{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:01:13Z","timestamp":1790424073464,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Genetics &amp; Development"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1016\/j.gde.2007.02.003","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T07:16:43Z","timestamp":1172042203000},"page":"121-125","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["MeCP2 in Rett syndrome: transcriptional repressor or chromatin architectural protein?"],"prefix":"10.1016","volume":"17","author":[{"given":"Lisa Helbling","family":"Chadwick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A","family":"Wade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gde.2007.02.003_bib1","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrg1655","article-title":"DNA methylation and human disease","volume":"6","author":"Robertson","year":"2005","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.gde.2007.02.003_bib2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/13810","article-title":"Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2","volume":"23","author":"Amir","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/j.gde.2007.02.003_bib3","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1002\/bies.10008","article-title":"Methyl CpG-binding proteins and transcriptional repression","volume":"23","author":"Wade","year":"2001","journal-title":"Bioessays"},{"key":"10.1016\/j.gde.2007.02.003_bib4","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/30764","article-title":"Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex","volume":"393","author":"Nan","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.gde.2007.02.003_bib5","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/561","article-title":"Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription","volume":"19","author":"Jones","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.gde.2007.02.003_bib6","doi-asserted-by":"crossref","first-page":"34115","DOI":"10.1074\/jbc.M105747200","article-title":"The Ski protein family is required for MeCP2-mediated transcriptional repression","volume":"276","author":"Kokura","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.gde.2007.02.003_bib7","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1093\/emboj\/21.6.1389","article-title":"In vivo repression of an erythroid-specific gene by distinct corepressor complexes","volume":"21","author":"Rietveld","year":"2002","journal-title":"EMBO J"},{"key":"10.1016\/j.gde.2007.02.003_bib8","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00439-004-1200-0","article-title":"The impact of MECP2 mutations in the expression patterns of Rett syndrome patients","volume":"116","author":"Ballestar","year":"2005","journal-title":"Hum Genet"},{"key":"10.1016\/j.gde.2007.02.003_bib9","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1006\/nbdi.2001.0428","article-title":"Gene expression profiling in postmortem Rett Syndrome brain: differential gene expression and patient classification","volume":"8","author":"Colantuoni","year":"2001","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.gde.2007.02.003_bib10","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1093\/hmg\/ddi229","article-title":"Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome","volume":"14","author":"Nuber","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.gde.2007.02.003_bib11","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1471-2350-3-12","article-title":"Gene expression patterns vary in clonal cell cultures from Rett syndrome females with eight different MECP2 mutations","volume":"3","author":"Traynor","year":"2002","journal-title":"BMC Med Genet"},{"key":"10.1016\/j.gde.2007.02.003_bib12","doi-asserted-by":"crossref","first-page":"15536","DOI":"10.1073\/pnas.242566899","article-title":"Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain","volume":"99","author":"Tudor","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.gde.2007.02.003_bib13","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1126\/science.1086446","article-title":"Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2","volume":"302","author":"Chen","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.gde.2007.02.003_bib14","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1126\/science.1090842","article-title":"DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation","volume":"302","author":"Martinowich","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.gde.2007.02.003_bib15","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/0896-6273(93)90335-O","article-title":"Multiple promoters direct tissue-specific expression of the rat BDNF gene","volume":"10","author":"Timmusk","year":"1993","journal-title":"Neuron"},{"key":"10.1016\/j.gde.2007.02.003_bib16","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1523\/JNEUROSCI.23-07-02572.2003","article-title":"Upstream stimulatory factors are mediators of Ca2+-responsive transcription in neurons","volume":"23","author":"Chen","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.gde.2007.02.003_bib17","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0896-6273(00)81011-9","article-title":"Identification of a signaling pathway involved in calcium regulation of BDNF expression","volume":"20","author":"Shieh","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.gde.2007.02.003_bib18","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0896-6273(00)81010-7","article-title":"Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism","volume":"20","author":"Tao","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.gde.2007.02.003_bib19","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0896-6273(01)00561-X","article-title":"A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF","volume":"33","author":"Tao","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.gde.2007.02.003_bib20","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1074\/jbc.M210256200","article-title":"The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation","volume":"278","author":"Fuks","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.gde.2007.02.003_bib21_1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.neuron.2005.12.027","article-title":"The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression","volume":"49","author":"Chang","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.gde.2007.02.003_bib22","doi-asserted-by":"crossref","first-page":"12560","DOI":"10.1073\/pnas.0506071102","article-title":"Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome","volume":"102","author":"Dani","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.gde.2007.02.003_bib23","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1128\/MCB.17.1.309","article-title":"A 