{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:38:36Z","timestamp":1787837916154,"version":"build-2784847793"},"reference-count":43,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["bmn.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Opinion in Genetics &amp; Development"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.gde.2013.04.001","type":"journal-article","created":{"date-parts":[[2013,5,21]],"date-time":"2013-05-21T07:15:51Z","timestamp":1369120551000},"page":"461-469","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Genetic dissection of ventral folding morphogenesis in mouse: embryonic visceral endoderm-supplied BMP2 positions head and heart"],"prefix":"10.1016","volume":"23","author":[{"given":"Svetlana","family":"Gavrilov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Lacy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.gde.2013.04.001_bib0005","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/ajmg.c.30176","article-title":"The embryology of body wall closure: relevance to gastroschisis and other ventral body wall defects","volume":"148C","author":"Sadler","year":"2008","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"10.1016\/j.gde.2013.04.001_bib0010","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/ajmg.c.30179","article-title":"Animal models of ventral body wall closure defects: a personal perspective on gastroschisis","volume":"148C","author":"Williams","year":"2008","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"10.1016\/j.gde.2013.04.001_bib0015","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1007\/s00383-010-2701-7","article-title":"Clinical risk factors for gastroschisis and omphalocele in humans: a review of the literature","volume":"26","author":"Frolov","year":"2010","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.gde.2013.04.001_bib0020","series-title":"The Atlas of Mouse Development","author":"Kaufman","year":"1992"},{"key":"10.1016\/j.gde.2013.04.001_bib0025","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1053\/j.sempedsurg.2010.03.006","article-title":"The embryologic origin of ventral body wall defects","volume":"19","author":"Sadler","year":"2010","journal-title":"Semin Pediatr Surg"},{"key":"10.1016\/j.gde.2013.04.001_bib0030","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/BF00174084","article-title":"The development of the myocardium and endocardium in mouse embryos. Fusion of two heart tubes?","volume":"185","author":"DeRuiter","year":"1992","journal-title":"Anat Embryol (Berl)"},{"key":"10.1016\/j.gde.2013.04.001_bib0035","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ydbio.2005.01.003","article-title":"Distinct populations of endoderm cells converge to generate the embryonic liver bud and ventral foregut tissues","volume":"280","author":"Tremblay","year":"2005","journal-title":"Dev Biol"},{"key":"10.1016\/j.gde.2013.04.001_bib0040","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.mod.2008.04.001","article-title":"Regionalisation of the endoderm progenitors and morphogenesis of the gut portals of the mouse embryo","volume":"125","author":"Franklin","year":"2008","journal-title":"Mech Dev"},{"key":"10.1016\/j.gde.2013.04.001_bib0045","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.1242\/dev.128.18.3623","article-title":"The organizer of the mouse gastrula is composed of a dynamic population of progenitor cells for the axial mesoderm","volume":"128","author":"Kinder","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.gde.2013.04.001_bib0050","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0925-4773(97)00204-9","article-title":"The prechordal midline of the chondrocranium is defective in Goosecoid-1 mouse mutants","volume":"72","author":"Belo","year":"1998","journal-title":"Mech Dev"},{"key":"10.1016\/j.gde.2013.04.001_bib0055","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.devcel.2007.10.016","article-title":"Live imaging and genetic analysis of mouse notochord formation reveals regional morphogenetic mechanisms","volume":"13","author":"Yamanaka","year":"2007","journal-title":"Dev Cell"},{"key":"10.1016\/j.gde.2013.04.001_bib0060","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ydbio.2008.11.022","article-title":"Mouse Shh is required for prechordal plate maintenance during brain and craniofacial morphogenesis","volume":"327","author":"Aoto","year":"2009","journal-title":"Dev Biol"},{"key":"10.1016\/j.gde.2013.04.001_bib0065","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.gde.2010.05.008","article-title":"Cellular dynamics in the early mouse embryo: from axis formation to gastrulation","volume":"20","author":"Nowotschin","year":"2010","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/j.gde.2013.04.001_bib0070","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0012-1606(86)90253-8","article-title":"Cell fate and cell lineage in the endoderm of the presomite