi.org\/10.1016\/j.gastrohep.2015.10.004","relation":{},"ISSN":["0210-5705"],"issn-type":[{"value":"0210-5705","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u00bfTiene alg\u00fan papel la pentoxifilina en el tratamiento de la hepatitis alcoh\u00f3lica?","name":"articletitle","label":"Article Title"},{"value":"Gastroenterolog\u00eda y Hepatolog\u00eda","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gastrohep.2015.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 Elsevier Espa\u00f1a, S.L.U., AEEH y AEG. All rights reserved.","name":"copyright","label":"Copyright"}]}}