5\u2032 differentially methylated sequence and the 3\u2032-flanking region are necessary for H19 transgene imprinting","volume":"17","author":"Elson","year":"1997","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.gde.2007.02.003_bib24","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/hmg\/ddg022","article-title":"Epigenetic modifications in an imprinting cluster are controlled by a hierarchy of DMRs suggesting long-range chromatin interactions","volume":"12","author":"Lopes","year":"2003","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.gde.2007.02.003_bib25","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/ng1410","article-title":"Microdeletions in the human H19 DMR result in loss of IGF2 imprinting and Beckwith-Wiedemann syndrome","volume":"36","author":"Sparago","year":"2004","journal-title":"Nat Genet"},{"key":"10.1016\/j.gde.2007.02.003_bib26","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/ng1731","article-title":"Identification of an imprinting control region affecting the expression of all transcripts in the Gnas cluster","volume":"38","author":"Williamson","year":"2006","journal-title":"Nat Genet"},{"key":"10.1016\/j.gde.2007.02.003_bib27","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/39631","article-title":"Imprinted expression of the Igf2r gene depends on an intronic CpG island","volume":"389","author":"Wutz","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.gde.2007.02.003_bib28","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/0092-8674(92)90610-O","article-title":"Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA","volume":"69","author":"Lewis","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.gde.2007.02.003_bib29","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s00439-002-0724-4","article-title":"MECP2 mutations in Rett syndrome adversely affect lymphocyte growth, but do not affect imprinted gene expression in blood or brain","volume":"110","author":"Balmer","year":"2002","journal-title":"Hum Genet"},{"key":"10.1016\/j.gde.2007.02.003_bib30_1","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1093\/hmg\/ddi097","article-title":"MeCP2 deficiency in Rett syndrome causes epigenetic aberrations at the PWS\/AS imprinting center that affects UBE3A expression","volume":"14","author":"Makedonski","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.gde.2007.02.003_bib31_1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1093\/hmg\/ddi045","article-title":"Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3","volume":"14","author":"Samaco","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.gde.2007.02.003_bib32_1","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1093\/hmg\/ddl146","article-title":"Ube3a expression is not altered in Mecp2 mutant mice","volume":"15","author":"Jordan","year":"2006","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.gde.2007.02.003_bib33_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/ng1491","article-title":"Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome","volume":"37","author":"Horike","year":"2005","journal-title":"Nat Genet"},{"key":"10.1016\/j.gde.2007.02.003_bib34","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S0888-7543(03)00052-1","article-title":"A new imprinted cluster on the human chromosome 7q21-q31, identified by human-mouse monochromosomal hybrids","volume":"81","author":"Okita","year":"2003","journal-title":"Genomics"},{"key":"10.1016\/j.gde.2007.02.003_bib35","doi-asserted-by":"crossref","first-page":"32181","DOI":"10.1074\/jbc.M305308200","article-title":"Chromatin compaction by human MeCP2. Assembly of novel secondary chromatin structures in the absence of DNA methylation","volume":"278","author":"Georgel","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.gde.2007.02.003_bib36_1","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1093\/hmg\/ddl124","article-title":"Inhibitors of differentiation (ID1, ID2, ID3 and ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome","volume":"15","author":"Peddada","year":"2006","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.gde.2007.02.003_bib37_1","doi-asserted-by":"crossref","first-page":"5033","DOI":"10.1128\/MCB.01665-05","article-title":"Gene expression analysis exposes mitochondrial abnormalities in a mouse model of Rett syndrome","volume":"26","author":"Kriaucionis","year":"2006","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.gde.2007.02.003_bib38","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1126\/science.1100576","article-title":"Chromatin compaction by a Polycomb group protein complex","volume":"306","author":"Francis","year":"2004","journal-title":"Science"}],"container-title":["Current Opinion in Genetics &amp; Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959437X07000317?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959437X07000317?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T11:33:58Z","timestamp":1760700838000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959437X07000317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["S0959437X07000317"],"URL":"https:\/\/doi.org\/10.1016\/j.gde.2007.02.003","relation":{},"ISSN":["0959-437X"],"issn-type":[{"value":"0959-437X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MeCP2 in Rett syndrome: transcriptional repressor or chromatin architectural protein?","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Genetics & Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gde.2007.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}