{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:59:36Z","timestamp":1781715576839,"version":"3.54.5"},"reference-count":44,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterolog\u00eda y Hepatolog\u00eda"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.gastrohep.2020.01.002","type":"journal-article","created":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T07:52:59Z","timestamp":1582271579000},"page":"266-272","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Melanosis coli: A comprehensive review"],"prefix":"10.1016","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1853-1446","authenticated-orcid":false,"given":"Ningning","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8463-522X","authenticated-orcid":false,"given":"Mengting","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8177-0140","authenticated-orcid":false,"given":"Shizhu","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gastrohep.2020.01.002_bib0225","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1159\/000007743","article-title":"Influence of a highly purified senna extract on colonic epithelium","volume":"61","author":"van Gorkom","year":"2000","journal-title":"Digestion"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0230","doi-asserted-by":"crossref","first-page":"86","DOI":"10.11604\/pamj.2013.16.86.3331","article-title":"Melanosis coli: a rarity in digestive endoscopy","volume":"16","author":"Mellouki","year":"2013","journal-title":"Pan Afr Med J"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0235","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1056\/NEJMicm020208","article-title":"Images in clinical medicine. Melanosis coli","volume":"349","author":"Ahmed","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0240","first-page":"1354","article-title":"[One hundred books which built up neurology (35) \u2013 Cruveilhier J \u201cAnatomie Pathologique du Corps Humain\u201d (1829\u20131842)]","volume":"61","author":"Sakuta","year":"2009","journal-title":"Brain Nerve"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0245","first-page":"54","article-title":"Pseudo-obstruction with pitch black colon \u2013 a very rare presentation of melanosis coli","volume":"77","author":"Malik","year":"2008","journal-title":"Ulster Med J"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0250","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1749-7922-2-25","article-title":"Ischemic colitis or melanosis coli: a case report","volume":"2","author":"Chaudhary","year":"2007","journal-title":"World J Emerg Surg"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0255","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1046\/j.1365-2559.1997.d01-574.x","article-title":"Melanosis coli is associated with an increase in colonic epithelial apoptosis and not with laxative use","volume":"30","author":"Byers","year":"1997","journal-title":"Histopathology"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0260","first-page":"105","article-title":"The clinical importance of melanosis coli","volume":"52","author":"Samenius","year":"1959","journal-title":"Proc R Soc Med"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0265","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/BF02616828","article-title":"Melanosis coli: general review and a study of 887 cases","volume":"1","author":"Wittoesch","year":"1958","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0270","doi-asserted-by":"crossref","first-page":"e4483","DOI":"10.7717\/peerj.4483","article-title":"Gender, age, and concomitant diseases of melanosis coli in China: a multicenter study of 6,090 cases","volume":"6","author":"Wang","year":"2018","journal-title":"PeerJ"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0275","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1136\/pgmj.56.662.854","article-title":"Melanosis coli in a child of four years","volume":"56","author":"Price","year":"1980","journal-title":"Postgrad Med J"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0280","doi-asserted-by":"crossref","first-page":"18","DOI":"10.7812\/TPP\/18-063","article-title":"Melanosis coli: a case of mistaken identity \u2013 a case report","volume":"23","author":"Moeller","year":"2019","journal-title":"Perm J"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0285","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1177\/1066896912468212","article-title":"Melanosis coli in hyperplastic polyps and adenomas","volume":"21","author":"Coyne","year":"2013","journal-title":"Int J Surg Pathol"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0290","first-page":"378","article-title":"Melanosis coli: a case report in a trauma patient and review of the literature","volume":"57","author":"Sosa","year":"1991","journal-title":"Am Surg"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0295","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.2337\/dc08-2175","article-title":"New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes","volume":"32","author":"Libby","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0300","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1136\/jcp.46.2.118","article-title":"Importance of apoptosis in the histopathology of drug related lesions in the large intestine","volume":"46","author":"Lee","year":"1993","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0305","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1177\/0300985814559403","article-title":"Evidence of oxidative injury in pigs with melanosis coli","volume":"52","author":"Wilberts","year":"2015","journal-title":"Vet Pathol"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0310","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1053\/gast.1996.v111.pm8780584","article-title":"Human aberrant crypt foci with carcinoma in situ from a patient with sporadic colon cancer","volume":"111","author":"Konstantakos","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0315","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1067\/mge.2001.115323","article-title":"An unusual case of melanosis coli","volume":"54","author":"Lestina","year":"2001","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0320","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.5858\/2001-125-1110-CLHIMC","article-title":"Colonic lymphoid hyperplasia in melanosis coli","volume":"125","author":"Pearce","year":"2001","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0325","doi-asserted-by":"crossref","first-page":"565","DOI":"10.5858\/2004-128-565-MCIPLN","article-title":"Melanosis coli involving pericolonic lymph nodes associated with the herbal laxative Swiss Kriss: a rare and incidental finding in a patient with colonic adenocarcinoma","volume":"128","author":"Ewing","year":"2004","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0330","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1177\/002215549904700601","article-title":"Reduction of lipofuscin-like autofluorescence in fluorescently labeled tissue","volume":"47","author":"Schnell","year":"1999","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0335","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1365-2559.1978.tb01692.x","article-title":"Yellow-brown