mouse embryo, studied with an intracellular tracer","volume":"115","author":"Lawson","year":"1986","journal-title":"Dev Biol"},{"key":"10.1016\/j.gde.2013.04.001_bib0075","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1242\/dev.101.3.627","article-title":"Cell fate, morphogenetic movement and population kinetics of embryonic endoderm at the time of germ layer formation in the mouse","volume":"101","author":"Lawson","year":"1987","journal-title":"Development"},{"key":"10.1016\/j.gde.2013.04.001_bib0080","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1242\/dev.113.3.891","article-title":"Clonal analysis of epiblast fate during germ layer formation in the mouse embryo","volume":"113","author":"Lawson","year":"1991","journal-title":"Development"},{"key":"10.1016\/j.gde.2013.04.001_sbref0085","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.devcel.2008.07.017","article-title":"The endoderm of the mouse embryo arises by dynamic widespread intercalation of embryonic and extraembryonic lineages","volume":"15","author":"Kwon","year":"2008","journal-title":"Dev Cell"},{"key":"10.1016\/j.gde.2013.04.001_bib0090","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1242\/dev.122.10.2977","article-title":"Mice deficient for BMP2 are nonviable and have defects in amnion\/chorion and cardiac development","volume":"122","author":"Zhang","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.gde.2013.04.001_bib0095","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1242\/dev.126.3.535","article-title":"BMP signaling plays a role in visceral endoderm differentiation and cavitation in the early mouse embryo","volume":"126","author":"Coucouvanis","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.gde.2013.04.001_bib0100","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1006\/dbio.2001.0173","article-title":"Cooperation of endoderm-derived BMP2 and extraembryonic ectoderm-derived BMP4 in primordial germ cell generation in the mouse","volume":"232","author":"Ying","year":"2001","journal-title":"Dev Biol"},{"key":"10.1016\/j.gde.2013.04.001_bib0105","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1242\/dev.02413","article-title":"Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning","volume":"133","author":"Mesnard","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.gde.2013.04.001_bib0110","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1083\/jcb.200808044","article-title":"Antagonism between Smad1 and Smad2 signaling determines the site of distal visceral endoderm formation in the mouse embryo","volume":"184","author":"Yamamoto","year":"2009","journal-title":"J Cell Biol"},{"key":"10.1016\/j.gde.2013.04.001_sbref0115","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.devcel.2011.08.027","article-title":"Anterior visceral endoderm directs ventral morphogenesis and placement of head and heart via BMP2 expression","volume":"21","author":"Madabhushi","year":"2011","journal-title":"Dev Cell"},{"key":"10.1016\/j.gde.2013.04.001_bib0120","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1101\/gad.9.24.3027","article-title":"Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis","volume":"9","author":"Mishina","year":"1995","journal-title":"Genes Dev"},{"key":"10.1016\/j.gde.2013.04.001_bib0125","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1006\/dbio.1994.1350","article-title":"Expression of TGF-beta s and their receptors during implantation and organogenesis of the mouse embryo","volume":"166","author":"Roelen","year":"1994","journal-title":"Dev Biol"},{"key":"10.1016\/j.gde.2013.04.001_bib0130","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1101\/gad.9.17.2105","article-title":"Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse","volume":"9","author":"Winnier","year":"1995","journal-title":"Genes Dev"},{"key":"10.1016\/j.gde.2013.04.001_bib0135","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ydbio.2004.01.048","article-title":"BMP receptor IA is required in the mammalian embryo for endodermal morphogenesis and ectodermal patterning","volume":"270","author":"Davis","year":"2004","journal-title":"Dev Biol"},{"key":"10.1016\/j.gde.2013.04.001_bib0140","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1016\/j.bbagen.2012.08.025","article-title":"The TGFbeta superfamily in stem cell biology and early mammalian embryonic development","volume":"1830","author":"Beyer","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.gde.2013.04.001_bib0145","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1242\/dev.126.8.1631","article-title":"Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects","volume":"126","author":"Chang","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.gde.2013.04.001_bib0150","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nrg2084","article-title":"Gene function in mouse embryogenesis: get set for