{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:15:27Z","timestamp":1790176527084,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterolog\u00eda y Hepatolog\u00eda"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.gastrohep.2020.03.015","type":"journal-article","created":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T18:47:18Z","timestamp":1600195638000},"page":"640-648","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy and Safety of Tenofovir in the Prevention of Perinatal Transmission of Hepatitis B, a Meta-Analysis"],"prefix":"10.1016","volume":"43","author":[{"given":"Qingqing","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kecelia T.","family":"Flomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gastrohep.2020.03.015_bib0140","unstructured":"WHO. Global hepatitis report. 2017 http:\/\/publications\/global hepatitis-report 2017\/en\/. Accessed on Oct 18, 2017."},{"key":"10.1016\/j.gastrohep.2020.03.015_bib0145","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.jhep.2014.04.038","article-title":"Efficacy and safety of tenofovir disoproxil fumarate in pregnancy to prevent perinatal transmission of hepatitis B virus","volume":"61","author":"Astrid-Jane Greenup","year":"2014","journal-title":"J. Hepatol."},{"key":"10.1016\/j.gastrohep.2020.03.015_bib0150","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.1016\/j.vaccine.2013.04.083","article-title":"Post-vaccination serological test results of infants at risk of perinatal transmission of hepatitis B using an intensified follow-up programme in a London centre","volume":"31","author":"Cheuk","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.gastrohep.2020.03.015_bib0155","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1056\/NEJMoa1508660","article-title":"Transmission in Mothers with High Viral Load[J]","volume":"374","author":"Pan","year":"2016","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.gastrohep.2020.03.015_bib0160","doi-asserted-by":"crossref","first-page":"4132","DOI":"10.1038\/s41598-017-04479-x","article-title":"Efficacy and safety of tenofovir disoproxil fumarate in preventing vertical transmission of hepatitis B in pregnancies with high viral load","volume":"7","author":"Jun-Ze Chen","year":"2017","journal-title":"Sci Rep."},{"key":"10.1016\/j.gastrohep.2020.03.015_bib0165","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1007\/s10096-012-1557-2","article-title":"The efficacy and safety of antiviral therapy with lamivudine to stop the vertical transmission of hepatitis B virus","volume":"31","author":"Yu","year":"2012","journal-title":"Eur J Clin Microbiol Infect Dis."},{"key":"10.1016\/j.gastrohep.2020.03.015_bib0170","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1365-2893.2008.01056.x","article-title":"Lamivudine in late pregnancy to prevent perinatal transmission of hepatitis B virus infection: a multicentre, randomized, double-blind, placebo-controlled study","volume":"16","author":"Xu","year":"2009","journal-title":"J Viral Hepat."},{"key":"10.1016\/j.gastrohep.2020.03.015_bib0175","doi-asserted-by":"crossref","first-page":"452","DOI":"10.4254\/wjh.v8.i9.452","article-title":"Comprehensive review of telbivudine in pregnant women with chronic hepatitis B","volume":"8","author":"Piratvisuth","year":"2016","journal-title":"World J Hepatol."},{"key":"10.1016\/j.gastrohep.2020.03.015_bib0180","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1007\/s10620-012-2187-3","article-title":"Tenofovir disoproxil fumarate for prevention of vertical transmission of hepatitis B virus infection by highly viremic pregnant women: a case series","volume":"57","author":"Pan","year":"2012","journal-title":"Dig Dis Sci."},{"key":"10.1016\/j.gastrohep.2020.03.015_bib0185","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/hep.28302","article-title":"Antiviral therapy in chronic hepatitis B viral infection during pregnancy: a systematic review and meta-analysis","volume":"63","author":"Brown","year":"2016","journal-title":"Hepatology."},{"issue":"4.","key":"10.1016\/j.gastrohep.2020.03.015_bib0190","article-title":"Update on Prevention, Diagnosis, and Treatment and of Chronic Hepatitis B: AASLD 2018 Hepatitis B Guidance[J]","volume":"67","author":"Terrault","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.gastrohep.2020.03.015_bib0195","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/hep.27837","article-title":"Efficacy of Maternal Tenofovir Disoproxil Fumarate in Interrupting Mother-to-Infant Transmission of Hepatitis B Virus","volume":"62","author":"Chen","year":"2015","journal-title":"HEPATOLOGY"},{"key":"10.1016\/j.gastrohep.2020.03.015_bib0200","first-page":"306","article-title":"Decreased neonatal hepatitis B virus (HBV) viremia by maternal tenofovir treatment predicts reduced chronic HBV infection in children born to highly viremic mothers.