spindle bodies in mesenteric lymph nodes: a possible relationship with melanosis coli","volume":"2","author":"Hall","year":"1978","journal-title":"Histopathology"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0340","doi-asserted-by":"crossref","first-page":"4296","DOI":"10.3748\/wjg.14.4296","article-title":"\u201cMelanosis\u201d in the small and large intestine","volume":"14","author":"Freeman","year":"2008","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0345","doi-asserted-by":"crossref","first-page":"13","DOI":"10.14309\/crj.2015.85","article-title":"Who turned out the lights? An impressive case of melanosis coli","volume":"3","author":"Cowley","year":"2015","journal-title":"ACG Case Rep J"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0350","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1056\/NEJMcibr0803116","article-title":"Tumor necrosis factor alpha and colitis-associated colon cancer","volume":"358","author":"Wilson","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0355","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3109\/00313029309084783","article-title":"Ultrastructure of human melanosis coli with reference to its pathogenesis","volume":"25","author":"Walker","year":"1993","journal-title":"Pathology"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0360","doi-asserted-by":"crossref","first-page":"681","DOI":"10.3109\/01913129109023199","article-title":"Unusual pigmented vesical lesion in a middle-aged woman (UP 1990;14:529\u2013535)","volume":"15","author":"Herrera","year":"1991","journal-title":"Ultrastruct Pathol"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0365","article-title":"Identification of candidate biomarkers associated with apoptosis in melanosis coli: GNG5, LPAR3, MAPK8, and PSMC6","volume":"39","author":"Hua X1","year":"2019","journal-title":"Biosci Rep"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0370","doi-asserted-by":"crossref","first-page":"913","DOI":"10.3109\/13880209.2014.948636","article-title":"Immunological changes in the intestines and skin after senna administration","volume":"53","author":"Yamate","year":"2015","journal-title":"Pharm Biol"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0375","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1046\/j.1365-2036.1999.00468.x","article-title":"Review article: anthranoid laxatives and their potential carcinogenic effects","volume":"13","author":"Van Gorkom","year":"1999","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0380","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.2042-7158.1986.tb04589.x","article-title":"Acceleration of large intestine transit time in rats by sennosides and related compounds","volume":"38","author":"Leng-Peschlow","year":"1986","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0385","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.3892\/mmr.2015.4126","article-title":"Histopathology of melanosis coli and determination of its associated genes by comparative analysis of expression microarrays","volume":"12","author":"Li","year":"2015","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0390","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.pharmthera.2013.01.010","article-title":"NADPH P450 oxidoreductase: structure, function, and pathology of diseases","volume":"138","author":"Pandey","year":"2013","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0395","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1021\/tx2004163","article-title":"Inhibition of cytochrome p450 enzymes by quinones and anthraquinones","volume":"25","author":"Sridhar","year":"2012","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0400","doi-asserted-by":"crossref","first-page":"E437","DOI":"10.1055\/s-0034-1377427","article-title":"Atypical melanosis coli resembling the appearance of cheetah skin","volume":"46","author":"Grilo","year":"2014","journal-title":"Endoscopy"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0405","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/BF02555359","article-title":"Melanosis coli. Ultrastructural study of 45 patients","volume":"29","author":"Balazs","year":"1986","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0410","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/MCG.0000000000000756","article-title":"Adenoma detection is increased in the setting of melanosis coli","volume":"52","author":"Blackett","year":"2018","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0415","doi-asserted-by":"crossref","first-page":"A33","DOI":"10.1016\/j.cgh.2017.10.011","article-title":"The rusty ring sign streamlining flat lesion detection in subtle melanosis coli","volume":"16","author":"Zimmer","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0420","first-page":"2015","article-title":"Melanosis coli or ischaemic colitis? That is the question","author":"Ricciuti","year":"2015","journal-title":"BMJ Case Rep"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0425","doi-asserted-by":"crossref","first-page":"4771","DOI":"10.3748\/wjg.v13.i35.4771","article-title":"Increasing dietary fiber intake in terms of kiwifruit improves constipation in Chinese patients","volume":"13","author":"Chan","year":"2007","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0430","doi-asserted-by":"crossref","first-page":"e72608","DOI":"10.1371\/journal.pone.0072608","article-title":"New onset of constipation during long-term physical inactivity: a proof-of-concept study on the immobility-induced bowel changes","volume":"8","author":"Iovino","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0435","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/ajg.2016.567","article-title":"Disappearance of melanosis coli after administration of IVIG","volume":"112","author":"Doll","year":"2017","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.gastrohep.2020.01.002_bib0440","doi-asserted-by":"crossref","first-page":"9736","DOI":"10.3748\/wjg.v21.i33.9736","article-title":"Comparison of two types of colectomy in treating slow transit constipation with or without melanosis coli","volume":"21","author":"Sun","year":"2015","journal-title":"World J Gastroenterol"}],"container-title":["Gastroenterolog\u00eda y Hepatolog\u00eda"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0210570520300224?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0210570520300224?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T12:43:38Z","timestamp":1759322618000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0210570520300224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S0210570520300224"],"URL":"https:\/\/doi.org\/10.1016\/j.gastrohep.2020.01.002","relation":{},"ISSN":["0210-5705"],"issn-type":[{"value":"0210-5705","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Melanosis coli: A comprehensive review","name":"articletitle","label":"Article Title"},{"value":"Gastroenterolog\u00eda y Hepatolog\u00eda","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gastrohep.2020.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}