gastrulation","volume":"8","author":"Tam","year":"2007","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.gde.2013.04.001_bib0155","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1242\/dev.060095","article-title":"Cell fate decisions and axis determination in the early mouse embryo","volume":"139","author":"Takaoka","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.gde.2013.04.001_sbref0160","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/ncb2251","article-title":"Origin and role of distal visceral endoderm, a group of cells that determines anterior\u2013posterior polarity of the mouse embryo","volume":"13","author":"Takaoka","year":"2011","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.gde.2013.04.001_bib0165","doi-asserted-by":"crossref","first-page":"e17620","DOI":"10.1371\/journal.pone.0017620","article-title":"Correct patterning of the primitive streak requires the anterior visceral endoderm","volume":"6","author":"Stuckey","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.gde.2013.04.001_bib0170","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/dvg.20695","article-title":"Afp::mCherry, a red fluorescent transgenic reporter of the mouse visceral endoderm","volume":"49","author":"Viotti","year":"2011","journal-title":"Genesis"},{"key":"10.1016\/j.gde.2013.04.001_sbref0175","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1089\/scd.2011.0293","article-title":"Bone morphogenetic protein-2-induced signaling and osteogenesis is regulated by cell shape, RhoA\/ROCK, and cytoskeletal tension","volume":"21","author":"Wang","year":"2012","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.gde.2013.04.001_sbref0180","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1741-7007-10-37","article-title":"BMP2 and mechanical loading cooperatively regulate immediate early signalling events in the BMP pathway","volume":"10","author":"Kopf","year":"2012","journal-title":"BMC Biol"},{"key":"10.1016\/j.gde.2013.04.001_sbref0185","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1101\/gad.11.8.1048","article-title":"GATA4 transcription factor is required for ventral morphogenesis and heart tube formation","volume":"11","author":"Kuo","year":"1997","journal-title":"Genes Dev"},{"key":"10.1016\/j.gde.2013.04.001_sbref0190","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1101\/gad.11.8.1061","article-title":"Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis","volume":"11","author":"Molkentin","year":"1997","journal-title":"Genes Dev"},{"key":"10.1016\/j.gde.2013.04.001_sbref0195","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1101\/gad.13.11.1475","article-title":"Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis","volume":"13","author":"Komada","year":"1999","journal-title":"Genes Dev"},{"key":"10.1016\/j.gde.2013.04.001_bib0200","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1242\/dev.127.2.245","article-title":"Tissue-specific requirements for the proprotein convertase furin\/SPC1 during embryonic turning and heart looping","volume":"127","author":"Constam","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.gde.2013.04.001_sbref0205","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ydbio.2008.03.021","article-title":"Ventral closure, headfold fusion and definitive endoderm migration defects in mouse embryos lacking the fibronectin leucine-rich transmembrane protein FLRT3","volume":"318","author":"Maretto","year":"2008","journal-title":"Dev Biol"},{"key":"10.1016\/j.gde.2013.04.001_sbref0210","doi-asserted-by":"crossref","first-page":"4863","DOI":"10.1242\/dev.125.24.4863","article-title":"Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin","volume":"125","author":"Roebroek","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.gde.2013.04.001_bib0215","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1002\/bies.20137","article-title":"Finally, a sense of closure? Animal models of human ventral body wall defects","volume":"26","author":"Brewer","year":"2004","journal-title":"Bioessays"}],"container-title":["Current Opinion in Genetics &amp; Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959437X13000555?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0959437X13000555?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T11:42:32Z","timestamp":1760701352000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0959437X13000555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S0959437X13000555"],"URL":"https:\/\/doi.org\/10.1016\/j.gde.2013.04.001","relation":{},"ISSN":["0959-437X"],"issn-type":[{"value":"0959-437X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic dissection of ventral folding morphogenesis in mouse: embryonic visceral endoderm-supplied BMP2 positions head and heart","name":"articletitle","label":"Article Title"},{"value":"Current Opinion in Genetics & Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.gde.2013.04.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}