[J] .Aliment","volume":"50","author":"Chang","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.gastrohep.2020.03.015_bib0205","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/jvh.12436","article-title":"Clinical course of 161 untreated and tenofovir-treated chronic hepatitis B pregnant patients in a low hepatitis B virus endemic region","volume":"23","author":"Samadi Kochaksaraei","year":"2016","journal-title":"Journal of Viral Hepatitis"},{"key":"10.1016\/j.gastrohep.2020.03.015_bib0210","doi-asserted-by":"crossref","first-page":"9377","DOI":"10.3748\/wjg.v19.i48.9377","article-title":"Efficacy and safety of tenofovir disoproxil fumarate in pregnancy for the prevention of vertical transmission of HBV infection","volume":"19","author":"Celen","year":"2013","journal-title":"World J Gastroenterol"},{"issue":"1.","key":"10.1016\/j.gastrohep.2020.03.015_bib0215","article-title":"Efficacy of tenofovir in preventing perinatal transmission of HBV infection in pregnant women with high viral loads[J]","volume":"8","author":"Lin","year":"2018","journal-title":"Scientific Reports"},{"issue":"s1","key":"10.1016\/j.gastrohep.2020.03.015_bib0220","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1478-3231.2008.01933.x","article-title":"Hepatitis B and pregnancy: an underestimated issue[J]","volume":"29","author":"Jonas","year":"2009","journal-title":"Liver International"},{"key":"10.1016\/j.gastrohep.2020.03.015_bib0225","first-page":"1","article-title":"Maternal Hepatitis B Virus Infection and Pregnancy Outcomes: A Hospital-based Case-control Study in Wuhan, China[J]","volume":"52","author":"Wan","year":"2017","journal-title":"Journal of Clinical Gastroenterology"},{"key":"10.1016\/j.gastrohep.2020.03.015_bib0230","first-page":"CD008545","article-title":"Hepatitis B immunoglobulin during pregnancy for prevention of mother-to-child transmission of hepatitis B virus[J]","volume":"2","author":"Eke","year":"2017","journal-title":"Cochrane database of systematic reviews (Online)"},{"key":"10.1016\/j.gastrohep.2020.03.015_bib0235","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.cgh.2011.10.041","article-title":"An Algorithm for Risk Assessment and Intervention of Mother to Child Transmission of Hepatitis B Virus[J]","volume":"10","author":"Pan","year":"2012","journal-title":"Clinical Gastroenterology and Hepatology"},{"key":"10.1016\/j.gastrohep.2020.03.015_bib0240","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1086\/514133","article-title":"Low Detection Rate and Maternal Provenance of Hepatitis B Virus S Gene Mutants in Cases of Failed Postnatal Immunoprophylaxis in England and Wales[J]","volume":"176","author":"Ngui","year":"1997","journal-title":"The Journal of Infectious Diseases"},{"key":"10.1016\/j.gastrohep.2020.03.015_bib0245","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s12876-018-0847-2","article-title":"Efficacy and safety of tenofovir in preventing mother-to-infant transmission of hepatitis B virus: a meta-analysis based on 6 studies from China and 3 studies from other countries[J]","volume":"18","author":"Wenhui","year":"2018","journal-title":"BMC Gastroenterology"},{"issue":"suppl 1.","key":"10.1016\/j.gastrohep.2020.03.015_bib0250","article-title":"Systematic review with meta-analysis: The efficacy and safety of tenofovir to prevent mother-to-child transmission of hepatitis B virus[J]","volume":"45","author":"Hyun","year":"2017","journal-title":"Alimentary Pharmacology & Therapeutics"},{"key":"10.1016\/j.gastrohep.2020.03.015_bib0255","doi-asserted-by":"crossref","first-page":"4132","DOI":"10.1038\/s41598-017-04479-x","article-title":"Efficacy and safety of tenofovir disoproxil fumarate in preventing vertical transmission of hepatitis B in pregnancies with high viral load[J]","volume":"7","author":"Chen","year":"2017","journal-title":"Scientific Reports"},{"key":"10.1016\/j.gastrohep.2020.03.015_bib0260","doi-asserted-by":"crossref","unstructured":"Antiviral therapy in chronic hepatitis B viral infection during pregnancy: A systematic review and meta-analysis[J]. Hepatology, 2016, 63.(1).","DOI":"10.1002\/hep.28302"},{"key":"10.1016\/j.gastrohep.2020.03.015_bib0265","doi-asserted-by":"crossref","DOI":"10.1111\/liv.13716","article-title":"ALT flares during nucleotide analogue therapy are associated with HBsAg loss in genotype A HBeAg-positive chronic hepatitis B[J]","author":"Wong","year":"2018","journal-title":"Liver International"},{"key":"10.1016\/j.gastrohep.2020.03.015_bib0270","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1111\/apt.12726","article-title":"Anti-viral therapy for prevention of perinatal HBV transmission: extending therapy beyond birth does not protect against post-partum flare[J]","volume":"39","author":"Nguyen","year":"2014","journal-title":"Alimentary Pharmacology & Therapeutics"}],"container-title":["Gastroenterolog\u00eda y Hepatolog\u00eda"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0210570520302260?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0210570520302260?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T12:43:48Z","timestamp":1759322628000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0210570520302260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S0210570520302260"],"URL":"https:\/\/doi.org\/10.1016\/j.gastrohep.2020.03.015","relation":{},"ISSN":["0210-5705"],"issn-type":[{"value":"0210-5705","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and Safety of Tenofovir in the Prevention of Perinatal Transmission of Hepatitis B, a Meta-Analysis","name":"articletitle","label":"Article Title"},{"value":"Gastroenterolog\u00eda y Hepatolog\u00eda","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gastrohep.2020.03.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}]}}